Plant ID: NPO4070
Plant Latin Name: Eupatorium Sternbergianum
Taxonomy Genus: Eupatorium
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC9202
Ingredient ID: NPC72675
Ingredient ID: NPC71460
Ingredient ID: NPC70064
Ingredient ID: NPC65225
Ingredient ID: NPC64500
Ingredient ID: NPC61762
Ingredient ID: NPC53002
Ingredient ID: NPC45258
Ingredient ID: NPC41291
Ingredient ID: NPC35596
Ingredient ID: NPC32230
Ingredient ID: NPC31618
Ingredient ID: NPC311690
Ingredient ID: NPC304309
Ingredient ID: NPC301204
Ingredient ID: NPC291158
Ingredient ID: NPC28657
Ingredient ID: NPC26744
Ingredient ID: NPC240868
Ingredient ID: NPC238950
Ingredient ID: NPC228994
Ingredient ID: NPC226813
Ingredient ID: NPC216420
Ingredient ID: NPC214199
Ingredient ID: NPC2110
Ingredient ID: NPC200517
Ingredient ID: NPC192501
Ingredient ID: NPC191089
Ingredient ID: NPC171545
Ingredient ID: NPC16449
Ingredient ID: NPC160719
Ingredient ID: NPC158208
Ingredient ID: NPC157192
Ingredient ID: NPC134847
Ingredient ID: NPC111289
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H3 | LXR-alpha | Q13133 | CHEMBL2808 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 4 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00965068 | Cholesterol in ASD: Characterization and Treatment | Asperger syndrome;autism | Cholesterol (NPC28657) | NP level |
NCT00009841 | Gene Therapy in Treating Patients With Advanced Head and Neck Cancer | head and neck malignant neoplasia | Cholesterol (NPC28657) | NP level |
NCT00272844 | Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome | Smith-Lemli-Opitz syndrome | Cholesterol (NPC28657) | NP level |
NCT04359823 | DSAP Treatment Comparison | porokeratosis | Cholesterol (NPC28657) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA,NR1H3
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
RORC
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
RORC
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
RORC
|
Autoimmune diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40-4A45 |
RORC
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
RORC
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
RORC
|
Autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional languageDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02.0 |
NCT00965068
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT00965068
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT00009841
|
Disorders of cholesterol synthesisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52.10 |
NCT00272844
|
PorokeratosesDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED52 |
NCT04359823
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
RORC
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
RORC
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
RORC
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
NR1H3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
RORC
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|