TCM-ID Component

Description of the Component

Component ID	TCMH1453
Latin Name	Ilex pubescens
English Name	Pubescent holly
Chinese Pinyin Name	Mao Dong Qing
中文名	毛冬青
TCM Properties
TCM Meridians
Therapeutic Class English	Blood activation and stasis removal
Therapeutic Class Chinese	活血化淤
Functions	promote blood circulation remove stasis, dredge the channels and collaterals, clear heat and toxic materials, eliminate phlegm, and relieve cough and asthma
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	ITSAN840-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx3828	Bo Gu Decoction	驳骨水
TCMFx4786	Hu Xin Capsules	护心胶囊
TCMFx4403	Jian Xin Tablets	健心片
TCMFx4063	Kang Feng Shi Oral Liquid	抗风湿液
TCMFx4295	Mao Dong Qing Capsules	毛冬青胶囊
TCMFx4303	Mao Dong Qing Zhu She Oral Liquid	毛冬青注射液
TCMFx4503	Pen Yan Qing Shuan	盆炎清栓
TCMF6376	Xiao Yan Ling Tablets	消炎灵片
TCMF6822	Xin Mai Tong Tablets	心脉通片
TCMFx384	Xin Shu Ning Tablet	心舒宁片
TCMFx5997	Xin Shu Ning Tablets	心舒宁片
TCMFx6561	Xue Shuan Xin Mai Ning Capsules	血栓心脉宁胶囊
TCMFx142	Xue Shuan Xin Mo Ning Tablets	血栓心脉宁片
TCMF6575	Xue Ya Ping Tablets	血压平片
TCMFx458	Xue Shuan Xin Mai Ning Capsule	血栓心脉宁胶囊
TCMFx6659	Yan Jian Ning Tablets	炎见宁片
TCMFx7131	Zhi Shang Ruan Ointment	治伤软膏
TCMFx6309	Zhong Gan Ling Tablets	重感灵片

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT103	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	Hydrolase	P10586
TCMT171	PTPN6	Protein-tyrosine phosphatase 1C	Hydrolase	P29350
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT30	PTGS2	Cyclooxygenase-2	Oxidoreductase	P35354

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1107	Protease
TCMT1218	Staphylococcus aureus
TCMT1229	Enterococcus faecalis
TCMT1255	Human immunodeficiency virus 1
TCMT1257	Colletotrichum lagenarium

Ingredient Structrues

Ingredient ID: TCMC943
Formula: C30H48O4

Common Name	Corosolic Acid
IUPAC Name	(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Canonical SMILES	C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=CC[C@H]3[C@@]([C@@]1(CC2)C)(C)CC[C@@H]1[C@]3(C)C[C@@H](O)[C@@H](C1(C)C)O)C(=O)O
Standard InCHI	InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
Standard InCHIKey	HFGSQOYIOKBQOW-ZSDYHTTISA-N
External Identifiers	ChEMBL [CHEMBL391533]; PubChem [6918774];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2729	Campsis grandiflora	Zi Wei Gen Pi	紫葳根皮
TCMH1862	Cornus officinalis	Shan Zhu Yu	山茱萸
TCMH611	Rubus idaeus	Fu Pen Zi	覆盆子
TCMH1753	Boswellia carterii	Ru Xiang	乳香
TCMH1453	Ilex pubescens	Mao Dong Qing	毛冬青
TCMH1333	Clerodendron cyrtophyllum	Lu Bian Qing	路边青
TCMH2134	Smilax glabra	Tu Fu Ling	土茯苓
TCMH25	Styrax benzoin	An Xi Xiang	安息香
TCMH719	Dryopteris crassirhizoma	Guan Zhong	贯众
TCMH108	Perilla frutescens	Bai Su Zi	白苏子
TCMH1432	Vitex trifolia	Man Jing Zi	蔓荆子
TCMH2286	Berberis julianae	Xiao Bo Gen	小檗根
TCMH95	Aquilaria sinensis	Bai Mu Xiang	白木香
TCMH388	Ziziphus jujuba	Da Zao	大枣
TCMH1615	Eriobotrya japonica	Pi Ba Ren	枇杷仁
TCMH2261	Fritillaria thunbergii	Xiang Bei	象贝
TCMH1033	Centella asiatica	Ji Xue Cao	积雪草
TCMH2206	Schisandra chinensis	Wu Wei Zi Liu Jin Gao	五味子流浸膏
TCMH970	Vitex negundo	Huang Jing Zi	黄荆子
TCMH1660	Senecio scandens	Qian Li Guang	千里光
TCMH1135	Rosa laevigata	Jin Ying Zi Ti Qu Ye	金樱子提取液
TCMH906	Viscum coloratum	Hu Ji Sheng	槲寄生
TCMH2213	Ipomoea cairica	Wu Zhao Long	五爪龙
TCMH1175	Cornus officinalis	Jiu Yu Rou	酒萸肉
TCMH1431	Vitex trifolia	Man Jing Ye	蔓荆叶
TCMH1133	Rosa laevigata	Jin Ying Zi	金樱子
TCMH1134	Rosa laevigata	Jin Ying Zi Rou	金樱子肉
TCMH2202	Schisandra chinensis	Wu Wei Zi	五味子
TCMH2203	Schisandra chinensis	Wu Wei Zi Chun Jin Gao	五味子醇浸膏
TCMH2204	Schisandra chinensis	Wu Wei Zi Jin Chu Wu	五味子浸出物
TCMH2205	Schisandra chinensis	Wu Wei Zi Jin Gao	五味子浸膏

