South Africa; Tanzania; Zimbabwe; Rwanda; Namibia; Kenya; Botswana
Ingredient ID: NPC83774
Ingredient ID: NPC78733
Ingredient ID: NPC78359
Ingredient ID: NPC73994
Ingredient ID: NPC72455
Ingredient ID: NPC69577
Ingredient ID: NPC65846
Ingredient ID: NPC65403
Ingredient ID: NPC61011
Ingredient ID: NPC474749
Ingredient ID: NPC474687
Ingredient ID: NPC46895
Ingredient ID: NPC33256
Ingredient ID: NPC311991
Ingredient ID: NPC298093
Ingredient ID: NPC292958
Ingredient ID: NPC284842
Ingredient ID: NPC274082
Ingredient ID: NPC259115
Ingredient ID: NPC244554
Ingredient ID: NPC218614
Ingredient ID: NPC171403
Ingredient ID: NPC162847
Ingredient ID: NPC15919
Ingredient ID: NPC150131
Ingredient ID: NPC143977
Ingredient ID: NPC133965
Ingredient ID: NPC121327
Ingredient ID: NPC104682
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Therapeutic Target | Oxidoreductase | ND4 | NADH-ubiquinone oxidoreductase chain 4 | P03905 | CHEMBL4499 |
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Therapeutic Target | Protein Kinase | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR6 | Serotonin 6 (5-HT6) receptor | P50406 | CHEMBL3371 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Unclassified protein | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 32 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00463879 | Galantamine for Cognitive Deficits in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT00301574 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00309725 | A Cardiac Safety Study of Galantamine in the Treatment of Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00509067 | Use of Galantamine and CDP-choline (Citicoline) to Treat Adults With Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT01548638 | Effect of Galantamine on Smoking Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT02248636 | Cholinesterase Inhibitor Discontinuation | Dementia | Galantamine (NPC78359) | NP level |
NCT00645190 | A Randomized, Double-blind, Flexible Dose, Multicenter Study to Evaluate the Effectiveness and Safety of Galantamine IR in Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00230997 | Safety and Efficacy of Galantamine in Patients With Dementia With Lewy Bodies | Lewy body dementia | Galantamine (NPC78359) | NP level |
NCT00814658 | The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life | Dementia | Galantamine (NPC78359) | NP level |
NCT00969696 | Galantamine Effects on Cognitive Function in Marijuana Users | memory impairment | Galantamine (NPC78359) | NP level |
NCT00000172 | Evaluation of Galantamine in the Treatment of Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00809835 | Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse | cocaine dependence | Galantamine (NPC78359) | NP level |
NCT01417429 | Galantamine Effects on Nicotine Responses in Smokers | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT01100775 | Effects of Galantamine on Cognition | schizophrenia | Galantamine (NPC78359) | NP level |
NCT02872857 | Subarachnoid Hemorrhage Recovery And Galantamine | subarachnoid hemorrhage | Galantamine (NPC78359) | NP level |
NCT01669538 | Effect of Galantamine on Short-term Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT00082602 | Safety and Tolerability Study of Extended Release (ER) Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00252603 | Galantamine Versus Placebo in Childhood Autism | autism | Galantamine (NPC78359) | NP level |
NCT01372306 | Galantamine Bioequivalence Study of Dr. Reddy's Under Fed Condition | Fish-eye disease | Galantamine (NPC78359) | NP level |
NCT00814801 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT02374567 | Pharmacovigilance in Gerontopsychiatric Patients | anxiety;depressive disorder;schizophrenia;Dementia | Galantamine (NPC78359) | NP level |
NCT00035191 | A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia | vascular dementia | Galantamine (NPC78359) | NP level |
NCT00679627 | A Study of Galantamine Used to Treat Patients With Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00304629 | Long-term Safety and Efficacy of Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT03384784 | Effect of Galantamine on Inflammation and Cognition | HIV infection | Galantamine (NPC78359) | NP level |
NCT02234752 | Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia | schizoaffective disorder;schizophrenia | Galantamine (NPC78359) | NP level |
NCT01012167 | Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT03124355 | Vagal Stimulation in POTS | orthostatic hypotension | Galantamine (NPC78359) | NP level |
NCT01677754 | A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT01039194 | Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER) | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT02365285 | Racial Differences in Vagal Control of Glucose Homeostasis | obesity | Galantamine (NPC78359) | NP level |
NCT00750529 | Alzheimer and Sleep | Alzheimer disease | Galantamine (NPC78359) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
HTR6
NCT00509067,NCT01012167,NCT00463879,NCT02234752,NCT02374567,NCT01100775 |
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
NCT00230997,NCT00814658,NCT02248636,NCT02374567 |
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TDP1,ACHE,PMP22,SMN1,LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,BCHE,PMP22,CYP2C19,LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
BCHE,SMN1,TDP1,LMNA
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
HTR6,BCHE,ACHE
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
MTOR,BCHE,ACHE
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4,HTR6
NCT02374567 |
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT01669538,NCT01548638,NCT01417429
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
BCHE,ACHE,HTR6
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
BCHE,ACHE,HTR6
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
PMP22,ACHE,LMNA
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ACHE,CYP2C19,HTR6
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
BCHE,ACHE,SMN1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
MTOR,CYP3A4
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
HTR6
NCT02365285 |
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE,HTR6
|
Muscular atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B61 |
SMN2,SMN1
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TDP1,HTR6
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1,HTR6
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
PMP22,LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ACHE,CYP3A4
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
BCHE,CYP3A4
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
BCHE,ACHE,HTR6
NCT00000172,NCT00301574,NCT01677754,NCT00645190,NCT00309725,NCT01039194,NCT00082602,NCT00304629,NCT00679627,NCT00814801,NCT00750529 |
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
MTOR
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
MTOR
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Neurodegenerative disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20-8A23 |
HTR6
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MTOR
|
Dissociative neurological symptom disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B60 |
HTR6
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
MTOR
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
Eexposure to noxious substances harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE61 |
BCHE
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
MTOR
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
MTOR
|
Pleural mesotheliomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26 |
MTOR
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MTOR
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
MTOR
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
MTOR
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
MTOR
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
MTOR
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
MTOR
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
MTOR
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
MTOR
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
MTOR
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ACHE
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MTOR
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
MTOR
|
LymphangioleiomyomatosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB07 |
MTOR
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MTOR
|
Malignant mesenchymal neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5D-2B5Y |
MTOR
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
BCHE
|
HydrocephalusDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D64 |
MTOR
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00809835
|
HypoalphalipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C81.0 |
NCT01372306
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
NCT02234752
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
NCT03124355
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT03384784
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT00969696
|
Dementia due to cerebrovascular diseaseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D81 |
NCT00035191
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT02374567
|
Subarachnoid haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B01 |
NCT02872857
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT00252603
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
PMP22
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
BCHE
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ACHE
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ACHE
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
HTR6
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
HTR6
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|