TCM-ID Component

Description of the Component

Component ID	TCMH291
Latin Name	Cortex magnoliae officinalis
English Name	bark of officinal magnolia
Chinese Pinyin Name	Chuan Pu
中文名	川朴
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	SATCM
Barcode ID	ITSAM1591-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMF2871	Huo Pu Xia Ling Decoction	藿朴夏苓汤

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT1	EHMT2	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Transferase	Q96KQ7
TCMT114	CNR2	Cannabinoid CB2 receptor	GPCR	P34972
TCMT115	CNR1	Cannabinoid CB1 receptor	GPCR	P21554
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT150	RORC	Nuclear receptor ROR-gamma	Nuclear receptor	P51449
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT18	GAA	Lysosomal alpha-glucosidase	Hydrolase	P10253
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT248	CXCL8	Interleukin-8	Unclassified	P10145
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT735	RXRA	Retinoid X receptor alpha	Nuclear receptor	P19793
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1136	Neuraminidase
TCMT1183	Candida albicans SC5314
TCMT1201	Staphylococcus epidermidis ATCC 12228
TCMT1218	Staphylococcus aureus
TCMT1219	Enterococcus
TCMT1223	Staphylococcus epidermidis
TCMT1286	Bacillus cereus
TCMT1454	Bacillus subtilis
TCMT1464	Hepatitis B virus

Ingredient Structrues

Ingredient ID: TCMC2528
Formula: C18H13NO3

Common Name	Lysicamine
IUPAC Name	n.a.
Canonical SMILES	COc1c(OC)cc2c3c1c1ccccc1C(=O)c3ncc2
Standard InCHI	InChI=1S/C18H13NO3/c1-21-13-9-10-7-8-19-16-14(10)15(18(13)22-2)11-5-3-4-6-12(11)17(16)20/h3-9H,1-2H3
Standard InCHIKey	DPBMWJXWUINLQT-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL510090]; PubChem [122691];
Reference of Component-Ingredient Pair	23445637

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH600	Euonymus fortunei	Fu Fang Teng	扶芳藤
TCMH271	Clerodendrum trichotomum	Chou Wu Tong Ye	臭梧桐叶
TCMH2513	Rhododendron mucronulatum	Ying Shan Hong	映山红
TCMH213	Boschniakia rossica	Cao Cong Rong	草苁蓉
TCMH829	Semen pharbitidis	Hei Chou	黑丑
TCMH1601	Nelumbo nucifera	Ou Pian	藕片
TCMH1285	Orobanche coerulescens	Lie Dang	列当
TCMH890	Cortex magnoliae officinalis	Hou Pu	厚朴
TCMH2573	Ziziphus jujuba var. spinosa	Zao Ren	枣仁
TCMH2572	Ziziphus jujuba mill. var. inermis (bge.) rehd.	Zao Pi	枣皮
TCMH1662	Pharbitis nil	Qian Niu Zi	牵牛子
TCMH291	Cortex magnoliae officinalis	Chuan Pu	川朴
TCMH52	Semen pharbitidis	Bai Chou	白丑
TCMH270	Clerodendrum trichotomum	Chou Wu Tong	臭梧桐
TCMH814	Nelumbo nucifera	He Geng	荷梗
TCMH825	Nelumbo nucifera	He Ye	荷叶
TCMH1275	Nelumbo nucifera	Lian Zi	莲子
TCMH1276	Nelumbo nucifera	Lian Zi Xin	莲子心
TCMH1598	Nelumbo nucifera	Ou	藕
TCMH1599	Nelumbo nucifera	Ou Fen	藕粉
TCMH2051	Ziziphus jujuba var. spinosa	Suan Zao	酸枣
TCMH2052	Ziziphus jujuba var. spinosa	Suan Zao Ren	酸枣仁

Ingredient ID: TCMC1523
Formula: C18H18O2

Common Name	Magnolol
IUPAC Name	2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
Canonical SMILES	C=CCc1ccc(c(c1)c1cc(CC=C)ccc1O)O
Standard InCHI	InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
Standard InCHIKey	VVOAZFWZEDHOOU-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL180920]; PubChem [72300];
Reference of Component-Ingredient Pair	21355261

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH891	Flos magnoliae offcinalis	Hou Pu Hua	厚朴花
TCMH366	Rheum officinale	Da Huang Liu Jin Gao	大黄流浸膏
TCMH890	Cortex magnoliae officinalis	Hou Pu	厚朴
TCMH500	Benincasa hispida	Dong Gua Zi	冬瓜子
TCMH447	Illicium difengpi	Di Feng Pi	地枫皮
TCMH2320	Magnolia liliflora	Xin Yi Ren	辛夷仁
TCMH1965	Rheum palmatum	Shu Da Huang	熟大黄
TCMH291	Cortex magnoliae officinalis	Chuan Pu	川朴
TCMH498	Benincasa hispida	Dong Gua Pi	冬瓜皮
TCMH363	Rheum officinale	Da Huang	大黄
TCMH365	Rheum officinale	Da Huang Jin Gao	大黄浸膏
TCMH2316	Magnolia liliflora	Xin Yi	辛夷
TCMH2317	Magnolia liliflora	Xin Yi Hua	辛夷花
TCMH2319	Magnolia liliflora	Xin Yi Hua Jin Gao Fen	辛夷花浸膏粉

Ingredient ID: TCMC1334
Formula: C18H18O2

Common Name	Honokiol
IUPAC Name	2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Canonical SMILES	C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)O)O
Standard InCHI	InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
Standard InCHIKey	FVYXIJYOAGAUQK-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL16901]; PubChem [72303];
Reference of Component-Ingredient Pair	22766801

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH891	Flos magnoliae offcinalis	Hou Pu Hua	厚朴花
TCMH366	Rheum officinale	Da Huang Liu Jin Gao	大黄流浸膏
TCMH890	Cortex magnoliae officinalis	Hou Pu	厚朴
TCMH500	Benincasa hispida	Dong Gua Zi	冬瓜子
TCMH1965	Rheum palmatum	Shu Da Huang	熟大黄
TCMH291	Cortex magnoliae officinalis	Chuan Pu	川朴
TCMH498	Benincasa hispida	Dong Gua Pi	冬瓜皮
TCMH363	Rheum officinale	Da Huang	大黄
TCMH365	Rheum officinale	Da Huang Jin Gao	大黄浸膏

Ingredient ID: TCMC1108
Formula: C9H6Cl6O3S

Common Name	Endosulfan
IUPAC Name	n.a.
Canonical SMILES	O=S1OCC2C(CO1)C1(C(C2(Cl)C(=C1Cl)Cl)(Cl)Cl)Cl
Standard InCHI	InChI=1S/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2
Standard InCHIKey	RDYMFSUJUZBWLH-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL194399]; PubChem [3224];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH890	Cortex magnoliae officinalis	Hou Pu	厚朴
TCMH291	Cortex magnoliae officinalis	Chuan Pu	川朴

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC1108	C9H6Cl6O3S	Endosulfan	403.82	2.166	1.35	0.839	3	0	54.74	6	3	19	0
TCMC1334	C18H18O2	Honokiol	266.13	1.1368	3.22	5.024	0	2	40.46	7	2	20	1
TCMC1523	C18H18O2	Magnolol	266.13	1.1368	3.22	5.446	0	2	40.46	7	2	20	1
TCMC2528	C18H13NO3	Lysicamine	291.09	-0.3674	3	3.348	2	0	48.42	4	4	22	0

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Cortex magnoliae officinalis 川朴

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC2528

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1523

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1334

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1108

Occurrence of the ingredient across TCM components

Properties

Download Data