TCM Prescription: Decoction of Gardeniae and Zingiberis



Prescription Description
Prescription IDTCMF1503
Pinyin NameZhi Zi Jiang Tang
Chinese Name栀子姜汤
English NameDecoction of Gardeniae and Zingiberis
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1059 Glycine max TCMH1059 ITSAJ4675-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT601 F2 Thrombin Unclassified P00734
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.1553
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1883
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, SRC, TERT, XDH 8.58015
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 7.98876
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT 7.98876
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 6.74038
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, PIM1, XDH 6.47752
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC 6.14099
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, IGF1R, MMP2, MMP9, SRC 5.98084
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 5.87551
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FLT3, IGF1R, KIT, MMP2, SRC 5.87551
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.86682
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1 5.51782
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 5.26785
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F2, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH 5.26591
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1 5.06339
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.827
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, SRC 4.827
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.79026
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FUT7, HSD17B1, KIT, MET 4.79026
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC 4.75344
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 4.64841
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 4.61323
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, XDH 4.55682
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, XDH 4.54012
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.46597
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, KIT, SRC 4.44213
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PIM1, SRC, TERT 4.43263
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F2, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 4.34268
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 4.34268
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 4.34268
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT 4.34268
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 4.31231
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F2, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 4.27974
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, KDR, KIT, SRC 4.20221
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 4.13254
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, SRC 4.12484
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, ESR1, F2, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, TERT 4.05855
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F2, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, XDH 4.05697
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 3.95714
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.91742
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, FABP4, FLT3, HSD17B1, KDR, KIT, MET, SRC, TERT, XDH 3.85929
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.827
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.827
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 3.75911
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC 3.71552
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, KDR, SRC 3.6561
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, F2, FLT3, KDR, KIT, MMP9, PIM1, SRC 3.58365
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 3.58182
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.37203
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, KIT, SRC 3.35896
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, F2, FLT3, IGF1R, KDR, KIT, MET, SRC 3.35896
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.35896
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 3.35889
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 3.30928
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.28326
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28326
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.261
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 3.21593
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.17245
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.16801
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MMP9, PIM1, SRC, TERT, XDH 3.12174
[BP] GO:0030334 regulation of cell migration APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.12174
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F2, FABP4, FLT3, KDR, KIT, MET, MMP2, MMP9, SRC, TERT, XDH 3.11079
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F2, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, XDH 3.10527
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.08351
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 3.0824
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F2, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC, TERT, XDH 3.08159
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 3.02445
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.00773
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, F2, FLT3, KDR, KIT, MET, SRC, XDH 2.98739
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, F2, FABP4, FLT3, MET, SRC, TERT 2.96901
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.94884
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.94784
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.94248
[BP] GO:2000145 regulation of cell motility APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.93261
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.92363
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F2, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 2.88361
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.88361
[BP] GO:0009115 None AOX1, XDH 2.88361
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, SRC 2.84307
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, SRC, TERT 2.82279
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.82279
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.82279
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.795
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 2.77916
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, KIT, SRC 2.77008
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 2.72856
[BP] GO:0040012 regulation of locomotion APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.68313
[BP] GO:0051270 regulation of cellular component movement APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.67582
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F2, FABP4, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC 2.67582
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.66273
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, KDR, SRC 2.63678
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 2.63678
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, F2, KDR, SRC 2.61939
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.60265
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, SRC 2.5608
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F2, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 2.51217
[BP] GO:0046110 None AOX1, XDH 2.50985
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50985
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.50537
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.49664
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.44013
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.44013
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, KIT 2.43657
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, KIT, MET 2.43657
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A1, ESR1, ESRRB, KIT, MMP2, MMP9, SRC 2.43657
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.43657
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 2.41875
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40486
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, SRC 2.39061
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F2, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 2.37879
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.36237
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36237
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, F2, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, XDH 2.28157
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 2.28157
[BP] GO:0006145 None AOX1, XDH 2.28157
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28157
[BP] GO:0046425 regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.27811
[BP] GO:1904892 regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.25616
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, SRC 2.25616
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.25616
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, SRC, XDH 2.24051
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.24051
[BP] GO:0032879 regulation of localization ABCB1, ACHE, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.24051
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, SRC, TERT 2.23869
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, ESR1, FLT3, IGF1R, KIT, MMP2, SRC 2.2014
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9 2.19127
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, DYRK1A, ESR1, F2, FABP4, IGF1R, MET, MMP2, SRC, TERT, XDH 2.17173
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.14792
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.12489
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.12489
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, KIT, SRC 2.12489
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 2.12282
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.11004
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.1053
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.0684
[BP] GO:0009893 positive regulation of metabolic process APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 2.05709
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, ESR1, MET, SRC 2.0443
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, ESR1, ESR2, F2, FLT3, KIT, MET, MMP9, SRC, TERT, XDH 2.0443
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1 2.03464
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH 2.50985
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA5A, CA5B, CA6, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH 2.07881
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.76996
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F2, FLT3, IGF1R, KDR, KIT, MET, MMP2, PIM1, SRC, TERT 1.70079
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, MET 1.49708
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.5721
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, XDH 15.5169
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 12.7337
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.3145
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, F2, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 11.2366
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0822
[MF] GO:0008270 zinc ion binding CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9 7.93897
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F2, KIT, MMP1, MMP2, MMP9, PIM1, TERT, XDH 7.75336
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.35077
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F2, KIT, MMP1, MMP2, MMP9, PIM1, TERT, XDH 7.2321
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.06339
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.89068
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.55682
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.17487
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.91567
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.72779
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.71552
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.71552
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, TERT, XDH 3.35896
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 3.1653
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.0824
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.96901
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.94608
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 2.88361
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.88361
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.84306
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.84306
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.82279
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.82279
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.66311
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.58948
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.52141
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, XDH 2.43601
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.41156
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH 2.40441
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.28157
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.28157
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.28157
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.12658
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.11004
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CSNK2A1, DYRK1A, F2, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.0824


