TCM Prescription: Shouwu Pills



Prescription Description
Prescription IDTCMF1397
Pinyin NameShou Wu Wan
Chinese Name首乌丸
English NameShouwu Pills
Function Description斑秃
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationSkin
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH1797 Morus alba 桑叶 TCMH1797 ITSAL1073-14
TCMH848 Sesamum indicum 黑芝麻 TCMH848 GENG619-14, GBVT1400-13
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT244 HRH1 Histamine H1 receptor GPCR P35367
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT596 SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2 Transporter Q9H2J7
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 12.0927
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HRH1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR 11.1238
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HRH1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 11.1238
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GBA, GLO1, GRIK5, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.5125
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 10.2202
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, GBA, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 10.2202
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TERT 10.2202
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 10.1145
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.1145
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.065
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, GRM1, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.96221
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, GRM1, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.94225
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, INSR, KCNH2, MCL1, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 9.77105
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.50303
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, GRIK5, GRM1, GRM5, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 9.29771
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.24666
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, FABP3, FLT3, GBA, GRM5, HRH1, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 8.95184
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 8.87663
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, GPR35, GRIK5, GRM1, GRM5, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.6516
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HRH1, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 8.63108
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.41129
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, GRM1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.29088
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GPR35, GRIK5, GRM1, GRM5, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.25911
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 8.00595
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.80672
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.74598
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, MMP9, PTGS2, SRC, TERT 7.74598
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, GAA, GBA, GRM1, GRM5, GRM8, HIF1A, HRH1, HSD17B2, IGF1R, INSR, KCNH2, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 7.68647
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, GRM8, HIF1A, HRH1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.43007
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.38882
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, GBA, HRH1, PTGS2, RORC, SRC, TEK, TYR 7.38082
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, GRM8, HIF1A, HRH1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.38082
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.37989
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HRH1, PTGS2 7.33877
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HRH1, PTGS2 7.33877
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.05897
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 7.05897
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GRIK5, GRM1, GRM5, HIF1A, HRH1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 7.04925
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 6.99146
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, FABP3, FABP4, FUCA1, FUT7, GBA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.91667
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 6.84407
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.83422
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HRH1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.65118
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HRH1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.65118
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, INSR, PPARA, PTGS2, SRC, TEK 6.45925
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, INSR, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.41156
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.36594
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, XDH 6.36557
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.36557
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.2607
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.24764
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, GBA, GLO1, GPR35, GRM3, GRM8, HIF1A, HSPA1A, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.21344
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, XDH 5.94993
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GBA, GRM1, HIF1A, HRH1, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 5.94993
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, HSD17B2, PTGS2, RORC, SRC, TYR 5.94062
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.85547
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.81723
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 5.79731
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.68829
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 5.5772
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.55918
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.54528
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, HIF1A, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.52314
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.52314
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP9, PTGS2, PTPN1, SRC, XDH 5.52314
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HIF1A, HSD17B2, INSR, KDR, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.5089
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC 5.5089
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.504
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, GRM1, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.49861
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.49861
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.48836
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.46725
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, GPR35, GRM1, GRM3, GRM5, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.46144
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.45173
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, GBA, GLO1, GPR35, GRM3, GRM8, HCAR2, HIF1A, HSPA1A, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.44671
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.44128
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD17B1, HSD17B2 5.42858
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.42715
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, GAA, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.41617
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.37235
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, GRM1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.36008
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.30115
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.2781
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.24772
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.24209
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HIF1A, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT 5.19972
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.18606
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.14583
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.14037
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.14037
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 5.14037
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, GRM1, GRM5, HIF1A, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.11092
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.08709
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.0307
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.02241
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.02241
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, GRM5, HRH1, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.02241
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.02241
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.99581
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.99581
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HRH1, PTGS2, RORC, SRC 4.93538
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, GRM3, GRM8, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 4.91479
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GRM1, GRM5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.89975
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HIF1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 4.85253
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HIF1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.85173
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GBA, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.85173
