Cytochrome P450 Enzymes: |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 7.663E-08 | 8.025E-04 | ALOX12, ALOX15, HPGD |
BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.948E-07 | 8.025E-04 | ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.948E-07 | 8.025E-04 | ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 8.842E-07 | 1.925E-03 | ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 8.842E-07 | 1.925E-03 | ALOX12, ALOX15 |
BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 2.946E-06 | 4.581E-03 | ALOX12, ALOX15 |
BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 3.354E-06 | 4.806E-03 | ALOX12, ALOX15, CYP1A2 |
BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 3.752E-06 | 4.806E-03 | AKR1B1, ALOX12, ALOX15, CYP1A2, HPGD, KDM4E |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|
hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.108E-04 | 1.307E-03 | CYP1A2; ALOX15 |
hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 3.052E-04 | 2.212E-03 | HKDC1; CYP1A2; ALOX15; AKR1B1; ALOX12 |
hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.186E-04 | 1.307E-03 | HKDC1; AKR1B1 |
hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 5.108E-04 | 2.962E-03 | ALOX15; ALOX12 |
hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.352E-04 | 1.307E-03 | HKDC1; AKR1B1 |
hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.654E-03 | 7.994E-03 | ALOX15; ALOX12 |
hsa03013 | RNA transport_Homo sapiens_hsa03013 | 3.843E-03 | 1.238E-02 | SMN2; SMN1 |
hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.179E-02 | 4.972E-02 | CYP1A2 |
hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.963E-02 | 4.972E-02 | AKR1B1 |
hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 3.038E-02 | 4.972E-02 | HKDC1 |
hsa04930 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 2.609E-02 | 4.972E-02 | HKDC1 |
hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 2.448E-02 | 4.972E-02 | HKDC1 |
hsa00520 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 2.609E-02 | 4.972E-02 | HKDC1 |
hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 3.198E-02 | 4.972E-02 | AKR1B1 |
hsa00010 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 3.625E-02 | 4.972E-02 | HKDC1 |
hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 3.518E-02 | 4.972E-02 | CYP1A2 |
hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 3.625E-02 | 4.972E-02 | HKDC1 |
hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 3.145E-02 | 4.972E-02 | CYP1A2 |
hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 3.731E-02 | 4.972E-02 | CYP1A2 |
hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.943E-02 | 4.972E-02 | CYP1A2 |
hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 3.837E-02 | 4.972E-02 | SLCO1B3 |
hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.747E-03 | 9.959E-03 | CYP1A2 |
hsa00524 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.747E-03 | 9.959E-03 | HKDC1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
---|---|---|---|
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1 |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1 |
G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1 |
C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1 |