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Plant Name: Epimedium sagittatum


Taxonomic Information:

Plant ID: NPO10969
Plant Latin Name: Epimedium sagittatum
Taxonomy Genus: Epimedium
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: 253616
Plant-of-the-World-Online: 107314-1


Used in Medicines:

Country/Region:
China

Traditional Medicine System:
TCM


Medicinal Functions:

Antirheumatic; Aphrodisiac; Carminative; Expectorant; Infertility; Kidney; Ophthalmic; Tonic; Vasodilator


Geographical Distribution:

Japan; China

Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available



Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Peptide receptor (family A GPCR)
TSHR; NPSR1;
Small molecule receptor (family A GPCR)
FFAR1; FFAR4;
Enzyme_unclassified
BLM; TDP1; ALOX12; HSD17B1; HSD17B2; HSD17B10; ALOX15; NOX4; POLB;
Phosphodiesterase 5
PDE5A;
Hydrolase
ACHE;
Protein Kinase
PIM1; MET; AXL; FLT3; CDK1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase
CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A
ESR2;
Oxidoreductase
TYR;
Lysine demethylase
KDM4E;
Metallo protease
MMP9; MMP1; MMP12; MMP2;
Transcription Factor
AHR; HIF1A; NFKB1;
Transferase
FUT7;
Unclassified
LMNA; FABP3; THPO;
Methyl-lysine/arginine binding protein
SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Enzyme_unclassified BLM Bloom syndrome protein P54132 CHEMBL1293237
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Metallo protease MMP1 Matrix metalloproteinase-1 P03956 CHEMBL332
Metallo protease MMP12 Matrix metalloproteinase 12 P39900 CHEMBL4393
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A ESR2 Estrogen receptor beta Q92731 CHEMBL242
Oxidoreductase TYR Tyrosinase P14679 CHEMBL1973
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Phosphodiesterase 5 PDE5A Phosphodiesterase 5A O76074 CHEMBL1827
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Small molecule receptor (family A GPCR) FFAR1 Free fatty acid receptor 1 O14842 CHEMBL4422
Small molecule receptor (family A GPCR) FFAR4 G-protein coupled receptor 120 Q5NUL3 CHEMBL5339
Transcription Factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified FABP3 Fatty acid binding protein muscle P05413 CHEMBL3344
Unclassified THPO Thrombopoietin P40225 CHEMBL1293256
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 4.489E-08 5.090E-05 CA12, CA2, CA4, CA7
MF GO:0005488; binding GO:0019825; oxygen binding 8.672E-08 7.553E-05 CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
BP GO:0008283; cell proliferation GO:0008284; positive regulation of cell proliferation 1.600E-07 1.124E-04 ALOX12, CDK1, CSNK2A1, FLT3, HIF1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, THPO, TSHR
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 2.870E-07 1.838E-04 CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP GO:0050896; response to stimulus GO:0033993; response to lipid 1.178E-06 5.343E-04 AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FFAR1, FLT3, HSD17B2, NFKB1, TYR
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 1.147E-06 5.343E-04 AHR, CSNK2A1, HIF1A, KDR
BP GO:0008152; metabolic process GO:0055114; oxidation-reduction process 1.402E-06 6.106E-04 ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B10, HSD17B2, KDM4E, NOX4, TYR
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 1.707E-06 7.014E-04 CYP1A1, CYP1A2, CYP1B1
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.865E-06 7.519E-04 CA12, CA2, CA4, CA7
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 2.291E-06 8.751E-04 HIF1A, MMP1, MMP12, MMP2, MMP9
MF GO:0005488; binding GO:0005506; iron ion binding 2.706E-06 1.016E-03 ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP GO:0008152; metabolic process GO:0006703; estrogen biosynthetic process 4.047E-06 1.397E-03 CYP19A1, HSD17B1, HSD17B2
BP GO:0051179; localization GO:0015701; bicarbonate transport 4.235E-06 1.397E-03 CA12, CA2, CA4, CA7
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 6.047E-06 1.730E-03 ALOX12, ALOX15
BP Unclassified; GO:0044236; multicellular organism metabolic process 6.423E-06 1.730E-03 HIF1A, MMP1, MMP12, MMP2, MMP9
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 6.047E-06 1.730E-03 ALOX12, ALOX15
BP GO:0008152; metabolic process GO:0046777; protein autophosphorylation 8.703E-06 2.229E-03 AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
MF GO:0005488; binding GO:0020037; heme binding 1.610E-05 3.577E-03 CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.811E-05 3.829E-03 CA2, CA7
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.811E-05 3.829E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.811E-05 3.829E-03 ALOX12, ALOX15
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 1.856E-05 3.886E-03 CYP1A1, CYP1A2, CYP1B1
BP GO:0008152; metabolic process GO:0030574; collagen catabolic process 2.033E-05 4.176E-03 MMP1, MMP12, MMP2, MMP9
BP GO:0008152; metabolic process GO:0009404; toxin metabolic process 2.463E-05 4.920E-03 CYP1A1, CYP1A2, CYP1B1
MF GO:0005488; binding GO:0008270; zinc ion binding 2.522E-05 4.993E-03 BLM, CA12, CA2, CA4, CA7, ESR2, MMP1, MMP12, MMP2, MMP9
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 3.617E-05 6.508E-03 CYP1A1, CYP1A2
BP GO:0032502; developmental process GO:0031100; animal organ regeneration 3.776E-05 6.739E-03 AXL, CDK1, CSNK2A1, FLT3
BP GO:0009987; cellular process GO:0022617; extracellular matrix disassembly 4.398E-05 7.600E-03 MMP1, MMP12, MMP2, MMP9
BP GO:0008152; metabolic process GO:0008610; lipid biosynthetic process 5.900E-05 9.636E-03 ACHE, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2
BP GO:0008152; metabolic process GO:0051122; hepoxilin biosynthetic process 6.018E-05 9.636E-03 ALOX12, ALOX15
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)


Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways
Pathway Category Top Level Pathway Category Second Level Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
09150 Organismal Systems 09152 Endocrine system hsa04913 Ovarian steroidogenesis 2.028E-09 2.657E-07 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09100 Metabolism 09103 Lipid metabolism hsa00140 Steroid hormone biosynthesis 5.092E-09 3.335E-07 HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases 09161 Cancers hsa05200 Pathways in cancer 4.233E-06 1.386E-04 FLT3, MMP1, MMP2, HIF1A, MET, MMP9, NFKB1, IGF1R
09160 Human Diseases 09161 Cancers hsa05205 Proteoglycans in cancer 8.737E-06 2.289E-04 MMP2, KDR, HIF1A, MMP9, MET, IGF1R
09100 Metabolism 09102 Energy metabolism hsa00910 Nitrogen metabolism 6.791E-08 2.966E-06 CA12, CA2, CA4, CA7
09160 Human Diseases 09161 Cancers hsa05202 Transcriptional misregulation in cancer 6.990E-05 1.526E-03 FLT3, MMP9, MET, NFKB1, IGF1R
09100 Metabolism 09105 Amino acid metabolism hsa00380 Tryptophan metabolism 1.204E-04 2.124E-03 CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases 09161 Cancers hsa05219 Bladder cancer 1.297E-04 2.124E-03 MMP1, MMP2, MMP9
09160 Human Diseases 09161 Cancers hsa05221 Acute myeloid leukemia 3.466E-04 5.045E-03 FLT3, PIM1, NFKB1
Unclassified Unclassified hsa01100 Metabolic pathways 6.041E-04 6.982E-03 FUT7, HSD17B1, HSD17B2, CYP1A2, ALOX15, CYP1A1, ALOX12, TYR, CYP19A1, HSD17B10
09160 Human Diseases 09161 Cancers hsa05206 MicroRNAs in cancer 7.090E-04 6.982E-03 PIM1, CYP1B1, MMP9, MET, NFKB1
09160 Human Diseases 09161 Cancers hsa05230 Central carbon metabolism in cancer 5.580E-04 6.982E-03 FLT3, MET, HIF1A
09100 Metabolism 09111 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 7.172E-04 6.982E-03 CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes 09144 Cellular community - eukaryotes hsa04520 Adherens junction 7.462E-04 6.982E-03 CSNK2A1, MET, IGF1R
09160 Human Diseases 09161 Cancers hsa05204 Chemical carcinogenesis 1.006E-03 8.784E-03 CYP1A2, CYP1A1, CYP1B1
Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Associated Disease Targets
(Association Ref: TTD database)
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR;
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9;
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR;
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET;
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 KDR;
C00-D49: Neoplasms Lung cancer C33-C34 MMP2;
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET;
C00-D49: Neoplasms Myeloid leukemia C92 FLT3;
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3;
C00-D49: Neoplasms Myelodysplastic syndrome D46 KDR;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 FFAR1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R;
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2;
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MMP12;
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1;
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 CDK1; IGF1R; ACHE;
C00-D49: Neoplasms Pancreatic cancer C25 KDR; FLT3; MMP2;
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R;
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2;
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1;
NA: NA HIV infections NA AHR;
I00-I99: Diseases of the circulatory system Atherosclerosis I70 MMP12;
J00-J99: Diseases of the respiratory system Asthma J45 MMP12; PDE5A;
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 MMP1;
C00-D49: Neoplasms Ovarian cancer C56 KDR; MMP2;
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE;
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 MMP2;
I00-I99: Diseases of the circulatory system Hypertension I10-I16 PDE5A;
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR;
C00-D49: Neoplasms Lymphoma C81-C86 HIF1A;
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; IGF1R; KDR; AXL;
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 CA4;
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3;
I00-I99: Diseases of the circulatory system Angina pectoris I20 PDE5A;
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 ACHE;
I00-I99: Diseases of the circulatory system Aortic aneurysm I71 MMP12;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR;
