TCM Prescription: Zhang Yan Ming Tablet



Prescription Description
Prescription IDTCMF1129
Pinyin NameZhang Yan Ming Pian 
Chinese Name障眼明片
English NameZhang Yan Ming Tablet
Function Description白内障
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLiver, Kidney
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH1698 Semen celosiae 青葙子 TCMH1698
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1432 Vitex trifolia 蔓荆子 TCMH1432 ITSAO4721-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH1754 Nux prinsepiae 蕤仁 TCMH1754
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1487 Buddleja officinalis 密蒙花 TCMH1487 ITSAM868-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1160 Polygonatum sibiricum 酒黄精 TCMH1160 ITSAH4762-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH717 Phellodendron amurense 关黄柏 TCMH717 ITSAM1586-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, PRKCA, PTAFR, SLC1A1, SRC, TNKS, TNKS2, XDH 12.1944
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTAFR, RORC, SRC, TYR 10.7182
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.45641
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, PRKCA, PTAFR, RORC, SRC, TYR 9.27106
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EPHX2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 9.18388
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRM1, GRM3, GRM5, GRM8 8.78918
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 8.56072
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PRKCA, PTAFR, RORC, SRC, TYR 8.29449
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 8.25045
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.85136
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, PTAFR, RORC, SRC, TYR 7.7444
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, RORC, SRC, TNKS2, TYR 7.47617
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 7.28522
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 7.23737
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 7.21075
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, RORC, SRC, TNKS2, TOP2A, TYR 7.19337
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTAFR, RORC, SRC, TYR 7.01213
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, FABP3, FUT7, GBA2, GLO1, HMGCR, PIM1, PPARA, PTAFR, TYR, XDH 6.89935
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 6.74578
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 6.69008
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTAFR, SRC, XDH 6.69008
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.67422
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA 6.67422
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC 6.49328
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.44488
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 6.44488
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 6.20283
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.14775
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TOP2A, XDH 6.06324
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.06324
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, HMGCR, PTAFR, TYR 6.0525
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SRC, TOP2A, XDH 6.0525
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 5.89194
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, GRM5 5.88015
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.8533
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.8533
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTAFR 5.82525
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.78013
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 5.77427
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.77427
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.77427
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PHF8, TYR, XDH 5.7738
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8 5.76233
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8 5.76233
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 5.75057
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 5.71094
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.65949
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 5.59358
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 5.59358
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.59358
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2 5.59358
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SRC, TOP2A, XDH 5.59358
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTAFR, PTPN1, SRC 5.54391
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2 5.48187
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, EPHX2, HMGCR, KDR, SRC 5.41508
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTAFR, SRC 5.39042
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TOP2A, TYR 5.31355
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.30674
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.284
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PTAFR, RORC, SRC 5.19941
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.18536
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PRKCA, PTAFR, PTPN1, SRC, XDH 5.13068
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTAFR, PTPN1, SRC, TNKS, TNKS2 5.10768
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PTAFR, RORC, SRC 5.09779
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.08814
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PRKCA, PTAFR, PTPN1, SRC, XDH 5.08644
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.06694
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.0077
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F10, F3, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 4.97977
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.88006
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.88006
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HMGCR, HSD11B2, KDR, PTAFR, SRC 4.84518
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.81093
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.75796
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PHF8, PIM1, PPARA, RORC, SRC, TYR 4.73852
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EPHX2, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA 4.73241
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PTAFR, RORC, SRC 4.72997
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, F10, F3, FLT3, GRM1, HMGCR, KDR, MET, PRKCA, PTPN1, SRC, XDH 4.66
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PTAFR, PTPN1, SRC, XDH 4.59849
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PTAFR, PTPN1, SRC, XDH 4.59849
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PRKCA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 4.55171
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.52896
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 4.52474
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTAFR, RORC, SRC 4.3134
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.30927
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.29052
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.29052
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTAFR, SRC 4.27264
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, EPHX2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PRKCA, PTAFR, PTPN1, SRC, TNKS, XDH 4.27264
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS 4.26133
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 4.23395
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.22196
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, EPHX2, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 4.20273
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PHF8, PPARA, SRC, TYR 4.16375
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC 4.16375
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 4.12763
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 4.08963
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.07289
