TCM Prescription: Jing Zhi Guan Xin Granules



Prescription Description
Prescription IDTCMF1134
Pinyin NameJing Zhi Guan Xin Ke Li 
Chinese Name精制冠心颗粒
English NameJing Zhi Guan Xin Granules
Function Description冠心病, 心绞痛
IndicationsCoronary heart disease, Angina pectoris
Disease ICD-11 Category BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ];
BA40 [Angina pectoris, 心绞痛 ];
Human Tissues Associated with IndicationHeart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.41647
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 9.18619
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.05449
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 8.81204
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.78466
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.78466
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FUT7, HSPA1A, MIF, PIM1, PPARA, TYR, XDH 8.4475
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B2, MET, MIF, PPARA 8.2497
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 8.18105
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.13604
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 7.86265
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, MIF, PPARA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.45319
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.39178
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.30115
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.30115
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 7.30115
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 6.96259
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.9569
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 6.80451
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SMAD3, SRC, TERT 6.76506
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 6.75193
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 6.67916
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.61433
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 6.61433
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.5295
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 6.52046
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TEK, TYR 6.43137
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.22429
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 6.22208
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF 6.18191
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 6.18191
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.12297
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA 6.03408
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7 6.0021
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.0021
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF 6.0021
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.0021
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK 5.95848
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK, TERT 5.81385
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SLC6A4, SRC, TEK 5.81385
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 5.81196
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA 5.80347
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 5.80347
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.80347
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 5.79564
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.79564
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 5.77249
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MIF, MMP2, MMP9, NUAK1, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT 5.67558
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.66963
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.66963
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.57532
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.55992
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.54396
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B2 5.52706
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.49134
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.49134
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.44815
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.44336
[BP] GO:0033993 response to lipid AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SLC6A4, SRC, TYR 5.44336
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.40538
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.29073
[BP] GO:0030335 positive regulation of cell migration ADRA2A, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.19294
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.19294
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.19294
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.13904
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 5.10936
[BP] GO:2000147 positive regulation of cell motility ADRA2A, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.04877
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.01403
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.01403
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.9409
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.94023
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF 4.93447
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, KCNH2, MET, SMAD3, SRC, TERT 4.82563
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SLC6A4, SMAD3, SRC 4.82137
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 4.82137
[BP] GO:0040017 positive regulation of locomotion ADRA2A, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.79553
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, KCNH2, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TERT 4.75236
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.71007
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.71007
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.71007
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.71007
[BP] GO:0014070 response to organic cyclic compound CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, RORC, SLC6A4, SRC, TEK, TYR 4.65829
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.64468
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, EGFR, FLT3, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.6216
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.59204
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 4.52451
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 4.42115
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.39701
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.28931
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.28496
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.23345
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.23345
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.22418
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 4.15573
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SLC6A4, SRC, TERT 4.11427
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.0691
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.05012
[BP] GO:0032787 None ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA 4.04282
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.04207
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.03456
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, EGFR, INSR, KCNH2, MIF, MMP12, SLC6A4, SMAD3, SRC, TERT 4.03456
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.94695
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, INSR, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.9398
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.89883
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.89794
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.89785
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 3.84169
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.83109
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.81004
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.80568
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.76164
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B2, TYR, XDH 3.70071
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, HSPA1A 3.69568
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 3.68341
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.66976
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 3.63404
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.6276
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.62468
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.62468
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 3.60916
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.59152
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.56282
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.53109
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.4999
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, KCNH2, MET, SMAD3 3.47242
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.46442
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, MIF, PTPN1, SRC 3.42413
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.42
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.42
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC, TEK 3.35996
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.33298
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, KDR, MIF, PTPN1, SRC, TEK 3.32039
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 3.29998
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.29998
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.27297
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.26753
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.2552
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, TYR 3.2284
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC 3.22823
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.21141
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 3.1662
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.16468
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 3.11173
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SLC6A4, SRC 3.08493
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B2 3.07366
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 3.04905
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 3.01909
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.99944
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, CA2, CYP1B1, EGFR, ESRRB, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT 2.9905
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, TYR 2.95734
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, SMAD3, TEK 2.93297
