Component: Bombyx mori 蚕砂


Description of the Component

Component ID
TCMH201
Latin Name
Bombyx mori
English Name
Silkworm excrement
Chinese Pinyin Name
Can Sha
中文名
蚕砂
TCM Properties
Warm,Pungent,Sweet
TCM Meridians
Spleen,Stomach,Liver
Therapeutic Class English
For dispelling wind-dampness
Therapeutic Class Chinese
祛风湿
Functions
dispel wind and dampness, harmonize the stomach and transform dampness
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
AGIRI001-17
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2963 An Yang Hu Gu Yao Wine 安阳虎骨药酒
TCMFx2151 Decoction for Removing the Meridian Obstruction 宣痹汤
TCMF2205 Decoction of Excrementum Bombycis, Bombyx Droppings Decoction 蚕矢汤
TCMF3440 Feng Shi Ling Xian Oral Liquid 风湿灵仙液
TCMF3462 Feng Shi Ning Yao Wine 风湿宁药酒
TCMF3487 Feng Shi Sheng Yao Capsules 风湿圣药胶囊
TCMFx3495 Feng Shi Tong Yao Wine 风湿痛药酒
TCMF3682 Gan You Capsules 肝友胶囊
TCMF2350 Hepatitis B Decoction 益肝汤
TCMF4347 Jing Zhi Niu Huang Jie Du Tablets 京制牛黄解毒片
TCMFx5238 Qing Gong Shou Tao Pills 清宫寿桃丸
TCMF5317 Qing Jiang Pills 清降丸
TCMF5310 Qing Jiang Tablets 清降片
TCMF5167 Shi Guo Gong Yao Wine 史国公药酒
TCMFx2488 Shi Guo Gong's Prescription for Preparing Medicated Wine
TCMF1417 Shujin Huoluo Wine 舒筋活络酒
TCMF2572 Shujin Huoluo Wine 舒筋活络酒
TCMF5624 Wei Fu Granules 胃福颗粒
TCMFx6596 Xiao Er Chang Wei Kang Granules 小儿肠胃康颗粒
TCMFx6061 Yang Xue Yu Feng Wine 养血愈风酒

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT108 GRIA1 Glutamate receptor ionotropic, AMPA 1 Ion channel P42261
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT605 EDNRA Endothelin receptor ET-A GPCR P25101
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT661 FOLH1 Glutamate carboxypeptidase II Hydrolase Q04609
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1099 Neuraminidase
TCMT1207 Legionella pneumophila
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1412 Salmonella typhimurium
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC985
Formula: C3H7NO2

