Plant ID: NPO2073
Plant Latin Name: Ancistrocladus Korupensis
Taxonomy Genus: Ancistrocladus
Taxonomy Family: Ancistrocladaceae
NCBI TaxonomyDB:
63089
Plant-of-the-World-Online:
n.a.
China
Ingredient ID: NPC79402
Ingredient ID: NPC76336
Ingredient ID: NPC476565
Ingredient ID: NPC43847
Ingredient ID: NPC40496
Ingredient ID: NPC3295
Ingredient ID: NPC32843
Ingredient ID: NPC277728
Ingredient ID: NPC265547
Ingredient ID: NPC263124
Ingredient ID: NPC259350
Ingredient ID: NPC257269
Ingredient ID: NPC252603
Ingredient ID: NPC251593
Ingredient ID: NPC230276
Ingredient ID: NPC223236
Ingredient ID: NPC223077
Ingredient ID: NPC222611
Ingredient ID: NPC211871
Ingredient ID: NPC15658
Ingredient ID: NPC141765
Ingredient ID: NPC141737
Ingredient ID: NPC141268
Ingredient ID: NPC126029
Ingredient ID: NPC119068
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 36 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00241631 | Enhancement of in-Vitro GC Function in Patients With COPD | chronic obstructive pulmonary disease | Theophylline (NPC252603) | NP level |
NCT00252863 | DESOLO - SiT Peri-Launch: A Comparison of Symbicort Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent Asthma in Adults | asthma | Theophylline (NPC252603) | NP level |
NCT00252785 | Efficacy & Safety of Symbicort® TURBUHALER® 160/4.5 µg Twice Daily & Pulmicort® TURBUHALER® 200 µg Twice Daily + Theolong® Tablet 200 mg Twice Daily in Japanese Asthmatic Patients | asthma | Theophylline (NPC252603) | NP level |
NCT03990766 | Smell Changes & Efficacy of Nasal Theophylline | viral disease | Theophylline (NPC252603) | NP level |
NCT01017939 | A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer | prostate carcinoma | Theophylline (NPC252603) | NP level |
NCT02340520 | Enhancement of Corticosteroid Efficacy in COPD | chronic obstructive pulmonary disease | Theophylline (NPC252603) | NP level |
NCT04240821 | Theophylline for Treatment of Pseudohypoparathyroidism | Albright hereditary osteodystrophy;pseudohypoparathyroidism type 1A | Theophylline (NPC252603) | NP level |
NCT03984188 | Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD | chronic obstructive pulmonary disease | Theophylline (NPC252603) | NP level |
NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
NCT01696214 | A Pilot Study to Determine the Feasibility and Utility of Implementing of the Full Scale TOM Trial | asthma | Theophylline (NPC252603) | NP level |
NCT00000578 | NHLBI/NICHD Collaborative Studies of Asthma in Pregnancy | asthma | Theophylline (NPC252603) | NP level |
NCT02088502 | Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy | kidney disease | Theophylline (NPC252603) | NP level |
NCT01599871 | Low-dose Theophylline as Anti-inflammatory Enhancer in Severe Chronic Obstructive Pulmonary Disease | chronic obstructive pulmonary disease | Theophylline (NPC252603) | NP level |
NCT01066728 | CO2 Inhalation as a New Treatment Modality for Apnea of Prematurity | Apnea | Theophylline (NPC252603) | NP level |
NCT04309877 | Theophylline for Depression Study | depressive disorder | Theophylline (NPC252603) | NP level |
NCT02080078 | A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline | non-small cell lung carcinoma | Theophylline (NPC252603) | NP level |
NCT01799161 | Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung Cancer | non-small cell lung carcinoma | Theophylline (NPC252603) | NP level |
NCT01263106 | A Study of LY2216684 and Theophylline in Healthy Subjects | major depressive disorder | Theophylline (NPC252603) | NP level |
NCT01293734 | Research on Traditional Chinese Medicine (TCM) Clinical Treatment of the Acute Episode of Bronchial Asthma. | asthma | Theophylline (NPC252603) | NP level |
NCT02479451 | Helping Olfaction and Nutrition On Renal Replacement | chronic kidney disease | Theophylline (NPC252603) | NP level |
NCT00003684 | Theophylline in Treating Cancer Patients With Shortness of Breath | respiratory failure | Theophylline (NPC252603) | NP level |
NCT00634413 | Effect of ADC4022 Co-Administered With Budesonide on Pulmonary Inflammation in Subjects With Moderate to Severe COPD | chronic obstructive pulmonary disease | Theophylline (NPC252603) | NP level |
NCT00175812 | Differentiation Induction in Acute Myelogenous Leukemia | acute myeloid leukemia | Theophylline (NPC252603) | NP level |
NCT03029429 | Theophylline Treatment for Pseudohypoparathyroidism | Albright hereditary osteodystrophy;pseudohypoparathyroidism | Theophylline (NPC252603) | NP level |
NCT00119496 | Rosiglitazone Versus Theophylline in Asthmatic Smokers | asthma | Theophylline (NPC252603) | NP level |
NCT02463409 | Theophylline as a Treatment for Children With Pseudohypoparathyroidism Type 1a (Albright Hereditary Osteodystrophy) | Albright hereditary osteodystrophy;pseudohypoparathyroidism type 1A | Theophylline (NPC252603) | NP level |
NCT01902758 | Drug Combination on Exercise Performance at High Altitude | altitude sickness | Theophylline (NPC252603) | NP level |
NCT02537691 | Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers | asthma | Theophylline (NPC252603) | NP level |
NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
NCT03269318 | PRISTINE - Personalised Approach to Improve aSThma prescrIbing iN childrEn | asthma | Theophylline (NPC252603) | NP level |
NCT04551170 | Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old | Albright hereditary osteodystrophy;pseudohypoparathyroidism type 1A | Theophylline (NPC252603) | NP level |
NCT00756418 | Montelukast Post-marketing Comparative Study With Theophyline Added to Inhaled Corticosteroid (0476-396) | asthma | Theophylline (NPC252603) | NP level |
NCT03236662 | (-)- Epicatechin Becker Muscular Dystrophy | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
NCT00299858 | Theophylline in Chronic Obstructive Pulmonary Disease | chronic obstructive pulmonary disease | Theophylline (NPC252603) | NP level |
NCT00003808 | Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia | leukemia | Theophylline (NPC252603) | NP level |
NCT01566565 | The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary Hypertension | pulmonary arterial hypertension | Theophylline (NPC252603) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT02537691,NCT00119496,NCT01696214,NCT00000578,NCT03269318,NCT00252785,NCT00756418,NCT01293734,NCT00252863
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
ADORA2A
NCT03984188,NCT00241631,NCT00299858,NCT00634413,NCT02340520,NCT01599871 |
PseudohypoparathyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A50.1 |
NCT02463409,NCT04240821,NCT04551170,NCT03029429
|
Deletions of the long arm of chromosome 2Disease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD44.20 |
NCT02463409,NCT03029429,NCT04551170,NCT04240821
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CA9,NFKB1,HSD17B10,ADORA2A
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
NFKB1,CA9,ADORA2A
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ADORA2A
NCT01880866,NCT01566565 |
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA9,HSD17B10,ALPL
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA9,ADORA2A,SNCA
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
NCT00175812 |
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ADORA2A,SNCA
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
ADORA2A,NFKB1
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT02088502,NCT02479451
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT02080078,NCT01799161
|
Becker muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.0 |
NCT01856868,NCT03236662
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA9,ALPL
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ADORA2A,SNCA
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ALPL,ADORA2A
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CA9,HSD17B10
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CA9,CA9
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1,ADORA2A
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CA9,SNCA
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA9,CA9
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ADORA2A,KDM4E
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CA9,ALPL
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA9,ADORA2A
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ADORA2A,SNCA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA9,SNCA
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
Radionuclide imagingDisease Category: NADisease ICD-11 Code: N.A. |
ADORA2A
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ADORA2A
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ADORA2A
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ADORA2A
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NFKB1
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
ALPL
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
ADORA2A
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NFKB1
|
Unspecific substance use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4Z |
ADORA2A
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NFKB1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ADORA2A
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
ADORA2A
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
ADORA2A
|
Parasitic infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D0Y-1G2Z |
ALPL
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
ADORA2A
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
ADORA2A
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA9
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
ADORA2A
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
ADORA2A
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
ADORA2A
|
Genetic prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E02 |
ALPL
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT04309877
|
Malignant neoplasms of prostate, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.Z |
NCT01017939
|
Respiratory failureDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB41 |
NCT00003684
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00003808
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
NCT03990766
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT01263106
|
Other specified effects of air pressure or water pressureDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NF04.Y |
NCT01902758
|
ApnoeaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.0 |
NCT01066728
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
ALPL
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
ALPL
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ADORA2A
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
ALPL
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CA9
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CA9
|
Intrauterine growth restrictionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA20.1 |
ADORA2A
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA9
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
ADORA2A
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CA9
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
ADORA2A
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA9
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
SNCA
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA9
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CA9
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ALPL
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA9
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
ADORA2A
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA9
|