TCM-ID Component

Description of the Component

Component ID	TCMH1984
Latin Name	Typhonium flagelliforme
English Name	NA
Chinese Pinyin Name	Shui Ban Xia
中文名	水半夏
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	GBVT1159-13, GBVT1242-13
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx4765	Ju Hong Tan Ke Granules	橘红痰咳颗粒
TCMFx7169	Ju Hong Tan Ke Pao Teng Tablets	橘红痰咳泡腾片
TCMFx4428	Mi Lian Chuan Bei Pi Pa Ointment	蜜炼川贝枇杷膏
TCMFx5219	Qu Tan Zhi Ke Infusion	祛痰止咳冲剂
TCMF241	Xiao Er Kang Xian Capsule	小儿抗痫胶囊
TCMFx6034	Zhi Ke Chuan Bei Kai Ba Lu	治咳川贝楷杷露
TCMFx6937	Zhi Ke Ping Chuan Ointment	止咳平喘膏
TCMFx6527	Zhi Ke Ping Chuan Syrup	止咳平喘糖浆
TCMFx683	Zhi Ke Chuan Bei Pi Pa Di Pills	治咳川贝枇杷滴丸
TCMFx684	Zhi Ke Chuan Bei Pi Pa Lu	治咳川贝枇杷露

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT11	HIF1A	Hypoxia-inducible factor 1 alpha	Transcription factor	Q16665
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT220	CYP2J2	Cytochrome P450 2J2	Oxidoreductase	P51589
TCMT242	HRH3	Histamine H3 receptor	GPCR	Q9Y5N1
TCMT243	ADRA2C	Alpha-2c adrenergic receptor	GPCR	P18825
TCMT244	HRH1	Histamine H1 receptor	GPCR	P35367
TCMT245	HRH2	Histamine H2 receptor	GPCR	P25021
TCMT246	HRH4	Histamine H4 receptor	GPCR	Q9H3N8
TCMT247	ADRA2A	Alpha-2a adrenergic receptor	GPCR	P08913
TCMT3	ALOX15	Arachidonate 15-lipoxygenase	Oxidoreductase	P16050
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT42	KMT2A	Histone-lysine N-methyltransferase MLL	Transferase	Q03164
TCMT6	NFKB1	Nuclear factor NF-kappa-B p105 subunit	Transcription factor	P19838
TCMT99	SHBG	Testis-specific androgen-binding protein	Unclassified	P04278

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1463	Mycobacterium tuberculosis
TCMT1465	Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC938
Formula: C24H40N2

Common Name	Conessine
IUPAC Name	n.a.
Canonical SMILES	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C
Standard InCHI	InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
Standard InCHIKey	GPLGAQQQNWMVMM-MYAJQUOBSA-N
External Identifiers	ChEMBL [CHEMBL191703]; PubChem [441082];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏

Ingredient ID: TCMC2651
Formula: C21H32N2

Common Name	Conckurchine
IUPAC Name	n.a.
Canonical SMILES	N[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N=C2)C)C1)C
Standard InCHI	InChI=1S/C21H32N2/c1-13-17-5-6-19-16-4-3-14-11-15(22)7-9-20(14,2)18(16)8-10-21(17,19)12-23-13/h3,12-13,15-19H,4-11,22H2,1-2H3/t13-,15-,16+,17+,18-,19-,20-,21-/m0/s1
Standard InCHIKey	ALQAUMHHCJMVID-LQOGWUMHSA-N
External Identifiers	ChEMBL [CHEMBL2262637]; PubChem [76330309];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏

Ingredient ID: TCMC2568
Formula: C22H34N2

Common Name	Conessidine
IUPAC Name	n.a.
Canonical SMILES	CN[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N=C2)C)C1)C
Standard InCHI	InChI=1S/C22H34N2/c1-14-18-6-7-20-17-5-4-15-12-16(23-3)8-10-21(15,2)19(17)9-11-22(18,20)13-24-14/h4,13-14,16-20,23H,5-12H2,1-3H3/t14-,16-,17+,18+,19-,20-,21-,22-/m0/s1
Standard InCHIKey	CHMBCKMSXBNZSX-QLPKIABKSA-N
External Identifiers	ChEMBL [CHEMBL2262847]; PubChem [22214027];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏

Ingredient ID: TCMC2473
Formula: C21H27NO2

Common Name	Holanamine
IUPAC Name	n.a.
Canonical SMILES	O=C1C=C[C@]2(C(=C1)CC[C@@H]1[C@@H]2[C@H](O)C[C@]23[C@H]1CC[C@@H]3[C@@H](N=C2)C)C
Standard InCHI	InChI=1S/C21H27NO2/c1-12-16-5-6-17-15-4-3-13-9-14(23)7-8-20(13,2)19(15)18(24)10-21(16,17)11-22-12/h7-9,11-12,15-19,24H,3-6,10H2,1-2H3/t12-,15-,16+,17-,18+,19+,20-,21-/m0/s1
Standard InCHIKey	IRJULQGCGHNQDS-RSOCUBRASA-N
External Identifiers	ChEMBL [CHEMBL2262648]; PubChem [76308534];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏

Ingredient ID: TCMC2452
Formula: C23H38N2

Common Name	Conessimine
IUPAC Name	n.a.
Canonical SMILES	CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](NC2)C)C1)C)C
Standard InCHI	InChI=1S/C23H38N2/c1-15-19-7-8-21-18-6-5-16-13-17(25(3)4)9-11-22(16,2)20(18)10-12-23(19,21)14-24-15/h5,15,17-21,24H,6-14H2,1-4H3/t15-,17-,18+,19+,20-,21-,22-,23-/m0/s1
Standard InCHIKey	PHYSDIZFXRPRAH-ALCLCTQTSA-N
External Identifiers	ChEMBL [CHEMBL2262636]; PubChem [12303831];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏

Ingredient ID: TCMC2421
Formula: C28H46O

Common Name	3-Beta-Hydroxyergost-5,24(28)-Diene
IUPAC Name	(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Canonical SMILES	O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC(=C)C(C)C)C)C)C1)C
Standard InCHI	InChI=1S/C28H46O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9,18,20,22-26,29H,3,7-8,10-17H2,1-2,4-6H3/t20-,22+,23+,24-,25+,26+,27+,28-/m1/s1
Standard InCHIKey	INDVLXYUCBVVKW-PXBBAZSNSA-N
External Identifiers	ChEMBL [CHEMBL477971]; PubChem [92113];
Reference of Component-Ingredient Pair	21895454

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2469	Fritillaria pallidiflora	Yi Bei Mu	伊贝母
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	绵马贯众
TCMH2134	Smilax glabra	Tu Fu Ling	土茯苓
TCMH859	Ormosia hosiei	Hong Dou	红豆
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏
TCMH943	Rhizoma dioscoreae	Huai Shan Yao	淮山药

Ingredient ID: TCMC2401
Formula: C23H38N2

Common Name	Isoconessimine
IUPAC Name	n.a.
Canonical SMILES	CN[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C
Standard InCHI	InChI=1S/C23H38N2/c1-15-19-7-8-21-18-6-5-16-13-17(24-3)9-11-22(16,2)20(18)10-12-23(19,21)14-25(15)4/h5,15,17-21,24H,6-14H2,1-4H3/t15-,17-,18+,19+,20-,21-,22-,23-/m0/s1
Standard InCHIKey	UBWOPONWVXRTKE-ALCLCTQTSA-N
External Identifiers	ChEMBL [CHEMBL371125]; PubChem [11772257];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏

Ingredient ID: TCMC2343
Formula: C30H48N2O2

Common Name	n.a.
IUPAC Name	n.a.
Canonical SMILES	O=C(O[C@@H]1C[C@H]2[C@H]([C@H]3[C@@]41CN([C@H]([C@H]4CC3)C)C)CC=C1[C@]2(C)CC[C@@H](C1)N(C)C)CC=C(C)C
Standard InCHI	InChI=1S/C30H48N2O2/c1-19(2)8-13-28(33)34-27-17-26-23(25-12-11-24-20(3)32(7)18-30(24,25)27)10-9-21-16-22(31(5)6)14-15-29(21,26)4/h8-9,20,22-27H,10-18H2,1-7H3/t20-,22-,23-,24+,25-,26-,27+,29-,30+/m0/s1
Standard InCHIKey	WGJLLAVOYXFCTC-BMSXNQCFSA-N
External Identifiers	ChEMBL [CHEMBL364090]; PubChem [11225162];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏

Ingredient ID: TCMC1340
Formula: C21H30O5

Common Name	Hydrocortisone
IUPAC Name	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Canonical SMILES	OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C
Standard InCHI	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Standard InCHIKey	JYGXADMDTFJGBT-VWUMJDOOSA-N
External Identifiers	ChEMBL [CHEMBL389621]; PubChem [5754];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2367	Linum usitatissimum	Ya Ma Zi	亚麻子
TCMH523	Lamiophlomis rotata	Du Yi Wei	独一味
TCMH2710	Homo sapiens	Zi He Che	紫河车
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏
TCMH1734	Homo sapiens	Ren Zhong Bai	人中白

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC938	C24H40N2	Conessine	356.32	0.5176	3.88	4.999	2	0	6.48	6	5	26	0
TCMC1340	C21H30O5	Hydrocortisone	362.21	-1.1216	3.22	0.553	5	3	94.83	7	4	26	0
TCMC2343	C30H48N2O2		468.37	1.9047	4.32	5.518	4	0	32.78	12	5	34	1
TCMC2401	C23H38N2	Isoconessimine	342.3	-0.0183	3.77	4.76	2	1	15.27	5	5	25	0
TCMC2421	C28H46O	3-Beta-Hydroxyergost-5,24(28)-Diene	398.35	2.1615	4.43	10.105	1	1	20.23	11	4	29	1
TCMC2452	C23H38N2	Conessimine	342.3	-0.0183	3.77	4.76	2	1	15.27	5	5	25	0
TCMC2473	C21H27NO2	Holanamine	325.2	-0.2801	3.44	2.843	3	1	49.66	3	5	24	0
TCMC2568	C22H34N2	Conessidine	326.27	-0.2917	3.66	4.579	2	1	24.39	4	5	24	0
TCMC2651	C21H32N2	Conckurchine	312.26	-0.7235	3.55	4.189	2	1	38.38	3	5	23	0

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Typhonium flagelliforme 水半夏

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC938

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2651

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2568

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2473

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2452

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2421

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2401

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2343

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1340

Occurrence of the ingredient across TCM components

Properties

Download Data