TCM Prescription: Boyun Tuiyi Pills



Prescription Description
Prescription IDTCMF1452
Pinyin NameBo Yun Tui Yi Wan
Chinese Name拨云退翳丸
English NameBoyun Tuiyi Pills
Function Description风热上扰所致的目翳外障, 视物不清, 隐痛流泪
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLiver
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1487 Buddleja officinalis 密蒙花 TCMH1487 ITSAM868-14
TCMH73 Tribulus terrestris 白蒺藜 TCMH73 ITSAJ4258-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1535 Equisetum hiemale 木贼 TCMH1535
TCMH1878 Periostracum serpentis 蛇蜕 TCMH1878
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH1432 Vitex trifolia 蔓荆子 TCMH1432 ITSAO4721-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH267 Fructus broussonetiae 楮实 TCMH267
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7743
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8835
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.92708
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 8.39032
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 8.34014
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, GLO1, NISCH, PIM1, PPARA, TYR, XDH 7.94825
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.94825
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, KIT, MAOA, MET, NISCH, PPARA, PRKCA, SRC, TNKS, TNKS2, XDH 7.34956
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TNKS 7.29616
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP2, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 7.09794
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, KIT, MET, PPARA 7.07395
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PRKCA, SRC, TNKS, TOP2A 6.91915
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOA, PHF8, TYR, XDH 6.83251
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 6.68846
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, PRKCA, RORC, SRC, TYR 6.68237
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, DYRK3, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PRKCA, SRC, TOP2A, XDH 6.2347
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.16324
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, DYRK3, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCA, SRC, TOP2A, XDH 6.12837
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, NISCH 6.09532
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.99477
[BP] GO:0016310 phosphorylation AURKB, AXL, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TNKS 5.96342
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.71626
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CA9, CBR1, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK1A, DYRK1B, DYRK3, FABP4, FLT3, GLO1, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS2, TOP2A, TYR 5.44552
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PRKCA, RORC, SRC, TYR 5.42786
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.34428
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DYRK1A, DYRK1B, DYRK2, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.12535
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.09283
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PRKCA, SRC 5.00073
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA 4.98816
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.98607
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, KDR, KIT, MET, MMP12, MMP9, PRKCA, SRC, TNKS, TNKS2, XDH 4.9195
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TNKS, XDH 4.9195
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, KDR, KIT, MET, MMP12, MMP9, PRKCA, SRC, TNKS, TNKS2, XDH 4.90569
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, DYRK3, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIM1, PRKCA, SRC, TOP2A, XDH 4.90569
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.87275
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.72117
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.62927
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PRKCA, SRC 4.61312
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PRKCA, SRC 4.61312
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PRKCA, SRC 4.60295
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TNKS, XDH 4.60295
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC 4.60282
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.60236
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.59186
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.57622
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, CNR1, DRD1, HCAR2, KDR, SRC, TNKS, TNKS2 4.50291
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.47658
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK2, DYRK3, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PRKCA, SRC, TNKS, TNKS2, XDH 4.47658
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK2, DYRK3, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PRKCA, SRC, TNKS, TNKS2, XDH 4.36557
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, KDR, SRC 4.32128
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PRKCA, SRC 4.30983
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DYRK1A, DYRK1B, DYRK2, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.30983
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, KIT, MET, PPARA 4.23716
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FLT3, RORC, SRC, TYR 4.21585
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCA, SRC 4.06206
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK2, DYRK3, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.06206
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA, TNKS 4.0484
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, GLO1, HASPIN, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.02541
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK3, FABP3, FABP4, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.95245
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.9489
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK2, F3, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PPARA, PRKCA, SRC 3.89476
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA, TNKS 3.86481
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, RORC, SRC 3.84594
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.63843
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, KIT, NISCH 3.58686
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, KIT, NISCH 3.58686
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.54681
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, HCAR2, TNKS, TNKS2 3.52739
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.50847
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.50847
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.50847
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.50847
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, SRC 3.49463
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, FABP3, KDR, SRC 3.45508
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, CLK1, DRD1, DYRK1A, PRKCA, SRC, TNKS 3.40202
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 3.376
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.33634
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, MAOA 3.32193
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, HASPIN, PRKCA 3.26615
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDK6, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, SRC, XDH 3.25798
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC 3.22138
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.21826
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, KIT, PHF8, PPARA, SRC, TYR 3.21325
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, PPARA, SRC 3.21036
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.15486
[BP] GO:0018209 peptidyl-serine modification AURKB, CLK1, DRD1, DYRK1A, PRKCA, SRC, TNKS 3.13614
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, CDK6, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RORC, SRC 3.09928
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05471
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.04862
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CA6, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PPARA, PRKCA, RORC, SRC, TOP2A, TYR 3.04004
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.00848
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC 2.92033
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA 2.91662
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DYRK1A, KIT, PPARA, RORC, SRC, TOP2A 2.9045
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDK6, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.88652
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, MMP9, PIM1, PRKCA, SRC 2.84354
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.83291
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, F3, FABP4, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR 2.81439
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK1A, DYRK1B, FLT3, HSD11B1, HSD17B2, KDR, KIT, MMP9, PHF8, PIM1, PPARA, RORC, SRC, TYR 2.79554
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PRKCA, SRC 2.79344
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, DYRK3, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, SRC, XDH 2.7668
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.73543
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, SRC, TNKS 2.7218
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDK6, CSNK2A1, F3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA 2.71444
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, XDH 2.69546
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.67586
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, MAOA, TYR 2.63941
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.62755
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, F3, FLT3, KDR, KIT, MET, MMP12, MMP9, PRKCA, SRC, TNKS, TNKS2, XDH 2.60128
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, F3, FABP4, KDR, MET, MMP12, PPARA, PRKCA 2.56468
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, SRC, TNKS, TNKS2, TOP2A 2.49043
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC, TOP2A 2.47632
[BP] GO:0030335 positive regulation of cell migration DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC 2.44331
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.41756
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.38441
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, FLT3, RORC, SRC 2.33595
[BP] GO:2000147 positive regulation of cell motility DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC 2.33595
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.3349
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.32238
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK2, DYRK3, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PRKCA, SRC, TNKS, TNKS2, XDH 2.32191
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.32191
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.31732
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.29778
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.28335
[BP] GO:0051272 positive regulation of cellular component movement DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC 2.26938
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, MAOA 2.24081
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.23658
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.23658
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CNR1, CSNK2A1, CYP1B1, F3, FABP4, FLT3, KDR, KIT, MET, MMP12, MMP2, MMP9, PRKCA, SRC, TNKS, TNKS2, XDH 2.22717
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MAOA 2.18789
[BP] GO:0040017 positive regulation of locomotion DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC 2.16729
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.16426
[BP] GO:0034502 protein localization to chromosome AURKB, HASPIN, TNKS, TNKS2 2.16426
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.13779
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.13008
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.11412
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.11262
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.10239
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, IGF1R, MMP2, MMP9, RORC, SRC 2.10239
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.08739
[BP] GO:0070213 None TNKS, TNKS2 2.08739
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.08739
[BP] GO:0038171 None CNR1, CNR2 2.08739
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.08739
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.07153
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1 2.06317
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.06317
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.0511
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.0511
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC 2.0511
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.04732
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.0352
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, DRD1, DYRK1A, DYRK1B, DYRK2, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PHF8, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.02982
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, MMP1, MMP2, PHF8, PIM1, PRKCA, SRC, TNKS, TNKS2, TOP2A 2.00324
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PHF8, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.00193
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, IGF1R, KDR, KIT, MAOA, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.62809
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CLK1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, IGF1R, KDR, KIT, MAOA, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.08739
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, CA4, CA5A, CA5B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP4, FLT3, GLO1, HASPIN, IGF1R, KDR, KIT, MAOA, MMP12, MMP2, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 1.61115
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK2, DYRK3, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD17B1, HSD17B2, KDR, KIT, MAOA, MMP2, MMP9, NISCH, PIM1, PRKCA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 1.34842
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F3, FLT3, GLO1, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MET, MMP2, NISCH, PHF8, PIM1, PRKCA, SRC, TNKS, TNKS2, TYR 1.28594
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.9574
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK2, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, RORC, TNKS, TYR, XDH 16.5049
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PRKCA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 16.5049
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 14.7276
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.1086
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8835
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CLK1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PPARA, PRKCA, SRC, TOP2A 9.32096
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 8.45827
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.41126
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.30879
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOA, PHF8, TYR, XDH 8.10187
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC 7.94825
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DYRK2, DYRK3, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 7.79668
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PRKCA, RORC, TNKS 7.41259
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.88908
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK2, DYRK3, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 6.84852
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC 6.84852
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PHF8, XDH 6.74504
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC 6.29825
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.03356
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PHF8, TYR 5.68219
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.42786
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC 5.31459
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.26786
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.11992
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 4.9195
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.57622
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.4327
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.02541
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.88006
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIM1, PRKCA 3.87734
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 3.84594
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 3.69596
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 3.65716
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PRKCA, SRC 3.64133
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A, XDH 3.45237
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.18748
[MF] GO:0043168 anion binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, NISCH, PIM1, PRKCA, SRC, TOP2A, XDH 3.17729
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.13502
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 2.89157
[MF] GO:0000166 nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A, XDH 2.88429
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A, XDH 2.88425
[MF] GO:0008389 None CYP2A13, CYP2A6 2.72386
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 2.72026
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 2.59861
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 2.56462
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 2.55755
[MF] GO:0035173 histone kinase activity AURKB, HASPIN, PRKCA 2.41756
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.32191
[MF] GO:0004949 None CNR1, CNR2 2.32191
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, SRC 2.28722
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 2.24324
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.08739
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.08739
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA, RORC 2.0511


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.4554
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.7755
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9322
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.1233
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.9322
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, AKR1B1, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.107
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, IGF1R 3.9194
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, PRKCA, MMP9, MET, IGF1R 3.8811
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KIT, KDR, PRKCA, MET, IGF1R 3.8811
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.8262
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8207
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.0573
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, CYP3A4 3.0178
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, PRKCA, F3 2.4339
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 2.9274
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0178
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, PRKCA, MMP9, MET 2.3506
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, PRKCA, MET, IGF1R 2.296
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, PRKCA, MET, IGF1R 2.1221
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, PRKCA, MET, IGF1R 2.1221
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.1376
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, PRKCA, MMP9 2.0529
Glioma_Homo sapiens_hsa05214 CDK6, PRKCA, IGF1R 2.0529
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.9931
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.3506
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.11
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, PRKCA, DRD1 2.0529
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1, DRD1 1.8811
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.0529
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.002
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8058
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.7897
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, PPARA 1.7317
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA, DRD1 1.7897
Gap junction_Homo sapiens_hsa04540 SRC, PRKCA, DRD1 1.8058
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7317
Melanogenesis_Homo sapiens_hsa04916 KIT, PRKCA, TYR 1.7317
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0041
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, PRKCA 1.6356
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, PRKCA, DRD1 1.4961
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4022
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1, PRKCA 1.5724
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.583
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.4227
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 0.9767
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA 1.0478
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PRKCA 0.9069
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCA, IGF1R 0.9578
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PRKCA 0.9666
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7773
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.1575
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.7513
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.0478
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT, PRKCA 0.7488
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 0.9863
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 0.8722
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0478
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA 0.6959
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1226
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6696
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCA, DRD1 0.6413
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1 0.6413
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PRKCA 1.3377
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3377
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2108
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5714
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.2971
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1834
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3029
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA 0.2305
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2773
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2916
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.2782
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3127
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3225
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3218
Influenza A_Homo sapiens_hsa05164 PRKCA 0.3225
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3123
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3776
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3512
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PRKCA 0.3667
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3631
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3776
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3905
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.3885
Platelet activation_Homo sapiens_hsa04611 SRC 0.4052
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3905
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1 1.4227
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4052
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4052
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4244
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4244
Cell cycle_Homo sapiens_hsa04110 CDK6 0.4052
Axon guidance_Homo sapiens_hsa04360 MET 0.4
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.415
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4052
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4062
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4488
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.4531
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4552
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA 0.4483
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4531
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4483
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4483
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.4488
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.4531
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4531
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4548
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4531
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.4552
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.4569
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4552
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4564
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.4671
Peroxisome_Homo sapiens_hsa04146 XDH 0.4619
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4985
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4726
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4998
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.505
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5123
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5123
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5024
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5123
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5183
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5123
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5123
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.501
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5036
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7317
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5123
Shigellosis_Homo sapiens_hsa05131 SRC 0.5123
Legionellosis_Homo sapiens_hsa05134 CLK1 0.5478
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7347
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5478
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6398
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5683
Malaria_Homo sapiens_hsa05144 MET 0.5714
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5714
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.5814
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8713
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCA 0.6413
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7055
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6356
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.6696
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6413
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6413
Base excision repair_Homo sapiens_hsa03410 APEX1 0.683
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7111
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7488
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7773
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9069
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9666


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)