Brazil; Madagascar; Bangladesh; Kenya; Sudan; Costa Rica; Cambodia; Bahamas; Ethiopia; Peru; Argentina; Bolivia; Venezuela; Malawi; Ecuador; Australia; Cuba; El Salvador; Zambia; Suriname; Guatemala; Zimbabwe; China; Thailand; Dominican Republic; Uganda; Pakistan; Indonesia; United States; Trinidad and Tobago; Gabon; Guyana; Honduras; Haiti; Jamaica; Angola; Chad; Mexico; Nicaragua; Uruguay; India; Mozambique; Colombia; Paraguay; French Guiana; Taiwan; Fiji
Ingredient ID: NPC78274
Ingredient ID: NPC66052
Ingredient ID: NPC63735
Ingredient ID: NPC62563
Ingredient ID: NPC47450
Ingredient ID: NPC46042
Ingredient ID: NPC43634
Ingredient ID: NPC42619
Ingredient ID: NPC41031
Ingredient ID: NPC36395
Ingredient ID: NPC31485
Ingredient ID: NPC311088
Ingredient ID: NPC310610
Ingredient ID: NPC295708
Ingredient ID: NPC288268
Ingredient ID: NPC288068
Ingredient ID: NPC281457
Ingredient ID: NPC271343
Ingredient ID: NPC264889
Ingredient ID: NPC240722
Ingredient ID: NPC23900
Ingredient ID: NPC226124
Ingredient ID: NPC225049
Ingredient ID: NPC215288
Ingredient ID: NPC206632
Ingredient ID: NPC205595
Ingredient ID: NPC204195
Ingredient ID: NPC19074
Ingredient ID: NPC189527
Ingredient ID: NPC173565
Ingredient ID: NPC157663
Ingredient ID: NPC156222
Ingredient ID: NPC145936
Ingredient ID: NPC136520
Ingredient ID: NPC13403
Ingredient ID: NPC130230
Ingredient ID: NPC128124
Ingredient ID: NPC127074
Ingredient ID: NPC120989
Ingredient ID: NPC116995
Ingredient ID: NPC114665
Ingredient ID: NPC110304
Ingredient ID: NPC110070
Ingredient ID: NPC106526
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Therapeutic Target | Protein Phosphatase | PTPRS | Receptor-type tyrosine-protein phosphatase S | Q13332 | CHEMBL2396508 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 9 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT04762758 | Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients | Charcot-Marie-Tooth disease | Sorbitol (NPC66052) | NP level |
NCT00374881 | A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects | pain | Sorbitol (NPC66052) | NP level |
NCT04573153 | Metabolic Cofactor Supplementation and Hydroxychloroquine Combination in Covid-19 Patients | COVID-19 | Sorbitol (NPC66052) | NP level |
NCT03636971 | Gait Analysis Following Knee Viscosupplementation | osteoarthritis | Sorbitol (NPC66052) | NP level |
NCT05450458 | Hyaluronic Acid in Overuse Knee Pain | injury | Sorbitol (NPC66052) | NP level |
NCT01528969 | Effect of Xylitol on Oral Microbiota in Children | bacterial disease | Sorbitol (NPC66052) | NP level |
NCT04330326 | Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Sorbitol (NPC66052) | NP level |
NCT03747679 | Palatability (Taste) of Oral Formulations of Bosutinib | chronic myelogenous leukemia | Sorbitol (NPC66052) | NP level |
NCT01474499 | A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation | Constipation | Sorbitol (NPC66052) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,KIT
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
KIT,PTPRS
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
KIT
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KIT
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
KIT
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
KIT
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
KIT
|
Phakomatoses/hamartoneoplastic syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2D |
KIT
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
KIT
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
KIT
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KIT
|
Bone/articular cartilage neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7B |
KIT
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
KIT
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
KIT
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
KIT
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
KIT
|
Malignant intestine neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C0Z |
KIT
|
Bone paget diseaseDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB85 |
PTPRS
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
KIT
|
MastocytosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A21 |
KIT
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KIT
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
KIT
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
KIT
|
Hereditary sensory or autonomic neuropathy, unspecifiedDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C21.Z |
NCT04762758
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04573153
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
NCT04330326
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
NCT01528969
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT00374881
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT03636971
|
Chronic myeloid leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4XG8 |
NCT03747679
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT01474499
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
NCT05450458
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
KIT
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
KIT
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
PTPRS
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
KIT
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CYP1B1
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
KIT
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP1B1
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
PTPRS
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP1B1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
KIT
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
KIT
|