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.06579
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTAFR, PTPN1, RORC, SRC, TOP2A 4.0542
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC, TYR 3.99855
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.99855
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SRC 3.99855
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 3.98311
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, EPHX2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PRKCA, PTAFR, PTPN1, SRC, TNKS, XDH 3.94871
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.93191
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, GRM1, HMGCR, HSD11B2, MMP2, PPARA, PTAFR, SRC, TYR 3.88382
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PTAFR, SLC1A1, SRC, TNKS2, XDH 3.85291
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTAFR 3.85291
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTAFR 3.85291
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTAFR, SRC 3.84791
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PRKCA, PTPN1, SRC, XDH 3.74742
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.73313
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.72884
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTAFR 3.68707
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 3.6799
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTAFR 3.67085
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.67085
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC, TYR 3.63868
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.6362
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC, TNKS 3.63038
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 3.58521
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.58393
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.55342
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2 3.53814
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.4925
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.4925
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTAFR, SRC 3.48783
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2 3.47673
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SRC 3.45615
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.44848
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42731
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, PTAFR, SRC 3.42154
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, RORC, SRC, TOP2A 3.40383
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.40227
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.37791
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 3.37791
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DRD2, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 3.37791
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 3.37195
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.37195
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.33816
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.31297
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, EPHX2, GRM1, GRM5, GRM8, HMGCR, HSD11B2, PTAFR, SRC, TYR 3.31096
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, ESRRB, F3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PTAFR, SLC1A1, SRC 3.26721
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.25838
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 3.24475
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2, TNKS, TNKS2 3.23374
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.23261
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.22601
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PRKCA, PTAFR, PTPN1, SRC, TNKS, XDH 3.1962
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR, SRC 3.17983
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.16004
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.16004
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, GRIK5, GRM5, HCAR2, HMGCR, MMP12, MMP9, PPARA, PRKCA, PTAFR, PTPN1, SRC 3.15837
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.13998
[BP] GO:0042391 None ADORA1, APP, BCL2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.12407
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F10, F3, MET, PRKCA, XDH 3.12407
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTAFR 3.07835
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05895
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, RORC 3.04614
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PRKCA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 3.04614
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.03939
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 3.02519
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.01044
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, GRM1, HMGCR, KDR, PRKCA, PTPN1, SRC, XDH 2.9978
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.96819
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, GRM1, HCAR2, PRKCA, PTAFR, SLC1A1 2.94054
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTAFR, SRC, TOP2A 2.92253
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 2.91734
[BP] GO:1900543 None DRD2, GRM3, GRM8, PPARA, PRKCA 2.91676
[BP] GO:0045980 None DRD2, GRM3, GRM8, PPARA, PRKCA 2.88883
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.87348
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.84422
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PHF8, PPARA, PTAFR, RORC, SRC, TNKS, TNKS2, TOP2A 2.83819
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.83692
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.81039
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, SRC 2.80621
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.79716
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 2.79716
[BP] GO:0009115 None AOX1, XDH 2.79716
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, FLT3, IGF1R, KDR, MET, PRKCA, SRC, TNKS, TOP2A 2.78636
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 2.78031
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.77537
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.75658
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, TYR 2.7533
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74925
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.73243
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC, TNKS 2.68388
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, FABP3, GRM1, GRM5 2.67522
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PRKCA 2.67337
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 2.66306
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.66288
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66288
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.65531
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, RORC, SRC, TOP2A 2.65531
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, PTAFR, SLC1A1 2.63327
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTAFR, PTPN1, SRC, TNKS, XDH 2.62831
[BP] GO:0045776 None ADORA1, DRD2, PPARA, PTAFR 2.61313
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, F3, MET, SRC, XDH 2.58612
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.57703
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, PTPN1, SRC, XDH 2.56043
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GBA2, GLO1, PPARA 2.55819
[BP] GO:0030818 None DRD2, GRM3, GRM8, PRKCA 2.54527
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PPARA 2.53569
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PTAFR, PTPN1, SRC, XDH 2.52402
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50873
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTAFR, SRC 2.50375
[BP] GO:0008217 None ADORA1, DRD2, EPHX2, HSD11B2, PPARA, PTAFR 2.49779
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PHF8, PPARA, PTAFR, RORC, SRC, TNKS, TNKS2, TOP2A 2.49323
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.4858
