Component: Ilex cornuta 枸骨叶


Description of the Component

Component ID
TCMH1177
Latin Name
Ilex cornuta
English Name
FOLIUM iLICIS cORNUTAE
Chinese Pinyin Name
Ju Gu Ye
中文名
枸骨叶
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAN835-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF3598 Feng Tong Pills 风痛丸
TCMFx1109 Hua Mo Yan Capsule 滑膜炎胶囊
TCMFx1110 Hua Mo Yan Granules 滑膜炎颗粒
TCMFx94 Hua Mo Yan Tablets 滑膜炎片
TCMF5722 Qing Shen Yin Infusion 清身饮冲剂

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT218 CYP2B6 Cytochrome P450 2B6 Oxidoreductase P20813
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT620 HSPA8 Heat shock cognate 71 kDa protein Unclassified P11142
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT640 CTSD Cathepsin D Unclassified P07339
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1107 Protease
TCMT1121 Sialidase
TCMT1218 Staphylococcus aureus
TCMT1229 Enterococcus faecalis
TCMT1246 Escherichia coli
TCMT1255 Human immunodeficiency virus 1
TCMT1412 Salmonella typhimurium
TCMT1458 Filobasidiella neoformans
TCMT1463 Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC850
Formula: C8H10N4O2

Ingredient ID: TCMC732
Formula: C30H48O5

Ingredient ID: TCMC724
Formula: C30H48O5

Ingredient ID: TCMC632
Formula: C10H13N5O4

Ingredient ID: TCMC350
Formula: C30H48O4

Ingredient ID: TCMC2807
Formula: C24H24O6

Ingredient ID: TCMC2522
Formula: C24H24O6

Ingredient ID: TCMC2216
Formula: C30H48O3

Ingredient ID: TCMC1520
Formula: C23H22O6

Ingredient ID: TCMC1244
Formula: C23H24O6

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC350 C30H48O4 23-Hydroxyursolic Acid 472.36 0.3931 4.32 8.251 4 3 77.76 11 5 34 1
TCMC632 C10H13N5O4 Adenosine 267.1 -2.2791 1.57 -1.809 9 4 139.54 6 3 19 0
TCMC724 C30H48O5 Arjunolic Acid 488.35 0.8164 4.21 7.537 5 4 97.99 12 5 35 1
TCMC732 C30H48O5 Asiatic Acid 488.35 0.1704 4.21 7.439 5 4 97.99 12 5 35 1
TCMC850 C8H10N4O2 Caffeine 194.08 -0.4311 1.68 -0.625 6 0 58.44 3 2 14 0
TCMC1244 C23H24O6 Gerontoxanthone I 396.16 1.24 3.33 3.35 1 4 107.22 12 3 29 0
TCMC1520 C23H22O6 Macluraxanthone 394.14 0.7307 3.33 3.28 1 3 96.22 9 4 29 0
TCMC2216 C30H48O3 Ursolic Acid 456.36 1.4838 4.43 8.954 3 2 57.53 10 5 33 1
TCMC2522 C24H24O6 5-O-Methylxanthone V1 408.16 1.3949 3.44 3.04 1 2 85.22 10 4 30 0
TCMC2807 C24H24O6 10-O-Methylmacluraxanthone 408.16 1.1392 3.44 3.37 1 2 85.22 10 4 30 0

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)