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.93297
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 2.93297
[BP] GO:0009115 None AOX1, XDH 2.91053
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 2.91053
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT 2.90818
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.88091
[BP] GO:0050730 None ADORA1, ADRA2A, EGFR, FLT3, MIF, PTPN1, SRC 2.87412
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.85705
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.8537
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, SLC6A4, SRC, TEK 2.84208
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 2.83907
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.83606
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, TYR 2.83606
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, TERT, XDH 2.82482
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SLC6A4, SMAD3, SRC 2.78532
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.77827
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 2.77764
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 2.77231
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 2.77112
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, TYR 2.77087
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.76992
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.75978
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.75179
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 2.74622
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.71306
[BP] GO:0070920 None EGFR, ESR1, TERT 2.71306
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.67363
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.66424
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 2.66424
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.66424
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.66424
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.66424
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.66424
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, SLC6A2, SLC6A4, SMAD3 2.65581
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.65212
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.63971
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, MIF, PTPN1, SRC 2.62739
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.61514
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SLC6A4, SMAD3, SRC, TERT 2.59383
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.5878
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, EGFR, KDR, MIF, SRC 2.57885
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.57885
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, SLC6A2, SLC6A4, SRC 2.54059
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.53527
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.53339
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.53339
[BP] GO:0046110 None AOX1, XDH 2.53128
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53128
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.52989
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.52248
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 2.51573
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.4922
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.48991
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.47628
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT 2.4726
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.46892
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.46892
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.46892
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.46767
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, MIF, MMP12, SLC6A4, SRC 2.46721
[BP] GO:0051172 None ADRA2A, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.46647
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.45445
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, SRC 2.43875
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.42602
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.40855
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.40855
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, KDR, MIF, SRC, TEK 2.37385
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.36898
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.36821
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.36821
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.36338
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTPN1, TERT, XDH 2.33595
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.33595
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.33595
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, SLC6A4 2.32367
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32287
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.32287
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.31169
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.30451
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, SLC6A4, SRC, TEK 2.30451
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.30451
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 2.30388
[BP] GO:0006145 None AOX1, XDH 2.30388
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.30388
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30388
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.2979
[BP] GO:0051894 None KDR, SMAD3, TEK 2.28833
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.28833
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.28833
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.28369
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.26903
[BP] GO:0001775 cell activation ADRA2A, ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC 2.25744
[BP] GO:2001234 negative regulation of apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC, TERT 2.25744
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.23555
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 2.22534
[BP] GO:1903393 None KDR, SMAD3, TEK 2.19609
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD17B2, MIF 2.1814
[BP] GO:0048869 cellular developmental process ACHE, AXL, CDC25B, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MIF, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT 2.17969
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.17439
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.15842
[BP] GO:0050793 regulation of developmental process AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, INSR, KDR, MIF, NUAK1, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.15391
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.15391
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.13191
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.1251
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, GPR35, KCNH2, MMP9 2.11605
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PPARA, PTPN1 2.09266
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DUSP3, INSR, TERT 2.07711
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.07601
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.05528
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, CYP1B1, EGFR, IGF1R, INSR, KCNH2, KDR, MET, MIF, NUAK1, PTPN1, SRC, TEK 2.0479
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HSPA1A, MIF, MMP12, MMP2, PTPN1, SMAD3, SRC 2.04608
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.03818
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.03818
[BP] GO:0022414 reproductive process AKR1B1, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, SLC6A4, SRC 2.03445
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.03174
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, ALDH2, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, HSPA1A, SRC, XDH 2.02752
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.02625
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.0239
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.01042
[BP] GO:0051098 regulation of binding AURKB, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.01042
[BP] GO:1901890 None KDR, SMAD3, TEK 2.01005
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.01005
[BP] GO:2000352 None KDR, TEK, TERT 2.01005
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA12, CA14, CA2, CA4, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 2.49287
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, EGFR, TEK 2.48815
[CC] GO:0045121 membrane raft EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.34826
[CC] GO:0098857 membrane microdomain EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.33595
[CC] GO:0009986 cell surface ACHE, AXL, CA4, EGFR, KCNH2, MET, MIF, SLC6A2, TEK 2.24078
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK 2.21371
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MIF, MMP2, MMP9, PIM1, PTPN1, SLC6A4, SMAD3, SRC, TERT, TYR, XDH 2.01005
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 14.6859
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, F10, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TERT, TYR, XDH 10.5626
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 9.79555
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 9.40458
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.4032
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 6.96259
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.75193
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.40943
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.31822
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.0021
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.93969
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 5.86284
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.68317
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 5.68317
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.52706
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.39273
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.39273
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK 5.23303
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 5.13904
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.95887
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.7787
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B2, TYR, XDH 4.64468
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 4.28496
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 4.17149
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.12882
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK 4.06972
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.05914
