TCM Prescription: Yao Bi Tong Capsule



Prescription Description
Prescription IDTCMF1117
Pinyin NameYao Bi Tong Jiao Nang 
Chinese Name腰痹通胶囊
English NameYao Bi Tong Capsule
Function Description腰椎间盘突出
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationSkeletaMuscle
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH693 Cudrania cochinchinensis 狗脊 TCMH693
TCMH1965 Rheum palmatum 熟大黄 TCMH1965 ITSAJ4687-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCHE, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD11B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK 15.7142
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, BCHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 14.8646
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, BCHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 14.8646
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCHE, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 14.2677
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCHE, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 14.1986
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 12.9184
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 12.9134
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, BCHE, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GRIK5, GRM5, HSD11B2, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TEK 12.4836
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, ALPL, APP, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GRIK5, GRM5, HSD11B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK 12.4642
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 12.2948
[BP] GO:0007187 None ADORA1, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 12.2867
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALOX15, ALPL, APP, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GRIK5, GRM5, HSD11B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK 12.0864
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, PIK3CA, PIK3CB, SMAD3 11.9897
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CYP1B1, DRD2, EGFR, F10, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 11.7065
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 11.1991
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 10.9018
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 10.8212
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, BCHE, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTGS1, PTGS2, SMAD3, SRC, TEK 10.8016
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 10.8016
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.5862
[BP] GO:0007188 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 10.5862
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 10.2682
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SIGMAR1, SRC 9.95759
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, BCHE, BCL2, CA2, CA9, CSNK2A1, DRD1, EGFR, ESR1, FABP3, GRM5, HSD11B2, HTR5A, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 9.89782
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRIK5, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 9.89507
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALPL, APP, BCHE, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK 9.87407
[BP] GO:0007193 None ADORA1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.71339
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 9.35126
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 9.24812
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 9.10462
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 8.92955
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 8.92955
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, GPR35, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 8.87986
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCHE, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, HSD11B2, HTR5A, PTGS2, SRC, TEK 8.77563
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, BCHE, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HSD11B2, HTR2A, HTR2B, KDR, PTGS2, SRC 8.68313
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALPL, APP, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, GRIK5, GRM1, GRM5, HSD11B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 8.68313
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.58427
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, BCHE, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, INSR, PIK3CA, PTGS2, SRC, TEK 8.53893
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 8.46236
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, BCL2, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK 8.3574
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 8.34846
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK 8.34422
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 8.16321
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, INSR, PTGS2, SLC1A1, SMAD3 8.14984
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.12171
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 8.11187
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2 7.94069
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.93275
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.92109
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 7.88016
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 7.8718
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK 7.86867
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, PIK3CA, PIK3CB, SMAD3 7.77851
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 7.75649
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, BCHE, BCL2, CA2, CA9, CSNK2A1, EGFR, ESR1, FABP3, HSD11B2, HTR5A, INSR, PPARA, PTGS2, SRC, TEK 7.73178
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP4, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.72604
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 7.69175
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, BCHE, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK 7.66233
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 7.44092
[BP] GO:0099536 None CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.4223
[BP] GO:0099537 None CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.4223
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 7.4223
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, CNR2, DRD1, DRD2, HTR2A, PTGS2 7.4223
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 7.41211
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.41211
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.40286
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HSD11B2, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 7.3754
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 7.27553
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 7.23838
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.22522
[BP] GO:0007267 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, TEK 7.22522
[BP] GO:0007610 None APP, BCHE, BCL2, CNR1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B, INSR, PPARA, PTGS2 7.22522
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 7.21057
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 7.207
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, BCHE, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK 7.19111
