Plant ID: NPO17954
Plant Latin Name: Narcissus Tazetta
Taxonomy Genus: Narcissus
Taxonomy Family: Amaryllidaceae
NCBI TaxonomyDB:
54860
Plant-of-the-World-Online:
66240-1
Analgesic; Antiphlogistic; Cancer; Demulcent; Emetic; Poultice
Turkey; Afghanistan; Italy; Turkmenistan; France; Australia; Iran; Algeria; China; Iraq; Spain; Libya; United States; Morocco; New Zealand; Russia; Albania; Portugal; Mexico; Egypt; Tajikistan; South Africa; India; Uzbekistan; Tunisia; Greece; Japan; Cyprus
Ingredient ID: NPC93376
Ingredient ID: NPC90096
Ingredient ID: NPC78359
Ingredient ID: NPC7645
Ingredient ID: NPC74418
Ingredient ID: NPC68464
Ingredient ID: NPC62307
Ingredient ID: NPC57954
Ingredient ID: NPC5290
Ingredient ID: NPC477640
Ingredient ID: NPC41518
Ingredient ID: NPC312971
Ingredient ID: NPC307122
Ingredient ID: NPC294438
Ingredient ID: NPC287207
Ingredient ID: NPC272713
Ingredient ID: NPC271974
Ingredient ID: NPC267691
Ingredient ID: NPC266176
Ingredient ID: NPC261681
Ingredient ID: NPC261096
Ingredient ID: NPC252960
Ingredient ID: NPC248222
Ingredient ID: NPC247312
Ingredient ID: NPC244940
Ingredient ID: NPC241909
Ingredient ID: NPC230301
Ingredient ID: NPC218614
Ingredient ID: NPC213832
Ingredient ID: NPC213645
Ingredient ID: NPC189224
Ingredient ID: NPC179215
Ingredient ID: NPC17810
Ingredient ID: NPC16712
Ingredient ID: NPC162742
Ingredient ID: NPC146563
Ingredient ID: NPC14319
Ingredient ID: NPC136923
Ingredient ID: NPC129854
Ingredient ID: NPC118246
Ingredient ID: NPC113733
Ingredient ID: NPC110676
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 36 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00230997 | Safety and Efficacy of Galantamine in Patients With Dementia With Lewy Bodies | Lewy body dementia | Galantamine (NPC78359) | NP level |
NCT00000172 | Evaluation of Galantamine in the Treatment of Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00969696 | Galantamine Effects on Cognitive Function in Marijuana Users | memory impairment | Galantamine (NPC78359) | NP level |
NCT03124355 | Vagal Stimulation in POTS | orthostatic hypotension | Galantamine (NPC78359) | NP level |
NCT00814658 | The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life | Dementia | Galantamine (NPC78359) | NP level |
NCT01669538 | Effect of Galantamine on Short-term Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT02365285 | Racial Differences in Vagal Control of Glucose Homeostasis | obesity | Galantamine (NPC78359) | NP level |
NCT01417429 | Galantamine Effects on Nicotine Responses in Smokers | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT00463879 | Galantamine for Cognitive Deficits in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT02872857 | Subarachnoid Hemorrhage Recovery And Galantamine | subarachnoid hemorrhage | Galantamine (NPC78359) | NP level |
NCT00809835 | Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse | cocaine dependence | Galantamine (NPC78359) | NP level |
NCT02374567 | Pharmacovigilance in Gerontopsychiatric Patients | anxiety;depressive disorder;schizophrenia;Dementia | Galantamine (NPC78359) | NP level |
NCT00301574 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
NCT01677754 | A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
NCT00814801 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT01012167 | Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT02234752 | Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia | schizoaffective disorder;schizophrenia | Galantamine (NPC78359) | NP level |
NCT00304629 | Long-term Safety and Efficacy of Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT02248636 | Cholinesterase Inhibitor Discontinuation | Dementia | Galantamine (NPC78359) | NP level |
NCT03384784 | Effect of Galantamine on Inflammation and Cognition | HIV infection | Galantamine (NPC78359) | NP level |
NCT00035191 | A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia | vascular dementia | Galantamine (NPC78359) | NP level |
NCT00252603 | Galantamine Versus Placebo in Childhood Autism | autism | Galantamine (NPC78359) | NP level |
NCT01039194 | Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER) | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00645190 | A Randomized, Double-blind, Flexible Dose, Multicenter Study to Evaluate the Effectiveness and Safety of Galantamine IR in Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00275418 | Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease | Crohn's disease | Beta Carotene (NPC17810) | NP level |
NCT01100775 | Effects of Galantamine on Cognition | schizophrenia | Galantamine (NPC78359) | NP level |
NCT01548638 | Effect of Galantamine on Smoking Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT01372306 | Galantamine Bioequivalence Study of Dr. Reddy's Under Fed Condition | Fish-eye disease | Galantamine (NPC78359) | NP level |
NCT00082602 | Safety and Tolerability Study of Extended Release (ER) Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00509067 | Use of Galantamine and CDP-choline (Citicoline) to Treat Adults With Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT00679627 | A Study of Galantamine Used to Treat Patients With Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00750529 | Alzheimer and Sleep | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
NCT00309725 | A Cardiac Safety Study of Galantamine in the Treatment of Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT00463879,NCT02374567,NCT01100775,NCT00509067,NCT02234752,NCT01012167
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
NCT02248636,NCT00230997,NCT00814658,NCT02374567 |
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
F2,SLCO1B1,ACHE,BCHE
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT01417429,NCT01669538,NCT01548638
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
F2,BCHE,SLCO1B1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
BCHE,ACHE,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2,ACHE,BCHE
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,ACHE,SLCO1B1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
NCT00000541 |
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ACHE,BCHE
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
BCHE,ACHE
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2,F3
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT00000152,NCT00000161
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
BCHE,ACHE
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,SLCO1B1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ACHE,F3
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
F2,SLCO1B1
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F2,F3
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
F2,SLCO1B1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ACHE,SLCO1B1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ACHE,F3
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
BCHE,ACHE
NCT00309725,NCT00000172,NCT00750529,NCT00301574,NCT00082602,NCT00304629,NCT00814801,NCT00679627,NCT00645190,NCT01039194,NCT01677754 |
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
BCHE
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
F3
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
F2
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Eexposure to noxious substances harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE61 |
BCHE
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ACHE
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
F2
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
F2
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT00000541
|
HypoalphalipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C81.0 |
NCT01372306
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
NCT00000161
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02365285
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
NCT03124355
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00809835
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT00252603
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT02374567
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
NCT00275418
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT00969696
|
Dementia due to cerebrovascular diseaseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D81 |
NCT00035191
|
Subarachnoid haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B01 |
NCT02872857
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
NCT02234752
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
NCT02374567
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT03384784
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
F3
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
BCHE
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ACHE
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
SLCO1B1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ACHE
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
F2
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
F3
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ACHE
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
BCHE
|