[BP] GO:0030803 None DRD2, GRM3, GRM8, PRKCA 2.48516
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, GRM5, IGF1R, MMP2, PTAFR, SRC 2.4684
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.44139
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 2.4353
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, GRM1, HMGCR, IGF1R, KDR, PRKCA, PTPN1, SRC, XDH 2.4353
[BP] GO:0008542 None APP, DRD1, DRD2, HMGCR 2.42374
[BP] GO:0030815 None DRD2, GRM3, GRM8, PRKCA 2.42374
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, HCAR2, MMP12, PTAFR, SRC 2.42374
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTAFR, SRC 2.42374
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.42374
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CHRM1, DRD1, DRD2, GRM5, MMP9, PTAFR 2.42374
[BP] GO:0099566 None GRM1, GRM5 2.41708
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.41708
[BP] GO:0046110 None AOX1, XDH 2.41708
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41708
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PHF8, PPARA, PTAFR, RORC, SRC, TNKS, TNKS2, TOP2A 2.41286
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.40674
[BP] GO:1900372 None DRD2, GRM3, GRM8, PRKCA 2.40674
[BP] GO:0030809 None DRD2, GRM3, GRM8, PRKCA 2.40674
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.39119
[BP] GO:0030800 None DRD2, GRM3, GRM8, PRKCA 2.37474
[BP] GO:0030817 None DRD1, DRD2, GRM3, GRM8, PRKCA 2.37261
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.37261
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.37047
[BP] GO:1900542 None DRD1, DRD2, ESRRB, GRM3, GRM8, PPARA, PRKCA 2.36996
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PTAFR, PTPN1, SRC, XDH 2.36691
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 2.36691
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.36691
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 2.34768
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.34768
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.34305
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.33988
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.32923
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, PRKCA, SRC, TNKS 2.314
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.31009
[BP] GO:0006140 None DRD1, DRD2, ESRRB, GRM3, GRM8, PPARA, PRKCA 2.30846
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.30468
[BP] GO:0007632 None APP, DRD1, DRD2, HMGCR 2.3045
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.3045
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.28383
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, GRM5, IGF1R, MMP2, PTAFR, SRC 2.26785
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, GRM1, GRM5 2.26616
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PHF8, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A 2.25042
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC, TNKS 2.24036
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.22824
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, GRIK5, GRM1, GRM5 2.20978
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.18771
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.18771
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.18771
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.18771
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MET, MMP9, PTAFR, PTPN1, SRC, TNKS, XDH 2.18771
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, PRKCA, TNKS, TOP2A 2.18726
[BP] GO:0070213 None TNKS, TNKS2 2.18726
[BP] GO:0006145 None AOX1, XDH 2.18726
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18726
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1848
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.17519
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.16095
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.15784
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, GRIK5, GRM1, GRM5 2.15007
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.14023
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.14023
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.14023
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.13861
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.13861
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.13334
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.11546
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, PRKCA, SRC, TNKS 2.11207
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.10874
[BP] GO:0030814 None DRD1, DRD2, GRM3, GRM8, PRKCA 2.10512
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.09137
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.09137
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, GRM1, GRM5 2.09137
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, GRIK5, HCAR2, HMGCR, MMP12, PRKCA, PTAFR, SRC 2.08833
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DRD1, ESR1, F10, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.08833
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, ESR1, FLT3, GRM5, IGF1R, MMP2, PTAFR, SRC 2.08477
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DRD1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.08415
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.08052
[BP] GO:0030802 None DRD1, DRD2, GRM3, GRM8, PRKCA 2.06557
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.06455
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD1, DRD2, GRM5, HMGCR 2.05851
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PRKCA, PTPN1, SRC, XDH 2.05851
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.05851
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.05851
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.05851
[BP] GO:0048169 None APP, DRD2, GRM5 2.05851
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, HCAR2, HMGCR, MMP12, PRKCA, PTPN1, SRC 2.05846
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, HMGCR, KDR, PRKCA, PTPN1, SRC 2.04524
[BP] GO:0010675 None ESRRB, PPARA, PTAFR, RORC, SRC 2.04493
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.03841
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EPHX2, ESR1, GRM1, GRM5 2.03018
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, HMGCR, PTAFR 2.03018
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.03005
[BP] GO:0021853 None DRD1, DRD2 2.03005
[BP] GO:0046541 None CHRM1, CHRM3 2.03005
[BP] GO:0043696 None CDK6, ESRRB 2.03005
[BP] GO:0043697 None CDK6, ESRRB 2.03005
[BP] GO:0010641 None F3, SRC 2.03005
[BP] GO:0007598 None F10, F3 2.03005
[BP] GO:1904936 None DRD1, DRD2 2.03005
[BP] GO:0042321 None ADORA1, DRD2 2.03005
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, PRKCA, SRC 2.02874
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.02805
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.02805
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.0078
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.00648
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, DRD2, HMGCR, KDR, PRKCA, SRC 2.0012
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC 2.0012
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 5.88015
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 5.76082
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, ESR1, F10, F3, FLT3, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PTAFR, PTPN1, SLC1A1, SRC 5.30674
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PHF8, PIM1, PRKCA, PTAFR, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TYR 5.18536
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 5.12062
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.08644
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 4.30352
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, SRC 3.94136
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.58481
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.58481
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.41219
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PTAFR, PTPN1, SLC1A1, SRC, TYR 3.37791
