CMAUP Plant Collective Molecular Activities

Plant Name: Rhaponticum carthamoides

Taxonomic Information:

Plant ID: NPO223
Plant Latin Name: Rhaponticum carthamoides
Taxonomy Genus: Rhaponticum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 362630
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Russia

Traditional Medicine System:

TCM

Geographical Distribution:

China; Russia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; HTR7; HTR5A; ADRA1A; ADRB2; ADRB3; ADRA1D; ADRA2A; ADRA2B; DRD2; HTR4; HTR1F; HTR1B; HTR1D; HTR1E; DRD3; HTR2B; HTR2A; HTR1A; HTR2C; HTR6;
Peptide receptor (family A GPCR)	OPRD1; OPRM1;
Hydrolase	ACHE;
Enzyme_unclassified	BLM; MPO; HSD17B1; HSD17B10;
5HT3 receptor	HTR3A;
GABA-A receptor	GABRR1;
Protein Kinase	CSNK2A1;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Plant homeodomain	KMT2A;
SLC superfamily of solute carriers	SLCO1B3;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
5HT3 receptor	HTR3A	Serotonin 3a (5-HT3a) receptor	P46098	CHEMBL1899
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	MPO	Myeloperoxidase	P05164	CHEMBL2439
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Peptide receptor (family A GPCR)	OPRM1	Mu opioid receptor	P35372	CHEMBL233
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR5A	Serotonin 5a (5-HT5a) receptor	P47898	CHEMBL3426
Small molecule receptor (family A GPCR)	ADRA1A	Alpha-1a adrenergic receptor	P35348	CHEMBL229
Small molecule receptor (family A GPCR)	ADRB2	Beta-2 adrenergic receptor	P07550	CHEMBL210
Small molecule receptor (family A GPCR)	ADRB3	Beta-3 adrenergic receptor	P13945	CHEMBL246
Small molecule receptor (family A GPCR)	ADRA1D	Alpha-1d adrenergic receptor	P25100	CHEMBL223
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Small molecule receptor (family A GPCR)	HTR4	Serotonin 4 (5-HT4) receptor	Q13639	CHEMBL1875
Small molecule receptor (family A GPCR)	HTR1F	Serotonin 1f (5-HT1f) receptor	P30939	CHEMBL1805
Small molecule receptor (family A GPCR)	HTR1B	Serotonin 1b (5-HT1b) receptor	P28222	CHEMBL1898
Small molecule receptor (family A GPCR)	HTR1D	Serotonin 1d (5-HT1d) receptor	P28221	CHEMBL1983
Small molecule receptor (family A GPCR)	HTR1E	Serotonin 1e (5-HT1e) receptor	P28566	CHEMBL2182
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	1.418E-11	5.940E-09	HTR1A, HTR1B, HTR5A, HTR7
MF	GO:0005488; binding	GO:0051379; epinephrine binding	9.872E-10	3.412E-07	ADRA2A, ADRA2B, ADRB2, ADRB3
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	4.634E-09	1.462E-06	DRD2, DRD3, HTR1B, HTR2B
BP	GO:0008152; metabolic process	GO:0010513; positive regulation of phosphatidylinositol biosynthetic process	7.588E-08	1.777E-05	HTR2A, HTR2B, HTR2C
MF	GO:0005488; binding	GO:0051380; norepinephrine binding	7.588E-08	1.777E-05	ADRA2A, ADRB2, ADRB3
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	8.170E-08	1.892E-05	ADRB3, CYP1A1, CYP1B1, DRD2, DRD3, HTR1B, HTR1D, HTR3A, OPRD1
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	1.204E-07	2.569E-05	ADRA1A, DRD2, HTR2A, HTR2B, HTR2C, OPRM1, THPO
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.222E-07	2.583E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0014059; regulation of dopamine secretion	2.805E-07	5.092E-05	DRD2, DRD3, HTR1B, HTR2A
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	4.898E-07	8.204E-05	ADRA2A, DRD2, DRD3, OPRM1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	9.043E-07	1.387E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	1.991E-06	2.710E-04	DRD2, HTR2A, HTR2B, HTR2C
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.991E-06	2.710E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	2.728E-06	3.600E-04	DRD2, HTR1B, HTR2A
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	3.972E-06	5.118E-04	HTR2A, HTR2C
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	3.972E-06	5.118E-04	HTR2A, HTR2C
MF	GO:0005488; binding	GO:0020037; heme binding	5.677E-06	6.793E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, MPO
MF	GO:0005488; binding	GO:0001965; G-protein alpha-subunit binding	7.211E-06	8.264E-04	HTR2A, HTR2B, OPRM1
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	7.475E-06	8.478E-04	ADRA1D, ADRA2A, CSNK2A1, DRD2, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, THPO
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	8.471E-06	9.411E-04	DRD2, DRD3, HTR2A
MF	GO:0005488; binding	GO:0051378; serotonin binding	4.804E-31	3.487E-27	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	1.855E-27	5.049E-24	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	1.855E-27	5.049E-24	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.869E-06	1.059E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	1.190E-05	1.222E-03	DRD2, DRD3
