Brazil; Afghanistan; Bangladesh; Nepal; Costa Rica; Cambodia; Bahamas; Rwanda; Peru; Laos; Nigeria; Bolivia; Vanuatu; Thailand; Ecuador; Australia; Cuba; Papua New Guinea; Suriname; Guatemala; China; Jordan; Dominican Republic; Belize; United States; Tanzania; Netherlands; Pakistan; Philippines; Indonesia; New Caledonia; Mauritius; Trinidad and Tobago; Vietnam; French Guiana; Guyana; Haiti; Jamaica; Honduras; Myanmar; Nicaragua; India; Malaysia; Colombia; Sri Lanka; Kenya; Taiwan; Fiji
Ingredient ID: NPC98742
Ingredient ID: NPC98125
Ingredient ID: NPC8747
Ingredient ID: NPC86727
Ingredient ID: NPC85346
Ingredient ID: NPC836
Ingredient ID: NPC82346
Ingredient ID: NPC8202
Ingredient ID: NPC76950
Ingredient ID: NPC76446
Ingredient ID: NPC76074
Ingredient ID: NPC7149
Ingredient ID: NPC67144
Ingredient ID: NPC58053
Ingredient ID: NPC54733
Ingredient ID: NPC5380
Ingredient ID: NPC49776
Ingredient ID: NPC49103
Ingredient ID: NPC42060
Ingredient ID: NPC39535
Ingredient ID: NPC37819
Ingredient ID: NPC3601
Ingredient ID: NPC35573
Ingredient ID: NPC33434
Ingredient ID: NPC328788
Ingredient ID: NPC327978
Ingredient ID: NPC322074
Ingredient ID: NPC316926
Ingredient ID: NPC316806
Ingredient ID: NPC3165
Ingredient ID: NPC316468
Ingredient ID: NPC31603
Ingredient ID: NPC315669
Ingredient ID: NPC312479
Ingredient ID: NPC308597
Ingredient ID: NPC308276
Ingredient ID: NPC30416
Ingredient ID: NPC300943
Ingredient ID: NPC300417
Ingredient ID: NPC295714
Ingredient ID: NPC294902
Ingredient ID: NPC291472
Ingredient ID: NPC290598
Ingredient ID: NPC285507
Ingredient ID: NPC284159
Ingredient ID: NPC281580
Ingredient ID: NPC280717
Ingredient ID: NPC27430
Ingredient ID: NPC270088
Ingredient ID: NPC268537
Ingredient ID: NPC265047
Ingredient ID: NPC262473
Ingredient ID: NPC261893
Ingredient ID: NPC259910
Ingredient ID: NPC253208
Ingredient ID: NPC250238
Ingredient ID: NPC249196
Ingredient ID: NPC248041
Ingredient ID: NPC24327
Ingredient ID: NPC24288
Ingredient ID: NPC241498
Ingredient ID: NPC236404
Ingredient ID: NPC234520
Ingredient ID: NPC234106
Ingredient ID: NPC232883
Ingredient ID: NPC23168
Ingredient ID: NPC230085
Ingredient ID: NPC229747
Ingredient ID: NPC228705
Ingredient ID: NPC225710
Ingredient ID: NPC22307
Ingredient ID: NPC222821
Ingredient ID: NPC21806
Ingredient ID: NPC217532
Ingredient ID: NPC214770
Ingredient ID: NPC210401
Ingredient ID: NPC201310
Ingredient ID: NPC200984
Ingredient ID: NPC197575
Ingredient ID: NPC196776
Ingredient ID: NPC192877
Ingredient ID: NPC176017
Ingredient ID: NPC174730
Ingredient ID: NPC173467
Ingredient ID: NPC168062
Ingredient ID: NPC167821
Ingredient ID: NPC167072
Ingredient ID: NPC160951
Ingredient ID: NPC159669
Ingredient ID: NPC159630
Ingredient ID: NPC154672
Ingredient ID: NPC148790
Ingredient ID: NPC146493
Ingredient ID: NPC146413
Ingredient ID: NPC145885
Ingredient ID: NPC143329
Ingredient ID: NPC140506
Ingredient ID: NPC137167
Ingredient ID: NPC137050
Ingredient ID: NPC133856
Ingredient ID: NPC131877
Ingredient ID: NPC126709
Ingredient ID: NPC123965
Ingredient ID: NPC123223
Ingredient ID: NPC120163
Ingredient ID: NPC111119
Ingredient ID: NPC109851
Ingredient ID: NPC109131
Ingredient ID: NPC107261
Ingredient ID: NPC106141
Ingredient ID: NPC10077
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Therapeutic Target | Oxidoreductase | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Therapeutic Target | Protein Kinase | MKNK2 | MAP kinase signal-integrating kinase 2 | Q9HBH9 | CHEMBL4204 |
Therapeutic Target | Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
Therapeutic Target | Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Therapeutic Target | Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 2 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
NCT04648917 | GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC) | esophageal cancer | Caffeic Acid (NPC294902) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
KDR,LMNA,MMP9,AURKA,FUT7,MMP1,TDP1,AURKB
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
AURKA,AURKB,MMP1,MMP9,AURKA,AURKB,MMP1,MMP9
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,MMP2,CYP1B1,AURKA,FUT7,MMP1,AURKB
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
NFKB1,MMP9,AURKB,KDR,MKNK2,AURKA
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HSD17B10,MMP9,FUT7,MMP1,TDP1,AURKB
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,MMP2,MMP9,AURKA,MMP1,AURKB
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
AURKB,MMP9,MMP9,FUT7,MMP1,AURKB
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KDR,MMP2,MMP1,AURKA,MMP9
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
MMP9,AURKA,FUT7,MMP1,TDP1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
MMP2,MMP9,AURKA,MMP1,AURKB
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP1A1,MMP9,AURKA,MMP1,AURKB
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
NFKB1,HSD17B10,CYP1B1,MMP9,FUT7
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
MMP9,AURKA,FUT7,MMP1,AURKB
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
MMP9,AURKA,FUT7,MMP1,AURKB
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
KDR,MMP2,MMP9,MMP1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
MMP2,MMP9,FUT7,MMP1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP9,AURKA,MMP1,AURKB
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
MMP9,AURKA,MMP1,AURKB
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
MMP9,AURKA,MMP1,AURKB
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
MMP9,AURKA,MMP1,AURKB
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
AURKA,AURKB,MMP1,MMP9
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
AURKA,AURKB,MMP1,MMP9
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
MMP9,AURKA,MMP1,AURKB
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
KDR,MMP2,FUT7,MMP1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
MKNK2,KDR,AURKA
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
MMP2,KDR,MMP9
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKA,AURKB,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKA,NFKB1,AURKB
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
MMP9,MMP1,NFKB1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MKNK2,KDR,AURKA
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
MMP9
MMP1,MMP9 |
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
FUT7,MMP1,MMP9
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
KDM4E,CYP1A1,MMP9
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1,MMP1,MMP9
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
GABRA6,MMP1,CYP1B1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
KDR,LMNA,CYP1B1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
AURKA,CYP1A1,AURKB
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1,FUT7,MMP2
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
MKNK2,KDR
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MMP2,MMP1
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
AURKA,AURKB
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
AURKB,AURKA
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
KDR,MMP9
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
MMP1,MMP9
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
MMP9,MMP2
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP1A1,MMP1
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
FUT7,ALDH1A1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1,MMP9
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA,MMP2
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
KDR,LMNA,MMP2,HSD17B10,AURKA,MMP1,TDP1,GFER,AURKB,ALDH1A1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NFKB1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
KDR
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
MMP9
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
KDR
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
KDR
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
KDR
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KDR
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
KDR
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
KDR
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
MKNK2
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
KDR
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
KDR
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
KDR
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ALDH1A1
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
KDR
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
MMP9
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
KDR
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NFKB1
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
MMP2
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Digestive organ benign neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E92 |
KDR
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KDR
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KDR
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
KDR
|
Malignant digestive organ neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C11 |
KDR
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NCT04648917
|
Immune thrombocytopenic purpuraDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64.10 |
NCT02351622
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
AURKB
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
MMP9
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
MMP9
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
MMP1
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FUT7
|
Parkinson diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00.0 |
ALDH1A1
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
MMP9
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MMP9
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
MMP9
|