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 3.1962
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.16004
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2, GRIK5 3.15504
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.97016
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.93414
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F10, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.67307
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.61313
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.55874
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.55874
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, GRIK5, HMGCR, KDR, PRKCA, PTPN1, XDH 2.50873
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.45848
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.37261
[CC] GO:0031233 None CA4, F10, F3 2.28383
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.25017
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.14579
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.1259
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.08477
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.07488
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, PTAFR, SLC1A1, TYR 2.0587
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, TNKS, TYR, XDH 14.4415
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.45641
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTAFR, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.45641
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.45641
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 9.45641
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 8.77331
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 8.73237
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 8.40384
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.7582
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PRKCA, PTPN1, RORC, TNKS 7.7582
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 7.52573
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TOP2A, TYR, XDH 7.24826
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PHF8, TYR, XDH 6.94589
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.70628
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.27622
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR 6.18709
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PTAFR 6.18709
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.14775
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.89194
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.88015
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TOP2A, TYR, XDH 5.48317
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, XDH 5.18536
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.0576
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.04813
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.89737
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.89737
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.81093
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.7592
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PRKCA, SRC, TOP2A 4.64558
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PTAFR, RORC 4.57138
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.47875
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.88382
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.73313
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.41497
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.31006
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, TYR 3.31006
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25838
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B2, HSD17B1, SRC, XDH 3.18512
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.18341
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.16004
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.16004
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.11165
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR 2.81039
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.79716
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.79716
[MF] GO:0003845 None HSD11B1, HSD11B2 2.79716
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.75658
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.73155
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1 2.67522
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.65483
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.54527
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, EPHX2, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, TOP2A, TYR, XDH 2.50375
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.48615
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41708
[MF] GO:0099583 None GRM1, GRM5 2.41708
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.34474
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.33988
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.33988
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1 2.28934
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.21037
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.20978
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18726
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.18726
[MF] GO:0004971 None GRIA2, GRIA4 2.18726
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.18726
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.14023
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.1259
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.05851
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.03005
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.03005


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, PTAFR, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4 11.4372
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.9788
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.628
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 7.3997
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.3625
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, PTAFR, PRKCA, DRD1, GRM1 5.8324
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD1, DRD2, PPARA, GRIA4 5.5259
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2, PRKCA 5.1221
Metabolic pathways_Homo sapiens_hsa01100 CBR1, EPHX2, AKR1B1, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.0729
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, IGF1R 4.6267
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.0454
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.4099
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, PRKCA, DRD1, DRD2, GRM1 4.6428
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.7862
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, PRKCA, MMP9, MET, IGF1R 3.5039
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8324
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, CDC25B 3.5611
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, PRKCA, F3 3.3445
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, PRKCA, MET, IGF1R 3.2452
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PRKCA, GRM1, GRIA4 3.3445
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.6503
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6334
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, PRKCA, MET, IGF1R 2.9914
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.3942
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, PRKCA, DRD2, MET, IGF1R 2.919
Long-term depression_Homo sapiens_hsa04730 GRIA2, PRKCA, GRM1, IGF1R 3.1262
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, PRKCA, DRD1, DRD2, GRIA4 2.9914
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, PRKCA, DRD1, GRIA4 3.0062
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, PRKCA, GRM1 3.0062
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, PRKCA, MMP9 2.7823
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, PRKCA, GRM1 2.7967
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.0082
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.061
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9914
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1, PRKCA 2.1444
Glioma_Homo sapiens_hsa05214 CDK6, PRKCA, IGF1R 1.9851
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.0413
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9083
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9014
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.6609
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.659
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 1.8775
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 1.9223
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2 2.0326
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA, DRD1 1.6609
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9083
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, PRKCA, GRIA4 1.639
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, PRKCA, IGF1R 1.5675
Ras signaling pathway_Homo sapiens_hsa04014 KDR, PRKCA, MET, IGF1R 1.4177
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 1.6349
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PRKCA 1.4934
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2705
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA, ESR1 1.4607
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.4607
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.3063
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2059
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7852
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2603
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2672
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2793
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2861
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0156
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8732
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.738
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9393
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2667
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7959
Influenza A_Homo sapiens_hsa05164 PRKCA 0.2793
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7508
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 0.9393
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2861
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7582
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA 0.9952
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8187
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 0.9285
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5538
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7959
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.738
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9931
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.738
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3153
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA 1.0025
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.7194
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6151
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6151
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3367
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3367
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5538
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0474
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6509
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA 0.6855
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.3429
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9987
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3451
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 0.9931
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.4651
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9694
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA 0.9931
Platelet activation_Homo sapiens_hsa04611 SRC 0.3653
Axon guidance_Homo sapiens_hsa04360 MET 0.3574
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.0156
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3679
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3653
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0431
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.3679
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3918
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1563
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA 0.4186
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4186
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4186
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.4299
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.4203
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4284
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4292
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4387
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4387
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1503
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2705
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4387
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4387
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PRKCA 1.2705
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2623
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.4646
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4966
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2466
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5103
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.506
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5038
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5081
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5183
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5183
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5183
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3208
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5183
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5308
Shigellosis_Homo sapiens_hsa05131 SRC 0.5183
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5217
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5183
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.3812
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5538
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PRKCA 1.4934
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5538
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3921
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5758
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4796
Malaria_Homo sapiens_hsa05144 MET 0.5879
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6498
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5923
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5967
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.6609
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.561
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6205
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5452
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6494
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.6914
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8315
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7286
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7113
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.738
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7627
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.738
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7557
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8136
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8831
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9694
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0062
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2466


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)