TCM Prescription: Bi Yuan Shu Oral Liquid



Prescription Description
Prescription IDTCMF1183
Pinyin NameBi Yuan Shu Kou Fu Ye 
Chinese Name鼻渊舒口服液
English NameBi Yuan Shu Oral Liquid
Function Description鼻窒, 鼻渊
IndicationsNasal sinusitis disorder, Rhinitis, Chronic sinusitis
Disease ICD-11 Category SC91 [Nasal sinusitis disorder (TM1), 鼻渊 (TM1) ];
CA09.0 [Chronic rhinitis, 慢性鼻炎 ];
CA0A [Chronic rhinosinusitis, 慢性鼻窦炎 ];
Human Tissues Associated with IndicationLung, Nose
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH2316 Magnolia liliflora 辛夷 TCMH2316 GBVT919-13, GBVT884-13
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH287 Clematidis armandii caulis 川木通 TCMH287
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, FLT3, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.92905
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, FLT3, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.92905
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, SRC, TERT 8.92905
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD17B1, KIT, MET, PPARA 8.13376
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTAFR, SRC, TERT, TOP1 7.49348
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, PIM1, SRC 7.49348
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, XDH 7.40779
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, KDR, KIT, MET, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, XDH 7.3953
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, FLT3, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.34952
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.34952
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.23195
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, PTAFR, SRC 7.21383
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.13737
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 6.98889
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.97566
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTAFR, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 6.90016
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTAFR, SRC, TERT, XDH 6.87802
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTAFR, SRC, TERT 6.85849
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, XDH 6.85849
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.85849
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, PPARA, PTAFR, SRC 6.85652
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, FABP4, FLT3, KDR, KIT, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.85652
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1 6.85652
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 6.80838
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 6.80838
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 6.76114
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTAFR, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 6.67648
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F10, FLT3, KDR, KIT, MET, PTPN1, SRC, XDH 6.64313
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 6.34702
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS2 6.34702
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 6.33475
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.21404
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 6.21404
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, PTAFR, SRC 6.04511
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 5.97393
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT 5.95461
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, PIM1, PPARA, PTAFR, XDH 5.93868
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUT7, KIT, MET, PPARA 5.91454
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, TERT 5.88082
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, IGF1R, MMP2, MMP9, PPARA, PTAFR, SRC 5.74498
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 5.70605
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, F10, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.69573
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP1 5.66359
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1 5.66359
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 5.52652
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, KIT, PPARA, PTAFR, SRC 5.49267
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1 5.42006
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 5.38526
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTAFR, PTPN1, SRC, TERT 5.37264
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 5.26501
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, PTAFR 5.2503
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, KDR, KIT, MMP9, PTAFR, PTPN1, SRC, XDH 5.20085
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, KDR, KIT, MMP9, PTAFR, PTPN1, SRC, XDH 5.20085
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, IGF1R, KDR, KIT, MET, MMP9, PTAFR, SRC, TERT 5.12916
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 5.02913
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 4.90947
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, F10, FABP4, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, SRC, TNKS2, TOP1 4.87672
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTAFR, TERT 4.84996
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, KDR, KIT, PPARA, PTPRS, SRC 4.76789
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.70753
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA 4.68711
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.68038
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT, TOP1 4.58263
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 4.54589
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.52055
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.51628
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 4.51183
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR, TERT 4.51183
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, EGFR, KDR, SRC, TNKS, TNKS2 4.35337
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, KIT, PPARA, SRC, TOP1 4.32002
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 4.30485
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, PTAFR, SRC 4.28672
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 4.27863
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTAFR, SRC 4.27118
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, KIT, MMP2, PPARA, PTAFR, SRC, TERT 4.25712
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.25574
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, KIT, MET, SRC, XDH 4.24766
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PTAFR, SRC, TOP1 4.22722
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.2119
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, ERBB2, FLT3, KDR, KIT, PTPN1, SRC, XDH 4.10392
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, MET, SRC, TERT 4.06666
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, KIT, MET, SRC 4.06666
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 4.02292
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.97758
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.97718
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, FLT3, KIT, MET, PIM1, SRC 3.94803
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, FLT3, KIT, MET, MMP9, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.94523
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, XDH 3.91694
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.89971
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, XDH 3.86357
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1 3.86357
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PIM1, PPARA, PTPRS, SRC 3.86207
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.85785
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.85785
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.85785
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TNKS, TNKS2 3.85785
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.85785
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1 3.8383
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PTAFR, PTPN1, SRC, XDH 3.79326
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.79326
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.782
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.7674
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, XDH 3.76141
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.72555
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.68149
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9 3.66782
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1 3.65508
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT 3.63134
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, PTPN1, SRC, XDH 3.63134
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.61501
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 3.5981
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 3.59727
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.59536
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.59129
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.59129
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, KDR, KIT, MMP9, PTAFR, PTPN1, SRC, XDH 3.50756
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, MMP9, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.50656
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, KIT, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT 3.45734
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.42478
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR, TERT 3.4239
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.33893
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.33019
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 3.33009
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.32617
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, KIT, MET 3.30524
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT 3.30524
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT 3.30524
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, FLT3, KIT, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.28507
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, SRC, TNKS, TNKS2 3.28177
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, PTAFR 3.23125
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.22105
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTAFR, SRC 3.21049
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, ERBB2, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PTPRS, SRC, TERT 3.18612
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, PTAFR 3.16423
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.15279
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DYRK1A, EGFR, FABP4, IGF1R, MET, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.15279
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, PTAFR, SRC, TERT 3.15279
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.15279
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1 3.13117
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1 3.13117
