Component: Buddleja officinalis 密蒙花


Description of the Component

Component ID
TCMH1487
Latin Name
Buddleja officinalis
English Name
Pale butterflybush
Chinese Pinyin Name
Mi Meng Hua
中文名
密蒙花
TCM Properties
Minor cold,Sweet
TCM Meridians
Liver
Therapeutic Class English
Heat clearence
Therapeutic Class Chinese
清热
Functions
remove heat, replenish the liver and clear the eye of corneal opacity
Toxicity
NA
Geo-authentic habitats (道地产区)
Hubei Province
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAM868-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF1452 Boyun Tuiyi Pills 拨云退翳丸
TCMF2635 Boyun Tuiyi Pills 拨云退翳丸
TCMFx3838 Er Mao Guan Yan Yao 鹅毛管眼药
TCMF995 Huang Lian Yang Gan Pills 黄连羊肝丸
TCMF4085 Huang Lian Yang Gan Tablets 黄连羊肝片
TCMF648 Jin Hua Ming Mu Pills 金花明目丸
TCMF4504 Ming Mu Ji Li Pills 明目蒺藜丸
TCMF5198 Tui Zhang Yan Ointment 退障眼膏
TCMF1129 Zhang Yan Ming Tablet 障眼明片
TCMF6040 Zhang Yan Ming Tablets 障眼明片
TCMF323 Zhi Sou Hua Tan Pills 止嗽化痰丸
TCMF6581 Zhi Sou Hua Tan Pills 止嗽化痰丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT331 PLG Plasminogen Unclassified P00747
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT377 INSR Insulin receptor Kinase P06213
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT59 BCL2L1 Apoptosis regulator Bcl-X Ion channel Q07817
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT60 FASN Fatty acid synthase Unclassified P49327
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1092 Fatty acid synthase
TCMT1093 Enoyl-acyl-carrier protein reductase
TCMT1094 3-oxoacyl-acyl-carrier protein reductase
TCMT1099 Neuraminidase
TCMT1121 Sialidase
TCMT1189 Pseudomonas fluorescens
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC851
Formula: C23H26O11

Ingredient ID: TCMC7173
Formula: C54H88O21

Ingredient ID: TCMC711
Formula: C21H20O10

Ingredient ID: TCMC710
Formula: C15H10O5

Ingredient ID: TCMC6982
Formula: C25H30O12

Ingredient ID: TCMC614
Formula: C29H36O15

Ingredient ID: TCMC606
Formula: C16H12O5

Ingredient ID: TCMC4801
Formula: C34H42O18

Ingredient ID: TCMC4533
Formula: C28H32O14

Ingredient ID: TCMC2709
Formula: C21H20O10

Ingredient ID: TCMC1920
Formula: C35H46O19

Ingredient ID: TCMC1516
Formula: C15H10O6

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC606 C16H12O5 Acacetin 284.07 -1.476 2.67 2.086 1 2 75.99 5 3 21 0
TCMC614 C29H36O15 Acetoside 624.21 -4.2978 3 -0.202 11 9 245.29 21 4 44 3
TCMC710 C15H10O5 Apigenin 270.05 -1.8845 2.56 1.567 1 3 86.99 4 3 20 0
TCMC711 C21H20O10 Apigetrin 432.11 -3.6314 2.67 0.459 6 6 166.14 10 4 31 1
TCMC851 C23H26O11 Calceolarioside A 478.15 -3.0509 2.78 0.632 7 7 186.37 16 3 34 1
TCMC1516 C15H10O6 Luteolin 286.05 -2.3448 2.45 1.033 1 4 107.22 5 3 21 0
TCMC1920 C35H46O19 Poliumoside 770.26 -5.5447 3.22 -0.607 15 11 304.21 26 5 54 3
TCMC2709 C21H20O10 Apigenin-7-O-Glucoside 432.11 -3.6314 2.67 0.459 6 6 166.14 10 4 31 1
TCMC4533 C28H32O14 Acacini,Linarin 592.1792057 -4.1028 3 -0.297 10 7 204.83 7 5 42 1
TCMC4801 C34H42O18 Neobudofficide 738.2371145 -5.5243 3.22 -1.107 17 9 263.75 9 6 52 2
TCMC6982 C25H30O12 6-P-Methoxycinnamoyl Catalpol 522.1737264 -3.6648 2.89 0.518 11 5 176.9 9 5 37 1
TCMC7173 C54H88O21 Mimengoside A 1072.58181 -4.7769 5.09 2.613 21 12 325.83 11 10 75 3

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1. General Information of the Component  
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3. Putative Targets  
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5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)