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.85173
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.83823
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DAO, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.82257
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GPR35, GRM1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 4.79037
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, GBA, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 4.67938
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, GAA, GBA, GPR35, GRM1, HCAR2, HIF1A, HRH1, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 4.65444
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, GRM5, HRH1, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.62542
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.58764
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.57581
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.5574
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GRM1, GRM5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.5136
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, MMP9, PTGS2, TERT 4.49054
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.4901
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GBA, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.4901
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HIF1A, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 4.4901
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, HRH1, IGF1R, INSR, MMP2, PTGS2, SRC 4.48058
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.45535
[BP] GO:0042391 None ADORA1, APP, BCL2, GBA, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 4.4278
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 4.39935
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, HIF1A, INSR, KCNH2, MMP12, PTGS2, SMAD3, SRC, TERT 4.39935
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 4.39935
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GAA, HIF1A, HSD17B2, INSR, KDR, MCL1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 4.37396
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA, HIF1A, HRH1, HSPA1A, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 4.37158
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HIF1A, KCNH2, PIK3CB, SMAD3 4.35009
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.31279
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 4.31279
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31279
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.2872
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 4.26799
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, GRM5, HRH1, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 4.25201
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.22075
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, ESR1, GAA, GPR35, GRIK5, GRM1, GRM5, HIF1A, MCL1, PIK3CA, PIK3CB, SMAD3 4.21632
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 4.21157
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 4.19951
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.1936
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC, TERT 4.1936
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.17637
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 4.17637
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, HRH1, IGF1R, INSR, MMP2, PTGS2, SRC 4.17593
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HIF1A, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.13006
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.13006
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.13006
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.13006
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC 4.13006
[BP] GO:0044057 None ADORA1, ADORA3, EGFR, GAA, GBA, GPR35, GRM1, HCAR2, HRH1, KCNH2, PTGS2, SLC1A1, SMAD3 4.12882
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 4.10566
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, PIK3CA, SRC 4.08758
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, GBA, GRM1, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.0352
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, RORC 3.99307
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 3.95854
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HIF1A, INSR, PTGS2, SMAD3, XDH 3.93318
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, GBA, HCAR2, HIF1A, HRH1, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT 3.93318
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, ESR1, FABP4, GBA, GRM3, GRM8, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.9255
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, GBA, KCNH2, KDR, PTGS2, SRC 3.91454
[BP] GO:0016137 None AKR1B1, AKR1B10, FUCA1, GBA 3.88537
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, KCNH2, PIK3CB, SMAD3 3.88468
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HIF1A, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.87987
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, GBA, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.85801
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.85801
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.85638
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 3.84316
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.81204
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.80955
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.79118
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 3.77591
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, HIF1A, KDR, PIK3CB, PTGS2, SRC 3.77591
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 3.76673
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, HIF1A, PPARA, PTGS1, PTGS2 3.74428
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.69001
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.63722
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, GBA, HIF1A, TYR 3.55991
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.54615
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.52374
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MCL1, MET, PIK3CA, PPARA, SMAD3 3.51569
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.51264
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HIF1A, HSD17B1, HSD17B2 3.49985
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, PIK3CA, SRC 3.49523
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, GRM1, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.48622
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT 3.46351
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA 3.43416
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.43353
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42702
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.41232
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.40575
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.39525
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.36297
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GBA, GRIK5, HIF1A, MCL1, PIK3CA, PPARA, TERT 3.34784
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, KCNH2, PIK3CB, SMAD3 3.32499
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.30427
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KCNH2, KDR, PTGS2, SRC 3.30427
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.30427
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.30367
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 3.27562
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.25681
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.25667
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2, SRC 3.21824
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.21552
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, GBA, PTGS2, SRC 3.20929
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 3.20312
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 3.20001
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.18885
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.17568
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, HIF1A, PIK3CA, PIK3CB, SMAD3 3.17078
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, HIF1A, PIK3CB, PTGS2 3.12311
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 3.11756
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.1069
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.08531
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PTGS2, SMAD3, TEK 3.05706
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05697
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 3.01792
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HIF1A, KDR, MCL1, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 3.01682
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CYP1B1, EGFR, GAA, GRM1, GRM5, GRM8, HIF1A, HRH1, INSR, KCNH2, PIK3CA, PTGS2, SRC, TEK, TYR 2.98893
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GBA, MMP12, PPARA, SMAD3, TEK 2.97634
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.97447
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.96588
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, EGFR, GRM5, HRH1, IGF1R, INSR, KCNH2, KDR, MCL1, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.95638
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GBA, PPARA, SMAD3, TEK 2.94829
[BP] GO:0045913 None HIF1A, HRH1, INSR, PPARA, SRC 2.94006
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.93927
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.93927
[BP] GO:1902893 None HIF1A, PPARA, SMAD3, TERT 2.93516
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.90971
[BP] GO:2001240 None BCL2, HSPA1A, MCL1, TERT 2.89156
