CMAUP Plant Collective Molecular Activities

Plant Name: Ajuga decumbens

Taxonomic Information:

Plant ID: NPO17539
Plant Latin Name: Ajuga decumbens
Taxonomy Genus: Ajuga
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 167911
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Anticoagulant; Depurative; Febrifuge; Haemostatic; Miscellany

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; PKM; HSD17B1; NOX4; ALOX15; USP2; TNKS; TNKS2;
Chloride channel	CFTR;
Protein Kinase	GSK3B; SYK; FLT3; CDK6; CSNK2A1;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Oxidoreductase	MAOA; PTGS2; XDH;
Transcription Factor	HIF1A; TP53;
ATP-binding cassette	ABCG2; ABCC1;
Unclassified	HTT; NPC1; MAPT; THPO; TTR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Chloride channel	CFTR	Cystic fibrosis transmembrane conductance regulator	P13569	CHEMBL4051
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	GSK3B	Glycogen synthase kinase-3 beta	P49841	CHEMBL262
Protein Kinase	SYK	Tyrosine-protein kinase SYK	P43405	CHEMBL2599
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	TTR	Transthyretin	P02766	CHEMBL3194

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.089E-10	7.134E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.529E-10	1.204E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.384E-09	3.070E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4, PTGS2
MF	GO:0005488; binding	GO:0005496; steroid binding	1.142E-08	8.021E-06	AR, CYP3A4, ESR1, ESR2, HSD17B1, NPC1
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.600E-08	9.954E-06	ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH
BP	GO:0008152; metabolic process	GO:0016579; protein deubiquitination	4.190E-08	2.074E-05	AR, CFTR, ESR1, HIF1A, TNKS, TNKS2, TP53, USP2
MF	GO:0005488; binding	GO:0019899; enzyme binding	5.462E-07	1.775E-04	AR, CFTR, CYP1A1, CYP1A2, CYP3A4, ESR1, ESR2, GSK3B, HIF1A, HTT, MAPT, PTGS2, SYK, TNKS2, TP53, USP2
MF	GO:0005488; binding	GO:0042802; identical protein binding	5.630E-07	1.803E-04	ABCG2, ACHE, CSNK2A1, ESR1, ESR2, FLT3, HTT, MAPT, PKM, PTGS2, TP53, TTR, USP2, XDH
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	6.602E-07	1.997E-04	MAPT, NOX4, PTGS2, TP53, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	7.070E-07	2.081E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032501; multicellular organismal process	GO:0060736; prostate gland growth	9.709E-07	2.547E-04	AR, CYP19A1, ESR1
MF	GO:0005488; binding	GO:0034452; dynactin binding	9.709E-07	2.547E-04	GSK3B, HTT, MAPT
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	3.388E-06	6.768E-04	AR, CDK6, CSNK2A1, ESR1, FLT3, HIF1A, PTGS2, SYK, THPO, TSHR
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	3.377E-06	6.768E-04	ESR1, ESR2
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	7.623E-06	1.407E-03	CYP1A1, HIF1A, NOX4, PKM, PTGS2, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.727E-06	1.414E-03	CYP1A1, CYP1A2, CYP1B1
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	8.038E-06	1.446E-03	ABCG2, ACHE, AR, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FLT3, GSK3B, HIF1A, HTT, MAOA, MAPT, NOX4, NPC1, PKM, PTGS2, SYK, TDP1, TNKS, TNKS2, TP53, XDH
MF	GO:0005488; binding	GO:0002039; p53 binding	8.534E-06	1.523E-03	GSK3B, HIF1A, HTT, TP53
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	1.012E-05	1.722E-03	ALOX15, PTGS2
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	1.012E-05	1.722E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.026E-05	1.732E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0043065; positive regulation of apoptotic process	1.277E-05	2.064E-03	CYP1B1, GSK3B, HTT, MAPT, NOX4, PTGS2, TP53, XDH
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	1.501E-05	2.318E-03	CYP19A1, CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0008013; beta-catenin binding	1.602E-05	2.448E-03	AR, CSNK2A1, ESR1, GSK3B
BP	GO:0032501; multicellular organismal process	GO:0010575; positive regulation of vascular endothelial growth factor production	1.686E-05	2.544E-03	CYP1B1, HIF1A, PTGS2
BP	GO:0008152; metabolic process	GO:0008209; androgen metabolic process	1.886E-05	2.813E-03	CYP19A1, CYP3A4, ESR1
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	2.022E-05	2.915E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.022E-05	2.915E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	2.022E-05	2.915E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.022E-05	2.915E-03	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0080135; regulation of cellular response to stress	2.068E-05	2.963E-03	CDK6, GSK3B, HIF1A, MAPT, PTGS2, SYK, TP53, XDH
BP	GO:0051179; localization	GO:0051222; positive regulation of protein transport	2.537E-05	3.541E-03	ACHE, CFTR, GSK3B, HIF1A, PTGS2, SYK, TP53
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	2.578E-05	3.576E-03	ABCC1, ALOX15, SYK
