TCM Prescription: Zhi Kang Tablet



Prescription Description
Prescription IDTCMF1068
Pinyin NameZhi Kang Pian 
Chinese Name痔康片
English NameZhi Kang Tablet
Function Description痔疮出血, 肿痛
IndicationsHemorrhoids
Disease ICD-11 Category DB60 [Haemorrhoids, 痔 ];
Human Tissues Associated with IndicationLarge Intestine
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2238 Siegesbeckiae herba 豨莶草 TCMH2238 GQ434487
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH938 Sophora japonica 槐花 TCMH938 ITSAN2377-14
TCMH463 Sanguisorba officinalis 地榆炭 TCMH463 GENG545-14, GBVT2403-13
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 12.4208
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 12.2071
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, NR3C1, PTGS2, RORC, SRC, TYR 12.1256
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 12.0848
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 10.3685
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PTGS2, RORC, SRC, TYR 10.1682
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.1306
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 9.17918
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.69931
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 8.69931
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 8.66787
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 8.52058
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PPARA, PTGS2, SRC 8.15818
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SRC 7.80186
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 7.74481
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 7.5522
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 7.45078
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, NR3C1, PTGS2, SRC 7.43772
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 7.43042
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, PTGS1, PTGS2, SRC, XDH 7.36399
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 7.33466
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, SRC, TYR 7.31365
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC 7.28953
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.10101
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.09862
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 7.01346
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.98712
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 6.96183
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.91537
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 6.74623
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.62031
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TNKS2, TYR 6.50227
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.47652
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.31475
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.26059
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 6.26059
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.17871
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.17574
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 6.1714
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.02162
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, RORC, SRC, TNKS, TNKS2 5.96422
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 5.96009
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.95162
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.90502
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.84098
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.81882
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, PTPRS, SRC, TYR 5.77156
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.71726
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.59792
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SRC 5.59792
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.58033
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 5.50676
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.48688
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 5.32251
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.30595
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.25377
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC 5.24489
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.24489
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.21507
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.1412
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.0901
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 5.07901
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.07633
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.07633
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.05046
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.04848
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC 5.04537
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 4.98163
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.89891
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.87752
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 4.84878
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, SRC 4.84275
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 4.83648
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 4.83648
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PGR, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 4.8067
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 4.76838
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 4.64913
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 4.62976
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.58787
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.56498
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 4.54362
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.54362
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 4.54058
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.52848
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC 4.4611
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.44227
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 4.44227
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.44227
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.42765
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.42645
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.39351
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37681
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.36171
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 4.32255
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.31782
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.31782
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 4.31357
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 4.31048
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, PTGS2 4.31048
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC 4.31048
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TYR 4.31048
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.30916
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 4.29888
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.29298
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 4.28151
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.27708
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.27708
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 4.23051
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2 4.20773
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.20601
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 4.19872
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.19278
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 4.16039
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.06426
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.00465
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, SRC, XDH 3.90852
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 3.89029
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.8809
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 3.87883
[BP] GO:0007267 None ADORA1, AR, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR 3.78946
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.78841
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2 3.76619
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC 3.73756
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 3.71433
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.68774
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 3.66686
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 3.66686
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.62492
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SRC, TYR 3.58999
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, PGR, PPARA, RORC, SRC 3.58999
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.579
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 3.5496
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53384
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC 3.49362
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.42362
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.42362
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 3.41888
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.3847
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.34312
[BP] GO:0023052 None ADORA1, AR, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR 3.33278
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.27907
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.27907
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.2223
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, SRC, XDH 3.21538
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.21519
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PGR, PTGS2, SRC 3.19799
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.19799
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.19799
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.19799
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.18178
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, TYR 3.17877
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 3.1645
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.15428
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 3.11689
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.11689
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11689
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.11689
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TYR 3.08868
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 3.08519
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 3.05976
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.00858
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.00858
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.99736
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.99736
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.97986
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, XDH 2.94379
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, HTR1D, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.93655
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.93655
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, XDH 2.93199
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.93183
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.92917
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 2.88781
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.87998
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.87027
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.8607
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.8597
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.84898
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.83729
[BP] GO:0007208 None HTR2A, HTR2C 2.83729
[BP] GO:0009115 None AOX1, XDH 2.83729
[BP] GO:0090066 None ADORA1, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.80401
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80401
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KDR, NR3C1, PTGS2, SRC 2.79364
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.7716
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPRS, SRC, XDH 2.74012
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 2.73774
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.73774
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 2.73165
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 2.71798
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.71798
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71798
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.71798
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.71313
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC, XDH 2.70829
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.70754
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.70754
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.6925
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.66866
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CYP19A1, ESR1, ESRRB, HSD17B2, PGR, PTGS2, SRC 2.63374
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 2.63374
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.63374
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.6154
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.61249
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.58945
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.56156
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56156
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.56156
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC 2.55703
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, HTR2A, HTR2B, HTR2C, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TNKS2, XDH 2.53056
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.48487
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.48148
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.4367
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 2.43474
[BP] GO:0060748 None AR, PGR 2.43107
[BP] GO:0046110 None AOX1, XDH 2.43107
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43107
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.42089
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.40755
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.37203
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.36664
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.35364
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.34479
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 2.33697
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CNR1, CNR2, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPRS, SRC, XDH 2.33689
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.33509
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.32767
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CSNK2A1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.32466
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, KDR, MET, MMP12, PPARA, PTGS2, PTPRS 2.29424
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.29424
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, ESR1, PGR, PTGS2, SRC 2.28188
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.28188
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPRS, SRC 2.27899
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.27899
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.27372
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.27202
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.26564
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.26564
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.26564
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.2478
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.2478
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.23938
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.23196
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.21994
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 2.20702
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.2041
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, ESR1, FLT3, HTR1B, IGF1R, MMP2, NR3C1, PTGS2, SRC 2.19985
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.1979
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1979
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA 2.19667
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.1937
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.19262
[BP] GO:0070213 None TNKS, TNKS2 2.19262
[BP] GO:0006145 None AOX1, XDH 2.19262
[BP] GO:0038171 None CNR1, CNR2 2.19262
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.19262
[BP] GO:0014827 None HTR1D, HTR2B 2.19262
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.18449
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17471
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.15795
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.15795
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, ESRRA, MMP12, MMP2, PIK3CA, PIK3CB, PTPRS, SRC 2.15795
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.15795
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.15005
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.14959
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.14959
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC 2.14356
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TUBB3 2.14092
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA 2.13142
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.13142
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 2.13142
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.13142
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TNKS, XDH 2.12069
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.12018
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.11975
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.11975
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, XDH 2.09748
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.09064
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.09064
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 2.06992
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06693
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 2.0633
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.05411
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2 2.04683
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.03291
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.03291
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.02832
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.02669
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 2.0198
[BP] GO:0071502 None HTR1B, HTR2B 2.0186
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.00768
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.00768
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, BCL2, ESR1, ESR2, FLT3, HTR2A, HTR2B, MET, MMP9, PIK3CA, PIK3CB, SRC, TNKS, XDH 2.00768
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 6.23353
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR 5.86235
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 5.25377
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC 5.06016
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, PTPRS, SRC 4.91928
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, SRC, TYR 4.18207
[CC] GO:0043005 None ADORA1, APP, CA2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, PTGS2, PTPRS, SRC, TUBB3 2.25748
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4544
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4544
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TNKS, TYR, XDH 16.0739
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 15.7702
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.2251
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.1907
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 11.2974
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, RORC, TNKS, TNKS2, TYR, XDH 11.033
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.9504
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 10.386
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 10.3302
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 10.0832
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 9.74198
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.55308
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.28059
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 9.06241
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, RORC, TNKS 8.43169
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 7.96737
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.94467
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.94467
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.48766
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 6.32909
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 6.3061
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.9243
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, RORC, TNKS, TNKS2, TYR, XDH 5.18662
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 5.05046
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.80065
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.80065
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.76911
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TUBB3, XDH 4.43789
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TUBB3, XDH 4.37445
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.36171
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.15017
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.14291
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.10073
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.9392
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1 3.7992
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.74278
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.65053
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59966
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.44263
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.40224
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.34078
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.26224
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.24921
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.2254
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.99736
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.83729
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.83729
[MF] GO:0003845 None HSD11B1, HSD11B2 2.83729
[MF] GO:0071886 None HTR2A, HTR2C 2.83729
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.81984
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.61486
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.58065
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.48554
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.43107
[MF] GO:0004949 None CNR1, CNR2 2.43107
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.19889
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.19262
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.17717
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.02832
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.02823
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0186


