Component: Swertia mileensis 青叶胆


Description of the Component

Component ID
TCMH1703
Latin Name
Swertia mileensis
English Name
Mileen swertia
Chinese Pinyin Name
Qing Ye Dan
中文名
青叶胆
TCM Properties
Cold,Sweet,Bitter
TCM Meridians
Bladder,Liver,Gallbladder
Therapeutic Class English
Therapeutic Class Chinese
Functions
increase the flow of bile, and remove heat and damp
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
DQ317486
Barcode Source
GenBank

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF4011 Huang Dan Gan Yan Pills 黄疸肝炎丸
TCMF997 Huang Dan Gan Yan Pills 黄疸肝炎丸
TCMFx664 Qing Ye Dan Tablet 青叶胆片
TCMFx1388 Shisanwei Bangga Powder 十三味榜嘎散
TCMFx2422 Shisanwei Bangga Powder 十三味榜嘎散

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1107 Protease
TCMT1178 Actinomyces viscosus
TCMT1229 Enterococcus faecalis
TCMT1248 Hepatitis C virus
TCMT1255 Human immunodeficiency virus 1
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC3909
Formula: C22H22O11

Ingredient ID: TCMC3590
Formula: C16H22O9

Ingredient ID: TCMC1786
Formula: C30H48O3

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC1786 C30H48O3 Oleanolic_Acid 456.36 2.1298 4.43 9.052 3 2 57.53 10 5 33 1
TCMC3590 C16H22O9 Sweroside 358.1263823 -2.8201 2.23 -0.256 9 4 131.67 4 3 25 0
TCMC3909 C22H22O11 Swertiajaponin 462.1162115 -3.9796 2.67 -0.94 9 7 177.14 4 4 33 1

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)