Anodyne; Antiinflammatory; Antiscorbutic; Antiseptic; Cathartic; Diuretic; Expectorant; Febrifuge; Stimulant; Tonic
Belgium; Canada; United States; China; France
Ingredient ID: NPC76884
Ingredient ID: NPC73492
Ingredient ID: NPC63646
Ingredient ID: NPC55470
Ingredient ID: NPC49075
Ingredient ID: NPC488272
Ingredient ID: NPC488271
Ingredient ID: NPC488270
Ingredient ID: NPC488269
Ingredient ID: NPC488268
Ingredient ID: NPC488267
Ingredient ID: NPC488266
Ingredient ID: NPC488265
Ingredient ID: NPC488264
Ingredient ID: NPC47721
Ingredient ID: NPC471628
Ingredient ID: NPC313133
Ingredient ID: NPC306195
Ingredient ID: NPC298979
Ingredient ID: NPC293624
Ingredient ID: NPC290582
Ingredient ID: NPC279533
Ingredient ID: NPC278525
Ingredient ID: NPC2785
Ingredient ID: NPC252643
Ingredient ID: NPC249405
Ingredient ID: NPC244016
Ingredient ID: NPC232924
Ingredient ID: NPC231560
Ingredient ID: NPC22481
Ingredient ID: NPC217280
Ingredient ID: NPC205421
Ingredient ID: NPC196231
Ingredient ID: NPC181255
Ingredient ID: NPC173840
Ingredient ID: NPC166688
Ingredient ID: NPC159589
Ingredient ID: NPC146264
Ingredient ID: NPC145980
Ingredient ID: NPC142713
Ingredient ID: NPC141977
Ingredient ID: NPC134462
Ingredient ID: NPC128560
Ingredient ID: NPC127274
Ingredient ID: NPC123331
Ingredient ID: NPC118804
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1A | Alpha-1a adrenergic receptor | P35348 | CHEMBL229 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1D | Alpha-1d adrenergic receptor | P25100 | CHEMBL223 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 36 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00128466 | Treatment and Diagnosis of Plague | Yersinia pestis infectious disease | Gentamicin (NPC471628) | NP level |
NCT02314806 | Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla | breast cancer | Gentamicin (NPC471628) | NP level |
NCT00600925 | A Study of an Antibiotic Implant in General Surgical Subjects at Higher Risk for Surgical Wound Infection | infection | Gentamicin (NPC471628) | NP level |
NCT02479971 | Effect of Peritoneal Lavage With Clindamycin-gentamicin on Laparoscopic Sleeve Gastrectomy | pain | Gentamicin (NPC471628) | NP level |
NCT00593567 | Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With a Mild Infection of a Foot Ulcer | diabetic foot | Gentamicin (NPC471628) | NP level |
NCT01244256 | Efficacy and Comparative of the Association Beclomethasone Clotrimzaol + Gentamicin in Patients With Acne Contaminated | folliculitis | Gentamicin (NPC471628) | NP level |
NCT01083576 | Pharmacokinetics, Safety, and Efficacy Trial of WR 279,396 (Paromomycin + Gentamicin Topical Cream) and Paromomycin Topical Cream for the Treatment of Cutaneous Leishmaniasis in Panama | Leishmaniasis | Gentamicin (NPC471628) | NP level |
NCT03475680 | Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery | malignant colon neoplasm | Gentamicin (NPC471628) | NP level |
NCT00600483 | Safety and Efficacy of an Antibiotic Implant in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Infection | infection | Gentamicin (NPC471628) | NP level |
NCT01551394 | Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis | Sepsis | Gentamicin (NPC471628) | NP level |
NCT02099240 | Patients Response to Early Switch To Oral:Osteomyelitis Study | osteomyelitis | Gentamicin (NPC471628);Chloramphenicol (NPC159589) | NP level |
NCT00879190 | Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis | chorioamnionitis | Gentamicin (NPC471628) | NP level |
NCT01994993 | Antibiotic Safety (SCAMP) | infection | Gentamicin (NPC471628) | NP level |
NCT03491540 | Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery | rectum cancer | Gentamicin (NPC471628) | NP level |
NCT00802529 | Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease | Meniere disease | Gentamicin (NPC471628) | NP level |
NCT05398705 | Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19 | COVID-19 | Cepharanthine (NPC73492) | NP level |
NCT04544943 | Safety, Tolerability, Pharmacokinetics and Efficacy of Twice Daily Application of Topical BioLexa in Adult Healthy Subjects and Patients With Mild to Moderate Atopic Dermatitis | atopic eczema | Gentamicin (NPC471628) | NP level |
NCT04789928 | Conservative Treatment of Catheter - Related Injections With Gentamicine/EDTA | infection | Gentamicin (NPC471628) | NP level |
NCT03632109 | Gent for Pharyngeal Gonorrhea (GC) | infection | Gentamicin (NPC471628) | NP level |
NCT00657917 | Topical Treatment of Recalcitrant Ulcerative Old World Leishmaniasis With WR 279,396 | cutaneous Leishmaniasis | Gentamicin (NPC471628) | NP level |
NCT00659646 | The Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With Moderately Infected Foot Ulcers | diabetic foot | Gentamicin (NPC471628) | NP level |
NCT01429701 | Effectiveness of Polymyxin B Sulphate + Prednisolone + Benzocaine + Clioquinol in Acute and Sub-acute Dermatitis Eczematous | Eczema | Gentamicin (NPC471628) | NP level |
NCT01032382 | Safety, Efficacy and Pharmacokinetics (PK) Study of WR 279,396 Versus Paromomycin for Treatment of Cutaneous Leishmaniasis (Peru-PK) | Leishmaniasis | Gentamicin (NPC471628) | NP level |
NCT01931592 | Controling Intestinal Colonization With Extended Spectrum ß-Lactamase Producing Enterobacteriaceae ESBL-E | cancer | Gentamicin (NPC471628) | NP level |
NCT03132116 | Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis | cat-scratch disease | Gentamicin (NPC471628) | NP level |
NCT03392909 | Intravenous Gentamicin Therapy for Recessive Dystrophic Epidermolysis Bullosa (RDEB) | recessive dystrophic epidermolysis bullosa | Gentamicin (NPC471628) | NP level |
NCT02698735 | Gentamicin Therapy for Recessive Dystrophic Epidermolysis Bullosa (RDEB) Nonsense Mutation Patients | recessive dystrophic epidermolysis bullosa | Gentamicin (NPC471628) | NP level |
NCT02036528 | Safety and Efficacy of Gentamicin Topical Gel (AppliGel-G) for Treatment of Mild to Moderately Infected Diabetic Foot Ulcers | diabetic foot | Gentamicin (NPC471628) | NP level |
NCT00451074 | Six Month Study of Gentamicin in Duchenne Muscular Dystrophy With Stop Codons | Duchenne muscular dystrophy | Gentamicin (NPC471628) | NP level |
NCT00376428 | Interest of Gentamicin-induced Readthrough in Cystic Fibrosis Patients | cystic fibrosis | Gentamicin (NPC471628) | NP level |
NCT02515448 | A Pharmacokinetic-pharmacodynamic Dose Comparison Study of 8 mg/kg of Inhaled or Parenteral Gentamicin in 12 Mechanically Ventilated Critically Ill Patients Treated for Ventilator-associated Pneumonia | ventilator-associated pneumonia | Gentamicin (NPC471628) | NP level |
NCT00189384 | Efficacy Study of Community-Based Treatment of Serious Bacterial Infections in Young Infants | Sepsis;bacterial disease | Gentamicin (NPC471628) | NP level |
NCT00658957 | Prevention of Infection Using a Topical Gentamicin-Collagen Sponge in Diabetic Patients With An Uninfected Foot Ulcer | diabetic foot | Gentamicin (NPC471628) | NP level |
NCT00005574 | Gentamicin Treatment of Muscular Dystrophy | Becker muscular dystrophy;Duchenne muscular dystrophy | Gentamicin (NPC471628) | NP level |
NCT03213249 | Bacterial Biofilms in Reconstructive Breast Prostheses Following Mastectomy | infection | Gentamicin (NPC471628) | NP level |
NCT04967859 | Evaluation of the Efficacy of Prophylactic Topical Gentamicin in Tunnelled Catheters for Hemodialysis | infection | Gentamicin (NPC471628) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT01994993,NCT04789928,NCT00600925,NCT00600483,NCT04967859,NCT03213249,NCT03632109
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
NCT02036528,NCT00658957,NCT00659646,NCT00593567
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ADRA1A,ADRA1D
NCT02479971 |
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
NCT01083576,NCT01032382,NCT00657917
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
ADRA1D,MAPT,MAPT
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ADRA1D,ADRA1A
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
ADRA1A,ADRA1D
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ADRA1A,MAPT
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT04544943,NCT01429701
|
Dystrophic epidermolysis bullosaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC32 |
NCT02698735,NCT03392909
|
SepsisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G40-1G41 |
NCT00189384,NCT01551394
|
Duchenne muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.1 |
NCT00005574,NCT00451074
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
ADRA1D
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
ADRA1D
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
ADRA1D
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAPT
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ADRA1D
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
ADRA1A
|
Becker muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.0 |
NCT00005574
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT00376428
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
NCT00189384
|
Malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
NCT03475680
|
Ventilation associated with injury or harm in therapeutic useDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PK81.0 |
NCT02515448
|
PlagueDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B93 |
NCT00128466
|
Superficial bacterial folliculitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B74 |
NCT01244256
|
Osteomyelitis or osteitisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB84 |
NCT02099240
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT01931592
|
Cat-scratch diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B98 |
NCT03132116
|
Meniere diseaseDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AB31.0 |
NCT00802529
|
Rectum cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B92 |
NCT03491540
|
Infection of amniotic sac or membranesDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA88.1 |
NCT00879190
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT05398705
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT02314806
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
MAPT
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
MAPT
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
ADRA1D
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ADRA1D
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
ADRA1A
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
MAPT
|