Plant ID: NPO26233
Plant Latin Name: Helenium Autumnale
Taxonomy Genus: Helenium
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
138408
Plant-of-the-World-Online:
n.a.
Unknown.
Ingredient ID: NPC90451
Ingredient ID: NPC86961
Ingredient ID: NPC70762
Ingredient ID: NPC55505
Ingredient ID: NPC52198
Ingredient ID: NPC51813
Ingredient ID: NPC48803
Ingredient ID: NPC32189
Ingredient ID: NPC320934
Ingredient ID: NPC318570
Ingredient ID: NPC310185
Ingredient ID: NPC297271
Ingredient ID: NPC289004
Ingredient ID: NPC287779
Ingredient ID: NPC281259
Ingredient ID: NPC27791
Ingredient ID: NPC274356
Ingredient ID: NPC256776
Ingredient ID: NPC249626
Ingredient ID: NPC242987
Ingredient ID: NPC242977
Ingredient ID: NPC241498
Ingredient ID: NPC23310
Ingredient ID: NPC230531
Ingredient ID: NPC224583
Ingredient ID: NPC215015
Ingredient ID: NPC21272
Ingredient ID: NPC212103
Ingredient ID: NPC205896
Ingredient ID: NPC197352
Ingredient ID: NPC193645
Ingredient ID: NPC192033
Ingredient ID: NPC190208
Ingredient ID: NPC187713
Ingredient ID: NPC183331
Ingredient ID: NPC182403
Ingredient ID: NPC167739
Ingredient ID: NPC166143
Ingredient ID: NPC15743
Ingredient ID: NPC151511
Ingredient ID: NPC150737
Ingredient ID: NPC142105
Ingredient ID: NPC137352
Ingredient ID: NPC136060
Ingredient ID: NPC1356
Ingredient ID: NPC123219
Ingredient ID: NPC121190
Ingredient ID: NPC116824
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
Therapeutic Target | Protein Kinase | MKNK2 | MAP kinase signal-integrating kinase 2 | Q9HBH9 | CHEMBL4204 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
MAPT,MAPT
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
MKNK2
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MKNK2
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAPT
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
MKNK2
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
MKNK2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
MKNK2
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
MAPT
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
MAPT
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
GFER
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
GABRA6
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
MAPT
|