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, KDR, MMP2, PTAFR, SRC 3.12733
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.12209
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, EGFR, ERBB2, FLT3, IGF1R, KIT, MMP2, PTAFR, SRC 3.11522
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 3.08983
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CYP19A1, DYRK1A, EGFR, ERBB2, IGF1R, MET, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.0813
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, XDH 3.08048
[BP] GO:0043412 macromolecule modification ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1 3.02676
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTAFR, SRC 3.02676
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.02676
[BP] GO:0045776 None ADORA1, ADRB1, PPARA, PTAFR 3.00875
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.99155
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, KIT, PTPN1, SRC 2.98457
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.9793
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.96631
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, EGFR, ERBB2, IGF1R, KDR, KIT, MET, PTAFR, PTPN1, SRC 2.96292
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, PTPN1, SRC, TNKS 2.9591
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ERBB2, IGF1R, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2 2.93076
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, FLT3, PTAFR, SRC 2.90745
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.90434
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.8707
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.84851
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.84564
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.82754
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.82754
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.81714
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.79129
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, EGFR, IGF1R, MMP2, MMP9, PTAFR, SRC 2.78255
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, KIT, PTPN1, SRC 2.78255
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.77848
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.75516
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTAFR, SRC 2.75342
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.74763
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.73022
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.72835
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CYP1B1, EGFR, ERBB2, KDR, KIT, MET, MMP9, PIM1, PTAFR, PTPRS, SRC, TERT, TNKS2, XDH 2.71685
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.71157
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, ERBB2, KDR, PTPN1, SRC 2.69816
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.69816
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.69816
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.68472
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.68356
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.67545
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD17B1 2.65563
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTAFR, SRC 2.63585
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, PTPN1, SRC 2.63585
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, EGFR, ERBB2, IGF1R, MET, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.61584
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.60759
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, MMP2, PTAFR, SRC 2.60759
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, EGFR, ERBB2, IGF1R, MET, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.60668
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58257
[BP] GO:0071229 cellular response to acid chemical DNMT1, EGFR, KDR, MMP2, PTAFR, SRC 2.58257
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.58257
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.58157
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.56923
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.56844
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.55608
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.53457
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.50824
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTAFR, SRC 2.50824
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.50824
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.50112
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.48131
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, KIT, PTPN1, SRC, TNKS 2.46083
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.45484
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.45269
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, BCL2, CA2, CYP1B1, EGFR, KDR, KIT, MET, MMP9, PIM1, PTAFR, SRC, TERT 2.42593
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.41974
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, MMP2, PTAFR, SRC 2.40972
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, KIT, MMP2, MMP9, PTAFR, SRC 2.40628
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KIT, PTPN1, SRC 2.40508
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40508
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.35768
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, TNKS2 2.35649
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.35649
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.35649
[BP] GO:0070213 None TNKS, TNKS2 2.34143
[BP] GO:1901529 None ABCB1, PTAFR 2.34143
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34143
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.3135
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2 2.29731
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, TNKS, TNKS2 2.28411
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTAFR 2.27691
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.27089
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.26682
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.2599
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, KIT, MET 2.25133
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.23285
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.23171
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.21985
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.18962
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTAFR, PTPN1, SRC, XDH 2.18786
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.18505
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, MMP9, PTAFR 2.16783
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA 2.16741
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.16741
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, EGFR, F10, FABP3, KIT, MMP9, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, XDH 2.16472
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.16454
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, KIT, PTPN1, SRC 2.15576
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, TNKS 2.15301
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.15301
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.13822
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.13822
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.13732
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.12221
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.12221
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, EGFR, F10, FABP3, KIT, MMP9, PPARA, PTAFR, SRC, TERT, TNKS, XDH 2.10327
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, PTAFR, SRC 2.10309
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.08967
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, KIT, PPARA, SRC 2.08967
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, MET 2.07497
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PTAFR 2.07243
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.05502
[BP] GO:1901989 None APP, CDC25B, CYP1A1, TERT 2.05502
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, EGFR, SRC, TERT 2.03923
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, TNKS 2.03923
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.03689
[BP] GO:1903961 None ABCB1, PTAFR 2.03689
[BP] GO:1904306 None KIT, PTAFR 2.03689
[BP] GO:1904304 None KIT, PTAFR 2.03689
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.03689
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, KIT, MMP9, PTAFR, SRC 2.03689
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, KIT, PTPN1, SRC 2.03689
[BP] GO:0042058 None ADORA1, APP, EGFR, MMP9 2.03689
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.03689
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, KIT, PTAFR 2.03689
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9 2.02656
[BP] GO:0080135 regulation of cellular response to stress APP, DYRK1A, EGFR, IGF1R, MET, PTPN1, PTPRS, TERT, XDH 2.01574
[BP] GO:0030177 positive regulation of Wnt signaling pathway CSNK2A1, SRC, TERT, TNKS, TNKS2 2.01265
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.00298
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTAFR, PTPN1, PTPRS, SRC, TERT 4.38568
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRB1, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, PTAFR, PTPRS, SRC 3.62055
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2 3.07374
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, KDR, KIT, MMP2, MMP9, PIM1, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.68503
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.66423
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, XDH 2.29383
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA4, F10, FLT3, IGF1R, KDR, MET, PTAFR, PTPRS 2.11334
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, XDH 2.08967
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.03689
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, XDH 12.6607
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, XDH 11.2207
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1044
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, XDH 8.92905
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 7.49348
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 6.97566
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 6.85849
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.70094
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.88082
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 5.52714
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR, KIT 5.42769
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP1 5.25047
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 4.66998
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PTAFR, PTPRS, SRC, TOP1, TUBB3, XDH 4.51183
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 4.27121
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, F10, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TERT, TNKS, TNKS2, XDH 4.27118
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT, TOP1 4.22722
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, F10, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TERT, TNKS, TNKS2, XDH 3.95272
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.94523
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.88025
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TOP1 3.85785
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 3.84082
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.72158
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TUBB3, XDH 3.68149
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.6318
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTAFR, PTPRS, SRC, TOP1, TUBB3 3.31076
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TUBB3, XDH 2.97957
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TUBB3, XDH 2.9793
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1 2.91339
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.91339
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.90116
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 2.59038
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, MET, PTPN1 2.5533
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 2.49765
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, KDR, KIT 2.49652
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.48091
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 2.47153
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.41254
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, KIT, MET 2.37732
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, KIT, MET 2.3147
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, XDH 2.3135
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.3135
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.28859
[MF] GO:0016740 transferase activity AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT, TNKS, TNKS2, TOP1 2.25319
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TUBB3 2.23233
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, KIT, MET 2.22267
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP9, TERT, XDH 2.19242
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TUBB3 2.13822
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TUBB3 2.11231
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TUBB3 2.10551
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.08967
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R 2.03923
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.03834
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03689


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.425
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.9863
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.9863
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.5719
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 6.3609
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 5.3275
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.4658
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 4.5078
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, ERBB2, MET, EGFR 4.5889
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.8526
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R 3.8398
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, EGFR, IGF1R 3.3518
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, ALOX15, AKR1B1, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 3.2643
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2035
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2643
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.9706
Calcium signaling pathway_Homo sapiens_hsa04020 PTAFR, ERBB2, ADRB1, CACNA1C, EGFR 2.8791
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.9555
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, ADRB1, EGFR 2.9706
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR 2.8557
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0604
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, BCL2, MET, EGFR, IGF1R 2.553
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR, IGF1R 2.8274
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, EGFR, IGF1R 2.5252
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, CACNA1C 2.7062
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.3104
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.2027
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.4981
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.4908
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8462
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0959
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, ADRB1, CACNA1C, PPARA 1.9731
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2818
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.3987
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3104
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.3726
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.9255
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.0764
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.841
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, PTAFR, ADORA1, ADRB1 1.5505
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.5505
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.766
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.5433
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.484
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.4374
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.0557
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1149
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0506
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1803
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.9212
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT, EGFR 0.8726
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1692
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9212
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0012
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1803
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.39
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8935
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0012
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6631
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8259
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1498
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2634
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4268
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7488
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6455
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.4733
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.385
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.518
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3325
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4383
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.39
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2711
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3381
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3652
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3786
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3891
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3647
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4396
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4214
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4177
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4421
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4396
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4396
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4396
Platelet activation_Homo sapiens_hsa04611 SRC 0.4653
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4653
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4819
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4653
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4653
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4653
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4722
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4653
Axon guidance_Homo sapiens_hsa04360 MET 0.46
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4577
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4653
Melanogenesis_Homo sapiens_hsa04916 KIT 0.51
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5113
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.51
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.51
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.51
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5113
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5163
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5113
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.528
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5167
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.511
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5171
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.51
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.528
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5171
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5229
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5223
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5496
Peroxisome_Homo sapiens_hsa04146 XDH 0.528
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5314
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5474
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5306
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.528
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5563
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5659
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5659
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5659
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.5645
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5474
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5804
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5575
Shigellosis_Homo sapiens_hsa05131 SRC 0.5659
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5722
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6031
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6055
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.631
Malaria_Homo sapiens_hsa05144 MET 0.6421
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6455
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9083
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9255
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6525
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6602
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6562
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7823
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8633
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0828
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8342
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7878
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8386
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8342
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.107
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.051


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)