Component: Gynura segetum 土三七


Description of the Component

Component ID
TCMH2146
Latin Name
Gynura segetum
English Name
Chrusanthemum-like groundsel
Chinese Pinyin Name
Tu San Qi
中文名
土三七
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3418 Die Da Wan Hua You 跌打万花油

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT640 CTSD Cathepsin D Unclassified P07339
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1207 Legionella pneumophila
TCMT1218 Staphylococcus aureus
TCMT1251 Candida albicans
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1442 Leishmania donovani

Ingredient Structrues

Ingredient ID: TCMC800
Formula: C29H48O

Ingredient ID: TCMC770
Formula: C7H6O2

Ingredient ID: TCMC338
Formula: C8H8O4

Ingredient ID: TCMC2658
Formula: C10H10O4

Ingredient ID: TCMC2491
Formula: C3H6O2

Ingredient ID: TCMC2223
Formula: C8H8O3

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1647
Formula: C29H50O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC338 C8H8O4 2,6-Dimethoxyquinone 168.04 -0.8026 1.9 0.252 4 0 52.6 4 1 12 0
TCMC770 C7H6O2 Benzoic Acid 122.04 -0.2398 2.01 2.666 2 1 37.3 2 1 9 0
TCMC800 C29H48O Beta-Sitostenone 412.37 1.8421 4.54 11.375 1 0 17.07 12 4 30 1
TCMC1647 C29H50O4 462.37 2.2634 4.21 8.661 4 1 63.6 21 2 33 2
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC2223 C8H8O3 Vanillin 152.05 -0.7045 2.01 1.04 1 1 46.53 4 1 11 0
TCMC2491 C3H6O2 Propionic Acid 74.04 -0.1537 1.57 0.173 2 1 37.3 3 0 5 0
TCMC2658 C10H10O4 (-)-Gynuraone 194.06 -1.4947 2.12 0.636 2 2 66.76 3 2 14 0

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3. Putative Targets  
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