Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC113733 POLB 2 Median: 51840
Range: 43400 to 60280
IC50 PMID: 14640519
PMID: 18343122
NPC142415 ACP1 4 Median: 22050
Range: 21200 to 22900
IC50 PMID: 21453996
PMID: 21453996
PMID: 25264584
PMID: 25264584
NPC142415 PTPN6 2 Median: 22760
Range: 14190 to 31330
IC50 PMID: 18707891
PMID: 27123900
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC281398 MGLL 1 48000 IC50 DOI: 10.1039/C4MD00186A
NPC281398 RECQL 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 ALOX12 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 POLB 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 L3MBTL1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC281398 KDM4E 3 Median: 19952.6
Range: 17782.8 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 TDP1 2 Median: 20085
Range: 17782.8 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 HPGD 2 Median: 15848.9
Range: 15848.9 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC281398 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC51700 PPARA 1 41310 EC50 PMID: 21855333
NPC51700 AKR1B1 1 41000 IC50 PMID: 21561086
NPC51700 CYP19A1 1 32000 IC50 PMID: 18192087
NPC51700 PTPN6 1 25780 IC50 PMID: 18707891
NPC51700 POLB 1 18600 IC50 PMID: 15165161
NPC51700 CTSD 1 18200 IC50 DOI: 10.1007/s00044-012-0397-z
NPC51700 SLCO1B1 1 15848.93 IC50 PMID: 23571415
NPC77000 PTPRC 1 41400 IC50 PMID: 23957426
NPC77000 RECQL 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 PTPN6 1 39500 IC50 PMID: 23957426
NPC77000 PTPRF 1 36900 IC50 PMID: 23957426
NPC77000 PTPN1 1 33500 IC50 PMID: 23957426
NPC77000 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 TDP1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 NPSR1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 PTPN11 2 Median: 33840
Range: 22500 to 45180
IC50 PMID: 23957426
PMID: 23957426
NPC77000 POLB 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 KDM4E 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC77000 L3MBTL1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC93241 CES1 1 26250 Ki PMID: 23286284
NPC93241 BLM 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC93241 POLB 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC142415 PTPRF 2 Median: 17055
Range: 11800 to 22310
IC50 PMID: 21453996
PMID: 27123900
NPC142415 PTPN11 1 11620 IC50 PMID: 27123900
NPC192638 TOP2A 1 10400 IC50 PMID: 11754608
NPC281398 TP53 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC51700 SLCO1B3 1 11481.54 IC50 PMID: 23571415
NPC77000 ALDH1A1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC93241 TDP1 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862