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.89547
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.89547
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 3.89281
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.81144
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 3.81004
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MIF, MMP9, SLC6A4, SMAD3, TERT, TYR, XDH 3.8097
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.62468
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.62468
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 3.42856
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.4034
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.2505
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.2284
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, KCNH2, MET, MIF, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK 3.19257
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.08493
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, RORC 2.93297
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91053
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.84208
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, PPARA, RORC 2.82482
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC, XDH 2.53286
[MF] GO:0005330 None SLC6A2, SLC6A4 2.53128
[MF] GO:0047374 None CES1, CES2 2.53128
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.4721
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.33006
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30388
[MF] GO:0032795 None ADORA1, ADRA2A 2.30388
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.25744
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.17758
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B2, XDH 2.17758
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12002
[MF] GO:0043559 insulin binding IGF1R, INSR 2.12002
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, CA1, CA2, CES1, CES2 2.10296
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.07601
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.01005


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA14 11.1194
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9223
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.1304
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.9281
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.2011
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.287
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.287
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.0529
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, TYR, CYP2C19, CYP19A1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 3.95
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.644
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.5618
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.2895
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0062
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0748
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.5518
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 2.8989
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.5891
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5123
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3298
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, CYP2C19, SLC6A4 2.5123
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3118
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7918
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3298
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.988
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.7786
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.5248
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2391
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2A 2.0857
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.3118
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, CYP2C19 2.2644
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2095
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1757
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2043
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1705
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2338
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9901
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8303
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.1989
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.937
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.52
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1651
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.758
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4817
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4567
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, ADRA2A 1.4432
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4803
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0933
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0345
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0897
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0605
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.301
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9165
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9165
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9165
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0915
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8401
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0879
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9101
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.334
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8972
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8505
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1733
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8401
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8972
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8303
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8256
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8401
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.301
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3814
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8173
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.301
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8044
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8044
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6672
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.6731
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6513
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4817
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.311
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3508
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3438
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3371
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3428
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.574
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3432
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3438
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3366
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3806
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4229
Platelet activation_Homo sapiens_hsa04611 SRC 0.4465
Axon guidance_Homo sapiens_hsa04360 MET 0.4384
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4465
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4766
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4766
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5011
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4938
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5011
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5011
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5021
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5068
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5064
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5158
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5112
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5213
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5213
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5315
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5206
Peroxisome_Homo sapiens_hsa04146 XDH 0.5324
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5666
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5474
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5651
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5536
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.574
Bile secretion_Homo sapiens_hsa04976 CA2 0.5735
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5862
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5901
Shigellosis_Homo sapiens_hsa05131 SRC 0.588
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6073
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5842
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5984
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6304
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8303
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6513
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6332
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6513
Malaria_Homo sapiens_hsa05144 MET 0.6578
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.654
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6615
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6655
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.794
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7178
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6784
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7575
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7124
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0257
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8242
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8024
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8049
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8024
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8242
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8044
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8242
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8242
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8401
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9172
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9974
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.301


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)