CMAUP Plant Collective Molecular Activities

Plant Name: Rubus coreanus

Taxonomic Information:

Plant ID: NPO18930
Plant Latin Name: Rubus coreanus
Taxonomy Genus: Rubus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 321593
Plant-of-the-World-Online: 736034-1

Used in Medicines:

Unknown.

Geographical Distribution:

China; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Small molecule receptor (family A GPCR)	GPR35;
Hydrolase	ATP1A1; ACHE;
Enzyme_unclassified	TDP1; RECQL; HPGD; ALOX12; AKR1B1; HSD17B2; HSD17B10; NOX4; AKR1B10; APEX1; POLB;
Protein Phosphatase	CDC25B;
Protein Kinase	TEK; PIM1; CDK1; INSR; AXL; MET; FLT3; IGF1R; EGFR; KDR; SRC; AURKB; CSNK2A1; NUAK1;
Lyase	CA2; CA12; CA14; CA7;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR;
Lysine demethylase	KDM4E;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	TP53; NFKB1; AHR; STAT3;
Transferase	FUT7;
SLC superfamily of solute carriers	SLCO4C1; SLC22A6;
Unclassified	LMNA; RAB9A; NPC1; PAX8; SMAD3; MAPT; HSPA1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Hydrolase	ATP1A1	Sodium/potassium-transporting ATPase alpha-1 chain	P05023	CHEMBL1807
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	TEK	Tyrosine-protein kinase TIE-2	Q02763	CHEMBL4128
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	INSR	Insulin receptor	P06213	CHEMBL1981
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Kinase	NUAK1	NUAK family SNF1-like kinase 1	O60285	CHEMBL5784
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
SLC superfamily of solute carriers	SLCO4C1	Solute carrier organic anion transporter family member 4C1	Q6ZQN7	CHEMBL2073690
SLC superfamily of solute carriers	SLC22A6	Solute carrier family 22 member 6	Q4U2R8	CHEMBL1641347
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HSPA1A	Heat shock 70 kDa protein 1	P0DMV8	CHEMBL5460
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	SMAD3	Mothers against decapentaplegic homolog 3	P84022	CHEMBL1293258