MF	GO:0060089; molecular transducer activity	GO:0004937; alpha1-adrenergic receptor activity	1.190E-05	1.222E-03	ADRA1A, ADRA1D
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.190E-05	1.222E-03	ADRA2A, ADRA2B
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.311E-05	1.315E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0065007; biological regulation	GO:0007202; activation of phospholipase C activity	1.496E-05	1.474E-03	ADRA1A, HTR2A, HTR2B
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.377E-05	2.193E-03	ADRA2A, ADRA2B
BP	GO:0065007; biological regulation	GO:0001994; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	2.377E-05	2.193E-03	ADRA1A, ADRA1D
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.377E-05	2.193E-03	ADRA2A, ADRA2B
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.377E-05	2.193E-03	CYP1A1, CYP1A2
BP	GO:0032501; multicellular organismal process	GO:0014827; intestine smooth muscle contraction	2.377E-05	2.193E-03	HTR1D, HTR2B
BP	GO:0007610; behavior	GO:0042755; eating behavior	2.407E-05	2.212E-03	ADRB3, OPRD1, OPRM1
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	2.882E-05	2.615E-03	ACHE, ADORA3, CYP1A1, DRD2, OPRM1
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	2.882E-05	2.615E-03	DRD2, DRD3, HTR2C, OPRD1, OPRM1
BP	GO:0050896; response to stimulus	GO:0043278; response to morphine	3.624E-05	3.132E-03	DRD2, DRD3, OPRM1
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	3.624E-05	3.132E-03	ADRA1A, DRD2, HTR1B
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	3.957E-05	3.296E-03	DRD2, DRD3
BP	GO:0050896; response to stimulus	GO:0071502; cellular response to temperature stimulus	3.957E-05	3.296E-03	HTR1B, HTR2B
BP	Unclassified;	GO:0045907; positive regulation of vasoconstriction	3.981E-05	3.296E-03	ADRA1A, ADRA1D, HTR2A
BP	GO:0050896; response to stimulus	GO:0071312; cellular response to alkaloid	3.981E-05	3.296E-03	BLM, HTR1B, OPRM1
BP	GO:0032501; multicellular organismal process	GO:0045987; positive regulation of smooth muscle contraction	4.361E-05	3.583E-03	ADRA1A, ADRA1D, ADRA2B
BP	GO:0065007; biological regulation	GO:0007190; activation of adenylate cyclase activity	5.638E-05	4.530E-03	ADORA3, ADRB2, ADRB3
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	5.898E-05	4.722E-03	DRD2, DRD3, HTR2A, HTR2B, HTR2C
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	7.887E-05	6.156E-03	ACHE, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, MPO
BP	GO:0009987; cellular process	GO:0014062; regulation of serotonin secretion	8.289E-05	6.400E-03	HTR1A, HTR1B
BP	GO:0032502; developmental process	GO:0007568; aging	9.680E-05	7.319E-03	ADRA1A, ADRB3, CYP1A1, HTR2A, MPO
BP	GO:0009987; cellular process	GO:0050709; negative regulation of protein secretion	1.017E-04	7.663E-03	ADRA2A, DRD2, DRD3, OPRM1
BP	GO:0009987; cellular process	GO:0038003; opioid receptor signaling pathway	1.104E-04	8.065E-03	OPRD1, OPRM1
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.104E-04	8.065E-03	CYP1A1, CYP1A2
BP	GO:0032501; multicellular organismal process	GO:0031649; heat generation	1.104E-04	8.065E-03	ADRB2, ADRB3
BP	GO:0023052; signaling	GO:0051584; regulation of dopamine uptake involved in synaptic transmission	1.104E-04	8.065E-03	DRD2, DRD3
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	1.104E-04	8.065E-03	ADRA2A, ADRA2B
MF	GO:0060089; molecular transducer activity	GO:0004985; opioid receptor activity	1.104E-04	8.065E-03	OPRD1, OPRM1
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	1.104E-04	8.065E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0008542; visual learning	1.236E-04	8.912E-03	DRD2, DRD3, KMT2A
MF	Unclassified;	GO:0004872; receptor activity	8.488E-20	9.727E-17	ADORA3, ADRA1A, ADRA1D, ADRA2A, ADRA2B, ADRB2, ADRB3, DRD2, DRD3, ESR2, GABRR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR4, HTR5A, HTR6, HTR7, OPRD1, OPRM1
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.709E-19	1.860E-16	ADORA3, ADRA1A, ADRA1D, ADRA2A, ADRA2B, ADRB2, ADRB3, DRD2, DRD3, GABRR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, OPRD1, OPRM1, SLCO1B3
BP	GO:0009987; cellular process	GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway	5.884E-15	3.051E-12	ADRA1A, ADRA1D, ADRA2A, ADRA2B, ADRB2, ADRB3, DRD2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.888E-35	1.133E-33	OPRD1, HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, ADRA1D, ADRB2, OPRM1, HTR2A, HTR5A, HTR4, ADRA2B, ADRA1A, ADRA2A, HTR6, GABRR1, HTR7, ADRB3, ADORA3, DRD2, DRD3