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	2.841E-05	3.867E-03	CSNK2A1, HIF1A, MAPT
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	3.365E-05	4.468E-03	CYP1A1, CYP3A4
BP	GO:0009987; cellular process	GO:0043410; positive regulation of MAPK cascade	3.733E-05	4.867E-03	ALOX15, AR, FLT3, NOX4, SYK, THPO, XDH
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	4.422E-05	5.534E-03	ALOX15, PTGS2, SYK
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	4.743E-05	5.802E-03	CYP19A1, CYP1A2, NOX4, XDH
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	5.042E-05	6.100E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.042E-05	6.100E-03	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	5.761E-05	6.781E-03	ALOX15, ESR1, GSK3B, MAPT, TP53
MF	GO:0005488; binding	GO:0000166; nucleotide binding	5.969E-05	6.875E-03	ABCC1, ABCG2, CDK6, CFTR, CSNK2A1, FLT3, GSK3B, HSD17B1, NOX4, PKM, SYK, TP53, XDH
MF	GO:0005488; binding	GO:0001085; RNA polymerase II transcription factor binding	6.270E-05	7.038E-03	AR, ESR1, GSK3B, TP53
BP	GO:0009987; cellular process	GO:0030154; cell differentiation	6.440E-05	7.191E-03	AR, CDK6, CYP1A1, ESR1, FLT3, GSK3B, HIF1A, MAPT, NOX4, PTGS2, THPO, TP53
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	7.051E-05	7.715E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0070324; thyroid hormone binding	7.051E-05	7.715E-03	PKM, TTR
MF	GO:0005215; transporter activity	GO:0008559; xenobiotic transmembrane transporting ATPase activity	7.051E-05	7.715E-03	ABCC1, ABCG2
MF	GO:0005488; binding	GO:0046983; protein dimerization activity	7.156E-05	7.791E-03	ABCG2, ACHE, AR, FLT3, HIF1A, MAPT, PTGS2, TP53, TTR, XDH
BP	GO:0009987; cellular process	GO:0034605; cellular response to heat	7.994E-05	8.660E-03	MAPT, PTGS2, TP53
BP	GO:0008152; metabolic process	GO:0016125; sterol metabolic process	9.195E-05	9.863E-03	CFTR, CYP19A1, CYP1B1, NPC1
BP	GO:0032501; multicellular organismal process	GO:0048699; generation of neurons	9.390E-05	9.925E-03	CDK6, MAPT
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	9.390E-05	9.925E-03	CYP1A1, CYP1A2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.381E-04	2.017E-02	CFTR, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, NOX4, PTGS2
CC	Unclassified;	GO:0043234; protein complex	2.859E-04	2.309E-02	AR, CDK6, CFTR, CSNK2A1, ESR1, FLT3, GSK3B, HIF1A, HTT, MAPT, PTGS2, SYK, TNKS, TP53, TTR
CC	GO:0043226; organelle	GO:0000242; pericentriolar material	6.283E-04	4.059E-02	TNKS, TNKS2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.301E-10	1.029E-07	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.827E-08	1.753E-06	HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.713E-07	2.391E-05	MAOA, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.494E-07	1.444E-05	CYP1A2, CYP1A1, CYP1B1, CYP3A4, PTGS2
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.850E-06	1.292E-04	AR, GSK3B, CDK6, FLT3, PTGS2, HIF1A, TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	6.249E-06	1.292E-04	PKM, FLT3, TP53, HIF1A
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.806E-06	1.560E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.627E-05	5.738E-04	PKM, MAOA, HSD17B1, CYP1A2, ALOX15, CYP1A1, PTGS2, CYP3A4, CYP19A1, XDH
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	5.861E-05	6.607E-04	GSK3B, TP53, ESR1, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	1.018E-04	9.707E-04	GSK3B, CDK6, CSNK2A1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.895E-05	2.937E-04	CYP1A2, ALOX15, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.805E-04	1.599E-03	ABCC1, CDK6, CYP1B1, PTGS2, TP53
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	6.742E-05	6.967E-04	ABCC1, CFTR, ABCG2
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	4.619E-04	2.921E-03	GSK3B, SYK, CSNK2A1, TP53
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	4.883E-04	2.921E-03	CDK6, PKM, SYK, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	2.933E-04	2.020E-03	GSK3B, ESR1, ESR2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.167E-04	1.791E-03	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.586E-04	2.004E-03	MAOA, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	5.469E-04	3.082E-03	GSK3B, AR, TP53
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.814E-04	2.020E-03	CYP3A4, CFTR, ABCG2
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	4.947E-04	2.921E-03	CDK6, PTGS2, TP53
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.067E-03	5.512E-03	MAOA, ALOX15, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	6.218E-04	3.352E-03	SYK, CSNK2A1, PTGS2
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	1.430E-03	7.095E-03	GSK3B, CDK6, TP53
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.139E-05	4.325E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases