TCM Prescription: Juan Xiao Tablet



Prescription Description
Prescription IDTCMF1198
Pinyin NameJuan Xiao Pian 
Chinese Name蠲哮片
English NameJuan Xiao Tablet
Function Description支气管哮喘急性发作期热
IndicationsAsthma
Disease ICD-11 Category CA23 [Asthma, 哮喘 ];
Human Tissues Associated with IndicationLung, Bronchus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2117 Lepidium apetalum 葶苈子 TCMH2117 ITSAB3973-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH970 Vitex negundo 黄荆子 TCMH970 ITSAJ554-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6479
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6479
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MAOA, MET, MIF, MTNR1B, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 14.6641
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B 13.2595
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, SRC, TRPV1, TYR 11.0262
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TRPV1 10.8062
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, SRC, TRPV1, TYR 10.5361
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PTGS2, SRC, TNKS, TNKS2, TRPV1 10.3794
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGES, PTGS2, SRC, TYR 10.1419
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGES, PTGS2, SRC, TRPV1, TYR 9.52162
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B, PIK3CA, PIK3CB, SRC 9.41664
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 9.39255
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.92526
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.71329
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, SRC, TNKS, TNKS2, TRPV1 8.65934
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2, TBXAS1 8.39358
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TNKS2, TRPV1, TYR 8.3669
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, SRC, TRPV1, TYR 8.33661
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2, TBXAS1 8.12025
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDK6, CHRM1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, SRC, XDH 7.9531
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 7.88847
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 7.86011
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 7.73941
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 7.63772
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 7.54492
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC, TRPV1 7.39055
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2C, MTNR1B 7.06872
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 7.01605
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 7.01605
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.98891
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, MIF, SRC, TNKS, TNKS2, TRPV1 6.85464
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1B, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 6.82946
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.73085
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, PTGS2, SRC 6.72698
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1B, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 6.69594
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2, TBXAS1 6.58468
[BP] GO:0003018 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 6.58468
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, SRC, TRPV1, TYR 6.46318
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2, SRC, TRPV1 6.44715
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.31672
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B, PTGS2, TRPV1 6.31007
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.29408
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.27044
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1 6.25341
[BP] GO:0097746 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.22998
[BP] GO:0035296 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.22998
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 6.20629
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 6.17221
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 6.17221
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.15754
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.12529
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.06379
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CYP19A1, CYP1B1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PTGS2, SRC, TRPV1 6.0558
[BP] GO:0050880 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.05073
[BP] GO:0035150 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.02693
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 5.96126
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2 5.89523
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.7731
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 5.74023
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.74023
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 5.71223
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 5.70445
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PTGS2, SRC, TRPV1 5.60969
[BP] GO:0003013 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.59019
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 5.53453
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDK6, CHRM1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2 5.51231
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CYP1B1, ESRRA, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 5.48926
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, MTNR1B, PIK3CA, PIK3CB, SRC, TRPV1 5.45246
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 5.36077
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM1, CHRM2, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TNKS2, TYR 5.35154
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.35154
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TRPV1, XDH 5.30665
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.26001
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 5.19699
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.18836
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, MTNR1B, PIK3CA, PIK3CB, TRPV1 5.13199
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.11894
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B2, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 5.03074
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, HTR1A, MET, MIF, PIK3CB, PIM1, SRC, TYR 4.97163
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.93556
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC, TRPV1 4.91687
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2 4.91687
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C 4.91338
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.89184
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.89184
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.89184
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC, TRPV1 4.86705
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, SRC 4.83986
[BP] GO:0019371 None PTGES, PTGS1, PTGS2, TBXAS1 4.83291
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, HTR1D, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 4.79188
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TRPV1, XDH 4.78235
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 4.74466
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGES, PTGS1, PTGS2 4.72857
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 4.6654
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.62334
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.58576
[BP] GO:0001516 None MIF, PTGES, PTGS1, PTGS2 4.53351
[BP] GO:0046457 None MIF, PTGES, PTGS1, PTGS2 4.53351
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, TRPV1 4.51327
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 4.51327
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.42255
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, SRC, TRPV1 4.41396
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38887
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.26176
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SRC, TNKS2, TRPV1, XDH 4.23965
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 4.22649
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.21537
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.21537
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.21179
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 4.19148
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TNKS, TNKS2, XDH 4.1885
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.17787
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.15115
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 4.14129
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TRPV1, TYR 4.12037
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 4.11821
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, SRC 4.05666
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.04474
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 4.04474
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.04474
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2 4.02499
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 3.90638
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, MAOA, TYR 3.8966
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 3.85924
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CHRM1, CNR1, HTR1A, HTR1B, HTR2A, MIF, MMP9, PTGS2 3.85452
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, SRC, XDH 3.8527