[BP] GO:0008217 None ADORA1, ADRA1A, CNR1, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 7.12199
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 7.10078
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.10078
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10078
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10078
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 7.10044
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCHE, BCL2, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC 7.08885
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, KDR, PIK3CB, PTGS2, SRC 7.07684
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 7.07434
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCHE, BCL2, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC 7.07434
[BP] GO:0042391 None ADORA1, ADRA1A, APP, BCL2, CNR1, CNR2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 7.05271
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 7.05138
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 7.00035
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 6.99191
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.94608
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CSNK2A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.94608
[BP] GO:0051896 regulation of protein kinase B signaling DRD2, DRD3, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 6.93704
[BP] GO:0050890 None ADORA1, APP, BCHE, CNR1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR, PTGS2 6.91855
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 6.90878
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, PTPN1, SRC, TEK 6.88944
[BP] GO:0007154 None ADORA1, ADRA1A, BCL2, CNR1, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PTGS2, SLC1A1, TEK 6.88332
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 6.88332
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, PTGS2, TEK 6.75758
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, PIK3CA, PIK3CB, SMAD3 6.72414
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 6.72414
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, EGFR, GRM1, HTR2A, HTR2B, INSR, KDR, PIK3CB, PTPN1, SRC, TEK 6.71101
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.68334
[BP] GO:0023052 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, TEK 6.65168
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.64926
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.64926
[BP] GO:0007268 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.61934
[BP] GO:0098916 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.61934
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK 6.58918
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK 6.51975
[BP] GO:0007611 None APP, BCHE, CNR1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR, PTGS2 6.5171
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, GRM1, HTR2A, HTR2B, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK 6.49877
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.43622
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.41019
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SRC 6.39751
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 6.3845
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 6.36016
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD11B1, HSD11B2 6.31148
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.27248
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, DRD3, GPR35, HTR2A, MMP9, PTGS2 6.21092
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.21092
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, BCL2, CSNK2A1, DRD2, EGFR, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 6.17733
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 6.1546
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 6.1402
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 6.12264
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, PIK3CB, SMAD3 6.12264
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.12204
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, SMAD3, SRC 6.11795
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 6.10926
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, SMAD3, SRC 6.04034
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 6.00129
[BP] GO:0006690 icosanoid metabolic process ALOX15, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.99983
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, PPARA, PTGS2, SMAD3, TEK 5.99969
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.99969
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.99969
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 5.9929
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.97137
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 5.96088
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK 5.95674
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HSD11B1, HSD11B2, HTR1A, HTR2A 5.89902
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, GPR35, GRM5, HTR1A, HTR2A, MMP9, PTGS2 5.81559
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.72527
[BP] GO:0033993 response to lipid ALPL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, EGFR, ESR1, FABP3, HSD11B2, HTR5A, PTGS2, SRC 5.69162
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 5.65341
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.6332
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.57977
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, GRM1, GRM5, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.51589
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.4985
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.48808
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.47592
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.41754
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 5.39693
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.39004
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FABP3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.36101
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, BCHE, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 5.34147
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.31041
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B 5.2463
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 5.22878
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 5.21316
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.20096
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.19178
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.19178
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, BCHE, BCL2, CA2, CA9, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SIGMAR1, SMAD3, SRC, TEK 5.18755
[BP] GO:0007612 None APP, BCHE, DRD1, DRD2, DRD3, GRM5, INSR, PTGS2 5.16932
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FABP3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.15473
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A 5.11147
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, BCHE, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.10768
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.05979
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, GRM1, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PTPN1, SRC 5.03214