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.061E-07	2.310E-05	ATP1A1, CA2, EGFR, HPGD, SLC22A6, SLCO4C1, TEK, TSHR
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.119E-07	2.412E-05	CA12, CA14, CA2, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.709E-07	5.363E-05	CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4
MF	GO:0005488; binding	GO:0005524; ATP binding	2.996E-07	5.825E-05	ATP1A1, AURKB, AXL, CDK1, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, RECQL, SRC, TEK, TP53
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	3.385E-07	6.467E-05	EGFR, IGF1R, INSR, KDR, SRC
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	4.430E-07	7.972E-05	AXL, EGFR, INSR, MET, NOX4, SRC, TEK
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	7.125E-07	1.124E-04	CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.270E-06	1.869E-04	AKR1B1, APEX1, AXL, CDK1, CYP1B1
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	1.314E-06	1.907E-04	CYP1A1, LMNA, MMP2, NOX4, SMAD3, SRC, TEK, TP53
MF	GO:0005488; binding	GO:0043548; phosphatidylinositol 3-kinase binding	1.885E-06	2.581E-04	ATP1A1, AXL, IGF1R, INSR
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	2.362E-06	3.025E-04	EGFR, INSR, KDR
MF	GO:0005488; binding	GO:0020037; heme binding	2.811E-06	3.498E-04	CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4, SRC
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	2.834E-06	3.506E-04	AHR, CSNK2A1, KDR, MAPT
MF	Unclassified;	GO:0004872; receptor activity	3.147E-06	3.828E-04	AHR, AXL, EGFR, FLT3, GPR35, HPGD, IGF1R, INSR, KDR, MET, NPC1, NPSR1, NR1H4, PAX8, RORC, TEK, TSHR
BP	GO:0009987; cellular process	GO:0071383; cellular response to steroid hormone stimulus	3.335E-06	3.990E-04	ATP1A1, EGFR, FLT3, NPC1, SRC
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.367E-06	4.006E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	3.806E-06	4.385E-04	AXL, CDK1, CSNK2A1, EGFR, FLT3
MF	GO:0005488; binding	GO:0042562; hormone binding	6.615E-06	7.027E-04	ACHE, ATP1A1, EGFR, IGF1R, INSR
MF	GO:0005488; binding	GO:0005496; steroid binding	7.007E-06	7.335E-04	ATP1A1, CYP3A4, NPC1, NR1H4, RORC
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	9.488E-06	9.477E-04	APEX1, POLB
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	9.488E-06	9.477E-04	PAX8, TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	9.488E-06	9.477E-04	PAX8, TSHR
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.040E-05	1.034E-03	CA12, CA14, CA2, CA7
BP	GO:0040007; growth	GO:0045927; positive regulation of growth	1.369E-05	1.313E-03	ALOX12, CDK1, CSNK2A1, EGFR, INSR, MAPT, PIM1
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.605E-05	1.507E-03	AHR, NR1H4, RORC, STAT3
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.694E-05	1.583E-03	AHR, NR1H4, PIM1, RORC, SRC, STAT3
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.925E-05	1.761E-03	ACHE, CDK1, CYP1A1, EGFR, SMAD3, TP53
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	2.548E-05	2.159E-03	CDK1, EGFR, IGF1R, INSR
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.841E-05	2.343E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.841E-05	2.343E-03	CYP1A1, CYP3A4
MF	Unclassified;	GO:0032403; protein complex binding	2.900E-05	2.381E-03	ACHE, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, SMAD3, SRC, TSHR
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	3.006E-05	2.442E-03	CDK1, HPGD, POLB, STAT3, TP53
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	3.263E-05	2.622E-03	EGFR, MAPT, MET, STAT3, TP53
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	3.403E-05	2.704E-03	ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A
MF	GO:0003824; catalytic activity	GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3.398E-05	2.704E-03	AKR1B1, AKR1B10, HPGD, HSD17B10, HSD17B2
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	3.642E-05	2.842E-03	CYP1A1, POLB, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.642E-05	2.842E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter	4.207E-05	3.226E-03	SMAD3, STAT3, TP53
