Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC126029 TSHR 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC133671 P4HB 1 19020 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC142415 ACP1 4 Median: 22050
Range: 21200 to 22900
IC50 PMID: 21453996
PMID: 21453996
PMID: 25264584
PMID: 25264584
NPC142415 PTPN6 2 Median: 22760
Range: 14190 to 31330
IC50 PMID: 18707891
PMID: 27123900
NPC149209 HDAC1 1 16000 IC50 PMID: 21874153
NPC149209 HDAC8 1 15000 IC50 PMID: 21874153
NPC161571 POLB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC161571 PMP22 1 42561.5 Potency PubChem BioAssay data set
CHEMBL1201862
NPC161571 GAA 1 39506.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC161571 CYP1A1 1 34000 IC50 PMID: 27265259
NPC161571 HSD17B10 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC161571 ALDH1A1 4 Median: 37646
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC161571 MAOB 1 29370 IC50 DOI: 10.1039/C3MD00376K
NPC161571 BCR 1 28000 IC50 PMID: 16686543
NPC161571 CYP19A1 2 Median: 25000
Range: 25000 to 25000
IC50 PMID: 22115839
PMID: 22386564
NPC161571 SIRT1 3 Median: 46200
Range: 23600 to 87200
EC50 PMID: 18046409
PMID: 23316803
PMID: 23316803
NPC161571 KDM4E 4 Median: 28370.85
Range: 22387.2 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC161571 RELA 1 20000 IC50 Patent: Patent: US20130178536 A1
NPC161571 ODC1 1 19000 IC50 PMID: 10075742
NPC169749 DPP4 1 37150 IC50 DOI: 10.1039/C0MD00245C
NPC169749 ALPL 1 33200 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALPPL2 1 32300 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 AMY1A;AMY1B;AMY1C 1 30200 IC50 PMID: 18507367
NPC169749 AKR1B1 1 29000 IC50 PMID: 18165015
NPC169749 CD38 1 24800 IC50 PMID: 21641214
NPC169749 DAPK1 1 23000 IC50 PMID: 26322379
NPC169749 ABCC2 1 22000 IC50 PMID: 19725578
NPC169749 ABCC1 1 20000 IC50 PMID: 19725578
NPC169749 CYP2D6 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 APOBEC3A 1 17500 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 MTOR 2 Median: 19881.25
Range: 16481.6 to 23280.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 BLM 3 Median: 14125.4
Range: 14125.4 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALOX12 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC17810 LMNA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC17810 ALDH1A1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC179950 EPHX2 1 28430 IC50 PMID: 24679441
NPC179950 XDH 1 26310 IC50 PMID: 12444671
NPC179950 MAPT 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC180508 ABCB1 1 42000 IC50 PMID: 16686543
NPC180508 MAPK1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC180508 KDM4E 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 CA14 2 Median: 48900
Range: 48900 to 48900
Ki PMID: 18579385
PMID: 20185318
NPC204932 BLM 2 Median: 44668.4
Range: 44668.4 to 44668.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 POLB 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 APEX1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 EGFR 1 26043 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC204932 MMP9 1 23367 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC204932 TDP1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 L3MBTL1 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 FYN 1 17431 IC50 DrugMatrix in vitro pharmacology data
CHEMBL1909046
NPC204932 RECQL 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 ALOX15 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 KDM4E 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 PMP22 1 47754.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 THRB 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 GALK1 1 42128.5 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK2 1 40000 IC50 PMID: 17178224
NPC20791 CD38 1 37900 IC50 PMID: 21641214
NPC20791 SORD 2 Median: 106300
Range: 35600 to 177000
IC50 PMID: 8893834
PMID: 12672241
NPC20791 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 EPHX2 1 33540 IC50 PMID: 24679441
NPC20791 DPP4 2 Median: 81365
Range: 32730 to 130000
IC50 PMID: 18650094
DOI: 10.1039/C0MD00245C
NPC20791 MAPK1 2 Median: 35716.75
Range: 31622.8 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ADORA3 1 30000 Ki PMID: 8576921
NPC20791 PTGS2 1 28600 IC50 PMID: 17378609
NPC20791 BLM 3 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 TDP1 2 Median: 26651.35
Range: 25118.9 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 ALDH1A1 6 Median: 37646
Range: 25118.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 CDK6 2 Median: 25000
Range: 25000 to 25000
IC50 PMID: 15689157
DOI: 10.1007/s00044-009-9233-5
NPC20791 PTPN1 2 Median: 23300
Range: 23300 to 23300
IC50 PMID: 12419367
PMID: 19297174
NPC20791 KMT2A 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 AMY1A;AMY1B;AMY1C 1 21400 IC50 PMID: 18507367
NPC20791 SYK 1 20000 IC50 PMID: 22257213
NPC20791 HPGD 2 Median: 21169.9
Range: 19952.6 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 APEX1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 CYP2D6 1 18800 IC50 PMID: 22328583
NPC20791 USP2 2 Median: 25057.75