Ingredient ID: TCMC902
Formula: C27H46O

Ingredient ID: TCMC834
Formula: C4H8O

Ingredient ID: TCMC825
Formula: C31H42N6O7

Ingredient ID: TCMC791
Formula: C40H56

Ingredient ID: TCMC774
Formula: C7H8O

Ingredient ID: TCMC770
Formula: C7H6O2

Ingredient ID: TCMC70
Formula: C10H12N2O4

Ingredient ID: TCMC498
Formula: C9H6O3

Ingredient ID: TCMC445
Formula: C6H13NO3

Ingredient ID: TCMC348
Formula: C27H44O7

Ingredient ID: TCMC2387
Formula: C10H9NO2

Ingredient ID: TCMC2381
Formula: C8H10O

Ingredient ID: TCMC2204
Formula: C9H6O3

Ingredient ID: TCMC2051
Formula: C10H8O4

Ingredient ID: TCMC1872
Formula: C10H13NO2

Ingredient ID: TCMC1854
Formula: C5H10O

Ingredient ID: TCMC1849
Formula: C5H8O

Ingredient ID: TCMC1743
Formula: C10H14N2

Ingredient ID: TCMC1535
Formula: C6H14O6

Ingredient ID: TCMC1515
Formula: C30H50O

Ingredient ID: TCMC1480
Formula: C5H9NO4

Ingredient ID: TCMC1422
Formula: C17H14O7

Ingredient ID: TCMC1372
Formula: C8H7N

Ingredient ID: TCMC1329
Formula: C16H12O6

Ingredient ID: TCMC1184
Formula: C19H19N7O6

Ingredient ID: TCMC1167
Formula: C6H13NO3

Ingredient ID: TCMC1160
Formula: C16H12O7

Ingredient ID: TCMC1159
Formula: C10H12O2

Ingredient ID: TCMC1122
Formula: C28H44O

Ingredient ID: TCMC1090
Formula: C6H13NO4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC70 C10H12N2O4 (2R)-4-(2-Amino-3-Hydroxyphenyl)-2-Azaniumyl-4-Oxobutanoate 224.08 -2.586 1.9 -2.464 5 4 126.64 8 1 16 0
TCMC348 C27H44O7 20-Hydroxyecdysone 480.31 -1.1982 3.66 1.049 7 6 138.45 16 4 34 1
TCMC445 C6H13NO3 3-Epifagomine 147.09 -2.2173 1.68 -0.757 4 4 72.72 4 1 10 0
TCMC498 C9H6O3 4-Hydroxycoumarins 162.03 -0.2931 2.12 2.292 2 1 46.53 1 2 12 0
TCMC770 C7H6O2 Benzoic Acid 122.04 -0.2398 2.01 2.666 2 1 37.3 2 1 9 0
TCMC774 C7H8O Benzyl Alcohol 108.06 -0.4487 2.12 2.409 1 1 20.23 2 1 8 0
TCMC791 C40H56 Beta Carotene 536.44 8.935 5.86 14.734 0 0 0 20 2 40 1
TCMC825 C31H42N6O7 Bq-123 610.31 -1.4727 3.44 2.506 13 6 203.76 16 4 44 2
TCMC834 C4H8O Butanal 72.06 -0.3943 1.79 1.156 1 0 17.07 3 0 5 0
TCMC902 C27H46O Cholesterol 386.35 1.5548 4.32 10.518 1 1 20.23 11 4 28 1
TCMC985 C3H7NO2 D-Alanine 89.05 -1.0955 1.46 -2.824 3 2 63.32 4 0 6 0
TCMC1090 C6H13NO4 Duvoglustat 163.08 -2.44 1.57 -0.929 5 5 92.95 5 1 11 0
TCMC1122 C28H44O Ergosterol 396.34 2.2555 4.43 9.499 1 1 20.23 11 4 29 1
TCMC1159 C10H12O2 Eugenol 164.08 0.5166 2.34 2.484 0 1 29.46 5 1 12 0
TCMC1160 C16H12O7 Eupafolin 316.06 -2.3966 2.45 0.589 1 4 116.45 7 3 23 0
TCMC1167 C6H13NO3 Fagomine 147.09 -2.2173 1.68 -0.757 4 4 72.72 4 1 10 0
TCMC1184 C19H19N7O6 Folic Acid 441.14 -2.6195 2.12 0.045 13 7 209.98 13 3 32 2
TCMC1329 C16H12O6 Hispidulin 300.06 -1.9363 2.56 1.123 1 3 96.22 6 3 22 0
TCMC1372 C8H7N Indole 117.06 -0.4204 2.23 2.45 1 1 15.79 0 2 9 0
TCMC1422 C17H14O7 Jaceosidine 330.07 -1.9881 2.56 0.679 1 3 105.45 8 3 24 0
TCMC1480 C5H9NO4 L-Glutamate 147.05 -1.6398 1.46 -3.349 5 3 100.62 7 0 10 0
TCMC1515 C30H50O Lupeol 426.39 3.2313 4.65 11.901 1 1 20.23 9 5 31 1
TCMC1535 C6H14O6 Mannitol 182.08 -2.9402 1.46 -3.896 6 6 121.38 11 0 12 1
TCMC1743 C10H14N2 Nicotine 162.12 -0.4993 2.34 1.485 2 0 16.13 2 2 12 0
TCMC1849 C5H8O Pent-1-En-3-One 84.06 0.4231 1.9 0.727 1 0 17.07 3 0 6 0
TCMC1854 C5H10O Pentanal 86.07 -0.6823 1.9 1.725 1 0 17.07 4 0 6 0
TCMC1872 C10H13NO2 Phenprobamate 179.09 0.2552 2.23 4.754 3 2 53.31 6 1 13 0
TCMC2051 C10H8O4 Scopoletin 192.04 -0.2421 2.12 1.088 1 1 55.76 3 2 14 0
TCMC2204 C9H6O3 Umbelliferone 162.03 -0.1903 2.12 1.532 1 1 46.53 1 2 12 0
TCMC2381 C8H10O Phenylethyl Alcohol 122.07 -0.1931 2.23 3.189 1 1 20.23 3 1 9 0
TCMC2387 C10H9NO2 Indole-3-Acetic Acid 175.06 -0.6254 2.23 1.679 3 2 53.09 3 2 13 0

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)