Bangladesh; Myanmar; Indonesia; India; Cambodia; Malaysia; Vietnam; China; Laos; Sri Lanka; Thailand
Ingredient ID: NPC94488
Ingredient ID: NPC94351
Ingredient ID: NPC80710
Ingredient ID: NPC78263
Ingredient ID: NPC71002
Ingredient ID: NPC7029
Ingredient ID: NPC53109
Ingredient ID: NPC46436
Ingredient ID: NPC35446
Ingredient ID: NPC310870
Ingredient ID: NPC304543
Ingredient ID: NPC294409
Ingredient ID: NPC284264
Ingredient ID: NPC279668
Ingredient ID: NPC277947
Ingredient ID: NPC270456
Ingredient ID: NPC262359
Ingredient ID: NPC257566
Ingredient ID: NPC245889
Ingredient ID: NPC243728
Ingredient ID: NPC243272
Ingredient ID: NPC236322
Ingredient ID: NPC233752
Ingredient ID: NPC230301
Ingredient ID: NPC228024
Ingredient ID: NPC226333
Ingredient ID: NPC225562
Ingredient ID: NPC225434
Ingredient ID: NPC222522
Ingredient ID: NPC22152
Ingredient ID: NPC221085
Ingredient ID: NPC218041
Ingredient ID: NPC192810
Ingredient ID: NPC192638
Ingredient ID: NPC182428
Ingredient ID: NPC181465
Ingredient ID: NPC168657
Ingredient ID: NPC152722
Ingredient ID: NPC147310
Ingredient ID: NPC143427
Ingredient ID: NPC143168
Ingredient ID: NPC135350
Ingredient ID: NPC112368
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Therapeutic Target | Isomerase | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
Therapeutic Target | Unclassified protein | MPEG1 | Macrophage-expressed gene 1 protein | Q2M385 | CHEMBL3414409 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2,CYP2C9,MPEG1,GPR84,MAOB,PTGES,ALOX5,CES1,CA7
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CYP2C9,GPR84,ALOX5,CYP19A1,F2,GPR84,ALOX5
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CA12,CYP2C9,F2,MPEG1,GPR84,MAPK1,ALOX5
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
MPEG1,GPR84,PTGES,ALOX5,CA12,CA7
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,CYP2C9,GPR84,PTGES,CA12,CA7
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA12,MPEG1,GPR84,PTGES,ALOX5
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
F2,CYP2C9,PTGES,CA12,CA7
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CYP19A1,PTGES,CA12,CYP19A1,CA12
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
XIAP,MAPK1,ALOX5,CA12
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
GPR84,PTGES,CYP19A1,CA7
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA12,MPEG1,GPR84,CYP19A1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CYP19A1,PTGES,CA12,CA7
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
XIAP,CYP19A1,CA12
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12,PTGES,MPEG1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
GPR84,ALOX5,PTGES
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CYP19A1,PTGES,CA12
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,GPR84,CYP19A1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CA12,MAOB,PTGES
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12,ALOX5,CA7
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
F2,CYP2C9,GPR84
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
CYP19A1,GPR84,PTGES
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP2C9,MPEG1,PTGES
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2,ALOX5
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2,ALOX5
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
ALOX5,GPR84
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
GPR84,F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAOB,PTGES
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
XIAP,ALOX5
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
F2
GPR84 |
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12,CYP2C9
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
GPR84,MPEG1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
CYP19A1,GPR84
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
GPR84,PTGES
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP2C9,GPR84
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA12,GPR84
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
GPR84,PTGES
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
GPR84,MPEG1
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
MAOB
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOB
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ALOX5
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Skin cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30-2C37 |
MAOB
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
XIAP
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
MAOB
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
XIAP
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ALOX5
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
XIAP
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
CYP19A1
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MAOB
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
ALOX5
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
MAOB
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
XIAP
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
MAOB
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
CES1
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ALOX5
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CYP19A1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
ALOX5
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
MAPK1
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
XIAP
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Primary psychotic disorder manifestationDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A25 |
MAOB
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
MAOB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
XIAP
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
F2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
MAOB
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAOB
|
Peroxisomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C57 |
CES1
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MAPK1
|
Synthesis disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52-5C59 |
CES1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ALOX5
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
MAOB
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
XIAP
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ALOX5
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
CYP19A1
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
CYP19A1
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
CES1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
XIAP
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
MAOB
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
ALOX5
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
GPR84
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
PTGES
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
CYP2C9
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
GPR84
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
F2
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F2
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
F2
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
GPR84
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
PTGES
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP2C9
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
GPR84
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
XIAP
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA12
|