China
Ingredient ID: NPC88923
Ingredient ID: NPC86148
Ingredient ID: NPC84786
Ingredient ID: NPC77777
Ingredient ID: NPC75457
Ingredient ID: NPC71074
Ingredient ID: NPC66333
Ingredient ID: NPC60946
Ingredient ID: NPC52289
Ingredient ID: NPC472209
Ingredient ID: NPC471593
Ingredient ID: NPC469501
Ingredient ID: NPC469470
Ingredient ID: NPC469462
Ingredient ID: NPC469461
Ingredient ID: NPC469460
Ingredient ID: NPC46354
Ingredient ID: NPC45462
Ingredient ID: NPC4051
Ingredient ID: NPC319522
Ingredient ID: NPC317876
Ingredient ID: NPC315634
Ingredient ID: NPC30676
Ingredient ID: NPC302462
Ingredient ID: NPC293454
Ingredient ID: NPC28804
Ingredient ID: NPC286880
Ingredient ID: NPC263672
Ingredient ID: NPC249078
Ingredient ID: NPC248068
Ingredient ID: NPC247928
Ingredient ID: NPC246229
Ingredient ID: NPC230691
Ingredient ID: NPC225518
Ingredient ID: NPC22502
Ingredient ID: NPC224878
Ingredient ID: NPC223573
Ingredient ID: NPC217156
Ingredient ID: NPC210327
Ingredient ID: NPC198868
Ingredient ID: NPC191899
Ingredient ID: NPC189661
Ingredient ID: NPC182442
Ingredient ID: NPC176130
Ingredient ID: NPC152152
Ingredient ID: NPC142301
Ingredient ID: NPC142167
Ingredient ID: NPC13565
Ingredient ID: NPC127046
Ingredient ID: NPC126707
Ingredient ID: NPC11917
Ingredient ID: NPC111845
Ingredient ID: NPC110364
Ingredient ID: NPC109813
Ingredient ID: NPC108737
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Therapeutic Target | Oxidoreductase | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
Therapeutic Target | Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 7 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00000499 | Systolic Hypertension in the Elderly Program (SHEP) (Pilot Study) | heart disease;hypertension | Reserpine (NPC88923) | NP level |
NCT00033033 | Reserpine for the Treatment of Cocaine Dependence - 1 | cocaine dependence | Reserpine (NPC88923) | NP level |
NCT00267657 | A Phase 1 Parallel-Group, Double-Blind, Placebo-Controlled Cardiovascular and Behavioral Study Assessing Interactions Between Single Doses of Oral Reserpine and Intravenous Methamphetamine - 1 | methamphetamine dependence | Reserpine (NPC88923) | NP level |
NCT02684786 | A Study of Stellate Ganglion Block and / or Reserpine in Group 2 Pulmonary Hypertension | pulmonary arterial hypertension | Reserpine (NPC88923) | NP level |
NCT00000620 | Action to Control Cardiovascular Risk in Diabetes (ACCORD) | atherosclerosis;coronary artery disease;Hypercholesterolemia;type 2 diabetes mellitus;hypertension | Reserpine (NPC88923) | NP level |
NCT00000514 | Systolic Hypertension in the Elderly Program (SHEP) | cerebrovascular disorder;heart disease;hypertension | Reserpine (NPC88923) | NP level |
NCT03223272 | Mechanisms of Refractory Hypertension (Reserpine) | hypertension | Reserpine (NPC88923) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
SLC18A2
NCT00000499,NCT03223272,NCT00000620,NCT02684786,NCT00000514 |
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
HSD11B1,PTGS1,CNR2,ABCB1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
PTGS1,HSD11B1,SLC18A2
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PTGS1,HSD11B1
NCT00000620 |
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
PTGS1,CNR2,ABCB1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
PTGS1,SLC18A2,CNR2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2,PTGS1
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CNR2
HSD11B1 |
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
HSD11B1,CNR2
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
HSD11B1,PTGS1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
CNR2,PTGS1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
PTGS1,ABCB1
|
Ischemic heart diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40-BA6Z |
NCT00000499,NCT00000514
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
PTGS1,SLC18A2
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HSD11B1,CNR2
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CNR2,ABCB1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
SLC18A2,CNR2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
SLC18A2,CYP1A2
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
HSD11B1
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
PTGS1
|
Tic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A05 |
SLC18A2
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
PTGS1
|
Cerebral ischaemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B1Z |
PTGS1
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
HSD11B1
|
Unspecific substance use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4Z |
SLC18A2
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
PTGS1
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ABCB1
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
HSD11B1
|
Eye anterior segment structural developmental anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA11 |
PTGS1
|
Otitis mediaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA80-AB0Z |
PTGS1
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PTGS1
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
PTGS1
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CNR2
|
VasculitisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A44 |
PTGS1
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
HSD11B1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
PTGS1
|
Spinal painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84 |
PTGS1
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
PTGS1
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
CNR2
|
HIV-infected patients with tuberculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B10-1B14 |
PTGS1
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
PTGS1
|
Movement disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A07-8A0Z |
SLC18A2
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
SLC18A2
|
Reactive arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA11 |
PTGS1
|
Joint painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME82 |
PTGS1
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
ABCB1
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
PTGS1
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
HSD11B1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
PTGS1
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
PTGS1
|
Dystonic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A02 |
SLC18A2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HSD11B1
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
HSD11B1
|
Inherited coagulation factor deficiencyDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B14 |
PTGS1
|
Ataxic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A03 |
PTGS1
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
PTGS1
|
Inflammatory spondyloarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA92 |
PTGS1
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
PTGS1
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
PTGS1
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
SLC18A2
|
Dissociative neurological symptom disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B60 |
SLC18A2
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
PTGS1
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
CNR2
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
PTGS1
|
Urinary system diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC2Z |
PTGS1
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
PTGS1
|
Cerebrovascular diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B22-8B2Z |
NCT00000514
|
HypercholesterolaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.0 |
NCT00000620
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00033033
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT00000620
|
Stimulant dependence including amphetamines, methamphetamine or methcathinoneDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C46.2 |
NCT00267657
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
NCT00000620
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
PTGS1
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CYP1A2
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
HSD11B1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
PTGS1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
CNR2
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP1A2
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
SLC18A2
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CNR2
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
CNR2
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
PTGS1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
HSD11B1
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
PTGS1
|