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.02102
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, GRM1, GRM5, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC 5.00304
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSPA1A, HTR2B, PIK3CA, PPARA, PTGS1, PTGS2 4.99394
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC 4.97795
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.92802
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.87856
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, BCHE, CYP1A1, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.87856
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, BCHE, BCL2, CA12, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SMAD3, SRC, TEK 4.80799
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.77444
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 4.77444
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, HTR2A, HTR2B, PPARA, PTGS2, SRC, TEK 4.77444
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.7667
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.75587
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, BCHE, BCL2, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK 4.75289
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, CYP1B1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, SRC 4.70527
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.68571
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.6574
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.6574
[BP] GO:0006631 fatty acid metabolic process ALOX15, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 4.64746
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, PIK3CB, PTGS2 4.62646
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 4.62049
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, BCHE, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.60423
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.58534
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.58534
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 4.5801
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, F3, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP9, PTGS2, SLC1A1, SMAD3, SRC, TEK 4.56793
[BP] GO:0050877 None ADORA1, APP, BCHE, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR2A, INSR, PTGS2 4.54821
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.53763
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1 4.53763
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CA9, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, SMAD3, SRC 4.53058
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 4.53058
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2B, HTR5A, KDR 4.50695
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2 4.46533
[BP] GO:0051347 positive regulation of transferase activity ADORA1, CDC25B, DRD2, EGFR, GRM1, GRM5, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.45595
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA 4.446
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, EGFR, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 4.42466
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, DRD2, EGFR, FABP4, MMP9, PTGS2 4.38651
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A 4.34158
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.34157
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, HTR2A, HTR2B, PPARA, PTGS2, SRC, TEK 4.33711
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK 4.2998
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A 4.28438
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 4.28345
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2 4.26367
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 4.24502
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, SRC, TEK 4.23768
[BP] GO:0016477 cell migration CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 4.21057
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, EGFR, GPR35, GRM1, HTR2A, PTGS2, SLC1A1, SMAD3 4.18141
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, BCHE, BCL2, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SMAD3, SRC, TEK 4.14734
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, PPARA, SMAD3 4.14151
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.13279
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, GRM1, HTR2A, HTR2B, INSR, PIK3CB, PTPN1, SRC 4.13099
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.09193
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.0598
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1B1, CYP2A13, CYP2A6 4.00928
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR2A, MET 3.97672
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.97415
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 3.94621
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.91837
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, PPARA, SRC 3.88565
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 3.86696
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP9, PIK3CA, PTGS2, SLC1A1, SMAD3, SRC, TEK 3.85263
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.85236
[BP] GO:0040011 locomotion CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.83905
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.82667
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.81143
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.80296
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.78652
[BP] GO:0006811 None ADRA1A, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1 3.77999
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, EGFR, HSD11B2, PTGS2, SRC 3.76616
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, BCL2, CNR1, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.759
[BP] GO:0048870 cell motility CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.74908
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.73188
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, EGFR, HSD11B2, PTGS2, SRC 3.73188
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, HSD11B1, HTR5A, INSR, KDR, MMP9, PIK3CA, PPARA, PTGS2, SIGMAR1, SMAD3, SRC, TEK 3.70989
[BP] GO:0048513 animal organ development ACHE, ADRA1A, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B1, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK 3.69449
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC 3.68761
[BP] GO:0051701 interaction with host EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.68507
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.66378
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.66378
[BP] GO:0006468 protein phosphorylation APP, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, SRC, TEK 3.65867
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.6528
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.65228
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.65228
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC 3.64779
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.62042
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR, PTGS2 3.61099
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, DRD2, DRD3, GPR35, HSPA1A, HTR2A, MMP9, PTGS2 3.60626
[BP] GO:1900542 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, INSR, PPARA 3.58654