Range: 18492.7 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC20791 GPR35 1 15400 IC50 PMID: 24900447
NPC20791 APP 1 15300 IC50 PMID: 26719209
NPC219876 HSD17B10 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 PTGS1 2 Median: 58350
Range: 36700 to 80000
IC50 PMID: 11858749
PMID: 16038536
NPC219876 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 BLM 2 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 ALDH1A1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 RECQL 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC219876 MAPT 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 APEX1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC226809 MMP9 1 27300 IC50 PMID: 20053563
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC243728 POLB 1 26500 IC50 PMID: 15165161
NPC248573 ALOX15 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC248573 HPGD 2 Median: 25665.1
Range: 15848.9 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC248573 SMN1;SMN2 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC260491 MAPT 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC260491 RECQL 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC279406 MMP2 1 31400 IC50 PMID: 20053563
NPC300326 PTGS1 1 39200 IC50 PMID: 22386242
NPC300326 PTGS2 1 28000 IC50 PMID: 22386242
NPC303422 MAPT 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 GAA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 KDM4E 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 MAPK1 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC303422 POLB 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC34864 L3MBTL1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC34864 PMP22 1 30131.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC34864 ALDH1A1 3 Median: 28183.8
Range: 28183.8 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC34864 BLM 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC34864 MTOR 2 Median: 23280.9
Range: 23280.9 to 23280.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC34864 KDM4E 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC34864 SMN1;SMN2 3 Median: 25118.9
Range: 15848.9 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC81010 ESR1 1 16120 EC50 PMID: 23608764
NPC97578 PTGS1 1 50000 IC50 PMID: 11170689
NPC126029 CYP3A4 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC126029 KDM4E 2 Median: 16803.7
Range: 11220.2 to 22387.2
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC142415 PTPRF 2 Median: 17055
Range: 11800 to 22310
IC50 PMID: 21453996
PMID: 27123900
NPC142415 PTPN11 1 11620 IC50 PMID: 27123900
NPC149209 HDAC2 1 12000 IC50 PMID: 21874153
NPC169749 HSP90AB1 1 13500 IC50 PMID: 24548207
NPC179950 ALPL 1 14000 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC179950 KDM4E 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC180508 MAPT 2 Median: 13534.55
Range: 11220.2 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC180508 GAA 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 ALDH1A1 2 Median: 15954.1
Range: 14125.4 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 CA3 2 Median: 13000
Range: 13000 to 13000
Ki PMID: 18579385
PMID: 20185318
NPC204932 SMN1;SMN2 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 HIF1A 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 LMNA 2 Median: 23350.75
Range: 11220.2 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 HPGD 2 Median: 14501.5
Range: 11220.2 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC204932 GMNN 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC204932 CA4 3 Median: 10900
Range: 10900 to 10900
Ki PMID: 18579385
PMID: 20185318
PMID: 22245047
NPC20791 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC20791 PIK3CG 1 13790 IC50 PMID: 25050878
NPC20791 PREP 1 13000 IC50 PMID: 18650094
NPC20791 LCK 2 Median: 13000
Range: 13000 to 13000
IC50 PMID: 1995903
PMID: 16441060
NPC20791 CALM1;CALM2;CALM3 1 12970 IC50 PMID: 21129983
NPC20791 PLAU 1 12100 IC50 PMID: 24610996
NPC20791 CA5B 1 11900 Ki PMID: 20185318
NPC20791 CYP2C19 1 10500 IC50 PMID: 22328583
NPC20791 MMP12 1 10230 IC50 PMID: 22658537
NPC20791 HIF1AN 1 10200 IC50 PMID: 19822432
NPC20791 CYP2C9 1 10200 IC50 PMID: 22328583
NPC219876 KDM4E 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC219876 POLB 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC226809 MMP2 1 12400 IC50 PMID: 20053563
NPC248573 MAPT 2 Median: 14125.4
Range: 14125.4 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC248573 THPO 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC248573 KDM4E 2 Median: 20386.55
Range: 12589.3 to 28183.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC248573 HSD17B10 4 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC260491 KDM4E 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC293378 ALDH1A1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC29883 CA2 2 Median: 10600
Range: 10600 to 10600
Ki PMID: 18501600
PMID: 18579385
NPC34864 MYLK 2 Median: 12000
Range: 12000 to 12000
IC50 PMID: 16441060
PMID: 18077363
NPC81010 HCAR2 1 14000 Ki PMID: 21167710
NPC99088 LMNA 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862