TCM-ID Component

Description of the Component

Component ID	TCMH2646
Latin Name	Rhizoma paridis
English Name	Paris root
Chinese Pinyin Name	Chong Lou
中文名	重楼
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	Yunnan Province, Jiangxi Province
Reference	Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx3105	Bai Bao Dan	百宝丹
TCMFx3621	Bi Yan Qing Du Granules	鼻咽清毒颗粒
TCMFx158	Bi Yan Qing Du Granules	鼻咽清毒颗粒
TCMF6009	Chang Chun Hong Yao Tablets	长春红药片
TCMFx3341	Die Da Bang Yao Wine	跌打榜药酒
TCMFx3332	Fu Fang Chuan Bei Zhi Ke Syrup	复方川贝止咳糖浆
TCMFx6861	Fu Fang Fu Rong Ye Ding	复方芙蓉叶酊
TCMF3944	Fu Fang She Dan Chuan Bei Powder	复方蛇胆川贝散
TCMFx3238	Fu Fang Yan Lian Tablets	复方岩连片
TCMFx6855	Fu Zhi Qing Ruan Ointment	肤痔清软膏
TCMFx3272	Gong Xue Ning Capsules	宫血宁胶囊
TCMFx854	Gong Xue Ning Capsule	宫血宁胶囊
TCMFx4481	Hong Wei She Yao Tablets	红卫蛇药片
TCMFx7194	Hong Yao Capsules	红药胶囊
TCMFx4528	Hou Shu Kou Han Tablets	喉舒口含片
TCMFx831	Jiang Huang Xiao Cuo Cha Ji	姜黄消痤搽剂
TCMF4299	Jin Gu Teng Tong Wine	筋骨疼痛酒
TCMF7177	Jiu Wei Shuang Jie Oral Liquid	九味双解口服液
TCMF4049	Kang Bing Du Granules	抗病毒颗粒
TCMFx4447	Ke Yang Min Xu	克痒敏醑
TCMF4756	Lu Jin Zhuang Gu Wine	鹿筋壮骨酒
TCMFx4456	Pan Long Qi Tablets	盘龙七片
TCMFx4463	Pan Long Qi Yao Wine	盘龙七药酒
TCMFx5006	Qing Yu Bi Wen Dan	庆余辟瘟丹
TCMF5330	Re Du Qing Tablets	热毒清片
TCMFx5237	San Jie Zhi Tong Ointment	散结止痛膏
TCMFx5106	San Qi Xue Shang Ning Capsules	三七血伤宁胶囊
TCMFx5113	San Qi Xue Shang Ning Powder	三七血伤宁散
TCMFx214	San Qi Xue Shang Ning Capsule	三七血伤宁胶囊
TCMFx5366	Shen Nong Zhen Tong Ointment	神农镇痛膏
TCMFx5293	Wai Yong Wu Di Ointment	外用无敌膏
TCMFx5542	Wei Sheng Powder	卫生散
TCMFx6291	Xiao Er Qing Re Ling	小儿清热灵
TCMF267	Xiao Er Tui Re Granules	小儿退热颗粒
TCMF6371	Xiao Er Tui Re Granules	小儿退热颗粒
TCMF6378	Xiao Er Tui Re Oral Liquid	小儿退热口服液
TCMF42	Xiao Er Tui Re Recipe	小儿退热合剂
TCMFx6436	Xue Shang Yi Zhi Hao Su Xiao Zhi Tong Cha Ji	雪上一枝蒿速效止痛搽剂
TCMF6394	Yi Gan Jie Du Capsules	乙肝解毒胶囊
TCMFx6312	Yi Li Zhi Tong Pills	一粒止痛丸
TCMF6825	Yin Lian Qing Gan Recipe	茵莲清肝合剂
TCMFx6656	Yun Nan Bai Yao Spray	云南白药气雾剂
TCMFx6649	Yun Nan Bai Yao Tablets	云南白药片
TCMFx6665	Yun Nan Hong Yao Capsules	云南红药胶囊
TCMFx6671	Yun Nan Hong Yao Powder	云南红药散
TCMFx6827	Zhan Jiang She Yao	湛江蛇药

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT127	PARP1	Poly [ADP-ribose] polymerase-1	Transferase	P09874
TCMT128	TNKS2	Tankyrase-2	Transferase	Q9H2K2
TCMT129	TNKS	Tankyrase-1	Transferase	O95271
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT132	BCHE	Butyrylcholinesterase	Hydrolase	P06276
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT150	RORC	Nuclear receptor ROR-gamma	Nuclear receptor	P51449
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT187	AR	Androgen Receptor	Nuclear receptor	P10275
TCMT208	MAOA	Monoamine oxidase A	Oxidoreductase	P21397
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT248	CXCL8	Interleukin-8	Unclassified	P10145
TCMT277	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Transporter	Q9NPD5
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1176	Streptococcus pneumoniae
TCMT1218	Staphylococcus aureus
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1243	Aspergillus flavus
TCMT1246	Escherichia coli
TCMT1251	Candida albicans
TCMT1438	Plasmodium falciparum
TCMT1458	Filobasidiella neoformans

Ingredient Structrues

Ingredient ID: TCMC348
Formula: C27H44O7

Common Name	20-Hydroxyecdysone
IUPAC Name	(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
Canonical SMILES	O[C@H]1C[C@@]2(C)[C@@H](C[C@H]1O)C(=O)C=C1[C@@H]2CC[C@]2([C@@]1(O)CC[C@@H]2[C@]([C@@H](CCC(O)(C)C)O)(O)C)C
Standard InCHI	InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,26+,27+/m0/s1
Standard InCHIKey	NKDFYOWSKOHCCO-YPVLXUMRSA-N
External Identifiers	ChEMBL [CHEMBL224128]; PubChem [5459840];
Reference of Component-Ingredient Pair	29126784

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1673	Gentiana macrophylla	Qin Jiao	秦艽
TCMH2595	Rhododendron micranthum	Zhao Shan Bai	照山白
TCMH1508	Commiphora myrrha	Mo Yao	没药
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	绵马贯众
TCMH281	Dipsacus asper	Chuan Duan	川断
TCMH2576	Paris polyphylla	Zao Xiu	蚤休
TCMH1674	Gentiana straminea	Qin Jiao Hua	秦艽花
TCMH2646	Rhizoma paridis	Chong Lou	重楼
TCMH255	Vigna angularis	Chi Dou	赤豆
TCMH2362	Artemisia lactiflora	Ya Jiao Ai	鸭脚艾
TCMH1102	Tinospora capillipes	Jin Guo Lan	金果榄
TCMH202	Bombyx mori	Can Yong	蚕蛹
TCMH1588	Achyranthes bidentata	Niu Xi	牛膝
TCMH1331	Rhaponticum uniflorum	Lou Lu	漏芦
TCMH1584	Achyranthes bidentata	Niu Teng	牛藤
TCMH75	Bombyx mori	Bai Jiang Can	白僵蚕
TCMH197	Bombyx mori	Can E	蚕蛾
TCMH200	Bombyx mori	Can Jian	蚕茧
TCMH201	Bombyx mori	Can Sha	蚕砂
TCMH1652	Paris polyphylla	Qi Ye Yi Zhi Hua	七叶一枝花
TCMH1507	Commiphora myrrha	Mo Xiang	没香
TCMH2017	Artemisia lactiflora	Si Ji Cai	四季菜

Ingredient ID: TCMC1179
Formula: C15H10O2

Common Name	Flavone
IUPAC Name	2-phenylchromen-4-one
Canonical SMILES	O=c1cc(oc2c1cccc2)c1ccccc1
Standard InCHI	InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
Standard InCHIKey	VHBFFQKBGNRLFZ-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL275638]; PubChem [10680];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2104	Folium aconiti szechenyiani	Tie Bang Chui Ye	铁棒锤叶
TCMH1154	Ilex rotunda	Jiu Bi Ying	救必应
TCMH2303	Pericarpium citri reticulatae viride	Xiao Qing Pi	小青皮
TCMH733	Desmodium styracifolium	Guang Jin Qian Cao	广金钱草
TCMH1519	Oroxylum indicum	Mu Hu Die	木蝴蝶
TCMH2646	Rhizoma paridis	Chong Lou	重楼
TCMH2360	Brucea javanica	Ya Dan Zi	鸦胆子
TCMH2370	Commelina communis	Ya Zhi Cao	鸭跖草
TCMH1181	Chrysanthemum morifolium	Ju Hua	菊花
TCMH1784	Radix tetrastigmatis hemsleyani	San Ye Qing	三叶青
TCMH458	Pericarpium citri reticulatae viride	Di Qing Pi	地青皮
TCMH1695	Pericarpium citri reticulatae viride	Qing Pi	青皮
TCMH809	Chrysanthemum morifolium	Hang Ju	杭菊

Ingredient ID: TCMC1063
Formula: C45H72O16

Common Name	Dioscin
IUPAC Name	n.a.
Canonical SMILES	OC[C@H]1O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@H](C)[C@]3(O4)CC[C@H](CO3)C)C)C2)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Standard InCHI	InChI=1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1
Standard InCHIKey	VNONINPVFQTJOC-ZGXDEBHDSA-N
External Identifiers	ChEMBL [CHEMBL507001]; PubChem [119245];
Reference of Component-Ingredient Pair	29389802

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2134	Smilax glabra	Tu Fu Ling	土茯苓
TCMH276	Dioscorea septemloba	Chuan Bi Xie	川萆薢
TCMH1538	Baphicacanthus cusia	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉
TCMH285	Dioscorea nipponica	Chuan Long Shu Yu	穿龙薯蓣
TCMH2375	Trigonella foenum-graecum	Yan Hu Lu Ba	盐胡芦巴
TCMH2646	Rhizoma paridis	Chong Lou	重楼
TCMH37	Smilax china	Ba Qia	菝葜
TCMH2092	Asparagus cochinchinensis	Tian Men Dong	天门冬
TCMH1759	Asparagus cochinchinensis	San Bai Bang	三百棒
TCMH2084	Asparagus cochinchinensis	Tian Dong	天冬
TCMH1537	Baphicacanthus cusia	Nan Ban Lan Gen	南板蓝根

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC348	C27H44O7	20-Hydroxyecdysone	480.31	-1.1982	3.66	1.049	7	6	138.45	16	4	34	1
TCMC1063	C45H72O16	Dioscin	868.48	-3.9636	4.65	2.836	16	8	235.68	21	9	61	2
TCMC1179	C15H10O2	Flavone	222.07	-0.5036	2.89	5.3	1	0	26.3	1	3	17	1

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1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Rhizoma paridis 重楼

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC348

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1179

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1063

Occurrence of the ingredient across TCM components

Properties

Download Data