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	4.207E-05	3.226E-03	HPGD, MMP2, MMP9
MF	GO:0005488; binding	GO:0003690; double-stranded DNA binding	4.205E-05	3.226E-03	AHR, APEX1, EGFR, NFKB1, NR1H4, PAX8, RORC, SMAD3, STAT3, TDP1, TP53
BP	GO:0032501; multicellular organismal process	GO:0010634; positive regulation of epithelial cell migration	4.302E-05	3.287E-03	KDR, MET, MMP9, SRC, TEK
BP	GO:0008152; metabolic process	GO:0010894; negative regulation of steroid biosynthetic process	4.828E-05	3.625E-03	ATP1A1, NFKB1, NR1H4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.828E-05	3.625E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019838; growth factor binding	5.189E-05	3.856E-03	EGFR, IGF1R, INSR, KDR, TEK
BP	GO:0000003; reproduction	GO:0022414; reproductive process	5.543E-05	4.064E-03	AKR1B1, AXL, CDC25B, CDK1, CYP1A1, EGFR, HPGD, HSD17B2, INSR, MMP2, MMP9, SLCO4C1, SRC, STAT3
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	5.670E-05	4.102E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.670E-05	4.102E-03	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	6.921E-05	4.830E-03	HSPA1A, MAPT, MET, MMP1, SRC, TP53
CC	GO:0016020; membrane	GO:0005901; caveola	6.996E-05	4.867E-03	ATP1A1, INSR, SLC22A6, SRC
BP	GO:0009987; cellular process	GO:0051262; protein tetramerization	9.298E-05	6.230E-03	ACHE, HSD17B10, IGF1R, INSR, TP53
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	9.332E-05	6.234E-03	AHR, AKR1B1, APEX1, AURKB, CDC25B, CDK1, CSNK2A1, HPGD, HSPA1A, LMNA, NFKB1, NR1H4, NUAK1, PAX8, PIM1, POLB, RECQL, RORC, SMAD3, SRC, STAT3, TP53
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	9.432E-05	6.242E-03	CYP1A1, CYP3A4
BP	GO:0009987; cellular process	GO:0046427; positive regulation of JAK-STAT cascade	9.609E-05	6.321E-03	AKR1B1, CYP1B1, FLT3, STAT3
BP	GO:0032502; developmental process	GO:0048732; gland development	1.034E-04	6.739E-03	CSNK2A1, EGFR, INSR, PAX8, SMAD3, TYR
BP	GO:0008152; metabolic process	GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity	1.090E-04	7.000E-03	FLT3, SRC, TEK
BP	GO:0009987; cellular process	GO:0071363; cellular response to growth factor stimulus	1.106E-04	7.082E-03	EGFR, INSR, KDR, NOX4, SMAD3, SRC
BP	Unclassified;	GO:0006461; protein complex assembly	1.136E-04	7.256E-03	ACHE, CDK1, HSD17B10, HSPA1A, IGF1R, INSR, MAPT, SLC22A6, SMAD3, SRC, TEK, TP53
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	1.158E-04	7.371E-03	ALOX12, CYP1B1, KDR, STAT3, TEK
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	1.204E-04	7.554E-03	CYP1A2, EGFR, MMP9
BP	GO:0050896; response to stimulus	GO:0033273; response to vitamin	1.228E-04	7.638E-03	CYP1A1, EGFR, TP53, TYR
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.385E-04	8.545E-03	ALOX12, CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.412E-04	8.612E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.412E-04	8.612E-03	ALOX12, HPGD
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.412E-04	8.612E-03	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:2000045; regulation of G1/S transition of mitotic cell cycle	1.468E-04	8.759E-03	APEX1, CDK1, CYP1A1, EGFR, TP53
BP	GO:0050896; response to stimulus	GO:0071375; cellular response to peptide hormone stimulus	1.468E-04	8.759E-03	APEX1, INSR, NFKB1, SRC, TSHR
BP	GO:0008152; metabolic process	GO:1903580; positive regulation of ATP metabolic process	1.592E-04	9.395E-03	CDK1, INSR, STAT3
CC	GO:0044464; cell part	GO:0048471; perinuclear region of cytoplasm	1.612E-04	9.474E-03	ACHE, AKR1B1, APEX1, EGFR, HSPA1A, NOX4, NPC1, SRC, TYR
BP	GO:0065007; biological regulation	GO:0043406; positive regulation of MAP kinase activity	1.661E-04	9.712E-03	CDK1, EGFR, FLT3, INSR, NOX4, SRC
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	4.712E-14	7.893E-11	AKR1B1, ALOX12, AURKB, AXL, CDK1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, LMNA, MMP9, NFKB1, NR1H4, PAX8, PIM1, SMAD3, SRC, STAT3, TEK, TP53

