China; Russia; South Africa
Ingredient ID: NPC8597
Ingredient ID: NPC84938
Ingredient ID: NPC84807
Ingredient ID: NPC84398
Ingredient ID: NPC78096
Ingredient ID: NPC76145
Ingredient ID: NPC72699
Ingredient ID: NPC71506
Ingredient ID: NPC70622
Ingredient ID: NPC67920
Ingredient ID: NPC66577
Ingredient ID: NPC64176
Ingredient ID: NPC62014
Ingredient ID: NPC61828
Ingredient ID: NPC56913
Ingredient ID: NPC56432
Ingredient ID: NPC51758
Ingredient ID: NPC49151
Ingredient ID: NPC42471
Ingredient ID: NPC327710
Ingredient ID: NPC323787
Ingredient ID: NPC31194
Ingredient ID: NPC304885
Ingredient ID: NPC30430
Ingredient ID: NPC30025
Ingredient ID: NPC28913
Ingredient ID: NPC288932
Ingredient ID: NPC288089
Ingredient ID: NPC277736
Ingredient ID: NPC272076
Ingredient ID: NPC268862
Ingredient ID: NPC261228
Ingredient ID: NPC256848
Ingredient ID: NPC254848
Ingredient ID: NPC253963
Ingredient ID: NPC246544
Ingredient ID: NPC243349
Ingredient ID: NPC241721
Ingredient ID: NPC233376
Ingredient ID: NPC231738
Ingredient ID: NPC23145
Ingredient ID: NPC230221
Ingredient ID: NPC229698
Ingredient ID: NPC224215
Ingredient ID: NPC220089
Ingredient ID: NPC214608
Ingredient ID: NPC213749
Ingredient ID: NPC210831
Ingredient ID: NPC208936
Ingredient ID: NPC202691
Ingredient ID: NPC198658
Ingredient ID: NPC19834
Ingredient ID: NPC19807
Ingredient ID: NPC193258
Ingredient ID: NPC188732
Ingredient ID: NPC182339
Ingredient ID: NPC182158
Ingredient ID: NPC179024
Ingredient ID: NPC171499
Ingredient ID: NPC153046
Ingredient ID: NPC146543
Ingredient ID: NPC143639
Ingredient ID: NPC142753
Ingredient ID: NPC141777
Ingredient ID: NPC139557
Ingredient ID: NPC139131
Ingredient ID: NPC138113
Ingredient ID: NPC135836
Ingredient ID: NPC13217
Ingredient ID: NPC132131
Ingredient ID: NPC116361
Ingredient ID: NPC111897
Ingredient ID: NPC102091
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 3 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
XerostomiaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.1 |
NCT04392622
|
Other specified non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.Y |
NCT04853082
|
Cannabis use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C41 |
NCT05432284
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TDP1
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TDP1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TDP1
|