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Plant Name: Nelumbo nucifera


Taxonomic Information:

Plant ID: NPO3478
Plant Latin Name: Nelumbo nucifera
Taxonomy Genus: Nelumbo
Taxonomy Family: Nelumbonaceae

Plant External Links:

NCBI TaxonomyDB: 4432
Plant-of-the-World-Online: n.a.


Used in Medicines:

Country/Region:
Indonesia; India; Malaysia; China; Thailand; South Korea

Traditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCM


Medicinal Functions:

Antidiarrhoeal; Astringent; Cancer; Cardiotonic; Febrifuge; Hypotensive; Miscellany; Miscellany; Resolvent; Stomachic; Styptic; Tonic; Vasodilator


Geographical Distribution:

Indonesia; India; Malaysia; China; Thailand; South Korea

Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available



Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Peptide receptor (family A GPCR)
TSHR; NPSR1;
Small molecule receptor (family A GPCR)
FFAR1; FFAR4; DRD2; HTR1A;
Hydrolase
ACHE;
Enzyme_unclassified
TDP1; RECQL; GLO1; PGD; ALOX12; HSD17B2; HSD17B10; NOX4; ALOX15; APEX1; POLB;
Miscellaneous ion channel
BCL2;
Isomerase
TOP2A;
Protein Kinase
PIM1; MET; AXL; FLT3; CDK1; MAPK1; KDR; IGF1R; AURKB;
Lyase
CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C
PPARA;
Nuclear hormone receptor subfamily 1 group H
NR1H4;
Oxidoreductase
TYR;
Lysine demethylase
KDM4E;
Metallo protease
MMP9; MMP1; MMP12; MMP2;
Transcription Factor
AHR; HIF1A; NFKB1;
Transferase
FUT7;
Unclassified
LMNA; FABP3; FABP5; FABP4;
Methyl-lysine/arginine binding protein
L3MBTL1; SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified PGD 6-phosphogluconate dehydrogenase P52209 CHEMBL3404
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Isomerase TOP2A DNA topoisomerase II alpha P11388 CHEMBL1806
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Metallo protease MMP1 Matrix metalloproteinase-1 P03956 CHEMBL332
Metallo protease MMP12 Matrix metalloproteinase 12 P39900 CHEMBL4393
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Miscellaneous ion channel BCL2 Apoptosis regulator Bcl-2 P10415 CHEMBL4860
Nuclear hormone receptor subfamily 1 group C PPARA Peroxisome proliferator-activated receptor alpha Q07869 CHEMBL239
Nuclear hormone receptor subfamily 1 group H NR1H4 Bile acid receptor FXR Q96RI1 CHEMBL2047
Oxidoreductase TYR Tyrosinase P14679 CHEMBL1973
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Small molecule receptor (family A GPCR) FFAR1 Free fatty acid receptor 1 O14842 CHEMBL4422
Small molecule receptor (family A GPCR) FFAR4 G-protein coupled receptor 120 Q5NUL3 CHEMBL5339
Small molecule receptor (family A GPCR) DRD2 Dopamine D2 receptor P14416 CHEMBL217
Small molecule receptor (family A GPCR) HTR1A Serotonin 1a (5-HT1a) receptor P08908 CHEMBL214
Transcription Factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified FABP3 Fatty acid binding protein muscle P05413 CHEMBL3344
Unclassified FABP5 Fatty acid binding protein epidermal Q01469 CHEMBL3674
Unclassified FABP4 Fatty acid binding protein adipocyte P15090 CHEMBL2083
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 5.010E-10 7.988E-07 CA12, CA14, CA2, CA4, CA7