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 18.2167
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, NR3C1, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 12.1398
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.0514
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.7314
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 6.869
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.739
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 8.8784
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.755
Pathways in cancer_Homo sapiens_hsa05200 AR, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.2267
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.7036
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.908
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.5693
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.9531
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3622
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.2023
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.357
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0896
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.9504
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 3.8918
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.8837
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.085
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.5759
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, BCL2, PIK3CB, IGF1R 3.8242
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2C, HTR2A 3.8312
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB, NR3C2 3.9158
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.2507
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8925
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.9582
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4035
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8887
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 2.9582
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.1584
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.1019
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.8339
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.0453
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.9017
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, IGF1R 2.6603
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9698
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1367
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.4881
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.8542
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4928
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.5896
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3736
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.2075
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4181
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.4181
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4181
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0322
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.1914
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 1.9618
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8617
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.7289
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.2101
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2124
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9066
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2433
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8416
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.7044
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5974
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8474
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2075
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5748
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4496
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4685
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5714
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2101
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5137
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.4936
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5137
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.4241
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4069
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2871
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2992
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3087
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1337
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3087
Phagosome_Homo sapiens_hsa04145 TUBB3 0.332
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1014
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3552
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2281
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9194
Axon guidance_Homo sapiens_hsa04360 MET 0.3891
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5232
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7095
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7176
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8801
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8713
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 0.8617
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8617
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.8438
Melanogenesis_Homo sapiens_hsa04916 TYR 0.466
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4655
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4783
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4776
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1014
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1101
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.06
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4908
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0356
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4917
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.06
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.046
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4936
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4936
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0704
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.046
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.06
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4927
Peroxisome_Homo sapiens_hsa04146 XDH 0.5088
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5232
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5438
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5418
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5563
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2697
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2697
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3026
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3168
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2825
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5812
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2825
Shigellosis_Homo sapiens_hsa05131 SRC 0.5812
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3026
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5812
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6019
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3848
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2958
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.4241
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4685
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3921
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6321
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6582
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5137
Malaria_Homo sapiens_hsa05144 MET 0.6706
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5536
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6801
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6753
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6851
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6992
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8371
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7265
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8474
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7891
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8297
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7093
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8459
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8713
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0146
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8392
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8636
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0889
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1367
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3848


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)