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Plant Name: Sedum sarmentosum


Taxonomic Information:

Plant ID: NPO13353
Plant Latin Name: Sedum sarmentosum
Taxonomy Genus: Sedum
Taxonomy Family: Crassulaceae

Plant External Links:

NCBI TaxonomyDB: 91146
Plant-of-the-World-Online: n.a.


Used in Medicines:

Country/Region:
South Korea; China

Traditional Medicine System:
TCM


Geographical Distribution:

South Korea; China

Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available



Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
CNR2;
Peptide receptor (family A GPCR)
NPSR1;
Hydrolase
ACHE;
Protein Kinase
AXL; MET; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase
CA12; CA7; CA4;
Nuclear hormone receptor subfamily 2 group B
RXRA;
Oxidoreductase
TYR;
Enzyme_unclassified
ALOX12; HSD17B2; HSD17B10; NOX4; POLB;
Metallo protease
MMP2;
Transcription Factor
AHR;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Nuclear hormone receptor subfamily 2 group B RXRA Retinoid X receptor alpha P19793 CHEMBL2061
Oxidoreductase TYR Tyrosinase P14679 CHEMBL1973
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Small molecule receptor (family A GPCR) CNR2 Cannabinoid CB2 receptor P34972 CHEMBL253
Transcription Factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 2.582E-07 4.324E-04 CYP1A1, CYP1A2, CYP1B1
MF GO:0005488; binding GO:0019825; oxygen binding 3.700E-07 5.443E-04 CYP1A1, CYP1A2, CYP1B1, NOX4
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 9.745E-07 1.010E-03 CA12, CA4, CA7
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 2.833E-06 2.460E-03 CYP1A1, CYP1A2, CYP1B1
BP GO:0050896; response to stimulus GO:0033993; response to lipid 3.148E-06 2.539E-03 AXL, CNR2, CYP1A1, CYP1A2, FLT3, HSD17B2, RXRA, TYR
BP GO:0008152; metabolic process GO:0009404; toxin metabolic process 3.766E-06 2.608E-03 CYP1A1, CYP1A2, CYP1B1
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 3.766E-06 2.608E-03 CYP1A1, CYP1A2, CYP1B1
BP GO:0008152; metabolic process GO:0018108; peptidyl-tyrosine phosphorylation 4.379E-06 2.664E-03 AXL, FLT3, IGF1R, KDR, MET
BP GO:0008152; metabolic process GO:0046777; protein autophosphorylation 5.654E-06 3.078E-03 AURKB, FLT3, IGF1R, KDR, PIM1
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 1.044E-05 5.014E-03 CYP1A1, CYP1A2
BP GO:0032502; developmental process GO:0007568; aging 1.255E-05 5.157E-03 AURKB, CDK1, CYP1A1, NOX4, POLB
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.501E-05 5.942E-03 CA12, CA4, CA7
BP GO:0008152; metabolic process GO:0055114; oxidation-reduction process 1.563E-05 5.973E-03 ALOX12, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, NOX4, TYR
BP GO:0008152; metabolic process GO:0008202; steroid metabolic process 1.734E-05 6.293E-03 CYP1A1, CYP1A2, CYP1B1, HSD17B2, RXRA
MF GO:0005488; binding GO:0020037; heme binding 2.456E-05 8.104E-03 CYP1A1, CYP1A2, CYP1B1, NOX4
BP GO:0051179; localization GO:0015701; bicarbonate transport 2.764E-05 8.584E-03 CA12, CA4, CA7
BP GO:0050896; response to stimulus GO:0010035; response to inorganic substance 2.778E-05 8.584E-03 AXL, CDK1, CYP1A1, CYP1A2, CYP1B1, KDR
CC GO:0016020; membrane GO:0016020; membrane 3.071E-05 9.287E-03 ACHE, ALOX12, AXL, CA12, CA4, CDK1, CNR2, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B10, HSD17B2, IGF1R, KDR, MET, MMP2, NOX4, NPSR1, PIM1, TYR
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)


Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways
Pathway Category Top Level Pathway Category Second Level Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
09150 Organismal Systems 09152 Endocrine system hsa04913 Ovarian steroidogenesis 4.961E-07 3.363E-05 HSD17B2, CYP1A1, CYP1B1, IGF1R
09100 Metabolism 09103 Lipid metabolism hsa00140 Steroid hormone biosynthesis 9.075E-07 3.363E-05 CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism 09105 Amino acid metabolism hsa00380 Tryptophan metabolism 1.866E-05 3.593E-04 CYP1A2, CYP1A1, CYP1B1
09100 Metabolism 09102 Energy metabolism hsa00910 Nitrogen metabolism 1.310E-06 3.363E-05 CA12, CA4, CA7
09160 Human Diseases 09161 Cancers hsa05200 Pathways in cancer 1.401E-04 1.349E-03 RXRA, FLT3, MMP2, MET, IGF1R
09160 Human Diseases 09161 Cancers hsa05205 Proteoglycans in cancer 1.293E-04 1.349E-03 MMP2, KDR, MET, IGF1R
09160 Human Diseases 09161 Cancers hsa05202 Transcriptional misregulation in cancer 8.125E-05 1.251E-03 RXRA, FLT3, MET, IGF1R
09100 Metabolism 09111 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1.142E-04 1.349E-03 CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing 09132 Signal transduction hsa04151 PI3K-Akt signaling pathway 9.227E-04 7.105E-03 RXRA, KDR, MET, IGF1R
09160 Human Diseases 09161 Cancers hsa05204 Chemical carcinogenesis 1.613E-04 1.380E-03 CYP1A2, CYP1A1, CYP1B1
Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Associated Disease Targets
(Association Ref: TTD database)
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R;
C00-D49: Neoplasms Acute myeloid leukemia C92.0 AURKB; FLT3;
C00-D49: Neoplasms Gliosarcoma NA FLT3;
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; KDR;
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE;
C00-D49: Neoplasms Colorectal cancer C18-C21 IGF1R; KDR; FLT3;
C00-D49: Neoplasms Colon cancer C50 FLT3;
C00-D49: Neoplasms Solid tumours C00-D48 MET; AURKB; IGF1R; KDR; FLT3; MMP2;
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR;
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE;
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR;
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE;
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3;
C00-D49: Neoplasms Prostate cancer C61 FLT3;
C00-D49: Neoplasms Lung cancer C33-C34 MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 CNR2;
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 CNR2; TYR;
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R;
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue Melasma L81.1 TYR;
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R;
NA: NA HIV infections NA AHR;
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET;
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3;
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 ACHE;
C00-D49: Neoplasms Multiple myeloma C90 IGF1R; AHR;
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE;
C00-D49: Neoplasms Hematological malignancies C81-C86 AURKB;
NA: NA Hematopoietic stem cell transplantation NA FLT3;
C00-D49: Neoplasms Renal cell carcinoma NA KDR; MMP2;
C00-D49: Neoplasms Renal cancer C64 KDR;
C00-D49: Neoplasms AML NA KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 ACHE;
C00-D49: Neoplasms Cutaneous T-cell lymphoma C84.0, C84.1 RXRA;
C00-D49: Neoplasms Breast cancer C50 CDK1; IGF1R; KDR; FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 FLT3;
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3;
NA: NA GIST NA FLT3;
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 ACHE;
C00-D49: Neoplasms Glioma C71 KDR;
C00-D49: Neoplasms Glioblastoma NA FLT3;
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 CNR2; CDK1; IGF1R; ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2;
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR;
C00-D49: Neoplasms Thyroid cancer C73 KDR;
C00-D49: Neoplasms Ovarian cancer C56 KDR; MMP2;
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 CNR2;
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR;
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET;
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 MMP2;
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE;
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R;
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R;
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 CA4;
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE;
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 KDR;
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms Non-small-cell lung cancer NA KDR; MMP2;
C00-D49: Neoplasms Leukemia C90-C95 FLT3;
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3;
C00-D49: Neoplasms Melanoma C43 KDR; TYR;
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR;
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 CNR2;
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1;
C00-D49: Neoplasms Cancer C00-C96 PIM1; MET; CDK1; IGF1R; KDR; FLT3; ACHE; MMP2;
NA: NA Early satiation associated with functional dyspepsia NA ACHE;
C00-D49: Neoplasms Biliary cancer C22, C24 KDR;
C00-D49: Neoplasms Metastasis C00-C97 AXL;
C00-D49: Neoplasms Metastatic breast cancer C50 KDR;
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR;
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 CA4; ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE;
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET;
C00-D49: Neoplasms Myeloid leukemia C92 FLT3;
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET;
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE;
NA: NA Upper abdominal bloating NA ACHE;
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Immune disorder D80-D89 CNR2;
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 CNR2;
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 CNR2;
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR;
C00-D49: Neoplasms Myelodysplastic syndrome D46 KDR;
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR;
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 TYR;
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 ACHE;
C00-D49: Neoplasms Pancreatic cancer C25 KDR; FLT3; MMP2;
C00-D49: Neoplasms Gastric cancer C16 KDR;
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET;
C00-D49: Neoplasms CLL NA FLT3;
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET;
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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