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 3.84464
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 3.84464
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.81052
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC 3.7858
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.77933
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.77933
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MIF, SRC 3.7494
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 3.7494
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.73092
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.66489
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MTNR1A, PPARA, PTGS2, TRPV1 3.64337
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 3.64249
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 3.63683
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 3.63672
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, SRC 3.60897
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 3.59062
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, HTR1B, KDR, PTGS2, SRC, TRPV1 3.58477
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.57874
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.53341
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, SRC, TRPV1 3.53341
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.44835
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 3.42636
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.42587
[BP] GO:0006693 None MIF, PTGES, PTGS1, PTGS2 3.39841
[BP] GO:0006692 None MIF, PTGES, PTGS1, PTGS2 3.39841
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.37771
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.34006
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, CNR1, HCAR2, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PTGS2, SRC 3.28373
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF, PIK3CB 3.27936
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B2 3.27641
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.27641
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.26465
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.25779
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 3.23368
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.18732
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.18732
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, PIK3CB, SRC, XDH 3.18153
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.17017
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, HCAR2, HTR2B, MIF, MMP12, PTGS2, SRC, TRPV1 3.13151
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.12703
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 3.11621
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.11621
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11574
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MTNR1A, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1 3.08697
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, SRC 3.06747
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA, TRPV1 3.06398
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.05622
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CNR1, CNR2, ESR1, ESR2, ESRRA, FABP4, HCAR2, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 3.05595
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.05232
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, HCAR2, MIF, MMP12, MMP2, PIK3CA, PIK3CB, SRC 3.03594
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MIF, MMP2, MMP9, PIK3CA, PTGS2, SRC, TRPV1 3.03594
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, HCAR2, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC, TRPV1 3.01418
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TRPV1, TYR 3.0128
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, SRC, TRPV1 3.01109
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.99956
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.99669
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC, TRPV1 2.99669
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, MMP12, PTGES, PTGS2, SRC, TRPV1, TYR 2.99105
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 2.98477
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.98477
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HTR2B, MET, PIK3CA, PPARA 2.96408
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR2A, HTR2C, MTNR1B 2.96408
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.94813
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC, TRPV1 2.93017
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.92199
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 2.89833
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 2.89424
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.88389
[BP] GO:0002791 None ACHE, ADORA1, CNR1, HCAR2, HTR2B, HTR2C, MIF, MMP12, MTNR1B, SRC 2.8768
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.8768
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.87285
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MIF, SRC 2.85407
[BP] GO:0007208 None HTR2A, HTR2C 2.85407
[BP] GO:0009115 None AOX1, XDH 2.85407
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.84933
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, MAOA, TYR 2.84933
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 2.84425
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.79348
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CYP1B1, ESR1, ESR2, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 2.77796
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.76586
[BP] GO:0048511 rhythmic process AXL, BCL2, ESR1, HTR7, MTNR1A, MTNR1B, PPARA, SRC 2.76479
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.75503
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGES, PTGS2, SRC 2.72787
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.72627
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.72627
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, MTNR1A, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1 2.72544
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDK6, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 2.70971
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, SRC, XDH 2.70202
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.70202
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, HTR2B, MIF, MMP12, SRC, TRPV1 2.692
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.68051
[BP] GO:0006633 None ALOX15, MIF, PTGES, PTGS1, PTGS2 2.67218
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.65993
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDK6, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TNKS, XDH 2.65628
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, MTNR1A, PTGS2, SRC 2.65628
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.65114
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.65114
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.61087
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.61087
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.59595
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.59309
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, TRPV1 2.59309
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, TRPV1 2.59309
[BP] GO:0009266 None ADORA1, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 2.58715
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.58329
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.58329
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.58329
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.58329
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.58329
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGES, PTGS2, SRC 2.58301
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.58144
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.53181
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, MIF, MMP12 2.52495
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50752
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, SRC 2.50108
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, PTGS2 2.4944
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 2.48295
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, HCAR2, HTR2B, MIF, MMP12, PTGS2, SRC 2.48295
[BP] GO:0046110 None AOX1, XDH 2.45953
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45953
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, SRC 2.44692
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.43207
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, MIF, PIK3CA, PTGS2 2.43207
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SRC, XDH 2.42447
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDK6, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TNKS, XDH 2.41452
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SRC, XDH 2.41112
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.3933
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.39079
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDK6, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.39079
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.38726
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.38691
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.38691
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.37339
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.36479
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.36124
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TNKS, TNKS2, XDH 2.35444
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, TRPV1 2.34206