BP GO:0008283; cell proliferation GO:0008284; positive regulation of cell proliferation 2.105E-08 1.273E-05 ALOX12, BCL2, CDK1, DRD2, FLT3, HIF1A, HTR1A, IGF1R, KDR, MAPK1, MMP12, MMP2, MMP9, PIM1, TSHR
BP GO:0051179; localization GO:0015701; bicarbonate transport 1.700E-07 7.257E-05 CA12, CA14, CA2, CA4, CA7
BP GO:0065007; biological regulation GO:0010817; regulation of hormone levels 1.947E-07 8.023E-05 ACHE, CYP1A1, CYP1B1, DRD2, FFAR1, FFAR4, HIF1A, HSD17B2, HTR1A, NFKB1, NR1H4
BP GO:0050896; response to stimulus GO:0001666; response to hypoxia 7.639E-07 2.411E-04 BCL2, CYP1A1, DRD2, HIF1A, LMNA, MMP2, NOX4, PPARA
BP GO:0050896; response to stimulus GO:0033993; response to lipid 8.365E-07 2.530E-04 AXL, BCL2, CA2, CYP1A1, CYP1A2, FABP3, FFAR1, FLT3, HSD17B2, NFKB1, NR1H4, TYR
MF GO:0005488; binding GO:0005504; fatty acid binding 1.058E-06 2.879E-04 FABP3, FABP4, FABP5, FFAR4
BP GO:0050896; response to stimulus GO:0010039; response to iron ion 1.880E-06 4.706E-04 BCL2, CYP1A1, DRD2, HIF1A
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 2.730E-06 6.392E-04 CYP1A1, CYP1A2, CYP1B1
MF GO:0005488; binding GO:0008270; zinc ion binding 2.885E-06 6.663E-04 CA12, CA2, CA4, CA7, GLO1, L3MBTL1, MMP1, MMP12, MMP2, MMP9, NR1H4, PPARA
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 3.483E-06 7.738E-04 CA12, CA2, CA4, CA7
BP GO:0032502; developmental process GO:0007568; aging 4.501E-06 9.516E-04 APEX1, AURKB, BCL2, CDK1, CYP1A1, NOX4, POLB
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 4.970E-06 1.031E-03 HIF1A, MMP1, MMP12, MMP2, MMP9
BP GO:0050896; response to stimulus GO:0035094; response to nicotine 5.923E-06 1.183E-03 BCL2, DRD2, MAPK1, NFKB1
MF GO:0005488; binding GO:0008134; transcription factor binding 6.576E-06 1.267E-03 AHR, APEX1, BCL2, FLT3, HIF1A, MAPK1, NFKB1, NR1H4, PIM1, PPARA
BP GO:0008152; metabolic process GO:0055114; oxidation-reduction process 7.976E-06 1.498E-03 ALOX12, ALOX15, APEX1, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, KDM4E, NOX4, PGD, TYR
BP GO:0009987; cellular process GO:0006286; base-excision repair, base-free sugar-phosphate removal 8.255E-06 1.498E-03 APEX1, POLB
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 8.255E-06 1.498E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 8.255E-06 1.498E-03 ALOX12, ALOX15
MF GO:0005488; binding GO:0019825; oxygen binding 8.640E-06 1.555E-03 CYP1A1, CYP1A2, CYP1B1, NOX4
BP Unclassified; GO:0044236; multicellular organism metabolic process 1.384E-05 2.336E-03 HIF1A, MMP1, MMP12, MMP2, MMP9
BP GO:0050896; response to stimulus GO:0071417; cellular response to organonitrogen compound 1.716E-05 2.768E-03 APEX1, IGF1R, MAPK1, MMP2, NFKB1, NOX4, NR1H4, TSHR
BP GO:0050896; response to stimulus GO:0009725; response to hormone 1.743E-05 2.791E-03 APEX1, BCL2, CA2, CYP1A2, FABP3, FFAR4, FLT3, NFKB1, PPARA, TSHR
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 2.472E-05 3.541E-03 CA2, CA7
BP GO:0019740; nitrogen utilization GO:0006808; regulation of nitrogen utilization 2.472E-05 3.541E-03 BCL2, NR1H4
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 2.472E-05 3.541E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 2.472E-05 3.541E-03 ALOX12, ALOX15
