TCM Prescription: Qian Yin Syrup



Prescription Description
Prescription IDTCMF1574
Pinyin NameQian Yin Tang Jiang
Chinese Name
English NameQian Yin Syrup
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2217 NA 茜草 TCMH2217
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 10.574
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, SLC6A3, SRC, TYR 10.4105
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, SLC6A3, SRC, TYR 10.3324
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, SLC6A2, SLC6A3, SRC, TYR 9.54468
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.44334
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FLT3, HSD11B2, SLC6A3, SRC, TYR 9.12426
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.27706
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, SLC6A3, SRC 8.14981
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET 7.96839
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.92178
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 7.42303
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 7.42303
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 7.42303
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.34669
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 7.03823
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 7.02109
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, GBA2, SLC6A3, TYR 6.902
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82396
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, SLC6A2, SLC6A3, SRC, TNKS2, TYR 6.72257
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, XDH 6.39993
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.33699
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, KIT, MMP2, SRC 6.32949
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, XDH 6.25806
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.25806
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 6.11943
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.97679
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.82866
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HSD11B2, KDR, SLC6A2, SLC6A3, SRC 5.74589
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.6961
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.6961
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 5.62421
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, SRC 5.54429
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1 5.53972
[BP] GO:0007193 None DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 5.43522
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, SLC6A3, TYR 5.3645
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, SLC6A3 5.28268
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, KDR, SLC6A3, SRC 5.28268
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, SRC, TYR 5.27683
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 5.26985
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, SRC 5.20522
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.17856
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, SLC1A1 5.1429
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, SRC 5.1429
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 5.11449
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 5.05569
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, DRD2, DRD4, F3, FLT3, GRM1, KDR, KIT, MET, PTPN1, SRC, XDH 5.03339
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESRRA, F3, FABP4, FLT3, GRM1, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.03339
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2 4.92088
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PIM1, TYR, XDH 4.92088
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, DRD3, F3, KIT, MET, SRC, XDH 4.82407
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, SLC6A2, SLC6A3, SRC, TYR 4.80735
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PTPN1, SRC, TNKS 4.74867
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, SLC6A3, SRC, TNKS2, TYR 4.52924
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 4.52924
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 4.51601
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, SLC6A3, TNKS2 4.49108
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.47933
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.46026
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.37929
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37929
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 4.3013
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, CDC25B, DRD2, DRD3, DRD4, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 4.25845
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3 4.24591
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, SLC6A3 4.24589
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, CDC25B, DRD2, DRD3, DRD4, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 4.21452
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, SRC 4.20856
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, SLC6A3, SRC, TYR 4.20856
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.20856
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, SLC6A3, SRC, TYR 4.19973
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, DRD3, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 4.1611
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.14017
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, SLC1A1 4.14017
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.09669
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.09669
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.09429
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 4.08806
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.06904
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.06625
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.97946
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, KIT, SRC 3.95057
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.95057
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, DRD2, DRD3, KDR, SRC, TNKS, TNKS2 3.90822
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.90822
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, SLC6A3, SRC, TYR 3.88797
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.88454
[BP] GO:0007268 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.88454
[BP] GO:0098916 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.88454
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.88454
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.88454
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.84349
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.84074
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.84074
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, GBA2, KIT, MET 3.84074
[BP] GO:0099536 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.82431
[BP] GO:0099537 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.82431
[BP] GO:0007188 None DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 3.73524
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SLC6A3, SRC, TNKS, TNKS2, XDH 3.73524
[BP] GO:0042327 positive regulation of phosphorylation APP, BCL2, CDC25B, DRD2, DRD4, ESRRB, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.7349
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, APP, AURKB, BCL2, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.7102
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.67706
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, KIT, MMP9, PTPN1, SRC, TNKS, XDH 3.65809
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, SLC1A1, SLC6A2, SLC6A3 3.62367
[BP] GO:0048169 None APP, DRD2, GRM5, KIT 3.61488
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.6118
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC 3.6118
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 3.603
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.56303
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD2, GRM1, GRM3, GRM5, GRM8 3.56303
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.56303
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.55903
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.53793
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.51981
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.51981
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.51981
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.51981
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.51981
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.51981
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.51981
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.49449
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SLC6A3, SRC, XDH 3.49215
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.48316
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.4717
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, SRC 3.4516
[BP] GO:0007626 None APP, DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 3.42876
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, GRM1, GRM5 3.42675
[BP] GO:0007187 None DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 3.37385
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.37385
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.33387
[BP] GO:0001934 positive regulation of protein phosphorylation APP, BCL2, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.33008
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.3142
[BP] GO:0032879 regulation of localization ACHE, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F3, GRIK5, GRM5, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC 3.29797
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.29797
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.28924
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.28924
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.26965
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.2519
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.2519
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.2519
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8 3.2519
[BP] GO:0044093 positive regulation of molecular function APP, AURKB, BCL2, CDC25B, DRD2, DRD4, ESR1, ESR2, F3, FLT3, GRM1, GRM5, KIT, MET, MMP9, PTPN1, SRC, TNKS, XDH 3.25144
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.23976
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8 3.22887
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 3.20117
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.18734
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.18471
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, SRC 3.14728
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.14015
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.14015
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.12982
[BP] GO:0060078 None DRD4, GRIA2, GRIA4, GRIK5, GRM5 3.10754
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.10146
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, GRM1, HSD11B2, KIT, MMP2, SRC, TYR 3.0986
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.08649
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC 3.0825
[BP] GO:0007154 None AKR1C3, AXL, BCL2, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.0825
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC 3.0825
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.06995
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.06995
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, XDH 3.06116
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC, TNKS 3.05797
[BP] GO:0042391 None APP, BCL2, DRD4, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.00577
[BP] GO:0043410 positive regulation of MAPK cascade APP, DRD2, DRD4, FLT3, GRM1, KDR, KIT, PTPN1, SRC, XDH 2.99044
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.95963
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.95963
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.95254
[BP] GO:0065009 regulation of molecular function ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, KIT, MET, MMP9, PIM1, PTPN1, SRC, TNKS, XDH 2.95008
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.95008
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.95008
[BP] GO:0016488 None AKR1B10, AKR1C3 2.93848
[BP] GO:0016487 None AKR1B10, AKR1C3 2.93848
[BP] GO:0016107 None AKR1B10, AKR1C3 2.93848
[BP] GO:0009115 None AOX1, XDH 2.93848
[BP] GO:0006714 None AKR1B10, AKR1C3 2.93848
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 2.93527
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.93527
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, TNKS, TNKS2 2.90063
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.89948
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F3, KDR, KIT, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC 2.88155
[BP] GO:0022898 None APP, BCL2, DRD2, DRD3, DRD4, GRM5, MMP9 2.88155
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRIK5, GRM1, GRM5 2.88119
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.88119
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.88119
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 2.87732
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, SRC 2.87692
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.87029
[BP] GO:0001932 regulation of protein phosphorylation APP, BCL2, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.86524
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC 2.8538
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, SRC 2.83774
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, GRM1, KDR, KIT, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC, TNKS2, XDH 2.81479
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.8051
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.76452
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 2.75581
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC 2.7508
[BP] GO:0032409 None APP, BCL2, DRD2, DRD3, DRD4, GRM5, MMP9 2.7508
[BP] GO:0003014 None AKR1B1, AKR1C3, BCL2, DRD2, HSD11B2 2.74653
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.74272
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.73327
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.73327
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, DRD2, DRD4, ESR1, F3, FLT3, GRM1, GRM5, KIT, PTPN1, SRC, TNKS, XDH 2.73327
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1 2.73327
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KIT, PTPN1, SRC, TNKS 2.73008
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.71507
[BP] GO:0008542 None APP, DRD2, DRD3, KIT 2.71493
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.69907
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.69554
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.66705
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.66705
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.64525
[BP] GO:0051247 positive regulation of protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, ESR1, F3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.64525
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, SRC 2.64079
[BP] GO:0048168 None APP, DRD2, GRM5, KIT 2.62611
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.62004
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.61728
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1 2.6133
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC 2.59642
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.59402
[BP] GO:0043408 regulation of MAPK cascade APP, DRD2, DRD4, FLT3, GRM1, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.57449
[BP] GO:0007632 None APP, DRD2, DRD3, KIT 2.57449
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.57449
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.57449
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.57449
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.57449
[BP] GO:0099566 None GRM1, GRM5 2.57449
[BP] GO:0051944 None DRD2, DRD4 2.57449
[BP] GO:0046110 None AOX1, XDH 2.57449
[BP] GO:0060160 None DRD2, DRD3 2.57449
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57449
[BP] GO:0051586 None DRD2, DRD4 2.57449
[BP] GO:0016095 None AKR1B10, AKR1C3 2.57449
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.5667
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.5667
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.56583
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.5649
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.51044
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.49976
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 2.48402
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, XDH 2.46021
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, KIT, MET, MMP2, MMP9, SRC 2.45631
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.44337
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.44107
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.4368
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.43359
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, DRD2, DRD3, DRD4, KIT, MMP9, SLC1A1, SLC6A3, XDH 2.42856
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, BCL2, CDC25B, DRD2, DRD4, ESR1, F3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.42365
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, IGF1R, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.42215
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.41117
[BP] GO:0007267 None DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.40658
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.40459
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD2, DRD3, KIT, TYR 2.40187
[BP] GO:0031401 positive regulation of protein modification process APP, BCL2, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.40187
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.40187
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.40187
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.39933
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.39439
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.37653
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD2, DRD4 2.37553
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.37326
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, HSD11B2, KIT, SLC6A3, SRC, TYR 2.36562
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.35701
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.35701
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35701
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KIT, PTPN1, SRC 2.35548
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.3541
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.35394
[BP] GO:0070213 None TNKS, TNKS2 2.34606
[BP] GO:0006145 None AOX1, XDH 2.34606
[BP] GO:0051582 None DRD2, DRD4 2.34606
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34606
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.34108
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.33304
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31673
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC 2.31513
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRIK5, GRM1, GRM5 2.31513
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, ESR2, GRIK5, IGF1R, KDR, KIT, MET, MMP1, MMP9, PTPN1, SRC, TNKS, TNKS2 2.29701
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.27692
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3 2.27425
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.26474
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.26474
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.25274
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.23708
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.2328
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 2.2328
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.2328
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.23095
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.23095
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.23095
[BP] GO:0007610 None APP, BCL2, DRD2, DRD3, DRD4, GRM1, GRM5, KIT, SLC6A3 2.22929
[BP] GO:0048638 regulation of developmental growth APP, BCL2, DRD2, DRD3, PIM1, SLC6A3, TNKS2 2.2256
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.20732
[BP] GO:0008306 None APP, DRD2, DRD3, KIT 2.19508
[BP] GO:0080090 regulation of primary metabolic process ADORA3, AKR1C3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, XDH 2.19151
[BP] GO:0007612 None APP, DRD2, DRD3, GRM5, KIT 2.19151
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.19151
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.19151
[BP] GO:0033674 positive regulation of kinase activity CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KIT, PTPN1, SRC 2.19148
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.17841
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, ESR1, FLT3, GRM5, IGF1R, KIT, MMP2, SRC 2.17436
[BP] GO:0043696 None CDK6, ESRRB 2.17436
[BP] GO:0043697 None CDK6, ESRRB 2.17436
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.17436
[BP] GO:0010641 None F3, SRC 2.17436
[BP] GO:0090325 None DRD2, DRD3 2.17436
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.17436
[BP] GO:0032412 None APP, DRD2, DRD3, DRD4, GRM5, MMP9 2.16786
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, HSD11B2, SRC, TYR 2.16611
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, SRC 2.15733
[BP] GO:0043271 negative regulation of ion transport BCL2, DRD2, DRD3, DRD4, MMP9 2.13827
[BP] GO:0032413 None DRD2, DRD3, DRD4, MMP9 2.12646
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.12609
[BP] GO:0034762 None APP, BCL2, CA2, DRD2, DRD3, DRD4, GRM5, MMP9 2.12488
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.12198
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.12198
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB 2.11732
[BP] GO:0023052 None DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.11721
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, SRC 2.11295
[BP] GO:0032845 None BCL2, DRD2, SRC, TNKS, TNKS2 2.10642
[BP] GO:0046717 None DRD2, DRD3, DRD4, SLC1A1 2.09418
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.09418
[BP] GO:0050730 None APP, FLT3, GRM5, KIT, PTPN1, SRC 2.09252
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.08925
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.08925
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.08925
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.08925
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.07891
[BP] GO:1900542 None DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8 2.0685
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.06256
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9 2.06256
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.06174
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, MMP9 2.05672
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.05672
[BP] GO:0045744 None DRD2, DRD3, MET 2.05672
[BP] GO:0043405 regulation of MAP kinase activity DRD4, FLT3, GRM1, IGF1R, KIT, PTPN1, SRC 2.05052
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.05052
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.05052
[BP] GO:0046113 None AOX1, XDH 2.05052
[BP] GO:0032415 None DRD3, DRD4 2.05052
[BP] GO:0051934 None SLC6A2, SLC6A3 2.05052
[BP] GO:0021984 None DRD2, SLC6A3 2.05052
[BP] GO:0090494 None SLC6A2, SLC6A3 2.05052
[BP] GO:0090493 None SLC6A2, SLC6A3 2.05052
[BP] GO:0051583 None SLC6A2, SLC6A3 2.05052
[BP] GO:0016115 None AKR1B10, AKR1C3 2.05052
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, TNKS 2.05049
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, SRC, TNKS 2.0371
[BP] GO:0040018 None BCL2, DRD2, SLC6A3 2.03549
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.03549
[BP] GO:0006140 None DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8 2.02897
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, AKR1C3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SLC6A3, SRC, TNKS, TNKS2, XDH 2.01556
[BP] GO:0032410 None DRD2, DRD3, DRD4, MMP9 2.00849
[BP] GO:1904063 None DRD2, DRD3, DRD4, MMP9 2.00849
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PTPN1, XDH 2.00593
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1 2.00309
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PTPN1, XDH 2.00309
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.00309
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, SRC 2.0019
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 4.91495
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TYR 4.74867
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 4.68592
[CC] GO:0044459 plasma membrane part ADORA3, APP, AXL, CA2, CA4, CA9, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, SLC1A1, SLC6A2, SLC6A3, SRC 4.1176
[CC] GO:0044456 None ACHE, APP, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 3.90822
[CC] GO:0044425 membrane part ACHE, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 3.81885
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 3.81298
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.49215
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 3.20117
[CC] GO:0098794 None APP, DRD2, DRD4, GRIA2, GRIA4, GRM3 2.87692
[CC] GO:0043005 None APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.83741
[CC] GO:0043197 None APP, DRD2, GRIA2, GRIA4, GRM3 2.41117
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.39002
[CC] GO:0044309 None APP, DRD2, GRIA2, GRIA4, GRM3 2.39002
[CC] GO:0014069 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.37298
[CC] GO:0099572 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.37298
[CC] GO:0042995 cell projection AKR1B1, APP, CA2, CDK6, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.37142
[CC] GO:0120025 None AKR1B1, APP, CA2, CDK6, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.12488
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.05052
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PTPN1, TNKS, TYR, XDH 10.4105
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.9211
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.13783
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 8.11057
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 6.31765
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.24776
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.15992
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.01711
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CDK6, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 5.95444
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TYR, XDH 5.82866
[MF] GO:0030594 None DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.6813
[MF] GO:0004872 receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 5.54429
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.46666
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.08223
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.9383
[MF] GO:0004871 signal transducer activity ADORA3, AXL, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 4.92551
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.81312
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.66131
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PTPN1, TNKS 4.57387
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.57183
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 4.36889
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 4.36889
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.33984
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.14947
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.06625
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TYR, XDH 4.0126
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.98011
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.9268
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, KIT, MET, PIM1, SLC6A3, SRC 3.81282
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.80701
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73908
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.67654
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.56303
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.51981
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.40197
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.36239
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3 3.20154
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DRD4, ESR1, ESR2, FLT3, GRIK5, IGF1R, KDR, KIT, MET, MMP9, TYR, XDH 3.0986
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.04656
[MF] GO:0045550 None AKR1B10, AKR1C3 2.93848
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93848
[MF] GO:0003845 None HSD11B1, HSD11B2 2.93848
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.88119
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.83774
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.8051
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.68573
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.68573
[MF] GO:0047718 None AKR1B10, AKR1C3 2.57449
[MF] GO:0005330 None SLC6A2, SLC6A3 2.57449
[MF] GO:0099583 None GRM1, GRM5 2.57449
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.5667
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.5649
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.5649
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, SRC, XDH 2.51433
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.43359
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.34606
[MF] GO:0004971 None GRIA2, GRIA4 2.34606
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.32123
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.29169
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.23095
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1 2.19794
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.17436
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.17436
[MF] GO:0051721 None BCL2, PTPN1, SLC6A3 2.15941
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.05672
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05672
[MF] GO:0005329 None SLC6A2, SLC6A3 2.05052
[MF] GO:0004064 arylesterase activity CA1, CA2 2.05052
[MF] GO:0043546 None AOX1, XDH 2.05052
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.05052


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 9.6398
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 10.704
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0445
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, DRD2, DRD3, DRD4, GRM1, GRIA4 7.1785
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.9241
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.6407
Metabolic pathways_Homo sapiens_hsa01100 AKR1C3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.326