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.1906
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.8775
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.764
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.9431
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 4.1459
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.2386
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.1503
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2386
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET 4.0201
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, AKR1B1, CYP19A1, XDH 3.4643
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.4643
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.9296
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.8732
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.5206
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.549
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.3584
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.4216
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, BCL2, MET, IGF1R 2.1604
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.4353
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2702
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 2.0481
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.3584
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.9935
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.2531
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.8145
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.6908
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.6099
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4789
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4132
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4938
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4124
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2694
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.4132
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2613
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1319
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2694
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1805
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.4124
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3565
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1 1.4132
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.1319
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2534
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.1251
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.1251
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1251
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9961
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0046
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.8881
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7956
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8687
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.7602
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9817
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.856
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.942
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1604
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 F2 0.305
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3231
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3938
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4445
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4344
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4917
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4211
Platelet activation_Homo sapiens_hsa04611 SRC 0.5194
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5194
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5421
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4981
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4907
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.586
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4645
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4839
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.5194
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4897
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5021
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4211
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5194
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5771
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5194
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5771
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5771
Axon guidance_Homo sapiens_hsa04360 MET 0.5148
Melanogenesis_Homo sapiens_hsa04916 KIT 0.574
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.586
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.586
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5771
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.586
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5771
Gap junction_Homo sapiens_hsa04540 SRC 0.586
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.586
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6216
Peroxisome_Homo sapiens_hsa04146 XDH 0.587
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.601
Glioma_Homo sapiens_hsa05214 IGF1R 0.6623
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6623
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6657
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6617
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6876
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6643
Shigellosis_Homo sapiens_hsa05131 SRC 0.6623
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6643
Malaria_Homo sapiens_hsa05144 MET 0.7298
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7196
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7342
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7321
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7368
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7418
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7392
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.8162
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8598
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8732
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8732
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8884
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8881
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2511
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1251
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3766


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)