C00-D49: Neoplasms Leukemia C90-C95 FLT3;
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR;
C00-D49: Neoplasms Melanoma C43 KDR; TYR;
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR;
L00-L99: Diseases of the skin and subcutaneous tissue Melasma L81.1 TYR;
C00-D49: Neoplasms Thyroid cancer C73 KDR; TSHR;
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3;
C00-D49: Neoplasms Colorectal cancer C18-C21 IGF1R; KDR; FLT3; PDE5A; MMP9;
C00-D49: Neoplasms Colon cancer C50 FLT3;
C00-D49: Neoplasms Metastasis C00-C97 AXL;
C00-D49: Neoplasms AML NA KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 ACHE;
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR;
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR;
C00-D49: Neoplasms Metastatic breast cancer C50 KDR;
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET;
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE;
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET;
C00-D49: Neoplasms Gastric cancer C16 KDR;
NA: NA Hematopoietic stem cell transplantation NA FLT3;
C00-D49: Neoplasms Hematological malignancies C81-C86 AURKB;
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR;
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR;
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R;
C00-D49: Neoplasms Multiple myeloma C90 IGF1R; AHR;
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE;
C00-D49: Neoplasms Advanced breast cancer C50 CYP19A1;
NA: NA Raynaud's disease NA PDE5A;
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2;
C00-D49: Neoplasms Acute myeloid leukemia C92.0 AURKB; FLT3;
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3;
K00-K95: Diseases of the digestive system Ulcerative colitis K51 MMP9;
NA: NA Upper abdominal bloating NA ACHE;
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE;
C00-D49: Neoplasms CLL NA FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 ACHE;
C00-D49: Neoplasms Renal cell carcinoma NA KDR; MMP2;
C00-D49: Neoplasms Renal cancer C64 KDR;
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3;
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 NFKB1; FFAR1;
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MMP12; PDE5A;
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 CA4; ACHE; CA2;
C00-D49: Neoplasms Gliosarcoma NA FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 FLT3;
C00-D49: Neoplasms Prostate cancer C61 FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 TYR;
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 ACHE;
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET;
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 PDE5A;
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE;
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 KDR; PDE5A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Spasm R25.2 PDE5A;
C00-D49: Neoplasms Solid tumours C00-D48 MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; MMP2;
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR;
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2;
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET;
C00-D49: Neoplasms Cancer C00-C96 PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; NFKB1; FLT3; ACHE; HIF1A; MMP9; MMP2;
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA2;
NA: NA Early satiation associated with functional dyspepsia NA ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 MMP1; TYR;
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R;
C00-D49: Neoplasms Breast cancer C50 CDK1; IGF1R; KDR; FLT3; CYP19A1;
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2;
NA: NA Edema NA CA2;
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1;
C00-D49: Neoplasms Bladder cancer C67 CYP19A1;
C00-D49: Neoplasms Biliary cancer C22, C24 KDR;
C00-D49: Neoplasms Non-small-cell lung cancer NA KDR; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 MMP1;
C00-D49: Neoplasms Glioma C71 KDR;
C00-D49: Neoplasms Glioblastoma NA FLT3;
NA: NA GIST NA FLT3;
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 ACHE;
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 ACHE;
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1;
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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