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 4.0684
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.1412
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.1412
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1412
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9539
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.2533
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, DRD2, MET, IGF1R 3.1861
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9454
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.6655
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, KIT, GRM8, GRM1 3.0503
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.0715
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.6531
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6531
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.8425
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.4728
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, MET, IGF1R 2.2814
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9397
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.1928
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.2893
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.1556
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2578
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.1928
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1928
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1928
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.1928
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.1556
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9416
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.154
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.64
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.1693
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.43
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3242
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, DRD2, GRIA4 1.1398
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0725
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2964
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0623
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0252
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2703
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9551
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0162
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0426
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0848
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0741
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1472
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0066
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0523
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2418
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9547
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3147
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9393
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8557
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2381
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9393
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9393
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8665
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.8401
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.9326
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3 1.2918
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.845
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8401
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9136
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.7124
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.7124
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7124
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6535
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4166
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6535
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2386
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2858
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.314
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3208
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3334
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3431
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3206
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3431
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3 0.3431
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3553
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3857
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3737
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3857
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3843
Platelet activation_Homo sapiens_hsa04611 SRC 0.4174
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4183
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4174
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4174
Axon guidance_Homo sapiens_hsa04360 MET 0.4125
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.4458
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4458
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4804
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4847
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.497
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4845
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4844
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5078
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.497
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.497
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.497
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.497
Peroxisome_Homo sapiens_hsa04146 XDH 0.5078
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5405
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6003
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5186
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5394
Bile secretion_Homo sapiens_hsa04976 CA2 0.547
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5669
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5669
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5538
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5669
Shigellosis_Homo sapiens_hsa05131 SRC 0.5669
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5738
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6826
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7924
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6094
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6094
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6692
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7481
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6535
Malaria_Homo sapiens_hsa05144 MET 0.6535
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6535
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6535
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6535
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7124
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9983
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7862
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8085
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8085
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8377
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8277
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9393
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.008
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0715
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2703


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)