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.32401
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, ESR1, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTGS2, SRC, XDH 2.31903
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.31583
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.31583
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.31558
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 2.31508
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, MIF, PIK3CB, SRC 2.31508
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.3141
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, PTGS2 2.29767
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.29427
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.29365
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.2889
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.2889
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28048
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28048
[BP] GO:0002793 None ACHE, ADORA1, HCAR2, HTR2B, MIF, MMP12, SRC 2.28048
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, TRPV1 2.26373
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.23902
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.23669
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.22935
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.22935
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.22935
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.227
[BP] GO:0070213 None TNKS, TNKS2 2.227
[BP] GO:0006145 None AOX1, XDH 2.227
[BP] GO:0038171 None CNR1, CNR2 2.227
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.227
[BP] GO:0014827 None HTR1D, HTR2B 2.227
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.22447
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.21257
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, MIF, PIK3CB, SRC 2.21219
[BP] GO:0003012 None ADORA1, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, TRPV1 2.21219
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.20943
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.20943
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.20297
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.19653
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1938
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.1938
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1938
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.1938
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.19228
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CNR1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 2.19228
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.18099
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.16559
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SRC 2.15785
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.14855
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.14855
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.14855
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.14855
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.14855
[BP] GO:0070201 None ACHE, APP, BCL2, CHRM1, CNR1, HCAR2, HTR2B, MIF, MMP12, MTNR1B, PTGS2, SRC 2.14532
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.14172
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.13208
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.11857
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, TRPV1 2.11857
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.11487
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, PTGS2, TRPV1, TYR 2.1113
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PTGES, PTGS2, SRC, TRPV1 2.10303
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.09894
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, PTGS2 2.09894
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, HCAR2, HTR2B, MIF, MMP12, PTGS2, SRC 2.08593
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.08137
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2 2.07371
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.06224
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.06109
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.06036
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.06036
[BP] GO:0043696 None CDK6, ESRRB 2.06036
[BP] GO:0043697 None CDK6, ESRRB 2.06036
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.06036
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B2 2.05294
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.03886
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.02725
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.02725
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.02725
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.02555
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2 2.0159
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 8.9513
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 8.62495
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR 7.12956
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TRPV1, TYR 7.01605
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PTGS2, SRC, TRPV1 6.45156
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, SRC, TRPV1 5.86351
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, TBXAS1, TRPV1, TYR 3.80459
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.39841
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, TBXAS1, TRPV1, TYR 3.36433
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC 2.34253
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, PTGS2, SRC 2.25811
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC 2.12957
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, HTR2A, MET, PTGS2, SRC, TRPV1 2.06109
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 19.6749
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.1012
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6479
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6479
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5268
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5268
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.5526
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, TBXAS1, TNKS, TYR, XDH 12.9682
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 12.9358
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 11.968
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 11.4867
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.8925
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 10.4367
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 10.4367
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0814
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 9.66907
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 9.66907
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.52901
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 8.81189
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B 7.86011
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.45207
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TRPV1 6.18193
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 6.17221
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.15675
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 5.39361
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.30995
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, TNKS 5.30665
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.99142
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, NQO2, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 4.87177
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.78829
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.43519
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.04474
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.75521
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B2, XDH 3.75521
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.69047
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.69047
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59419
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.53859
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.39841
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.34006
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.25779
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.24963
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.01186
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.00365
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85407
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85407
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85407
[MF] GO:0071886 None HTR2A, HTR2C 2.85407
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.82566
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2 2.67218
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.62156
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.59309
[MF] GO:0008502 None MTNR1A, MTNR1B 2.45953
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.45953
[MF] GO:0004949 None CNR1, CNR2 2.45953
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.44521
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, MTNR1A, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TRPV1, XDH 2.27192
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD11B2, PPARA, TRPV1 2.23654
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.227
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.227
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B2 2.14222
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TRPV1, XDH 2.10303
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.06224
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06036
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B2 2.02725
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.02725


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 19.8614
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, HTR1E, CHRM4, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, TRPV1, HTR2A, HTR5A, HTR4, HTR6, MTNR1A, HTR7, CNR2, CNR1, MTNR1B, ADORA3, ADORA1 18.9115
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4, HCAR2, HTR6, PIK3CA, ADORA1, PPARA 10.4395
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.5102
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9539
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.1217
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 6.0753
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.7464
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, TRPV1, HTR2A 5.7464
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.7739
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.5361
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.7464
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, BCL2, PIK3CB 5.5093
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.3398
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGES, PTGS1 5.6809
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 4.1674
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.4135
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.3153
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.1351
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.9718
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.1274
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 3.8972
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.8804
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.8681
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.5746
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.8804
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.9115
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.2276
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.2476
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB 3.082
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.9662
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4062
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.224
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 4.1002
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8972
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.8315
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.1856
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.908
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.082
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.823
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9897
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.505
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1608
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.6026
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.8315
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4186
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.4186
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4186
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.1886
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0509
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 1.9792
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8778
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.7238
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 1.8164
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2244
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.1072
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9278
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2476
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8539
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.2096
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.3667
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4468
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.714
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.6068
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2096
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5743
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4728
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5156
Measles_Homo sapiens_hsa05162 CDK6, PIK3CA, PIK3CB 1.4953
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5156
Adherens junction_Homo sapiens_hsa04520 SRC, MET, IGF1R 2.0976
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.213
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4022
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.4199
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.1255
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1 2.1695
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2954
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3049
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2931
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3049
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.204
Tight junction_Homo sapiens_hsa04530 SRC 0.361
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.901
Cell cycle_Homo sapiens_hsa04110 CDK6 0.3902
Axon guidance_Homo sapiens_hsa04360 MET 0.3851
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3902
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5129
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.3828
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6951
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7031
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.869
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8604
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 0.8468
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.8289
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4558
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4553
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.468
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4674
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0822
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0901
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4806
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0446
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0202
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4815
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0446
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0306
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4865
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.0746
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.055
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0306
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4865
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.0446
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.0822
Peroxisome_Homo sapiens_hsa04146 XDH 0.5017
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.7734
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5397
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5379
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5491
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2493
Bile secretion_Homo sapiens_hsa04976 CA2 0.547
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5513
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2965
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5591
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2667
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5699
Shigellosis_Homo sapiens_hsa05131 SRC 0.5674
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5913
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2965
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3876
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4728
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3914
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6511
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6554
Malaria_Homo sapiens_hsa05144 MET 0.66
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.66
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6657
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6609
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5156
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6708
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5605
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7156
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.815
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8536
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8697
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7238
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8111
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8351
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8645
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8567
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0416
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8897
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.2294
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0746
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1694
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3876


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)