Component: Arnebia euchroma 新疆紫草


Description of the Component

Component ID
TCMH2315
Latin Name
Arnebia euchroma
English Name
Arnebia root
Chinese Pinyin Name
Xin Jiang Zi Cao
中文名
新疆紫草
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAH4976-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx244 Xiao Er Fei Re Ping Capsule 小儿肺热平胶囊

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1108 Integrase
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC999
Formula: C10H20O2

Ingredient ID: TCMC915
Formula: C9H8O

Ingredient ID: TCMC857
Formula: C10H16O

Ingredient ID: TCMC796
Formula: C21H24O7

Ingredient ID: TCMC696
Formula: C10H12O

Ingredient ID: TCMC624
Formula: C18H18O6

Ingredient ID: TCMC473
Formula: C10H16O

Ingredient ID: TCMC280
Formula: C10H12O

Ingredient ID: TCMC2729
Formula: C21H24O6

Ingredient ID: TCMC2728
Formula: C25H22O6

Ingredient ID: TCMC2727
Formula: C26H22O8

Ingredient ID: TCMC2718
Formula: C21H24O6

Ingredient ID: TCMC2706
Formula: C20H22O6

Ingredient ID: TCMC2692
Formula: C16H16O4

Ingredient ID: TCMC2613
Formula: C30H48O5

Ingredient ID: TCMC2552
Formula: C21H24O6

Ingredient ID: TCMC2547
Formula: C18H18O6

Ingredient ID: TCMC2388
Formula: C21H22O6

Ingredient ID: TCMC2385
Formula: C16H16O5

Ingredient ID: TCMC2381
Formula: C8H10O

Ingredient ID: TCMC2366
Formula: C15H24O

Ingredient ID: TCMC2069
Formula: C16H16O5

Ingredient ID: TCMC2025
Formula: C18H16O8

Ingredient ID: TCMC195
Formula: C19H20O6

Ingredient ID: TCMC192
Formula: C21H24O6

Ingredient ID: TCMC1867
Formula: C14H10

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1826
Formula: C9H10O3

Ingredient ID: TCMC1730
Formula: C10H6O2

Ingredient ID: TCMC1712
Formula: C15H24O

Ingredient ID: TCMC1578
Formula: C11H14O2

Ingredient ID: TCMC1506
Formula: C27H22O12

Ingredient ID: TCMC1386
Formula: C20H22O6

Ingredient ID: TCMC1197
Formula: C5H4O2

Ingredient ID: TCMC1159
Formula: C10H12O2

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC192 C21H24O6 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] 3-Methylbutanoate 372.16 0.9953 3.11 2.499 4 2 100.9 13 2 27 0
TCMC195 C19H20O6 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] Propanoate 344.13 0.4737 2.89 1.422 4 2 100.9 11 2 25 0
TCMC280 C10H12O 1-Methoxy-4-[(Z)-Prop-1-Enyl]Benzene 148.09 0.8555 2.45 3.979 0 0 9.23 4 1 11 0
TCMC473 C10H16O 4,7,7-Trimethylbicyclo[2.2.1]Heptan-3-One 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC624 C18H18O6 Acetylshikonin 330.11 0.3975 2.78 1.169 4 2 100.9 10 2 24 0
TCMC696 C10H12O Anethole 148.09 0.8555 2.45 3.979 0 0 9.23 4 1 11 0
TCMC796 C21H24O7 Beta-Hydroxyisovalerylshikonin 388.15 0.5562 3 1.167 5 3 121.13 14 2 28 0
TCMC857 C10H16O Camphor 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC915 C9H8O Cinnamaldehyde 132.06 0.1687 2.34 3.985 1 0 17.07 2 1 10 0
TCMC999 C10H20O2 Decanoic Acid 172.15 -2.1697 2.34 4.156 2 1 37.3 10 0 12 0
TCMC1159 C10H12O2 Eugenol 164.08 0.5166 2.34 2.484 0 1 29.46 5 1 12 0
TCMC1197 C5H4O2 Furfural 96.02 -0.3465 1.79 1.057 1 0 30.21 1 1 7 0
TCMC1386 C20H22O6 Isobutylshikonin 358.14 1.1219 3 1.715 4 2 100.9 12 2 26 0
TCMC1506 C27H22O12 Lithospermic Acid 538.11 -2.955 3.11 1.877 6 7 211.28 16 4 39 1
TCMC1578 C11H14O2 Methyleugenol 178.1 0.9251 2.45 3.003 0 0 18.46 6 1 13 0
TCMC1712 C15H24O 220.18 1.9144 3 4.607 1 0 12.53 3 3 16 0
TCMC1730 C10H6O2 Naphthoquinone 158.04 -0.2732 2.34 1.96 2 0 34.14 0 2 12 0
TCMC1826 C9H10O3 Paeonol 166.06 -0.766 2.12 1.32 1 1 46.53 5 1 12 0
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC1867 C14H10 Phenanthrene 178.08 0 3 7.814 0 0 0 0 3 14 1
TCMC2025 C18H16O8 Rosmarinic Acid 360.08 -1.9057 2.56 2.083 4 5 144.52 12 2 26 0
TCMC2069 C16H16O5 Shikonin 288.1 0.0184 2.67 0.858 3 3 94.83 8 2 21 0
TCMC2366 C15H24O 220.18 1.9144 3 4.607 1 0 12.53 3 3 16 0
TCMC2381 C8H10O Phenylethyl Alcohol 122.07 -0.1931 2.23 3.189 1 1 20.23 3 1 9 0
TCMC2385 C16H16O5 Alkannin 288.1 0.0184 2.67 0.858 3 3 94.83 8 2 21 0
TCMC2388 C21H22O6 Beta,Beta-Dimethylacrylalkannin 370.14 1.8371 3.11 2.047 4 2 100.9 12 2 27 0
TCMC2547 C18H18O6 Acetylalkannin 330.11 0.3975 2.78 1.169 4 2 100.9 10 2 24 0
TCMC2552 C21H24O6 (S)-Alpha-Methylbutyryl Alkannin 372.16 0.4457 3.11 2.284 4 2 100.9 13 2 27 0
TCMC2613 C30H48O5 Tomentic Acid 488.35 0.822 4.21 5.966 5 4 97.99 12 5 35 1
TCMC2692 C16H16O4 Deoxyshikonin 272.1 0.5915 2.78 1.615 2 2 74.6 7 2 20 0
TCMC2706 C20H22O6 Isobutylalkannin 358.14 1.1219 3 1.715 4 2 100.9 12 2 26 0
TCMC2718 C21H24O6 Isovaleryl Alkannin 372.16 0.9953 3.11 2.499 4 2 100.9 13 2 27 0
TCMC2727 C26H22O8 3,4-(Methylenedioxy)Cinnamoyl Alkannin 462.13 0.446 3.44 2.926 4 2 119.36 11 4 34 0
TCMC2728 C25H22O6 Cinnamoyl Alkannin 418.14 0.7487 3.55 5.153 4 2 100.9 11 3 31 1
TCMC2729 C21H24O6 (R)-Alpha-Methylbutyryl Alkannin 372.16 0.4457 3.11 2.284 4 2 100.9 13 2 27 0

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1. General Information of the Component  
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3. Putative Targets  
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