Component: Isatis indigotica 木板蓝根


Description of the Component

Component ID
TCMH1510
Latin Name
Isatis indigotica
English Name
Indigowoad root
Chinese Pinyin Name
Mu Ban Lan Gen
中文名
木板蓝根
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
KJ765825
Barcode Source
GenBank

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF4099 Jin Qing Jie Du Pills 金青解毒丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT267 GABRR1 GABA receptor rho-1 subunit Ion channel P24046
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT341 NR1I2 Pregnane X receptor Nuclear receptor O75469
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT620 HSPA8 Heat shock cognate 71 kDa protein Unclassified P11142
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT827 NQO1 Quinone reductase 1) Oxidoreductase P15559
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1085 Neuraminidase
TCMT1099 Neuraminidase
TCMT1136 Neuraminidase
TCMT1151 Neuraminidase
TCMT1160 Neuraminidase
TCMT1161 Neuraminidase
TCMT1162 Neuraminidase
TCMT1163 Neuraminidase
TCMT1164 Neuraminidase
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1218 Staphylococcus aureus
TCMT1241 Human rhinovirus 14
TCMT1285 Human coxsackievirus B3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC860
Formula: C23H13N3O2

Ingredient ID: TCMC770
Formula: C7H6O2

Ingredient ID: TCMC632
Formula: C10H13N5O4

Ingredient ID: TCMC448
Formula: C9H7NO

Ingredient ID: TCMC309
Formula: C14H17NO6

Ingredient ID: TCMC2774
Formula: C19H18N2O2

Ingredient ID: TCMC2773
Formula: C22H18N4O2

Ingredient ID: TCMC2742
Formula: C21H16N4O

Ingredient ID: TCMC2737
Formula: C11H10N2O

Ingredient ID: TCMC2736
Formula: C10H10N2O2

Ingredient ID: TCMC2654
Formula: C15H10N2

Ingredient ID: TCMC2197
Formula: C11H12N2O2

Ingredient ID: TCMC2196
Formula: C15H8N2O2

Ingredient ID: TCMC2119
Formula: C9H10O5

Ingredient ID: TCMC2074
Formula: C9H8N2O

Ingredient ID: TCMC2040
Formula: C19H21NO4

Ingredient ID: TCMC2037
Formula: C7H6O3

Ingredient ID: TCMC1991
Formula: C8H6N2O

Ingredient ID: TCMC1928
Formula: C8H7NO4S.K

Ingredient ID: TCMC1915
Formula: C18H18F3N3O3

Ingredient ID: TCMC1895
Formula: C5H7NO3

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC183
Formula: C17H15NO4

Ingredient ID: TCMC1801
Formula: C16H28N2O4

Ingredient ID: TCMC1438
Formula: C10H9N5O

Ingredient ID: TCMC1377
Formula: C8H5NO2

Ingredient ID: TCMC1376
Formula: C20H18N2O4

Ingredient ID: TCMC1371
Formula: C16H10N2O2

Ingredient ID: TCMC1370
Formula: C16H10N2O2

Ingredient ID: TCMC1320
Formula: C16H14O6

Ingredient ID: TCMC1279
Formula: C21H18O6

Ingredient ID: TCMC1209
Formula: C4H9NO2

Ingredient ID: TCMC1015
Formula: C11H10N2O

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC183 C17H15NO4 (Z)-3-(4-Hydroxy-3,5-Dimethoxybenzylidene)Indolin-2-One 297.1 -0.3733 2.78 3.205 2 2 71.28 7 3 22 0
TCMC309 C14H17NO6 2-(Hydroxymethyl)-6-(1H-Indol-3-Yloxy)Oxane-3,4,5-Triol 295.11 -2.6276 2.23 0.379 6 5 115.17 7 3 21 0
TCMC448 C9H7NO 3-Formylindole 145.05 -0.6128 2.23 2.53 2 1 32.86 1 2 11 0
TCMC632 C10H13N5O4 Adenosine 267.1 -2.2791 1.57 -1.809 9 4 139.54 6 3 19 0
TCMC770 C7H6O2 Benzoic Acid 122.04 -0.2398 2.01 2.666 2 1 37.3 2 1 9 0
TCMC860 C23H13N3O2 Candidine 363.1 -1.4589 3.44 6.186 5 1 61.77 0 6 28 1
TCMC1015 C11H10N2O Deoxyvasicinone 186.08 -0.8417 2.34 1.937 3 0 32.67 0 3 14 0
TCMC1209 C4H9NO2 Gamma-Aminobutyric Acid 103.06 -1.2313 1.57 -0.668 3 2 63.32 5 0 7 0
TCMC1279 C21H18O6 Glycyrol 366.11 0.6598 3.11 2.978 1 2 89.13 8 4 27 0
TCMC1320 C16H14O6 Hesperetin 302.08 -1.8662 2.56 0.453 1 3 96.22 6 3 22 0
TCMC1370 C16H10N2O2 Indigo 262.07 -1.7942 2.78 4.628 4 2 58.2 0 4 20 0
TCMC1371 C16H10N2O2 Indirubin 262.07 -0.9404 2.78 4.524 4 2 61.69 1 4 20 0
TCMC1376 C20H18N2O4 Isaindigotone 350.13 -0.6246 3 2.627 3 1 71.36 6 4 26 0
TCMC1377 C8H5NO2 Isatin 147.03 -0.8986 2.01 1.653 3 1 46.17 0 2 11 0
TCMC1438 C10H9N5O Kinetin 215.08 -0.9833 1.9 0.608 5 2 79.63 3 3 16 0
TCMC1801 C16H28N2O4 Oseltamivir 312.2 -1.1666 2.56 1.536 6 2 94.14 14 1 22 0
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC1895 C5H7NO3 Pidolic Acid 129.04 -0.7317 1.57 -0.647 4 2 69.89 3 1 9 0
TCMC1915 C18H18F3N3O3 Pleconaril 381.13 2.3385 2.45 5.455 1 0 74.18 13 3 27 1
TCMC1928 C8H7NO4S.K Potassium;1H-Indol-3-Yl Sulfate 212 -1.6073 1.68 0.619 4 1 90.6 3 2 14 0
TCMC1991 C8H6N2O Quinazolinone 146.05 -0.4603 2.01 1.634 2 1 46.01 1 2 11 0
TCMC2037 C7H6O3 Salicylic Acid 138.03 -0.7001 1.9 2.264 2 2 57.53 3 1 10 0
TCMC2040 C19H21NO4 Salutaridine 327.15 -0.6163 3 1.283 3 1 59 6 4 24 0
TCMC2074 C9H8N2O Sid24824100 160.06 -0.502 2.12 2.522 3 3 59.87 2 2 12 0
TCMC2119 C9H10O5 Syringic Acid 198.05 -0.8037 1.9 0.182 2 2 75.99 7 1 14 0
TCMC2196 C15H8N2O2 Tryptanthrin 248.06 -0.8639 2.67 3.473 4 0 49.74 0 4 19 0
TCMC2197 C11H12N2O2 Tryptophan 204.09 -1.5048 2.23 -0.96 4 3 79.11 5 2 15 0
TCMC2654 C15H10N2 Quindoline 218.08 -0.4204 2.89 4.484 2 1 28.68 0 4 17 0
TCMC2736 C10H10N2O2 (+/-)-2-(2-Oxoindolin-3-Yl)Acetamide 190.07 -0.2731 2.12 1.965 4 3 76.67 4 2 14 0
TCMC2737 C11H10N2O Arvelexin 186.08 -0.4027 2.34 1.135 2 1 48.81 3 2 14 0
TCMC2742 C21H16N4O (2S)-2-[3-(Cyanomethyl)-4-Methoxy-1H-Indol-7-Yl]-2-(1H-Indol-3-Yl)Acetonitrile 340.13 -0.9331 3.22 2.274 4 2 88.39 5 4 26 0
TCMC2773 C22H18N4O2 (2S)-2-[3-(Cyanomethyl)-4-Methoxy-1H-Indol-7-Yl]-2-(4-Methoxy-1H-Indol-3-Yl)Acetonitrile 370.14 -0.9849 3.22 1.619 4 2 97.62 7 4 28 0
TCMC2774 C19H18N2O2 2-[7-[(1S)-1-(4-Hydroxyphenyl)Ethyl]-4-Methoxy-1H-Indol-3-Yl]Acetonitrile 306.14 -0.4578 3.11 3.213 2 2 69.04 7 3 23 0

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