Japan; China; South Africa
Ingredient ID: NPC94666
Ingredient ID: NPC92898
Ingredient ID: NPC90004
Ingredient ID: NPC85346
Ingredient ID: NPC83351
Ingredient ID: NPC83157
Ingredient ID: NPC81871
Ingredient ID: NPC81630
Ingredient ID: NPC80237
Ingredient ID: NPC80064
Ingredient ID: NPC78542
Ingredient ID: NPC7813
Ingredient ID: NPC76468
Ingredient ID: NPC75898
Ingredient ID: NPC73738
Ingredient ID: NPC73629
Ingredient ID: NPC67290
Ingredient ID: NPC65897
Ingredient ID: NPC63959
Ingredient ID: NPC61168
Ingredient ID: NPC58621
Ingredient ID: NPC54733
Ingredient ID: NPC482243
Ingredient ID: NPC482242
Ingredient ID: NPC482241
Ingredient ID: NPC482240
Ingredient ID: NPC482239
Ingredient ID: NPC478793
Ingredient ID: NPC478672
Ingredient ID: NPC471799
Ingredient ID: NPC471798
Ingredient ID: NPC471797
Ingredient ID: NPC471796
Ingredient ID: NPC471795
Ingredient ID: NPC471794
Ingredient ID: NPC471793
Ingredient ID: NPC471792
Ingredient ID: NPC471791
Ingredient ID: NPC46160
Ingredient ID: NPC45594
Ingredient ID: NPC43044
Ingredient ID: NPC42372
Ingredient ID: NPC38423
Ingredient ID: NPC320444
Ingredient ID: NPC319839
Ingredient ID: NPC31883
Ingredient ID: NPC314350
Ingredient ID: NPC308191
Ingredient ID: NPC282876
Ingredient ID: NPC267734
Ingredient ID: NPC264145
Ingredient ID: NPC263622
Ingredient ID: NPC261341
Ingredient ID: NPC260796
Ingredient ID: NPC258474
Ingredient ID: NPC255960
Ingredient ID: NPC254509
Ingredient ID: NPC254369
Ingredient ID: NPC247553
Ingredient ID: NPC239905
Ingredient ID: NPC236717
Ingredient ID: NPC231149
Ingredient ID: NPC230607
Ingredient ID: NPC221349
Ingredient ID: NPC221268
Ingredient ID: NPC221111
Ingredient ID: NPC219699
Ingredient ID: NPC205673
Ingredient ID: NPC193034
Ingredient ID: NPC192220
Ingredient ID: NPC181951
Ingredient ID: NPC179891
Ingredient ID: NPC173936
Ingredient ID: NPC167891
Ingredient ID: NPC166723
Ingredient ID: NPC165608
Ingredient ID: NPC163115
Ingredient ID: NPC16030
Ingredient ID: NPC159737
Ingredient ID: NPC159670
Ingredient ID: NPC153036
Ingredient ID: NPC146310
Ingredient ID: NPC137949
Ingredient ID: NPC136303
Ingredient ID: NPC133677
Ingredient ID: NPC1321
Ingredient ID: NPC131131
Ingredient ID: NPC130554
Ingredient ID: NPC127302
Ingredient ID: NPC117774
Ingredient ID: NPC117080
Ingredient ID: NPC115957
Ingredient ID: NPC113733
Ingredient ID: NPC112358
Ingredient ID: NPC110158
Ingredient ID: NPC109825
Ingredient ID: NPC108619
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Protein Kinase | PRKCD | Protein kinase C delta | Q05655 | CHEMBL2996 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 1 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01387711 | PEP005 Gel - Biological Effects in Actinic Keratosis Assessed by Histology | actinic keratosis | Ingenol (NPC261341) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA12,PRKCQ,CA9,PRKCD
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA12,CA9,CA12,CA9
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA12,PRKCQ,CYP3A4,CA9
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CYP3A4,CA9,CA12
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CA12,PRKCQ,CA9
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4,CA12,PRKCD
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,CA9
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
PRKCQ,CA9
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CA9,PRKCD
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA12,PRKCQ
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CA12,CA9
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CA9,CA9
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA12,CA9
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA9,PRKCD
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12,CA9
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4,CA9
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CA9
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP3A4,CA9
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA12,CA9
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA12,CA9
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
PRKCD
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
PRKCQ
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT01387711
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
PRKCQ
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CA9
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
PRKCQ
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CA9
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
PRKCQ
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
PRKCQ
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CA9
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CA9
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CA12
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
PRKCQ
|