[BP] GO:1901099 None BCL2, HSPA1A, MCL1, TERT 2.89156
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, PTGS2, SRC 2.88192
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.87566
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.87566
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, XDH 2.86864
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TOP2A 2.8662
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.84739
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.8444
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GRIK5, HCAR2, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.83705
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.81529
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3 2.8066
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.8066
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GRIK5, HCAR2, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.80379
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.79859
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.7889
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.78566
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.77299
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, HIF1A, HRH1, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.76682
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.75017
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74776
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.73441
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.72678
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 2.71793
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, EGFR, HSPA1A 2.71793
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.70195
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 2.69636
[BP] GO:0043523 regulation of neuron apoptotic process AXL, BCL2, GRIK5, HIF1A, MCL1, PIK3CA, TERT 2.69054
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.67099
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65833
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.64065
[BP] GO:0007610 None APP, BCL2, EGFR, GAA, GRM1, GRM5, HIF1A, HRH1, INSR, PPARA, PTGS2 2.63981
[BP] GO:0050890 None ADORA1, APP, EGFR, GRM5, HIF1A, HRH1, INSR, PTGS2 2.63866
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.63662
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 2.63549
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.63549
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.62935
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.62263
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.62263
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, HIF1A, PIK3CB 2.6215
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.6215
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.6215
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.61976
[BP] GO:0055065 metal ion homeostasis APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, KCNH2, PIK3CB, SMAD3 2.61976
[BP] GO:0007612 None APP, GRM5, HIF1A, HRH1, INSR, PTGS2 2.61976
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, GBA, GRIK5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.5853
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.5788
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2 2.57423
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.57423
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PTGS2, TEK 2.56052
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.56052
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.56052
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, GPR35, KCNH2, MMP9, PTGS2 2.54825
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.54825
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, GRIK5, HCAR2, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.54825
[BP] GO:0044259 multicellular organismal macromolecule metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.54542
[BP] GO:0016311 None ALPI, ALPL, APEX1, BCL2, CDC25B, DUSP3, PTPN1, PTPRS 2.544
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, SRC 2.544
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.54182
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HIF1A, HRH1, PTGS2, TYR 2.53891
[BP] GO:1903522 None ADORA1, ADORA3, EGFR, GAA, HRH1, KCNH2, PTGS2, SLC1A1 2.53891
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MCL1, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A 2.53257
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, HCAR2, HIF1A, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC 2.53039
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.53039
[BP] GO:0070920 None EGFR, ESR1, TERT 2.53039
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.53039
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 2.50381
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, FABP3, FABP4, FUCA1, GAA, GBA, HSPA1A, MGAM, PIK3CB, SRC, XDH 2.50381
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, GBA, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.49472
[BP] GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand BCL2, HSPA1A, MCL1, TERT 2.47478
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.47478
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.47478
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 2.47478
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, HIF1A, HRH1, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.47349
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.46115
[BP] GO:0099566 None GRM1, GRM5 2.45266
[BP] GO:0000023 None GAA, MGAM 2.45266
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45266
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.45108
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.44041
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 2.4298
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, HIF1A, HRH1, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.41757
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.38133
[BP] GO:0003018 None ADORA1, EGFR, HRH1, PTGS2, SRC, TEK 2.36689
[BP] GO:0010506 regulation of autophagy BCL2, GBA, HIF1A, KDR, MCL1, MET, PIK3CA, PIK3CB 2.35237
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.33113
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, SMAD3, SRC, TEK 2.32245
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, PTPN1, SRC 2.30859
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.30852
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.30796
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.29859
[BP] GO:0010676 None HRH1, INSR, PPARA, SRC 2.29859
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.29645
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.29593
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, GRM3, GRM8, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.29035
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.27829
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.27829
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.27829
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.27829
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, GPR35, GRM5, KCNH2, MMP9, PTGS2 2.2772
[BP] GO:0007611 None APP, EGFR, GRM5, HIF1A, HRH1, INSR, PTGS2 2.2772
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.26316
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.26128
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.26128
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.25222
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.25222
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, SRC, TERT 2.24939
[BP] GO:0071456 cellular response to hypoxia BCL2, HIF1A, PTGS2, SRC, TERT 2.23058
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.22746
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.22746
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, HIF1A, KDR, TEK, TYR 2.22599
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, HCAR2, HIF1A, MMP12, PTGS2, SMAD3, SRC 2.22181
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.20917
[BP] GO:0098908 None GBA, GPR35 2.20876
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.20876
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20876
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.20681
[BP] GO:0044236 multicellular organism metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.20681
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.18242
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.18242
[BP] GO:1902895 None HIF1A, SMAD3, TERT 2.18242
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.18242
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.17397
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.1612
[BP] GO:0006109 regulation of carbohydrate metabolic process HIF1A, HRH1, INSR, PPARA, RORC, SRC 2.14851
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.13592
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, FABP3, GBA, HIF1A, HRH1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A 2.13205
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.13101
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.13101
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, HIF1A, PTGS2, SRC, TERT 2.12736
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, PTGS2, SRC, TYR 2.1255
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, GBA, SRC 2.10348
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, HIF1A, MMP12, SRC 2.10101
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.08408
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.08408
[BP] GO:0051894 None KDR, SMAD3, TEK 2.08408
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08408
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, GBA 2.05868
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SMAD3 2.05774
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.04758
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.0418
[BP] GO:0050877 None ADORA1, APP, CYP1B1, EGFR, GAA, GRM1, GRM5, GRM8, HIF1A, HRH1, INSR, PTGS2, TYR 2.03079
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 2.03079
[BP] GO:0050900 leukocyte migration FUT7, HRH1, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.03079
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, GBA, MET, PIK3CA 2.02476
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.01989
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, INSR, PIK3CA, PIK3CB, SRC 2.00452
[BP] GO:0060249 None AKR1B1, APEX1, BCL2, GAA, HIF1A, SRC, TERT 2.00345
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.00345
[BP] GO:0046466 None CYP1B1, FUCA1, GBA 2.00345
[BP] GO:1903393 None KDR, SMAD3, TEK 2.00345
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.00345
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.00345
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT 6.63912
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, EGFR, ESR1, FLT3, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TYR 5.52314
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, MGAM, PTGS2, SLC1A1, SRC, TEK 5.50043
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HRH1, IGF1R, INSR, KCNH2, KDR, MET, MGAM, PTGS2, PTPRS, SLC1A1, SRC, TEK 4.79037
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MGAM, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TEK, TYR 3.84584
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GRIA4, GRIK5, GRM1, GRM5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 3.74644
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HRH1, IGF1R, INSR, KDR, MET, PTPRS, SLC1A1, TEK 3.69627
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HRH1, IGF1R, INSR, KDR, MET, PTPRS, SLC1A1, TEK 3.42316
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.11355
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.90971
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.83327
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GRIA2, GRIA4, GRIK5, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MCL1, MGAM, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.7889
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.57749
[CC] GO:1903561 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, MGAM, MMP9, NQO2, PTGS1, PTPRS, SLC1A1, SRC 2.53039
[CC] GO:0043230 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, MGAM, MMP9, NQO2, PTGS1, PTPRS, SLC1A1, SRC 2.53039
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.47349
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.4551
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC 2.45266
[CC] GO:0031982 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, BACE1, CA1, CA2, CA4, CBR1, DUSP3, EGFR, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, KDR, MGAM, MMP9, NQO2, PTGS1, PTPN1, PTPRS, SLC1A1, SRC, TYR 2.40375
[CC] GO:0044456 None ACHE, ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC 2.38477
[CC] GO:0120025 None ADORA1, AKR1B1, APP, BACE1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HIF1A, PIK3CA, PTGS2, PTPRS, SRC, TEK 2.36553
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.31053
[CC] GO:0070062 None ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRM5, HSPA1A, INSR, MGAM, MMP9, NQO2, PTGS1, PTPRS, SLC1A1, SRC 2.27079
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CA1, CA2, CA4, CBR1, DUSP3, EGFR, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, PTGS1, PTPRS, SLC1A1, SRC, XDH 2.1888
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, BACE1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HIF1A, PIK3CA, PTGS2, PTPRS, SRC, TEK 2.12914
[CC] GO:0097458 None ADORA1, APP, BACE1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, INSR, PTGS1, PTGS2, PTPRS, SRC 2.08271
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, KCNH2, MET, TEK 2.07589
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.02476
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.01989
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.01312
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.00345
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TOP2A, TYR, XDH 12.5495
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 11.1238
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.56625
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 8.41129
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.74598
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.77389
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.19355
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.01782
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 5.94062
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.87238
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.77229
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A 5.71698
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 5.68838
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.55325
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.12758
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.99581
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.9032
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.85818
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK 4.76565
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.76092
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 4.70255
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.69233
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.68646
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.61035
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 4.4901
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.40376
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TYR 4.17637
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 4.14476
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, IGF1R, INSR, KDR, MET, TEK 4.10082
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HRH1, IGF1R, INSR, KDR, MET, TEK 4.10082
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TERT, TOP2A, TYR, XDH 4.0404
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TERT, TOP2A, TYR, XDH 3.85003
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.72286
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.71091
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TOP2A, XDH 3.69993
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.61049
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, FLT3, GRIK5, IGF1R, KCNH2, KDR, MCL1, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 3.57121
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.36297
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.18885
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 3.14328
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.12285
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5, HRH1 3.06395
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.96588
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 2.92313
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 2.92121
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, CSNK2A1, DAO, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SLC1A1, SRC, TEK, TOP2A, XDH 2.84739
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.82114
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.69054
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.61976
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.5788
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.54867
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK 2.54542
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, AXL, BCL2, DAO, EGFR, FLT3, HIF1A, KCNH2, MCL1, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.54182
[MF] GO:0032450 None GAA, MGAM 2.45266
[MF] GO:0099583 None GRM1, GRM5 2.45266
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.33113
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.33113
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.27829
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.26092
[MF] GO:0019899 enzyme binding ALPI, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, GRM5, HIF1A, HSPA1A, KCNH2, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 2.22893
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HIF1A, HSPA1A, KDR 2.21713
[MF] GO:0004971 None GRIA2, GRIA4 2.20876
[MF] GO:0051425 None APP, INSR 2.20876
[MF] GO:0004558 None GAA, MGAM 2.20876
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.17452
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA2, INSR 2.1073
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.03728
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HIF1A, PTPN1, SMAD3, SRC, TOP2A 2.02999
[MF] GO:0043559 insulin binding IGF1R, INSR 2.0249
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.0249
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.01133
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HIF1A, HRH1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.0098
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2 2.00345


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.1168
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.1168
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, HSPA1A 7.5294
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R 7.2962
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.2962
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, PIK3CA, BCL2, MET 6.4331
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.8496
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B, MCL1 6.7642
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R 6.4331
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MGAM, DNMT1, GAA, GBA, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 6.0161
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, HRH1, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 6.2183
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.2183
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 5.5346
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.3565
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, MCL1, IGF1R 4.6353
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.5602
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, HIF1A, EGFR 5.2722
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.5784
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.7158
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.3385
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.2636
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.002
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.2636
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 3.7607
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.1965
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.9918
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.5916
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.5916
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.9488
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.3427
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1502
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.2121
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.7342
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, PTGS2, PTGS1 3.1692
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.1208
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1, HIF1A 3.1208
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2147
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.1073
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1334
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB, MCL1 2.6651
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.6651
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.1073
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.1334
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.1013
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.1965
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 2.5825
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 2.9743
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.6878
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 3.1013
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.6981
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8502
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 HRH1, PIK3CA, SRC, PIK3CB 2.5654
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1, EGFR 2.6776
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6105
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5654
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.3999
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, HIF1A, EGFR 2.5311
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.2998
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0362
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4076
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2884
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3223
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.2689
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.1569
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.1825
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB, MCL1 2.1305
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.1312
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0296
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.1138
Calcium signaling pathway_Homo sapiens_hsa04020 HRH1, GRM5, GRM1, EGFR 1.7886
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2405
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2498
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2615
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7886
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.5583
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3005
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3373
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3393
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.3256
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3016
Axon guidance_Homo sapiens_hsa04360 MET 0.3541
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3619
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3232
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.5054
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5291
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8099
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.0326
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.6794
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.677
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4257
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4265
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.1845
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6544
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6778
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1175
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4391
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.783
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4381
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.794
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7747
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8342
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8066
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8128
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7891
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4516
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4554
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4554
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4681
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4666
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4528
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4541
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9458
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9566
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9821
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.0605
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0262
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.994
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0138
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4927
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5065
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5045
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0437
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5193
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1569
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB, HIF1A 2.2517
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2517
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.3069
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.3802
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1022
Shigellosis_Homo sapiens_hsa05131 SRC 0.5441
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5471
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1312
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1907
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2308
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2087
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2087
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2384
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.4605
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.2232
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.6651
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6019
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2584
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2584
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.5311
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3232
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6358
Malaria_Homo sapiens_hsa05144 MET 0.6407
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6407
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.3479
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.654
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6544
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA 0.654
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4194
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6649
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6592
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4476
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6934
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7404
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6934
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8128
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7765
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7404
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5962
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7577
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7937
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8179
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7833
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8128
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6794
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7685
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0248
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA 2.1825
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.3529
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1073


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)