BP GO:0008152; metabolic process GO:0070988; demethylation 2.561E-05 3.621E-03 APEX1, CYP1A1, CYP1A2, KDM4E
MF GO:0060089; molecular transducer activity GO:0038023; signaling receptor activity 2.778E-05 3.877E-03 AHR, AXL, DRD2, FFAR1, FFAR4, FLT3, HTR1A, IGF1R, KDR, MET, NPSR1, NR1H4, PPARA, TSHR
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 2.924E-05 4.055E-03 APEX1, AXL, CDK1, CYP1B1
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 2.958E-05 4.077E-03 CYP1A1, CYP1A2, CYP1B1
BP Unclassified; GO:2000021; regulation of ion homeostasis 3.008E-05 4.094E-03 BCL2, CA2, CA7, DRD2, KDR, NPSR1
BP GO:0008152; metabolic process GO:0030574; collagen catabolic process 3.761E-05 4.874E-03 MMP1, MMP12, MMP2, MMP9
BP GO:0008152; metabolic process GO:0009404; toxin metabolic process 3.923E-05 4.995E-03 CYP1A1, CYP1A2, CYP1B1
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 3.923E-05 4.995E-03 CYP1A1, CYP1A2, CYP1B1
MF GO:0005488; binding GO:0042802; identical protein binding 4.312E-05 5.459E-03 ACHE, BCL2, DRD2, FLT3, IGF1R, KDR, L3MBTL1, MAPK1, MET, MMP9, NFKB1, SMN1, SMN2, TOP2A, TYR
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 4.935E-05 6.140E-03 CYP1A1, CYP1A2
BP GO:0008152; metabolic process GO:0019433; triglyceride catabolic process 5.074E-05 6.242E-03 FABP3, FABP4, FABP5
BP GO:0008152; metabolic process GO:0010557; positive regulation of macromolecule biosynthetic process 5.512E-05 6.699E-03 AHR, AURKB, CDK1, DRD2, HIF1A, IGF1R, KDR, MAPK1, MET, MMP12, NFKB1, NOX4, NR1H4, PPARA, TOP2A
BP GO:0009987; cellular process GO:0050714; positive regulation of protein secretion 5.941E-05 7.071E-03 ACHE, DRD2, FFAR1, HIF1A, MMP12, NR1H4
BP GO:0009987; cellular process GO:0010638; positive regulation of organelle organization 6.390E-05 7.551E-03 ALOX15, AURKB, BCL2, HIF1A, KDR, MAPK1, MET, MMP9, NOX4
BP GO:0050896; response to stimulus GO:1901652; response to peptide 6.415E-05 7.551E-03 APEX1, FABP3, FFAR4, IGF1R, NFKB1, PPARA, TSHR
BP GO:0009987; cellular process GO:0071407; cellular response to organic cyclic compound 6.650E-05 7.702E-03 APEX1, CYP1A1, CYP1B1, FLT3, MAPK1, NFKB1, NOX4
BP GO:0009987; cellular process GO:0071345; cellular response to cytokine stimulus 7.140E-05 8.097E-03 ALOX15, AXL, FABP4, FLT3, HIF1A, MAPK1, NFKB1
BP GO:0009987; cellular process GO:0022617; extracellular matrix disassembly 8.098E-05 8.849E-03 MMP1, MMP12, MMP2, MMP9
BP GO:0008152; metabolic process GO:0051122; hepoxilin biosynthetic process 8.209E-05 8.849E-03 ALOX12, ALOX15
MF GO:0005488; binding GO:0046982; protein heterodimerization activity 8.715E-05 9.257E-03 AHR, AXL, BCL2, DRD2, HIF1A, NFKB1, TOP2A, TYR
BP GO:0009987; cellular process GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway 8.961E-05 9.465E-03 AXL, FLT3, IGF1R, KDR, MAPK1, MET, MMP2, MMP9
CC GO:0016020; membrane GO:0005886; plasma membrane 8.998E-05 9.465E-03 ACHE, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, DRD2, FABP5, FFAR1, FFAR4, FLT3, GLO1, HSD17B10, HTR1A, IGF1R, KDR, L3MBTL1, MAPK1, MET, MMP2, NPSR1, PIM1, TDP1, TSHR
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)


Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways
Pathway Category Top Level Pathway Category Second Level Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
09160 Human Diseases 09161 Cancers hsa05200 Pathways in cancer 1.339E-07 1.071E-05 FLT3, MMP1, MMP2, BCL2, MAPK1, HIF1A, MET, MMP9, NFKB1, IGF1R
09100 Metabolism 09102 Energy metabolism hsa00910 Nitrogen metabolism 8.645E-10 1.383E-07 CA12, CA2, CA4, CA7, CA14
09160 Human Diseases 09161 Cancers hsa05205 Proteoglycans in cancer 1.523E-06 6.092E-05 MMP2, KDR, MAPK1, HIF1A, MMP9, MET, IGF1R
09150 Organismal Systems 09152 Endocrine system hsa03320 PPAR signaling pathway 1.406E-06 6.092E-05 FABP3, FABP4, FABP5, MMP1, PPARA
09160 Human Diseases 09166 Endocrine and metabolic diseases hsa04933 AGE-RAGE signaling pathway in diabetic complications 9.256E-06 2.307E-04 MMP2, PIM1, BCL2, MAPK1, NFKB1
09160 Human Diseases 09161 Cancers hsa05219 Bladder cancer 5.167E-06 1.654E-04 MMP1, MMP2, MAPK1, MMP9
09150 Organismal Systems 09152 Endocrine system hsa04913 Ovarian steroidogenesis 1.153E-05 2.307E-04 HSD17B2, CYP1A1, CYP1B1, IGF1R
09130 Environmental Information Processing 09132 Signal transduction hsa04066 HIF-1 signaling pathway 1.019E-05 2.307E-04 BCL2, MAPK1, HIF1A, NFKB1, IGF1R
09160 Human Diseases 09161 Cancers hsa05206 MicroRNAs in cancer 1.846E-05 2.786E-04 PIM1, BCL2, CYP1B1, MAPK1, MMP9, MET, NFKB1
09130 Environmental Information Processing 09132 Signal transduction hsa04024 cAMP signaling pathway 1.931E-05 2.786E-04 HTR1A, MAPK1, PPARA, DRD2, NFKB1, TSHR
09160 Human Diseases 09161 Cancers hsa05221 Acute myeloid leukemia 1.950E-05 2.786E-04 FLT3, PIM1, MAPK1, NFKB1
09160 Human Diseases 09161 Cancers hsa05230 Central carbon metabolism in cancer 3.705E-05 4.560E-04 FLT3, MAPK1, MET, HIF1A
09160 Human Diseases 09161 Cancers hsa05215 Prostate cancer 1.128E-04 1.289E-03 BCL2, MAPK1, NFKB1, IGF1R
09100 Metabolism 09103 Lipid metabolism hsa00140 Steroid hormone biosynthesis 2.090E-05 2.786E-04 CYP1A2, HSD17B2, CYP1A1, CYP1B1
09140 Cellular Processes 09144 Cellular community - eukaryotes hsa04510 Focal adhesion 2.515E-04 2.367E-03 KDR, BCL2, MAPK1, MET, IGF1R
09160 Human Diseases 09161 Cancers hsa05202 Transcriptional misregulation in cancer 1.471E-04 1.569E-03 FLT3, MMP9, MET, NFKB1, IGF1R
09130 Environmental Information Processing 09132 Signal transduction hsa04151 PI3K-Akt signaling pathway 3.723E-04 2.979E-03 KDR, BCL2, MAPK1, MET, NFKB1, IGF1R
09130 Environmental Information Processing 09132 Signal transduction hsa04015 Rap1 signaling pathway 3.075E-04 2.589E-03 KDR, MAPK1, DRD2, MET, IGF1R
09150 Organismal Systems 09156 Nervous system hsa04726 Serotonergic synapse 2.735E-04 2.431E-03 ALOX15, HTR1A, MAPK1, ALOX12
09130 Environmental Information Processing 09132 Signal transduction hsa04014 Ras signaling pathway 4.298E-04 3.275E-03 KDR, MAPK1, MET, NFKB1, IGF1R
09140 Cellular Processes 09143 Cell growth and death hsa04210 Apoptosis 6.370E-04 4.633E-03 LMNA, BCL2, MAPK1, NFKB1
09160 Human Diseases 09167 Infectious diseases hsa05161 Hepatitis B 7.455E-04 5.186E-03 BCL2, MAPK1, MMP9, NFKB1
09100 Metabolism 09105 Amino acid metabolism hsa00380 Tryptophan metabolism 1.909E-04 1.909E-03 CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases 09161 Cancers hsa05218 Melanoma 1.038E-03 6.646E-03 MAPK1, MET, IGF1R
09160 Human Diseases 09161 Cancers hsa05211 Renal cell carcinoma 8.397E-04 5.598E-03 MAPK1, MET, HIF1A
09140 Cellular Processes 09144 Cellular community - eukaryotes hsa04520 Adherens junction 1.171E-03 6.938E-03 MAPK1, MET, IGF1R
09100 Metabolism 09111 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1.126E-03 6.927E-03 CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases 09161 Cancers hsa05204 Chemical carcinogenesis 1.574E-03 8.997E-03 CYP1A2, CYP1A1, CYP1B1
Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Associated Disease Targets
(Association Ref: TTD database)
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R;
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Spasm R25.2 HTR1A;
K00-K95: Diseases of the digestive system Dermal necrosis K05 DRD2;
O00-O9A: Pregnancy, childbirth and the puerperium Postpartum haemorrhage O72 DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Hypoactive sexual desire disorder F52.0 HTR1A;
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET;
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 KDR;
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR;
NA: NA Early satiation associated with functional dyspepsia NA ACHE;
C00-D49: Neoplasms Thyroid cancer C73 KDR; TSHR;
C00-D49: Neoplasms Colon cancer C50 FLT3;
NA: NA Edema NA CA2;
C00-D49: Neoplasms Prostate cancer C61 FLT3; BCL2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Substance dependence F10-F19 DRD2;
I00-I99: Diseases of the circulatory system Aortic aneurysm I71 MMP12;
C00-D49: Neoplasms Breast cancer C50 CDK1; IGF1R; KDR; FLT3; DRD2; BCL2;
K00-K95: Diseases of the digestive system Gastrointestinal problems K30-K31, Q40-Q41 DRD2;
C00-D49: Neoplasms CLL NA FLT3;
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MMP12; DRD2;
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET; DRD2;
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 DRD2;
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases Acromegaly E22.0 DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 MMP1; TYR;
NA: NA Schizoaffective disorders NA DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 ACHE; HTR1A;
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR;
NA: NA False perceptions NA DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Female sexual dysfunction F52 HTR1A;
C00-D49: Neoplasms Gastric cancer C16 KDR;
J00-J99: Diseases of the respiratory system Asthma J45 MMP12; DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 MMP1;
I00-I99: Diseases of the circulatory system Atherosclerosis I70 MMP12;
E00-E89: Endocrine, nutritional and metabolic diseases Hyperprolactinemia E22.1 DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE;
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3;
I00-I99: Diseases of the circulatory system Hypotension I95 DRD2;
C00-D49: Neoplasms Renal cell carcinoma NA KDR; MMP2;
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1;
NA: NA Cervical dystonia NA HTR1A;
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 DRD2;
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Idiopathic thrombocytopenic purpura D69.3 DRD2;
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 ACHE;
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET;
L00-L99: Diseases of the skin and subcutaneous tissue Melasma L81.1 TYR;
C00-D49: Neoplasms Melanoma C43 KDR; TYR;
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR;
NA: NA Malignant phaeochromocytoma NA DRD2;
NA: NA Malignant essential hypertension NA DRD2;
C00-D49: Neoplasms Renal cancer C64 KDR;
E00-E89: Endocrine, nutritional and metabolic diseases Carcinoid syndrome E34.0 DRD2;
NA: NA Bulimia nervosa NA HTR1A;
C00-D49: Neoplasms Cancer C00-C96 PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; HIF1A; MMP9; MAPK1; MMP2; BCL2;
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR;
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R;
I00-I99: Diseases of the circulatory system Maintain blood pressure in hypotensive states I10 DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 DRD2; HTR1A;
I00-I99: Diseases of the circulatory system Pulmonary hypertension I27.0, I27.2 DRD2;
C00-D49: Neoplasms Hematological malignancies C81-C86 AURKB;
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE;
I00-I99: Diseases of the circulatory system Cardiotonic I50 DRD2;
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Huntington's disease F02.2, G10 DRD2;
G00-G99: Diseases of the nervous system G00-G99 Migraine G43 HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Migraine headaches G43 DRD2;
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychiatric disorder F01-F99 HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychosis F20-F29 DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Bipolar disorder F31, F40-F42 DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 ACHE; DRD2; HTR1A;
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR;
C00-D49: Neoplasms Ovarian cancer C56 KDR; MMP2;
NA: NA Peripheral vasoconstriction NA DRD2;
NA: NA Peripheral sensory neuropathies NA HTR1A;
C00-D49: Neoplasms Metastasis C00-C97 AXL;
C00-D49: Neoplasms Metastatic breast cancer C50 KDR;
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 FLT3; BCL2;
C00-D49: Neoplasms Multiple myeloma C90 IGF1R; AHR; BCL2;
C00-D49: Neoplasms Gliosarcoma NA FLT3;
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 ACHE;
NA: NA Itching NA DRD2;
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR;
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2;
NA: NA Social phobia NA HTR1A;
C00-D49: Neoplasms Solid tumours C00-D48 TOP2A; MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; MAPK1; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 FFAR1;
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; IGF1R; KDR; AXL; DRD2;
C00-D49: Neoplasms Non-small-cell lung cancer NA KDR; MMP2;
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MMP12; DRD2;
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 DRD2;
K00-K95: Diseases of the digestive system Ulcerative colitis K51 MMP9;
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE;
N00-N99: Diseases of the genitourinary system Urinary incontinence N39.3, N39.4, R32 HTR1A;
NA: NA Episode NA HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Sexual dysfunction F52 DRD2;
I00-I99: Diseases of the circulatory system Angina pectoris I20 DRD2;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE;
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3;
C00-D49: Neoplasms Myelodysplastic syndrome D46 KDR;
C00-D49: Neoplasms Myeloid leukemia C92 FLT3;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE;
NA: NA Upper abdominal bloating NA ACHE;
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE;
I00-I99: Diseases of the circulatory system Cardiac failure I50 DRD2;
C00-D49: Neoplasms Lymphoma C81-C86 HIF1A; BCL2;
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET;
C00-D49: Neoplasms Lung cancer C33-C34 MMP2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Emesis R11 DRD2;
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2;
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 CDK1; IGF1R; ACHE; DRD2; HTR1A;
C00-D49: Neoplasms Pancreatic cancer C25 KDR; FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 ACHE; DRD2; HTR1A;
C00-D49: Neoplasms AML NA KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 ACHE; DRD2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 DRD2; HTR1A;
C00-D49: Neoplasms Colorectal cancer C18-C21 IGF1R; KDR; FLT3; MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 NFKB1; FFAR1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Nausea R11 DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Severe mood disorders F30-F39 HTR1A;
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR;
G00-G99: Diseases of the nervous system G00-G99 Lateral sclerosis G12.2 HTR1A;
C00-D49: Neoplasms Leukemia C90-C95 FLT3; BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 TYR;
NA: NA Vomiting NA DRD2;
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA2;
E00-E89: Endocrine, nutritional and metabolic diseases Eating disorder E66, F50, I10-I16, I50 HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Advanced stage Parkinson's disease F02.3, G20 DRD2;
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET;
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE;
NA: NA Schizoaffective disorder NA HTR1A;
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; KDR;
NA: NA Hematopoietic stem cell transplantation NA FLT3;
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR;
NA: NA Anxiety disorders NA HTR1A;
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R;
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2;
NA: NA HIV infections NA AHR;
G00-G99: Diseases of the nervous system G00-G99 Amyotrophic lateral sclerosis G12.2 BCL2;
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 MMP1;
H00-H59: Diseases of the eye and adnexa Ophthalmic disease H00-H59 DRD2;
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 CA4;
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 CA4; ACHE; CA2;
NA: NA Hyperaemia NA DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 FFAR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Depressive fatigue R53.82 DRD2;
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3;
C00-D49: Neoplasms Acute myeloid leukemia C92.0 AURKB; FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 DRD2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Premature ejaculation F52.4 HTR1A;
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 MMP2;
J00-J99: Diseases of the respiratory system Bronchitis J20-J21, J42 DRD2;
I00-I99: Diseases of the circulatory system Hypertension I10-I16 DRD2; HTR1A;
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR;
NA: NA Benign prostatic hypertrophy NA DRD2;
C00-D49: Neoplasms Biliary cancer C22, C24 KDR;
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR;
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1;
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 DRD2;
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R;
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Generalized anxiety disorder F32, F40-F42, F41.1 HTR1A;
C00-D49: Neoplasms Ocular cancer C69 APEX1;
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR;
C00-D49: Neoplasms Advanced melanoma C43 BCL2;
NA: NA Corneal vascularity NA DRD2;
I00-I99: Diseases of the circulatory system Coronary artery disease I20-I25 HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 HTR1A;
C00-D49: Neoplasms Glioblastoma NA FLT3;
C00-D49: Neoplasms Glioma C71 KDR;
NA: NA GIST NA FLT3;
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 ACHE; DRD2;
J00-J99: Diseases of the respiratory system Nasal congestion J34.89 DRD2;
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3;
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3;
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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