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.58171
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.56923
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.55627
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, GRM1, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.55487
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR2A 3.55024
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HTR2B, INSR, PTGS2, SMAD3, SRC 3.52897
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.52641
[BP] GO:0006140 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, INSR, PPARA 3.50368
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.49887
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, PPARA, SMAD3, TEK 3.49174
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.4657
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, APP, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.44898
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.43935
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, GRM1, HTR2A, HTR2B 3.42187
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, SMAD3, TEK 3.40697
[BP] GO:0045777 None ADORA1, ADRA1A, CNR1, HSD11B2 3.38579
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.38579
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, PIK3CA 3.37604
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC 3.37336
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.35936
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.33669
[BP] GO:0043086 negative regulation of catalytic activity APP, CNR1, CNR2, CSNK2A1, DRD2, DRD3, DUSP3, FABP4, GRM3, IGF1R, MMP9, PTGS2, PTPN1, SRC 3.29632
[BP] GO:1903524 None ADRA1A, EGFR, HTR2A, PTGS2, SLC1A1 3.29207
[BP] GO:0045907 None ADRA1A, EGFR, HTR2A, PTGS2 3.28686
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.27496
[BP] GO:0016310 phosphorylation APP, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 3.26786
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 3.26786
[BP] GO:0006820 anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 3.26344
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.25077
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, PIK3CA 3.24847
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2 3.24789
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, SRC, TEK 3.24523
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 3.24523
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.24468
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.24468
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, GRM1, HTR2A, HTR2B, INSR, PIK3CB, PTPN1, SRC 3.24468
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, PTGS2, SRC 3.24468
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.23188
[BP] GO:0021885 forebrain cell migration DRD1, DRD2, EGFR, HTR6 3.20179
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.17863
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, IGF1R, INSR, KDR, SRC, TEK 3.14732
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALPL, APP, BCHE, BCL2, CA12, CA2, CA4, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SMAD3, SRC, TEK 3.14451
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.14173
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC 3.14043
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.135
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC 3.12574
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.11973
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, SRC 3.10579
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DRD1, EGFR, ESR1, GRM5, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.10061
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, PTGS2, SMAD3 3.09921
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 3.07169
[BP] GO:0045787 positive regulation of cell cycle APP, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.0716
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.0691
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CNR1, DRD2, DRD3, EGFR, HTR2B, PTGS2, PTPN1, SMAD3, SRC 3.05373
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, APP, BCHE, BCL2, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 3.046
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, DRD2, EGFR, HTR2A, PTGS2, SLC1A1 3.04499
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.04386
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.04386
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, HSD11B2, INSR, MMP2, MMP9, PTGS2, SRC 3.0365
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, APP, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.0193
[BP] GO:0032787 None ALOX15, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 3.01158
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, EGFR, PTGS2 3.00985
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, EGFR, HSD11B2, PTGS2 3.00521
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, BCHE, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, PTGS2, SMAD3 2.99986
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.98972
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, BCL2, CNR1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.98505
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.96382
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.96382
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, BCL2, CA2, CNR1, CNR2, CYP19A1, DRD2, DUSP3, ESR1, HSPA1A, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.9556
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.9556
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.9556
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.9556
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.94683
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, PIK3CA 2.94654
[BP] GO:0006928 movement of cell or subcellular component APP, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.94461
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.9343
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC 2.9343
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3, EGFR 2.90147
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.89436
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.89436
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, EGFR, FABP4, MMP9, PTGS2 2.87153
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.87153
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.85842
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.85842
[BP] GO:0010638 positive regulation of organelle organization ALOX15, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.84288
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.84102
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, SRC 2.84102
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.82341
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.8213
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC 2.8213
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.7949
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.7949
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.79298
[BP] GO:0022898 None APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9 2.79298
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, PTGS2 2.7904
[BP] GO:0050730 None ADORA1, APP, EGFR, GRM5, HTR2A, PTPN1, SRC 2.76001
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR2A 2.76001
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.73187
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.7265
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.7265
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, EGFR, FABP3, KDR, MMP2, PTGS2, SRC 2.71886
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.69377
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.69377
[BP] GO:0030817 None DRD1, DRD2, DRD3, GRM3, GRM8 2.6828
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.6626
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.6618
[BP] GO:0099566 None GRM1, GRM5 2.65846
[BP] GO:0060160 None DRD2, DRD3 2.65846
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.65846
[BP] GO:0033602 None CNR1, DRD2 2.65846
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.65846
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.65391
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3 2.65391
[BP] GO:0032409 None APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9 2.65391
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, SMAD3 2.64398
[BP] GO:0051828 entry into other organism involved in symbiotic interaction EGFR, HSPA1A, HTR2A, MET, SRC 2.63961
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction EGFR, HSPA1A, HTR2A, MET, SRC 2.63961
[BP] GO:0030260 entry into host cell EGFR, HSPA1A, HTR2A, MET, SRC 2.63961
[BP] GO:0044409 entry into host EGFR, HSPA1A, HTR2A, MET, SRC 2.63961
[BP] GO:0009991 response to extracellular stimulus ALPL, BCHE, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC 2.63961
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.61347
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB 2.61347
[BP] GO:0031329 regulation of cellular catabolic process BCL2, CNR1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.60647
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3 2.60102
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.60102
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.60102
[BP] GO:0034762 None APP, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, GRM5, MMP9 2.59412
[BP] GO:0098900 None ADRA1A, CNR1, CNR2, GPR35 2.59067
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.59067
[BP] GO:0019233 None CNR1, CNR2, GRM1, PTGS2 2.59067
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, EGFR, FABP4, MMP9, PTGS2 2.56418
[BP] GO:0051098 regulation of binding APP, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC 2.56309
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.56309
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.56309
[BP] GO:0000302 response to reactive oxygen species AKR1B1, BCL2, CYP1B1, EGFR, MMP9, SRC 2.54349
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.54349
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1B1, CYP2D6, EGFR 2.54043
[BP] GO:0031324 negative regulation of cellular metabolic process APP, BCL2, CNR1, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, FABP4, GRM3, GRM8, HSPA1A, HTR2B, IGF1R, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC 2.54039
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.53876
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.53876
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.52923
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1 2.52651
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.52651
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.50511
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.48841
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.48841
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.48841
[BP] GO:0007626 None APP, DRD1, DRD2, DRD3, GRM1, GRM5 2.48724
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.48724
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.48724
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.47867
[BP] GO:0010959 None ADORA1, BCL2, DRD1, DRD2, DRD3, GPR35, HTR2A, PTGS2 2.47867
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FUT7, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 2.4784
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, EGFR, HTR1A, HTR2A 2.46802
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.43292
[BP] GO:0070201 None ACHE, APP, BCL2, CNR1, DRD2, DRD3, EGFR, HTR2B, PTGS2, PTPN1, SMAD3, SRC 2.42993
[BP] GO:0038171 None CNR1, CNR2 2.4108
[BP] GO:0019229 None ADRA1A, EGFR, HTR2A, PTGS2 2.4108
[BP] GO:0030814 None DRD1, DRD2, DRD3, GRM3, GRM8 2.39898
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2 2.38535
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.38535
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.38535
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.38535
[BP] GO:0030802 None DRD1, DRD2, DRD3, GRM3, GRM8 2.35075
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK 2.33228
[BP] GO:0051894 None KDR, SMAD3, TEK 2.3311
[BP] GO:0007584 response to nutrient ALPL, BCHE, CNR1, CYP1A1, EGFR, PTGS2 2.32813
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, APP, BCHE, BCL2, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FUT7, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 2.32371
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.31749
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, PTGS2 2.31333
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.31333
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.30594
[BP] GO:0035690 cellular response to drug AKR1B1, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 2.30126
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, GPR35, PTGS2 2.28974
[BP] GO:0050927 None F3, KDR, SMAD3 2.28588
[BP] GO:0048169 None APP, DRD2, GRM5 2.28588
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HTR2B, SRC 2.28522
[BP] GO:0009416 response to light stimulus APP, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2 2.2769
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GRIK5, MMP9, PIK3CB, PTGS2, SMAD3, SRC 2.27488
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1B1, CYP2D6, EGFR 2.26489
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.24494
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GRIK5, MMP9, PIK3CB, PTGS2, SMAD3, SRC 2.24334
[BP] GO:0050926 None F3, KDR, SMAD3 2.24115
[BP] GO:1903393 None KDR, SMAD3, TEK 2.24115
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.22325
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.22325
[BP] GO:0021853 None DRD1, DRD2 2.22325
[BP] GO:0010641 None F3, SRC 2.22325
[BP] GO:0007598 None F10, F3 2.22325
[BP] GO:1904936 None DRD1, DRD2 2.22325
[BP] GO:0042321 None ADORA1, DRD2 2.22325
[BP] GO:0090325 None DRD2, DRD3 2.22325
[BP] GO:0010513 None HTR2A, HTR2B 2.22325
[BP] GO:1900371 None DRD1, DRD2, DRD3, GRM3, GRM8 2.21344
[BP] GO:0043393 regulation of protein binding APP, BCL2, MET, MMP9, PPARA, SRC 2.21092
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.20955
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.20475
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC 2.20475
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC 2.20475
[BP] GO:0030808 None DRD1, DRD2, DRD3, GRM3, GRM8 2.20475
[BP] GO:0060341 regulation of cellular localization APP, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, GRIK5, PTGS2, PTPN1, SMAD3, SRC 2.1955
[BP] GO:0051726 regulation of cell cycle APP, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PTGS2, SMAD3, SRC 2.19266
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.19226
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.19225
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DRD2, DUSP3, ESR1, HSPA1A, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.18746
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, SRC 2.18746
[BP] GO:0009653 anatomical structure morphogenesis APP, BCL2, CA2, CA9, CYP1B1, DRD2, EGFR, ESR1, HTR2B, INSR, MET, MMP2, SMAD3, SRC, TEK 2.1826
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CNR1, CSNK2A1, DRD2, DRD3, EGFR, HTR2B, PTGS2, PTPN1, SMAD3, SRC 2.17372
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3 2.17372
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.17372
[BP] GO:0051482 None DRD1, GPR35, GRM1 2.16971
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.16971
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.16971
[BP] GO:0009891 positive regulation of biosynthetic process APP, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, PPARA, PTGS2, SMAD3, SRC 2.16093
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.16056
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, HTR2B, PTGS2, SMAD3, SRC 2.15645
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.15621
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway KDR, PIK3CA, PIK3CB, SRC 2.15621
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.12839
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA 2.12839
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB 2.1224
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.1224
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.1224
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.1154
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, PIK3CB, SRC 2.09549
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.0951
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9 2.0951
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.0931
[BP] GO:0002209 None BCL2, DRD1, HTR1A 2.0931
[BP] GO:0001662 None BCL2, DRD1, HTR1A 2.0931
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.0931
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, DRD2, PIK3CB, PTPN1, SRC 2.08654
[BP] GO:0021843 None DRD1, DRD2 2.08593
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.08593
[BP] GO:1990535 None APP, INSR 2.08593
[BP] GO:0021830 None DRD1, DRD2 2.08593
[BP] GO:0032229 None ADORA1, CNR2 2.08593
[BP] GO:0021826 None DRD1, DRD2 2.08593
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.08237
[BP] GO:0051223 None ACHE, APP, CNR1, DRD2, DRD3, EGFR, HTR2B, PTGS2, PTPN1, SMAD3, SRC 2.06984
[BP] GO:0008283 cell proliferation ACHE, BCL2, CYP1A1, EGFR, ESR1, HTR1A, MET, PIK3CB, SRC, TEK 2.06747
[BP] GO:0032412 None APP, DRD2, DRD3, GPR35, GRM5, MMP9 2.06587
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.06587
[BP] GO:0042220 None CNR1, DRD2, DRD3 2.06587
[BP] GO:1901890 None KDR, SMAD3, TEK 2.06587
[BP] GO:0045744 None DRD2, DRD3, MET 2.06587
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.06587
[BP] GO:0030799 None DRD1, DRD2, DRD3, GRM3, GRM8 2.06587
[BP] GO:0050808 None ACHE, APP, DRD1, DRD2, GRM5 2.05244
[BP] GO:0007346 regulation of mitotic cell cycle APP, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, SMAD3 2.04957
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.04054
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GRIK5, MMP9, PIK3CB, PTGS2, SMAD3, SRC 2.04047
[BP] GO:0007194 None DRD2, DRD3, GRM3 2.0307
[BP] GO:0043278 None CNR1, DRD2, DRD3 2.0307
[BP] GO:0014072 None CNR1, DRD2, DRD3 2.0307
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.0307
[BP] GO:0042596 None BCL2, DRD1, HTR1A 2.0307
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, CA4, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 11.9633
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ALOX15, APP, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTGS2, SIGMAR1, SLC1A1, SRC, TEK 11.9061
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SRC, TEK 10.7027
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PTPN1, SLC1A1, SMAD3, SRC, TEK 10.4237
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SMAD3, SRC, TEK 9.95759
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, CNR1, CNR2, DRD1, DRD2, DRD3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 9.95759
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, CNR1, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, PTGS2, SIGMAR1, SLC1A1, SRC, TEK 9.93397
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC, TEK 6.55397
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC, TEK 6.28616
[CC] GO:0043005 None ADORA1, APP, CA2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PTGS2, SRC 5.93351
[CC] GO:0097458 None ADORA1, APP, CA2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, PTGS1, PTGS2, SIGMAR1, SRC 5.1622
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.8036
[CC] GO:0045121 membrane raft ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 4.68076
[CC] GO:0098857 membrane microdomain ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 4.6574
[CC] GO:0044432 endoplasmic reticulum part APP, BCHE, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, F10, GRIA2, HSD11B1, HSD11B2, PTGS1, PTGS2, PTPN1, SIGMAR1 4.43516
[CC] GO:0044456 None ACHE, ADORA1, APP, CNR1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 4.3874
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SIGMAR1, SRC 4.31905
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SIGMAR1, SRC 4.31905
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.06353
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.06353
[CC] GO:0098589 membrane region ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 4.0183
[CC] GO:0097060 None CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 3.85263
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, GRIA2, HSD11B1, HSD11B2, PTGS1, PTGS2, SIGMAR1 3.74473
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, CA12, CA14, CA4, CA9, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 3.68507
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.50368
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.35006
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.31179
[CC] GO:0005901 caveola ADRA1A, HTR2A, INSR, PTGS2, SRC 3.26786
[CC] GO:0044853 plasma membrane raft ADRA1A, HTR2A, INSR, PTGS2, SRC 2.8213
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.81728
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, ALPL, APP, CA12, CA14, CA9, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 2.7773
[CC] GO:0031233 None CA4, F10, F3 2.54349
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, GRIK5, HSPA1A, HTR5A, KDR, PTGS2, PTPN1, SIGMAR1 2.49234
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.40872
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.08593
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC 2.06589
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 14.1986
[MF] GO:0030594 None DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 13.6495
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 12.8388
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 12.6569
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 12.6569
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, SMAD3, TEK 12.618
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 12.5775
[MF] GO:0070405 ammonium ion binding ACHE, BCHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 9.87461
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.44001
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.2638
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, APP, BCHE, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK 8.14984
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.77373
[MF] GO:0046914 transition metal ion binding ALOX15, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, SMAD3 7.66233
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 7.55565
[MF] GO:0008144 drug binding ACHE, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, SIGMAR1, SRC, TEK 7.41211
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.10078
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.10078
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10078
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.10078
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.9206
[MF] GO:0042165 neurotransmitter binding ACHE, BCHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.66961
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 6.54251
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 6.28616
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.99969
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, APP, BCHE, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, NUAK1, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3 5.56826
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2D6 5.50272
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.11306
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.09589
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.8036
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 4.77444
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.69393
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, BCHE, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F3, FUT7, HSD11B1, HSD11B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK 4.5801
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.37424
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.25639
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2 4.16846
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2D6 4.14489
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.82667
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B2, NQO2, PTGS1, PTGS2, SRC 3.69453
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, SMAD3 3.67929
[MF] GO:0005506 iron ion binding ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.6558
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.49887
[MF] GO:0004713 protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.34491
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.135
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.06457
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.06457
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 3.06457
[MF] GO:0003845 None HSD11B1, HSD11B2 3.06457
[MF] GO:0008389 None CYP2A13, CYP2A6 3.06457
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.04386
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, NQO2 2.94683
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.65846
[MF] GO:0004949 None CNR1, CNR2 2.65846
[MF] GO:0099583 None GRM1, GRM5 2.65846
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.65846
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.65846
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.60102
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.60102
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.56375
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.54349
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.42862
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.4108
[MF] GO:0004971 None GRIA2, GRIA4 2.4108
[MF] GO:0051425 None APP, INSR 2.4108
[MF] GO:0001540 amyloid-beta binding ACHE, BCHE, GRIA2, INSR 2.4108
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.31333
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.26877
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.22325
[MF] GO:0043559 insulin binding IGF1R, INSR 2.22325
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.20955
[MF] GO:0042802 identical protein binding ACHE, APP, BCHE, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, GRIK5, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SMAD3 2.20475
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.20475
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.1154
[MF] GO:0004672 protein kinase activity CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, SRC, TEK 2.07135
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.06587
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06587


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 20.4698
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, CYP2D6, ALOX15, HTR2B, HTR1A, HTR2A, PTGS2, HTR5A, PTGS1 10.451
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 9.6584
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 7.9263
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.9263
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, GRM1, EGFR 7.5057
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.134
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, HTR6, PIK3CA, ADORA1, HTR1A, PIK3CB, DRD1, DRD2, PPARA, GRIA4 7.1758
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.5057
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, HTR2A, DRD1, DRD2, GRM1, EGFR 7.5057
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7924
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 8.9205
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 6.0641
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 5.5473
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 6.3668
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.6988
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.8576
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.1358
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A1, CYP1B1 5.5082
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 5.2453
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIK3CB, F3 4.7978
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, PTGS2, GRM1, GRIA4 4.7978
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.4777
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A1, CYP1B1, PTGS2 5.2525
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3973
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.6596
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.0647
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.572
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.014
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.3796
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.3643
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.9682
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, PIK3CB, HTR2A 3.7899
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, CYP1A1, CYP1B1, CYP19A1 4.752
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6078
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA1A 3.7352
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.604
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.4274
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, ADRA1A, IGF1R 3.3807
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, GRIA4 3.3292
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.9646
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.3807
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.4314
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.3665
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.5459
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.7873
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.9646
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.6077
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 4.1234
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.8474
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB, MET, EGFR 3.3509
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6146
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.969
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.7899
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1228
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4992
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5459
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB, HSPA1A 2.5459
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5459
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3199
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.3816
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.3593
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.3311
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.3186
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.2431
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB, ADRA1A 2.2688
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX15, CYP1A1, ALPL, AKR1B1, PTGS2, CYP19A1, PTGS1 1.8665
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.7693
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5449
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2822
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2922
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3189
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5449
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3458
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9776
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.8735
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3865
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIK3CB 1.4298
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7049
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.8489
Axon guidance_Homo sapiens_hsa04360 MET 0.4018
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4098
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.333
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4156
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9, MET, IGF1R 1.311
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9566
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1892
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 KDR, MET, EGFR 0.9638
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.9872
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7807
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2767
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4731
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.5459
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7479
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7471
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8914
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4895
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4885
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9076
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4053
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9205
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.2357
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8914
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.325
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5075
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.963
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5075
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.52
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5075
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.325
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5063
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0703
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.4852
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.3186
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0812
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1484
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1075
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1357
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1193
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1613
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.6146
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5494
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5635
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.166
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5613
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5733
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.2215
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3061
Bile secretion_Homo sapiens_hsa04976 CA2 0.5711
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX15, PTGS2, PTGS1 2.3775
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5986
Shigellosis_Homo sapiens_hsa05131 SRC 0.5986
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.311
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3466
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5986
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2564
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3248
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6 1.3392
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4345
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A1 1.3785
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.654
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.4672
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4437
Malaria_Homo sapiens_hsa05144 MET 0.6964
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7097
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.5449
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6 0.7151
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6385
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8119
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.727
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8582
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1 1.727
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15 0.8821
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9285
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8791
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9066
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8002
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1398
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1294
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6 1.4855


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)