CMAUP Plant Collective Molecular Activities

Plant Name: Swertia japonica

Taxonomic Information:

Plant ID: NPO28011
Plant Latin Name: Swertia japonica
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae

Plant External Links:

NCBI TaxonomyDB: 137129
Plant-of-the-World-Online: 370941-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Appetizer; Bitter; Stomachic

Geographical Distribution:

Japan; China; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	TDP1; RECQL; HPGD; HSD11B1; AKR1B10; ALOX12; AKR1B1; HSD17B2; HSD17B10; NOX4; APEX1; POLB;
Protein Kinase	TEK; MET; INSR; AXL; FLT3; CDK1; EGFR; PIM1; KDR; SRC; IGF1R; AURKB; CSNK2A1; NUAK1;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
Oxidoreductase	TYR; MAOA;
Transcription Factor	AHR;
Transferase	FUT7;
SLC superfamily of solute carriers	SLC22A6;
Unclassified	SMAD3; LMNA; APP; HSPA1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	TEK	Tyrosine-protein kinase TIE-2	Q02763	CHEMBL4128
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	INSR	Insulin receptor	P06213	CHEMBL1981
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Kinase	NUAK1	NUAK family SNF1-like kinase 1	O60285	CHEMBL5784
SLC superfamily of solute carriers	SLC22A6	Solute carrier family 22 member 6	Q4U2R8	CHEMBL1641347
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	SMAD3	Mothers against decapentaplegic homolog 3	P84022	CHEMBL1293258
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487
Unclassified	HSPA1A	Heat shock 70 kDa protein 1	P0DMV8	CHEMBL5460