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.880E-09	1.282E-07	SMAD3, PAX8, FLT3, MMP1, MMP2, STAT3, MET, TP53, MMP9, EGFR, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.337E-09	1.282E-07	MMP1, SRC, MMP2, MMP9, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	9.048E-09	3.710E-07	SRC, MMP2, STAT3, KDR, TP53, MMP9, MET, EGFR, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.345E-09	1.282E-07	SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.323E-08	2.074E-06	HPGD, PAX8, FLT3, TP53, MMP9, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.369E-07	5.550E-06	STAT3, PIM1, CYP1B1, TP53, MMP9, MET, EGFR, NFKB1, CDC25B
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.916E-07	8.027E-06	INSR, HSD17B2, CYP1A1, CYP1B1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	6.437E-07	1.173E-05	INSR, STAT3, TEK, EGFR, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.592E-06	2.374E-05	SMAD3, STAT3, TP53, EGFR, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	3.166E-06	4.135E-05	SRC, INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	5.125E-06	5.603E-05	INSR, KDR, TEK, MET, EGFR, NFKB1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.315E-07	1.364E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	7.779E-06	7.974E-05	INSR, KDR, TEK, TP53, MET, EGFR, NFKB1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.277E-06	4.135E-05	CSNK2A1, STAT3, RAB9A, TP53, NFKB1, HSPA1A
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	4.940E-06	5.603E-05	SMAD3, SRC, STAT3, TP53, MMP9, NFKB1
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	1.211E-05	1.104E-04	SMAD3, SRC, KDR, MET, EGFR, HSPA1A, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.302E-05	1.124E-04	SMAD3, MMP2, STAT3, PIM1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.181E-05	1.104E-04	SRC, MMP2, MMP9, EGFR, HSPA1A
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.691E-07	4.623E-06	CA12, CA2, CA7, CA14
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	3.134E-05	2.447E-04	CSNK2A1, STAT3, CDK1, TP53, NFKB1, HSPA1A
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	3.404E-05	2.537E-04	POLB, SRC, STAT3, CDK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.567E-05	2.105E-04	FLT3, STAT3, PIM1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	4.912E-05	3.222E-04	SMAD3, INSR, STAT3, EGFR, IGF1R
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	4.321E-05	3.081E-04	SMAD3, STAT3, RORC, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.140E-04	6.029E-04	MAPT, TP53, EGFR, NFKB1, HSPA1A, CDC25B
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.870E-05	3.222E-04	FLT3, TP53, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	6.119E-05	3.584E-04	TP53, MET, EGFR, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5.163E-05	3.257E-04	SRC, MET, EGFR, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.477E-04	7.570E-04	TP53, EGFR, NFKB1, IGF1R
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.824E-04	9.066E-04	INSR, TP53, NFKB1, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6.824E-05	3.859E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	3.480E-04	1.631E-03	SRC, KDR, MET, EGFR, IGF1R
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.119E-05	3.584E-04	CA2, NR1H4, ATP1A1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.075E-04	5.875E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	6.832E-04	3.028E-03	STAT3, TP53, EGFR, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	5.249E-04	2.391E-03	SMAD3, CDK1, TP53, CDC25B
09160 Human Diseases	09167 Infectious diseases	hsa05168	Herpes simplex infection	2.308E-03	8.379E-03	CSNK2A1, CDK1, TP53, NFKB1
09150 Organismal Systems	09149 Aging	hsa04213	Longevity regulating pathway - multiple species	9.390E-04	4.027E-03	INSR, HSPA1A, IGF1R
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	9.823E-04	4.027E-03	TP53, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.321E-03	5.160E-03	SRC, STAT3, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.375E-03	5.245E-03	SMAD3, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	2.585E-03	9.021E-03	SRC, MMP2, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.269E-03	5.076E-03	PAX8, ATP1A1, TSHR
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.823E-04	4.027E-03	CYP1A2, CYP1A1, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	2.350E-03	8.379E-03	SRC, CDK1, EGFR
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.343E-04	1.130E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.150E-03	8.014E-03	CA2, ATP1A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; NFKB1; FLT3; ACHE; TEK; MMP9; EGFR; SRC; STAT3; ATP1A1; TP53; MMP2; CDC25B;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	ATP1A1;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR; SRC; STAT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; MAPT;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ATP1A1;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	SRC;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypoglycemia	E16.0-E16.2	INSR;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	TEK; SRC;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9; EGFR; TP53;
NA: NA	Congestive cardiac insufficiency	NA	ATP1A1;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	INSR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR; TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Hunter syndrome	E76.1	INSR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE; CA2;
C00-D49: Neoplasms	Advanced breast cancer	C50	SRC;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; INSR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; EGFR; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
NA: NA	Upper abdominal bloating	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ATP1A1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR; MMP2;
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	SRC;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1/2 diabetes	E08-E13	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	INSR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperhidrosis	R61	ATP1A1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperglycaemia in type 2 diabetes	E11, R73.9	INSR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	INSR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	INSR; AKR1B1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; EGFR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; EGFR; STAT3;
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Lymphoma	C81-C86	INSR; EGFR;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR; TEK;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	INSR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; SRC; TP53;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; STAT3;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; EGFR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR; MMP2;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR; AKR1B1; TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ATP1A1;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	ATP1A1;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; MMP1; TYR;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; SRC;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ATP1A1;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; INSR; EGFR;
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR; SRC;
K00-K95: Diseases of the digestive system	Crohn's disease	K50	INSR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
NA: NA	Arrhythmias	NA	ATP1A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	TEK; MMP1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; TEK; MMP9; EGFR; SRC; STAT3; TP53; MMP2;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; INSR; MAPT;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases