Component: Agrimonia pilosa var. japonica 仙鹤草


Description of the Component

Component ID
TCMH2252
Latin Name
Agrimonia pilosa var. japonica
English Name
Japanese argimonia
Chinese Pinyin Name
Xian He Cao
中文名
仙鹤草
TCM Properties
Mild,Bitter,Punkery
TCM Meridians
Lung,Spleen,Liver
Therapeutic Class English
Bleeding control
Therapeutic Class Chinese
止血
Functions
arrest bleeding, stop malarial attacks, relieve dysentery, and counteract toxicity
Toxicity
NA
Geo-authentic habitats (道地产区)
Zhejiang Province
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2307 Added Flavor JA Four Object Decoction 加味胶艾四物汤
TCMFx1873 Added Flavor JH Drink 加味胶红饮
TCMF2938 An Shen Syrup 安神糖浆
TCMF7227 Bai Hua Cao Capsules 柏花草胶囊
TCMF6009 Chang Chun Hong Yao Tablets 长春红药片
TCMFx3692 Da Fei Cao 达肺草
TCMFx3451 Fu An Infusion 腹安冲剂
TCMFx3064 Fu Fang Tie Xian Zhi Xue Fen 复方铁苋止血粉
TCMFx768 Fu Fang Xian He Cao Chang Yan Capsule 复方仙鹤草肠炎胶囊
TCMFx3085 Fu Yan Ling Capsules 妇炎灵胶囊
TCMFx7037 Fu Yan Ling Pao Teng Tablets 妇炎灵泡腾片
TCMFx853 Gong Ning Granules 宫宁颗粒
TCMFx4390 He Chan Tablets 鹤蟾片
TCMF2175 Infectious Diarrhea Decoction
TCMF4330 Jian Shen Tablets 健神片
TCMFx4602 Kui Yang Capsules 溃疡胶囊
TCMF4927 Li Dan Zhi Tong Tablets 利胆止痛片
TCMF1179 Long Qing Tablet 癃清片
TCMF2468 Lung Clearing Decoction
TCMF2456 LX Pigment Removing Decoction
TCMF2380 Pigment Remover Decoction
TCMFx432 Ping Xiao Capsule 平消胶囊
TCMFx4646 Ping Xiao Capsules 平消胶囊
TCMFx431 Ping Xiao Tablet 平消片
TCMFx4654 Ping Xiao Tablets 平消片
TCMF4999 Qiang Xin Pills 强心丸
TCMFx1596 Rightness Supporting Recipe 扶正固本方
TCMFx7011 Shang Granulesng Spray 伤科灵喷雾剂
TCMFx3228 Shen Gui Zai Zao Pills 参桂再造丸
TCMF3293 Shen Lu Bu Ointment 参鹿补膏
TCMF3301 Shen Lu Bu Tablets 参鹿补片
TCMF2362 Three Ginseng and Two White Colon Disease Decoction 三参二白汤
TCMFx2114 Tonic Semifluid Extract of Ginseng 人参滋补膏
TCMF2222 Tonic Semifluid Extract of Ginseng and Venison 参鹿补膏
TCMFx5293 Wai Yong Wu Di Ointment 外用无敌膏
TCMF5515 Wei Xue Ning 维血宁
TCMF5522 Wei Xue Ning Infusion 维血宁冲剂
TCMF121 Wei Xue Ning Recipe 维血宁合剂
TCMF5892 Wei Yang Ning Pills 胃疡宁丸
TCMF1095 Wei Xue Ning Granules 维血宁颗粒
TCMFx5914 Xian He Capsules 仙鹤胶囊
TCMFx6859 Xin Fu Man Ling Ruan Ointment 新肤螨灵软膏
TCMFx6167 Xing Nao Zai Zao Capsules 醒脑再造胶囊
TCMFx1177 Xing Nao Zai Zao Capsules 醒脑再造胶囊
TCMFx6174 Xing Nao Zai Zao Pills 醒脑再造丸
TCMFx1556 XQ Bleeding Stoper Decoction 先期汤
TCMF6458 Xue Bao Capsules 血宝胶囊
TCMFx6007 Yang Xue An Shen Pills 养血安神丸
TCMFx5999 Yang Xue An Shen Syrup 养血安神糖浆
TCMFx5991 Yang Xue An Shen Tablets 养血安神片
TCMF1017 Yi Fei Qing Hua Ointment 益肺清化膏
TCMF7196 Yi Qi He Wei Capsules 益气和胃胶囊
TCMF6421 Yu Ye Jin Pills 玉液金丸
TCMF471 Zai Zao Sheng Xue Tablet 再造生血片
TCMF6746 Zai Zhang Sheng Xue Tablets 再障生血片
TCMFx6157 Zhi Chuang Zhi Xue Pills 痔疮止血丸
TCMF6208 Zhi Er Ling Gao Zi 稚儿灵膏滋
TCMF6200 Zhi Er Ling Infusion 稚儿灵冲剂

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT331 PLG Plasminogen Unclassified P00747
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT441 PTK2 Focal adhesion kinase 1 Kinase Q05397
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT620 HSPA8 Heat shock cognate 71 kDa protein Unclassified P11142
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT754 GSTP1 Glutathione S-transferase Pi Transferase P09211
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT757 CARM1 Histone-arginine methyltransferase CARM1 Transferase Q86X55
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1099 Neuraminidase
TCMT1108 Integrase
TCMT1109 Reverse transcriptase
TCMT1112 Quinolone resistance protein norA
TCMT1178 Actinomyces viscosus
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1212 Verticillium dahliae
TCMT1246 Escherichia coli
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC76
Formula: C15H12O7

Ingredient ID: TCMC7311
Formula: C37H46O12

Ingredient ID: TCMC7016
Formula: C26H34O8

Ingredient ID: TCMC4839
Formula: C25H32O8

Ingredient ID: TCMC4517
Formula: C36H44O12

Ingredient ID: TCMC4515
Formula: C34H40O12

Ingredient ID: TCMC3966
Formula: C29H50O

Ingredient ID: TCMC3930
Formula: C36H44O12

Ingredient ID: TCMC3596
Formula: C18H18O5

Ingredient ID: TCMC3483
Formula: C24H28O10

Ingredient ID: TCMC3068
Formula: C29H60

Ingredient ID: TCMC1959
Formula: C16H10O5

Ingredient ID: TCMC182
Formula: C9H8O4

Ingredient ID: TCMC1803
Formula: C15H16O3

Ingredient ID: TCMC1206
Formula: C21H20O11

Ingredient ID: TCMC1202
Formula: C7H6O5

Ingredient ID: TCMC1102
Formula: C14H6O8

Ingredient ID: TCMC1051
Formula: C14H14O3

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC76 C15H12O7 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-Trihydroxy-2,3-Dihydrochromen-4-One 304.06 -2.9269 2.34 0.028 2 5 127.45 6 3 22 0
TCMC182 C9H8O4 (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC1051 C14H14O3 Dihydroresveratrol 230.09 -1.2561 2.67 3.22 0 3 60.69 6 2 17 0
TCMC1102 C14H6O8 Ellagic Acid 302.01 -2.0234 2.12 -0.046 2 4 133.52 4 4 22 0
TCMC1202 C7H6O5 Gallic Acid 170.02 -1.6207 1.68 0.002 2 4 97.99 5 1 12 0
TCMC1206 C21H20O11 Galuteolin 448.1 -4.0917 2.56 -0.075 6 7 186.37 11 4 32 1
TCMC1803 C15H16O3 Osthole 244.11 2.0956 2.78 3.521 1 0 35.53 6 2 18 0
TCMC1959 C16H10O5 Pseudobaptogenin 282.05 -1.4297 2.67 2.477 1 1 64.99 2 4 21 0
TCMC3068 C29H60 Nonacosane 408.4695019 -7.6734 4.65 16.841 0 0 0 26 0 29 2
TCMC3483 C24H28O10 Agrimonolide-6-O-Β-D-Glucopyranoside 476.1682471 -3.024 3 2.506 7 5 155.14 7 4 34 0
TCMC3596 C18H18O5 Agrimonolide 314.1154237 -1.2771 2.89 3.614 2 2 75.99 4 3 23 0
TCMC3930 C36H44O12 Agrimol C 668.2832768 -2.5264 4.1 2.723 3 7 211.28 15 3 48 2
TCMC3966 C29H50O Sitosterol,Β-Sitosterol 414.3861662 1.3 4.54 11.595 1 1 20.23 6 4 30 1
TCMC4515 C34H40O12 Agrimol F 640.2519767 -2.3146 3.88 1.901 3 7 211.28 13 3 46 2
TCMC4517 C36H44O12 Agrimol G 668.2832768 0.2822 4.1 1.895 3 7 211.28 12 3 48 2
TCMC4839 C25H32O8 Pseudoaspidin 460.209718 -1.136 3.33 2.108 2 4 133.52 10 2 33 0
TCMC7016 C26H34O8 Agrimophol 473.217543 -2.0977 3.44 3.827 5 3 150.18 8 2 34 0
TCMC7311 C37H46O12 (R)-(–)-Agrimol B 682.2989269 -2.2664 4.21 3.016 3 7 211.28 15 3 49 2

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)