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.868E-20	5.604E-19	HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, HTR3A, HTR2A, HTR5A, HTR4, HTR6, HTR7
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	3.106E-14	6.212E-13	HTR6, HTR7, ADRB3, HTR2B, HTR2C, ADRA1D, ADRB2, HTR2A, HTR5A, HTR4, ADRA1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.306E-10	1.958E-09	HTR6, HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, ADRB2, HTR4, DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	9.857E-10	1.183E-08	OPRD1, ADRB3, ADORA3, ADRA1D, ADRB2, ADRA2B, ADRA1A, ADRA2A
09150 Organismal Systems	09157 Sensory system	hsa04742	Taste transduction	1.243E-08	1.243E-07	HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, HTR3A
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9.181E-08	7.870E-07	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.665E-06	1.999E-05	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	2.675E-05	1.605E-04	ADRB3, ADRA1D, ADRB2, ADRA1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	2.559E-05	1.605E-04	HTR2B, HTR2C, HTR2A, DRD2
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.443E-05	3.514E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.880E-04	1.940E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9.173E-04	3.931E-03	HTR2B, HTR2C, HTR2A
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.458E-04	2.519E-03	CYP1A2, CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA1A; ADRA1D; ADRB2; ADRB3; DRD2; HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe acute pain	R52, G89	OPRM1;
J00-J99: Diseases of the respiratory system	Chronic breathing disorders	J44-J47	ADRB2;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
NA: NA	Bradycardia	NA	ADRB2;
O00-O9A: Pregnancy, childbirth and the puerperium	Premature labour	O60.1, P07.3	ADRB2;
NA: NA	Primary insomnia	NA	HTR2C;
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	ADRA1A; ADRA1D;
C00-D49: Neoplasms	Prostate cancer	C61	ADRA1A;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	ADRA1A; ADRA1D; CYP19A1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Systemic pain	R52, G89	OPRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	OPRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
N00-N99: Diseases of the genitourinary system	Benign prostatic hyperplasia	N40	ADRA1A; ADRA1D;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD2; DRD3; HTR2C; HTR1A; HTR1B;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
NA: NA	Addiction	NA	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	OPRM1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA1A; ACHE; ADORA3; ADRA1D; ADRB3; DRD2; HTR2A;
C00-D49: Neoplasms	Pediatric cancer	C00-C96	ADRA1D;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRM1; ADRA1A; ACHE; ADRA2A; DRD2; OPRD1; HTR2C; HTR1A;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MPO; ACHE; DRD2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADRA1A; ACHE; HTR6; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Chronic schizophrenics	F20	HTR1B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep maintenance insomnia	F51.0, G47.0	HTR2A;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
A00-B99: Certain infectious and parasitic diseases	Diarrhea	A09, K59.1	OPRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3; HTR2C;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	General anesthesia	R20.0	OPRM1;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	OPRM1; ADRB3;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	ADRB3; OPRD1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MPO; ADRB2; ADRB3; DRD2;
NA: NA	Social phobia	NA	HTR1A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;
NA: NA	Heart block	NA	ADRB2;
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1; HTR1D;
NA: NA	Acute nonspecific diarrhea	NA	OPRD1;
C00-D49: Neoplasms	Breast cancer	C50	DRD2; CYP19A1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HTR6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2A; HTR2B; HTR2C; HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADRA1D; ADRB3; HTR2A; HTR2C;
G00-G99: Diseases of the nervous system G00-G99	Headache	G43-G44, R51	OPRM1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRB2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Opiate dependence	F11	OPRM1;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HTR2A;
NA: NA	Cervical dystonia	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3; DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Analgesia	R52, G89	OPRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	OPRM1;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HTR1D;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	ADRA1D;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRM1; HTR7; ADRA1A; ADRB3; DRD2; OPRD1; HTR2C; HTR1A; HTR1B; HTR1D;
K00-K95: Diseases of the digestive system	Opioid-induced constipation	K59.0	OPRM1;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
NA: NA	Anxiety disorders	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	ADRB3; DRD2;
NA: NA	Exacerbations of acute asthma	NA	ADRB2;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
NA: NA	Malignant essential hypertension	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR2C; HTR6;
N00-N99: Diseases of the genitourinary system	Neurogenic bladder dysfunction	N31.9	ADRB2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; HTR6;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B; DRD2; OPRD1; HTR2A; HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
L00-L99: Diseases of the skin and subcutaneous tissue	Aging skin	L00-L99	ADRB2;
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Narcotic depression	F19.20, F32	OPRM1;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; DRD2; HTR6; HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2; HTR3A;
NA: NA	Hyperaemia	NA	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2; DRD3; HTR6; HTR3A;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	OPRM1; HTR2A; HTR2B; HTR1F; HTR1A; HTR1D;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2; HTR2C; HTR1B; HTR1D;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRM1; ADRA1A; ADRA1D; ADRB3; OPRD1; HTR1A;
NA: NA	Upper abdominal bloating	NA	ACHE;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
A00-B99: Certain infectious and parasitic diseases	Infections disease	A00-B99	MPO;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	OPRM1; MPO; DRD2;
NA: NA	Inflammatory diseases	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	ADRB3;
NA: NA	Itching	NA	DRD2;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	ADRB3; HTR2B; HTR3A;
J00-J99: Diseases of the respiratory system	Asthma	J45	OPRM1; ADRB2; ADRB3; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fecal incontinence	R15	ADRA1D;
NA: NA	False perceptions	NA	DRD2;
NA: NA	Vomiting	NA	DRD2; HTR3A;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	HTR2A; HTR3A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ADRA1A; DRD3; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	ADRB3; HTR1A; HTR1D;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Local anaesthetic	R20.0	HTR3A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Mild pain	R52, G89	OPRM1;
NA: NA	Corneal vascularity	NA	DRD2;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B;
N00-N99: Diseases of the genitourinary system	Stress urinary incontinence	N39.3	ADRA1A;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	ADRA1D; HTR2B;
K00-K95: Diseases of the digestive system	Constipation	K59.0	OPRM1;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
NA: NA	Episode	NA	HTR1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Skin infections	L00-L99	ADRB2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7; HTR2A;
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Post-traumatic stress disorder	F43.1	ADRA1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	ADRB2; OPRD1; HTR1A;
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	ADRA1D;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2A; HTR2C; HTR1A; HTR1B; HTR1D;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1;
NA: NA	Schizoaffective disorder	NA	HTR1A;
NA: NA	Schizoaffective disorders	NA	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	OPRM1; DRD2;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	MPO;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Movement disorder	R25	OPRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; DRD2; DRD3; HTR2A; HTR2C; HTR6; HTR1A;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
I00-I99: Diseases of the circulatory system	Hemorrhoids	I84	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
J00-J99: Diseases of the respiratory system	Acute asthma	J45	ADRB2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C; HTR1A;
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	HTR3A;
NA: NA	Bulimia nervosa	NA	HTR1A;
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	ADRB2;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cancer pain	R52, G89	OPRM1;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; ACHE; ADORA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	ADRB2;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE; DRD2; OPRD1; HTR2A; HTR2C; HTR6; HTR1A; HTR1B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases