TCM Prescription: Jing Tong Granules



Prescription Description
Prescription IDTCMF1093
Pinyin NameJing Tong Ke Li 
Chinese Name颈痛颗粒
English NameJing Tong Granules
Function Description神经根型颈椎病
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationBrain
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1284 Penicillium expansum
TCMT1289 Shigella dysenteriae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1448 Enterobacter aerogenes
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.98947
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.98947
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 7.19382
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 6.93842
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 6.62851
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 6.41194
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 6.32479
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.75975
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.75975
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.63184
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.63184
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 5.59698
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 5.59698
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 5.59698
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.59698
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 5.56133
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, ESR1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.54161
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.54161
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.52972
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.47894
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 5.44858
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B 5.2903
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 5.1519
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 5.12806
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.92177
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B 4.86232
[BP] GO:0006820 anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 4.67309
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.66696
[BP] GO:0006811 None ADRA1A, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 4.66696
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B 4.44669
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 4.40114
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.40114
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, HTR1A, HTR2A, HTR2B, MMP2, MMP9 4.35024
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 4.31137
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 4.07284
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.94821
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.92991
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.92538
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.92538
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A 3.91822
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, HTR1A, HTR2A, HTR2B, HTR7, PPARA 3.85591
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.85591
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.78158
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 3.74358
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.7177
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, CA2, CA7, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, HTR1A, HTR2A, HTR2B, HTR6, MMP1, MMP2, MMP9, PPARA 3.68961
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, ALOX5, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, HTR1A, HTR2A, HTR2B, HTR7, MMP1, MMP2, MMP9, PPARA 3.65815
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 3.63778
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, CA2, CA9, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PPARA 3.62365
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.59668
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, CA2, CA7, DRD1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, MMP9 3.57364
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, CA2, CA7, DRD1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, MMP9 3.5569
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.54913
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.53575
[BP] GO:0097164 None ACHE, AKR1B1, DRD1, DRD2, DRD3, HTR1A 3.51623
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 3.50857
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 3.49266
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 3.48673
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 3.48673
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, CA2, CA9, DRD1, ESR1, ESRRA, FABP3, HTR5A, MMP2, PPARA 3.45776
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, CA2, CA7, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HTR1A, HTR2A, HTR2B, HTR6, MMP1, MMP2, MMP9, PPARA 3.4529
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR1A, HTR2A, MMP9 3.41613
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.3873
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.3873
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, CA2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MMP2, MMP9, PPARA, SIGMAR1 3.38016
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 3.3391
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.33209
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 3.31049
[BP] GO:0051580 None DRD1, DRD2, DRD3 3.3092
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 3.3092
[BP] GO:0032844 regulation of homeostatic process ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 3.2641
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, CA9, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HTR5A, MMP2, MMP9, PPARA 3.24288
[BP] GO:0001963 None DRD1, DRD2, DRD3 3.22711
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A 3.22711
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.22669
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 3.22107
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, CA2, CA9, ESR1, ESRRA, FABP3, HTR5A, PPARA 3.20222
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 3.16243
[BP] GO:0032225 None DRD1, DRD2, DRD3 3.16243
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 3.15989
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, DRD2, DRD3, ESR1, F3, HTR1A, HTR2A, HTR2B, MMP2, MMP9 3.0779
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 3.05932
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 3.0556
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 3.0556
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 3.0405
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 3.0405
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A 3.03797
[BP] GO:0014821 None DRD1, DRD2, HTR2B 3.03797
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.01423
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.99036
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.98713
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.97781
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.94533
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.94437
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.94382
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, HTR2A, MMP9 2.93615
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.93615
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.93433
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B 2.90524
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.89516
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.8819
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.88064
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.8524
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA 2.8512
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, CA2, CA9, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HTR5A, MMP2, PPARA 2.83769
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.79412
[BP] GO:0060160 None DRD2, DRD3 2.79412
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.79412
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1 2.78835
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.78172
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.7383
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.73017
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.72796
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.72028
[BP] GO:0019725 cellular homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.72028
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, CA2, CA7, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, HTR1A, HTR2A, HTR2B, HTR6, MMP9 2.71959
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD3, HTR2A, HTR2B, MMP2, PPARA 2.71959
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.6651
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.65783
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, CA2, CA7, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, HTR1A, HTR2A, HTR2B, HTR6, MMP9 2.65736
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.65077
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX5, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1 2.6429
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.62191
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.62191
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, CA2, CA9, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, HTR1A, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PPARA 2.61298
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.57882
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, ESR1, F10, FABP3, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1 2.57882
[BP] GO:0099536 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.57803
[BP] GO:0099537 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.57803
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.57803
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.57803
[BP] GO:0060191 regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.57769
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.56778
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A 2.50886
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, HTR2A, HTR2B, HTR6, MMP2, MMP9 2.50045
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A 2.49467
[BP] GO:0007154 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.44143
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.42515
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.42515
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR2B 2.41191
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.4107
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, DRD2 2.39882
[BP] GO:0021853 None DRD1, DRD2 2.38739
[BP] GO:0090325 None DRD2, DRD3 2.38739
[BP] GO:0007598 None F10, F3 2.38739
[BP] GO:1904936 None DRD1, DRD2 2.38739
[BP] GO:0042321 None ADORA1, DRD2 2.38739
[BP] GO:0010513 None HTR2A, HTR2B 2.38739
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A 2.38458
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA 2.38458
[BP] GO:0021885 forebrain cell migration DRD1, DRD2, HTR6 2.3381
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA 2.32247
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, DRD2, ESR1, HTR1A, HTR2A 2.30967
[BP] GO:0007212 None DRD1, DRD2, DRD3 2.27248
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, CA2, CA7, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, MMP9, PPARA 2.26315
[BP] GO:0071702 None ADORA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, PPARA, SIGMAR1 2.24544
[BP] GO:0014075 None DRD1, DRD2, DRD3 2.24394
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, CA12, CA2, CA4, CA7, CA9, CYP2D6, FABP3, HTR2B, PPARA 2.24285
[BP] GO:0021843 None DRD1, DRD2 2.24285
[BP] GO:0021830 None DRD1, DRD2 2.24285
[BP] GO:0021826 None DRD1, DRD2 2.24285
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP2D6, DRD1, DRD2, DRD3 2.22856
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, DRD1, DRD2, DRD3, ESR1, ESRRA, HTR5A 2.21984
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, DRD3, FABP3, HTR2A, HTR2B, PPARA 2.19737
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, HTR2A, HTR2B, MMP9, PPARA 2.19732
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B 2.17949
[BP] GO:0007610 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA 2.17754
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, HTR2A, HTR2B, MMP9, PPARA 2.1695
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CYP2D6, DRD2, ESR1, FABP3, FABP4, PPARA 2.16841
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, DRD2, DRD3 2.16059
[BP] GO:0055065 metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.16059
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, DRD2, F10, F3, HTR2A, HTR2B, HTR6 2.12811
[BP] GO:0010511 None HTR2A, HTR2B 2.12621
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B 2.12119
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, MMP9 2.0696
[BP] GO:0051209 None DRD2, HTR2A, HTR2B 2.0696
[BP] GO:0051283 None DRD2, HTR2A, HTR2B 2.0696
[BP] GO:0097366 None DRD1, DRD2, DRD3 2.0696
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, HTR2A, HTR2B, PPARA 2.06644
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, DRD2, DRD3, ESR1, F10, F3, HTR2A, HTR2B, HTR6, MMP9 2.03908
[BP] GO:0032101 regulation of response to external stimulus ADORA1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, PPARA 2.02671
[BP] GO:0050433 None DRD2, DRD3, HTR2A 2.02137
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, CA4, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.63184
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.87464
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.54913
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, CA12, CA14, CA2, CA4, CA9, DRD1, DRD2, DRD3, ESR1, F10, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MMP2 3.39929
[CC] GO:0031233 None CA4, F10, F3 2.93433
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, CA12, CA14, CA4, CA9, DRD1, DRD2, DRD3, ESR1, F10, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, MPEG1, SIGMAR1 2.3381
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, HTR2A, SIGMAR1 2.12621
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 9.62909
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.93659
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.93659
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.60901
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 8.49699
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.98947
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.98947
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 7.86217
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.79098
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.79098
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 7.73424
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA12, CA2, CA4, CA7, CA9, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA 7.32363
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 7.29228
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, CA12, CA14, CA2, CA4, CA7, CA9, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, PPARA 7.22392
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.98689
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.23399
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 6.11216
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, CA12, CA14, CA2, CA4, CA7, CA9, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, PPARA 6.11216
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA 5.85939
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.59698
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.50359
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.84294
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.84294
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.83493
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.83493
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.45391
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 3.49878
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.46814
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.3873
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.16243
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, PPARA 3.13138
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.93433
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP2, MMP9 2.67962
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.56778
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB 2.56519
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.38739
[MF] GO:0001609 None ADORA1, ADORA3 2.12621
[MF] GO:0001591 None DRD2, DRD3 2.02137
[MF] GO:0004252 None F10, F3, MMP1, MMP2, MMP9 2.00121


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, HTR2A, DRD1, HTR5A, DRD2, ADRA1A, DRD3 11.4208
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 9.2225
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 10.9458
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 6.2082
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 4.6386
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 4.0313
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, ESR2 3.5346
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2A, DRD1, DRD2 3.6782
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.3307
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.9508
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.6936
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9, ESR1 1.5317
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.6123
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.6936
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.4845
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2338
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, AOX1 1.4939
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, F3 1.3153
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 HTR2B, HTR2A 1.3199
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.4317
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.3599
Pathways in cancer_Homo sapiens_hsa05200 MMP1, MMP2, MMP9 0.9996
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.2123
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.2123
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 1.0942
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.9442
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.7044
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.6664
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7131
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.7033
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7062
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.6562
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.7062
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7033
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.6562
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7749
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.6269
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5 0.7698
Retinol metabolism_Homo sapiens_hsa00830 AOX1 0.7062
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.6402
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.6269
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.6269
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6562
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6 0.7033
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7749
Bile secretion_Homo sapiens_hsa04976 CA2 0.7033
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6519
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6519
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.6191
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.6191
Hepatitis B_Homo sapiens_hsa05161 MMP9 0.5738
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.6191
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5938
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.5758
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A 0.6137
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.573
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.5738
Jak-STAT signaling pathway_Homo sapiens_hsa04630 AOX1 0.5626
Rap1 signaling pathway_Homo sapiens_hsa04015 DRD2 0.4695
Metabolic pathways_Homo sapiens_hsa01100 ALOX5, AOX1, AKR1B1 0.387
Ras signaling pathway_Homo sapiens_hsa04014 HTR7 0.4501
Tryptophan metabolism_Homo sapiens_hsa00380 AOX1 0.8262
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.5207
MicroRNAs in cancer_Homo sapiens_hsa05206 MMP9 0.3712
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.8573
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8928
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8573
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8928
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8798
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9076
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3842


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)