Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1537	TCMT101	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50: 5930 (nM), Ref: 19846303
TCMC1537	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	IC50: 630 (nM), Ref: 21561086
TCMC1609	TCMT44	Glyoxalase I	Homo sapiens	IC50: 560 (nM), Ref: 18258440 IC50: 560 (nM), Ref: 21669529
TCMC1609	TCMT156	Cytochrome P450 19A1	Homo sapiens	IC50: 10000 (nM), Ref: 18778944
TCMC1609	TCMT737	DNA dC->dU-editing enzyme APOBEC-3G	Homo sapiens	IC50: 2390 (nM), Ref:
TCMC1609	TCMT739	G-protein coupled receptor 35	Homo sapiens	IC50: 2120 (nM), Ref: 24900447
TCMC1609	TCMT558	DNA topoisomerase II alpha	Homo sapiens	IC50: 390 (nM), Ref: 10.1007/s00044-009-9233-5
TCMC1609	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 2800 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC1609	TCMT131	Acetylcholinesterase	Homo sapiens	IC50: 12 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC1609	TCMT260	Tyrosine-protein kinase receptor FLT3	Homo sapiens	IC50: 1690 (nM), Ref: 23411073
TCMC1609	TCMT2	Microtubule-associated protein tau	Homo sapiens	IC50: 1200 (nM), Ref: 23484434 IC50: 3000 (nM), Ref: 25086914
TCMC1609	TCMT8	Lysine-specific demethylase 4D-like	Homo sapiens	IC50: 3000 (nM), Ref: 10.1039/C1MD00199J
TCMC1609	TCMT45	Beta amyloid A4 protein	Homo sapiens	IC50: 3000 (nM), Ref: 25086914
TCMC1609	TCMT740	PI3-kinase p110-gamma subunit	Homo sapiens	IC50: 4720 (nM), Ref: 25050878
TCMC1609	TCMT13	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	IC50: 320 (nM), Ref: 25280182
TCMC1202	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 7030 (nM), Ref: 20185318
TCMC1202	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 7780 (nM), Ref: 20185318
TCMC1202	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 6990 (nM), Ref: 20185318
TCMC1202	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 6070 (nM), Ref: 20185318
TCMC1202	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 6130 (nM), Ref: 20185318
TCMC1202	TCMT140	Carbonic anhydrase VB	Homo sapiens	Ki: 9970 (nM), Ref: 20185318
TCMC1202	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 4080 (nM), Ref: 20185318
TCMC1202	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 9800 (nM), Ref: 20185318
TCMC1202	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 7490 (nM), Ref: 20185318
TCMC1202	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 2250 (nM), Ref: 20185318
TCMC1202	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 3200 (nM), Ref: 20185318
TCMC1202	TCMT822	Alpha-(1,3)-fucosyltransferase 7	Homo sapiens	IC50: 60 (nM), Ref: 10.1039/C4MD00086B
TCMC1118	TCMT304	Matrix metalloproteinase 14	Homo sapiens	IC50: 6800 (nM), Ref: 19524436
TCMC1118	TCMT306	Matrix metalloproteinase-2	Homo sapiens	IC50: 9600 (nM), Ref: 19524436
TCMC1118	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 757 (nM), Ref: 22225636
TCMC1118	TCMT126	Telomerase reverse transcriptase	Homo sapiens	IC50: 1000 (nM), Ref: 22413845 IC50: 1080 (nM), Ref: 22413845 IC50: 1180 (nM), Ref: 22413845 IC50: 1000 (nM), Ref: 10.1039/C0MD00241K
TCMC1118	TCMT47	Apoptosis regulator Bcl-2	Homo sapiens	Ki: 335 (nM), Ref: 10.1007/s00044-009-9233-5
TCMC1118	TCMT2	Microtubule-associated protein tau	Homo sapiens	IC50: 1800 (nM), Ref: 23484434
TCMC1118	TCMT751	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Homo sapiens	IC50: 330 (nM), Ref: 24188002
TCMC1118	TCMT45	Beta amyloid A4 protein	Homo sapiens	IC50: 4600 (nM), Ref: 24878198 IC50: 3000 (nM), Ref: 24878198 IC50: 500 (nM), Ref: 25978520
TCMC1118	TCMT567	DNA (cytosine-5)-methyltransferase 1	Homo sapiens	IC50: 500 (nM), Ref: 25406944
TCMC1118	TCMT232	P-glycoprotein 1	Homo sapiens	IC50: 124.1 (nM), Ref: 25985195 IC50: 122.6 (nM), Ref: 25985195

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1609	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 26.29 (ug/ml), Ref: 20116898
TCMC1118	TCMT1092	Fatty acid synthase	Plasmodium falciparum	IC50: 0.03 (ug/ml), Ref: 20855214 IC50: 30 (nM), Ref: 24063369
TCMC1118	TCMT1094	3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum	IC50: 0.32 (ug/ml), Ref: 20855214
TCMC1537	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 64 (ug/ml), Ref: 21288041
TCMC1537	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 16 (ug/ml), Ref: 21288041
TCMC1609	TCMT1246	Escherichia coli	Escherichia coli	MIC: 62.5 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7 MIC: 3.9 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7 MIC: 15.6 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7 IC50: 0.88 (ug/ml), Ref: 24749980
TCMC1609	TCMT1412	Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium	MIC: 15.6 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC1609	TCMT1223	Staphylococcus epidermidis	Staphylococcus epidermidis	MIC: 62.5 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC1609	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 50 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC1117	TCMT1226	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC: 100 (ug/ml), Ref: 10425115
TCMC1117	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 6.89 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC1202	TCMT1178	Actinomyces viscosus	Actinomyces viscosus	MIC: 78 (ug/ml), Ref: 8904847
TCMC1202	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 14.8 (ug/ml), Ref: 15844943
TCMC2667	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 64 (ug/ml), Ref: 15104489 MIC: 100 (ug/ml), Ref: 20542692
TCMC1117	TCMT1093	Enoyl-acyl-carrier protein reductase	Plasmodium falciparum	Ki: 17.56 (nM), Ref: 17263522
TCMC1118	TCMT1093	Enoyl-acyl-carrier protein reductase	Plasmodium falciparum	Ki: 79 (nM), Ref: 17263522 Ki: 8 (nM), Ref: 17263522
TCMC1118	TCMT1222	Plasmodium falciparum D6	Plasmodium falciparum D6	IC50: 73 (nM), Ref: 25488841