Component: Herba acalyphae 铁苋菜


Description of the Component

Component ID
TCMH2113
Latin Name
Herba acalyphae
English Name
Copperleaf herb
Chinese Pinyin Name
Tie Xian Cai
中文名
铁苋菜
TCM Properties
TCM Meridians
Therapeutic Class English
Heat clearence
Therapeutic Class Chinese
清热
Functions
Clear away heat and toxic material, Stop bleeding and astringency, Relieve cough and dyspnea
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Classical Prescriptions
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3192 Deng Xin Zhi Xue Syrup 灯心止血糠浆
TCMFx3451 Fu An Infusion 腹安冲剂
TCMFx3064 Fu Fang Tie Xian Zhi Xue Fen 复方铁苋止血粉
TCMF4087 Li Yan Ning Tablets 痢炎宁片
TCMF4135 Lian Hua Feng Tea 莲花峰茶
TCMF4275 Ling Yuan Wan Ying Tea 灵源万应茶
TCMFx6887 Xian Cai Huang Lian Su Capsules 苋菜黄连素胶囊

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT191 STAT3 Signal transducer and activator of transcription 3 Transcription factor P40763
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1092 Fatty acid synthase
TCMT1099 Neuraminidase
TCMT1107 Protease
TCMT1178 Actinomyces viscosus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1229 Enterococcus faecalis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1454 Bacillus subtilis
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC811
Formula: C16H12O5

Ingredient ID: TCMC2632
Formula: C30H48O5

Ingredient ID: TCMC2519
Formula: C41H28O27

Ingredient ID: TCMC2509
Formula: C30H48O5

Ingredient ID: TCMC2112
Formula: C4H5NO2

Ingredient ID: TCMC2031
Formula: C27H30O16

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1786
Formula: C30H48O3

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC811 C16H12O5 Biochanin 284.07 -1.6391 2.67 2.031 1 2 75.99 5 3 21 0
TCMC1786 C30H48O3 Oleanolic_Acid 456.36 2.1298 4.43 9.052 3 2 57.53 10 5 33 1
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC2031 C27H30O16 Rutin 610.15 -6.139 2.67 -1.188 11 10 265.52 17 5 43 2
TCMC2112 C4H5NO2 Succinimide 99.03 -0.7817 1.57 -0.312 3 1 49.66 1 1 7 0
TCMC2509 C30H48O5 488.35 1.0764 4.21 6.952 5 4 97.99 15 5 35 1
TCMC2519 C41H28O27 Geraniin 952.08 -7.4549 3 -2.334 15 14 450.25 17 9 68 2
TCMC2632 C30H48O5 488.35 1.2696 4.21 6.741 5 4 97.99 15 5 35 1

Download Data

All data can be downloaded by:

   → Selecting data type in the below download table
   → Then click the download button.
Data Section
Select to Download
1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)