Antibacterial; Antiinflammatory; Antipyretic; Antiseptic; Antitussive; Cancer; Diuretic; Expectorant; Infertility; Nervine; Sialagogue; Stomachic; Tonic
South Africa; Philippines; Indonesia; Cambodia; Vietnam; China; Laos; Japan; Taiwan
Ingredient ID: NPC98382
Ingredient ID: NPC93950
Ingredient ID: NPC87898
Ingredient ID: NPC83296
Ingredient ID: NPC82664
Ingredient ID: NPC74478
Ingredient ID: NPC70741
Ingredient ID: NPC70314
Ingredient ID: NPC4925
Ingredient ID: NPC47319
Ingredient ID: NPC46190
Ingredient ID: NPC39591
Ingredient ID: NPC34908
Ingredient ID: NPC34176
Ingredient ID: NPC32955
Ingredient ID: NPC322197
Ingredient ID: NPC318650
Ingredient ID: NPC317207
Ingredient ID: NPC310338
Ingredient ID: NPC297348
Ingredient ID: NPC293444
Ingredient ID: NPC292730
Ingredient ID: NPC281298
Ingredient ID: NPC273855
Ingredient ID: NPC266932
Ingredient ID: NPC255038
Ingredient ID: NPC249204
Ingredient ID: NPC248944
Ingredient ID: NPC24795
Ingredient ID: NPC24469
Ingredient ID: NPC243728
Ingredient ID: NPC237461
Ingredient ID: NPC235779
Ingredient ID: NPC226945
Ingredient ID: NPC219530
Ingredient ID: NPC216520
Ingredient ID: NPC215584
Ingredient ID: NPC215377
Ingredient ID: NPC207356
Ingredient ID: NPC196776
Ingredient ID: NPC190830
Ingredient ID: NPC181810
Ingredient ID: NPC178981
Ingredient ID: NPC178853
Ingredient ID: NPC168101
Ingredient ID: NPC158823
Ingredient ID: NPC153370
Ingredient ID: NPC142753
Ingredient ID: NPC139617
Ingredient ID: NPC128572
Ingredient ID: NPC107482
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Therapeutic Target | Protein Kinase | FGFR4 | Fibroblast growth factor receptor 4 | P22455 | CHEMBL3973 |
Therapeutic Target | Protein Kinase | KIT | Stem cell growth factor receptor | P10721 | CHEMBL1936 |
Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 3 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01987908 | Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease | sickle cell anemia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
NCT01597401 | A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease | sickle cell anemia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
NCT01871142 | Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance | hypoxia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP1A2,CYP3A4,SLCO1B1,SLCO1B3
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
KIT,CYP1A2,CYP3A4,CYP1A1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
KIT,CYP3A4,FGFR4
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
SLCO1B1,FGFR4,SLCO1B3
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
SLCO1B1,SLCO1B3,FGFR4
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
SLCO1B1,CYP1A1,SLCO1B3
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
FGFR4,CYP1A1,SLCO1B3
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
KIT,SLCO1B1,FGFR4
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
KIT,CYP3A4,FGFR4
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
FGFR4,KIT
|
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT01987908,NCT01597401
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CYP1A2,SLCO1B3
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
SLCO1B1,SLCO1B3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
KIT,SLCO1B3
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
FGFR4,KIT
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
SLCO1B1,SLCO1B3
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1,SLCO1B3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SLCO1B1,SLCO1B3
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
KIT
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
KIT
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
KIT
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KIT
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
KIT
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
KIT
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
KIT
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
KIT
|
Malignant intestine neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C0Z |
KIT
|
MastocytosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A21 |
KIT
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
KIT
|
Bone/articular cartilage neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7B |
KIT
|
Phakomatoses/hamartoneoplastic syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2D |
KIT
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KIT
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
KIT
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
KIT
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
FGFR4
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
KIT
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KIT
|
AsphyxiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.1 |
NCT01871142
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
FGFR4
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
SLCO1B3
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
KIT
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
SLCO1B3
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
FGFR4
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
KIT
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
SLCO1B3
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FGFR4
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
SLCO1B3
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP1A1
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
KIT
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP3A4
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
FGFR4
|