Ingredient ID: TCMC618
Formula: C32H50O4

Common Name	Acetyl Oleanolic Acid
IUPAC Name	(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-acetyloxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Canonical SMILES	CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C
Standard InCHI	InChI=1S/C32H50O4/c1-20(33)36-25-12-13-29(6)23(28(25,4)5)11-14-31(8)24(29)10-9-21-22-19-27(2,3)15-17-32(22,26(34)35)18-16-30(21,31)7/h9,22-25H,10-19H2,1-8H3,(H,34,35)/t22-,23-,24+,25-,29-,30+,31+,32-/m0/s1
Standard InCHIKey	RIXNFYQZWDGQAE-DFHVBEEKSA-N
External Identifiers	ChEMBL [CHEMBL486822]; PubChem [151202];
Reference of Component-Ingredient Pair	16076639

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1453	Ilex pubescens	Mao Dong Qing	毛冬青
TCMH2218	Rubia cordifolia	Qian Cao Teng	茜草藤
TCMH213	Boschniakia rossica	Cao Cong Rong	草苁蓉
TCMH1597	Ligustrum lucidum	Nv Zhen Zi	女贞子
TCMH1272	Forsythia suspensa	Lian Qiao	连翘

Ingredient ID: TCMC1711
Formula: C42H30O9

Common Name	n.a.
IUPAC Name	n.a.
Canonical SMILES	Oc1cc2c3c(c1)O[C@H]([C@@H]3c1cc(O)cc3c1[C@@H](c1c4[C@H]2[C@H](Oc4cc(c1)O)c1ccc(cc1)O)[C@@H](O3)c1ccc(cc1)O)c1ccc(cc1)O
Standard InCHI	InChI=1S/C42H30O9/c43-22-7-1-19(2-8-22)40-37-28-13-25(46)17-32-35(28)39(42(50-32)21-5-11-24(45)12-6-21)30-15-27(48)18-33-36(30)38(29-14-26(47)16-31(49-40)34(29)37)41(51-33)20-3-9-23(44)10-4-20/h1-18,37-48H/t37-,38-,39+,40+,41+,42-/m1/s1
Standard InCHIKey	KUTVNHOAKHJJFL-ZSIJVUTGSA-N
External Identifiers	ChEMBL [CHEMBL443463]; PubChem [196402];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1453	Ilex pubescens	Mao Dong Qing	毛冬青
TCMH1446	Vaccinium oxycoccos	Man Yue Mei	蔓越莓
TCMH2232	Scutellaria amoena	Xi Nan Huang Qin	西南黄芩
TCMH1518	Chaenomeles sinensis	Mu Gua	木瓜

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC618	C32H50O4	Acetyl Oleanolic Acid	498.37	2.5089	4.54	9.792	4	1	63.6	12	5	36	1
TCMC943	C30H48O4	Corosolic Acid	472.36	1.2611	4.32	8.142	4	3	77.76	11	5	34	1
TCMC1711	C42H30O9		678.19	-3.768	5.09	5.784	0	6	149.07	9	10	51	2

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Ilex pubescens 毛冬青

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC943

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC618

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1711

Occurrence of the ingredient across TCM components

Properties

Download Data