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	8.104E-11	1.038E-07	AKR1B1, ALOX12, AURKB, AXL, CDK1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, LMNA, NR1H4, PIM1, SMAD3, SRC, TEK
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.697E-09	1.087E-06	AKR1B1, AKR1B10, ALOX12, APEX1, CYP1A1, CYP1A2, CYP1B1, HPGD, HSD11B1, HSD17B10, HSD17B2, KDM4E, MAOA, NOX4, TYR
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	7.052E-09	2.953E-06	AKR1B1, AKR1B10, APP, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B2, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.117E-08	1.263E-05	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	7.858E-08	2.312E-05	AXL, EGFR, INSR, MET, NOX4, SRC, TEK
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	9.735E-08	2.827E-05	EGFR, IGF1R, INSR, KDR, SRC
MF	GO:0005488; binding	GO:0005524; ATP binding	1.942E-07	4.918E-05	AURKB, AXL, CDK1, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, RECQL, SRC, TEK
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	3.681E-07	8.437E-05	AKR1B1, APEX1, AXL, CDK1, CYP1B1
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	3.872E-07	8.783E-05	AKR1B1, APEX1, CA2, CSNK2A1, CYP1A2, EGFR, FLT3, HPGD, INSR, SRC, TEK
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	1.112E-06	2.100E-04	AXL, CDK1, CSNK2A1, EGFR, FLT3
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	1.123E-06	2.100E-04	EGFR, INSR, KDR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.601E-06	2.882E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.711E-06	3.055E-04	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0071363; cellular response to growth factor stimulus	1.979E-06	3.475E-04	APP, EGFR, INSR, KDR, NOX4, SMAD3, SRC
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.888E-06	6.005E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.260E-06	6.487E-04	CYP1A1, CYP1A2, CYP1B1, NOX4
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	5.688E-06	8.203E-04	CA2, CA4, EGFR, HPGD, SLC22A6, TEK
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	5.795E-06	8.302E-04	APEX1, POLB
CC	GO:0016020; membrane	GO:0045121; membrane raft	6.434E-06	9.039E-04	APP, EGFR, INSR, KDR, SLC22A6, SRC, TEK
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	7.906E-06	1.076E-03	APP, EGFR, KDR, NOX4, SRC, TEK
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	9.580E-06	1.257E-03	CDK1, EGFR, IGF1R, INSR
BP	GO:0050896; response to stimulus	GO:1901653; cellular response to peptide	1.078E-05	1.389E-03	AKR1B1, APEX1, APP, IGF1R, INSR, SRC
MF	Unclassified;	GO:0004872; receptor activity	1.225E-05	1.542E-03	AHR, AXL, EGFR, FLT3, GPR35, HPGD, IGF1R, INSR, KDR, MET, NPSR1, NR1H4, RORC, TEK
BP	GO:0008152; metabolic process	GO:0070988; demethylation	1.269E-05	1.588E-03	APEX1, CYP1A1, CYP1A2, KDM4E
MF	GO:0005488; binding	GO:0020037; heme binding	1.450E-05	1.794E-03	CYP1A1, CYP1A2, CYP1B1, NOX4, SRC
MF	GO:0005488; binding	GO:0019838; growth factor binding	1.563E-05	1.850E-03	EGFR, IGF1R, INSR, KDR, TEK
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.736E-05	1.985E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.741E-05	1.985E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032502; developmental process	GO:0007568; aging	1.954E-05	2.193E-03	APEX1, AURKB, CDK1, CYP1A1, NOX4, POLB
CC	GO:0044464; cell part	GO:0048471; perinuclear region of cytoplasm	2.189E-05	2.385E-03	AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, NOX4, SRC, TYR
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.311E-05	2.491E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.311E-05	2.491E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:1901992; positive regulation of mitotic cell cycle phase transition	2.508E-05	2.677E-03	APEX1, APP, CDK1, CYP1A1
BP	GO:0040007; growth	GO:0045927; positive regulation of growth	3.405E-05	3.377E-03	ALOX12, CDK1, CSNK2A1, EGFR, INSR, PIM1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.466E-05	3.377E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0051425; PTB domain binding	3.466E-05	3.377E-03	APP, INSR
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	3.635E-05	3.512E-03	AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAOA
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	3.715E-05	3.563E-03	CYP1A1, LMNA, NOX4, SMAD3, SRC, TEK
BP	GO:0065007; biological regulation	GO:0043406; positive regulation of MAP kinase activity	4.133E-05	3.896E-03	CDK1, EGFR, FLT3, INSR, NOX4, SRC
MF	GO:0005488; binding	GO:0043548; phosphatidylinositol 3-kinase binding	4.719E-05	4.354E-03	AXL, IGF1R, INSR
BP	GO:0008152; metabolic process	GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity	5.235E-05	4.652E-03	FLT3, SRC, TEK
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	5.400E-05	4.722E-03	AXL, CYP1A1, CYP1A2, HPGD, NR1H4, SRC
BP	GO:0009987; cellular process	GO:1902905; positive regulation of supramolecular fiber organization	6.153E-05	5.275E-03	APP, HSPA1A, MET, NOX4, SMAD3
BP	GO:0048511; rhythmic process	GO:0048511; rhythmic process	6.201E-05	5.295E-03	AHR, AXL, CSNK2A1, EGFR, RORC, SRC
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	6.373E-05	5.421E-03	AHR, CSNK2A1, KDR
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	6.498E-05	5.506E-03	AHR, NR1H4, PIM1, RORC, SRC
BP	Unclassified;	GO:1990535; neuron projection maintenance	8.638E-05	6.916E-03	APP, INSR
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	8.638E-05	6.916E-03	ALOX12, HPGD
BP	GO:0008152; metabolic process	GO:0016101; diterpenoid metabolic process	9.032E-05	7.100E-03	AKR1B10, CYP1A1, CYP1B1, EGFR
BP	GO:0051179; localization	GO:0042307; positive regulation of protein import into nucleus	9.399E-05	7.310E-03	APP, CDK1, EGFR, SMAD3
BP	GO:0009987; cellular process	GO:0051495; positive regulation of cytoskeleton organization	1.083E-04	8.188E-03	HSPA1A, MET, NOX4, SMAD3, TEK
MF	GO:0005488; binding	GO:0044877; macromolecular complex binding	1.094E-04	8.240E-03	APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SMAD3, SRC
MF	GO:0003824; catalytic activity	GO:0032451; demethylase activity	1.160E-04	8.653E-03	CYP1A1, CYP1A2, KDM4E
BP	GO:0032501; multicellular organismal process	GO:0007435; salivary gland morphogenesis	1.208E-04	8.794E-03	EGFR, POLB
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	1.208E-04	8.794E-03	FLT3, KDR
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	1.237E-04	8.959E-03	AHR, APP, EGFR, IGF1R, INSR, SMAD3
BP	GO:0008152; metabolic process	GO:0045429; positive regulation of nitric oxide biosynthetic process	1.349E-04	9.693E-03	EGFR, INSR, SMAD3

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.967E-10	5.315E-08	SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.127E-07	5.034E-06	INSR, HSD17B2, CYP1A1, CYP1B1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	5.790E-07	1.552E-05	SRC, INSR, KDR, TEK, MET, EGFR, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.403E-07	8.051E-06	HSD11B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	2.277E-06	4.401E-05	SMAD3, SRC, KDR, MET, EGFR, HSPA1A, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.229E-08	4.173E-06	CA12, CA2, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.299E-06	4.401E-05	MAOA, CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.457E-05	2.440E-04	INSR, KDR, TEK, MET, EGFR, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.587E-05	3.852E-04	HSD11B1, CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.086E-04	1.065E-03	HSD11B1, FUT7, AKR1B10, MAOA, HSD17B2, CYP1A2, CYP1A1, AKR1B1, ALOX12, TYR, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.112E-04	1.065E-03	SRC, KDR, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.400E-04	1.251E-03	INSR, KDR, TEK, MET, EGFR, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.087E-04	1.065E-03	SRC, KDR, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	9.981E-05	1.065E-03	INSR, TEK, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.093E-05	5.485E-04	HSD11B1, CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	2.671E-04	2.237E-03	SMAD3, INSR, EGFR, IGF1R
09150 Organismal Systems	09149 Aging	hsa04213	Longevity regulating pathway - multiple species	4.583E-04	3.612E-03	INSR, HSPA1A, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	5.244E-04	3.862E-03	FLT3, MET, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5.476E-04	3.862E-03	SRC, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	6.215E-04	4.164E-03	MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	8.368E-04	5.339E-03	HPGD, FLT3, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.629E-03	9.095E-03	SRC, EGFR, HSPA1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	1.160E-03	7.068E-03	SRC, CDK1, EGFR
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.325E-03	7.720E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR; TEK;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperglycaemia in type 2 diabetes	E11, R73.9	INSR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	APP;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1; INSR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; EGFR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; APP;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1; INSR; AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	INSR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1; INSR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	TEK;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; HSD11B1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR;
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	SRC;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	SRC;
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; INSR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; EGFR;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR; TYR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
K00-K95: Diseases of the digestive system	Crohn's disease	K50	INSR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR; SRC;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; FLT3; TEK; EGFR; SRC; APP;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Lymphoma	C81-C86	INSR; EGFR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; EGFR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR; SRC;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypoglycemia	E16.0-E16.2	INSR;
NA: NA	HIV infections	NA	AHR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; SRC;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	INSR; MAOA; APP;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; INSR; EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1/2 diabetes	E08-E13	INSR;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	TEK; SRC;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1; INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hunter syndrome	E76.1	INSR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	INSR;
C00-D49: Neoplasms	Advanced breast cancer	C50	SRC;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR; AKR1B1;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA; TYR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; TEK; EGFR; SRC;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
NA: NA	Geographic retinal atrophy	NA	APP;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; SRC;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR; APP;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; EGFR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases